Huntsman Cancer Institute (HCI) investigator Katharine Ullman, PhD, is a professor in the Department of Oncological Sciences at the University of Utah School of Medicine, an adjunct professor in the Department of Biochemistry at the University of Utah, and a member and past leader of the Cell Response and Regulation Program. She served as the Associate Dean of the Graduate School at the University of Utah from 2016-2023.
Ullman and her research team focus on the coordination of cell division, with a particular interest in how disassembly and assembly of nuclear architecture is integrated with other events of cell division. The nucleus harbors a specialized environment, optimized to protect and regulate the cell's DNA. Mis-coordination of cellular remodeling during division leaves the DNA vulnerable to damage and mis-regulation. Elucidating this aspect of cell cycle control opens a new avenue to understanding cell function and how mistakes in division may contribute to tumorigenesis.
Ullman earned a PhD from Stanford University before going to the University of California at San Diego for her postdoctoral studies, which were funded in part by the American Cancer Society. She is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences and a Scholar award from the Leukemia and Lymphoma Society. Ullman is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation.
University of California at San Diego
- LaJoie D, Turkmen AM, Mackay DR, Jensen CC, Aksenova V, Niwa M, Dasso M, Ullman KS (2022). A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents. Mol Biol Cell, 33(13), ar117.
- Wenzel DM, Mackay DR, Skalicky JJ, Paine EL, Miller MS, Ullman KS, Sundquist WI (2022). Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. Elife, 11.
- Strohacker LK, Mackay DR, Whitney MA, Couldwell GC, Sundquist WI, Ullman KS (2021). Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing. Elife, 10.
- Wigington CP, Roy J, Damle NP, Yadav VK, Blikstad C, Resch E, Wong CJ, Mackay DR, Wang JT, Krystkowiak I, Bradburn DA, Tsekitsidou E, Hong SH, Kaderali MA, Xu SL, Stearns T, Gingras AC, Ullman KS, Ivarsson Y, Davey NE, Cyert MS (2020). Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling. Mol Cell, 79(2), 342-358.e12.
- von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A (2020). LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation. Nature, 582(7810), 115-118.
- Sadler JBA, Wenzel DM, Williams LK, Guindo-Martnez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J (2018). A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc Natl Acad Sci U S A, 115(38), E8900-E8908.
- Mackay DR, Howa AC, Werner TL, Ullman KS (2017). Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events. J Cell Sci, 130(19), 3347-3359.
- Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A (2017). LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A, 114(11), E2166-E2175.
- Sundquist WI, Ullman KS (2015). CELL BIOLOGY. An ESCRT to seal the envelope. Science, 348(6241), 1314-5.
- Mackay DR, Ullman KS (2015). ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission. Mol Biol Cell, 26(12), 2217-26.
- Fay MM, Clegg JM, Uchida KA, Powers MA, Ullman KS (2014). Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability. J Biol Chem, 289(25), 17541-52.
- Chow KH, Elgort S, Dasso M, Powers MA, Ullman KS (2014). The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. Mol Biol Cell, 25(1), 160-8.
- Makise M, Mackay DR, Elgort S, Shankaran SS, Adam SA, Ullman KS (2012). The Nup153-Nup50 protein interface and its role in nuclear import. J Biol Chem, 287(46), 38515-22.
- Chow KH, Factor RE, Ullman KS (2012). The nuclear envelope environment and its cancer connections. Nat Rev Cancer, 12(3), 196-209.
- Powers MA, Fay MM, Factor RE, Welm AL, Ullman KS (2011). Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4. Cancer Res, 71(16), 5579-87.
- Mackay DR, Makise M, Ullman KS (2010). Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol, 191(5), 923-31.
- Turkmen AM, Saik NO, Ullman KS (2023). The dynamic nuclear envelope: resilience in health and dysfunction in disease. [Review]. Curr Opin Cell Biol, 85, 102230.