Kristina Lisa Allen-Brady

Kristina Lisa Allen-Brady, PhD, MSPH, MPT

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine , Adjunct - Family & Preventive Medicine

Divisions: Epidemiology , Public Health

Academic Office Information

kristina.allen@utah.edu

Kristina Allen-Brady, PhD, MSPH, MPH, is a Research Assistant Professor at the University of Utah School of Medicine, Division of Genetic Epidemiology. As a genetic epidemiologist, her research interests include pelvic floor disorders, food allergies, autism, cancer, and development of new methods to analyze genetic data.

Allen-Brady has always been interested in research and seeking to understand the underlying causes of chronic diseases. This curiosity has led her to publish her findings in a number of different journals. She reviews frequently for different journals as well as various grant funding agencies.

 Allen-Brady received her PhD, MSPH, and MPT degrees all from the University of Utah. She is currently a member of the American Society of Human Genetics, the International Society of Genetic Epidemiology, a licensed physical therapist in the state of Utah, and serves on the University of Utah Institutional Review Board (IRB).

Education History

Postdoctoral Fellowship University of Utah, Department of Biomedical Informatics
 Postdoctoral Fellow
University of Utah
 Postdoctoral Fellow
Doctoral Training University of Utah
 PhD
University of Utah
 MSPH
Other Training Intermountain Healthcare
University of Utah
 MPT
Other Training Brigham Young University Jerusalem Center
Cambridge University
Undergraduate University of Utah
 BA

Selected Publications

Journal Article

  1. Cohan JN, Horns JJ, Ramsay JM, Huang LC, Allen-Brady K (2023). Diverticulitis Familiality: A Statewide Case-Control Study. J Am Coll Surg.
  2. Reddy CA, Allen-Brady K, Uchida AM, Peterson KA, Hoffman AM, Souza RF, Spechler SJ (2023). Achalasia is Strongly Associated with Eosinophilic Esophagitis and Other Allergic Disorders. Clin Gastroenterol Hepatol.
  3. Cannon-Albright LA, Stevens J, Facelli JC, Teerlink CC, Allen-Brady K, Agarwal N (2023). High-Risk Pedigree Study Identifies LRBA (rs62346982) as a Likely Predisposition Variant for Prostate Cancer. Cancers (Basel), 15(7).
  4. Kluivers KB, Lince SL, Ruiz-Zapata AM, Post WM, Cartwright R, Kerkhof MH, Widomska J, De Witte W, Pecanka J, Kiemeney LA, Vermeulen SH, Goeman JJ, Allen-Brady K, Oosterwijk E, Poelmans G (2023). Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology. Int J Mol Sci, 24(7).
  5. Cannon-Albright LA, Teerlink CC, Stevens J, Facelli JC, Carr SR, Allen-Brady K, Puri S, Bailey-Wilson JE, Musolf AM, Genetic Epidemiology of Lung Cancer Consortium, Akerley W (2023). A rare FGF5 candidate variant (rs112475347) for predisposition to nonsquamous, nonsmall-cell lung cancer. Int J Cancer.
  6. Cohan JN, Horns JJ, Hanson HA, Allen-Brady K, Kieffer MC, Huang LC, Brooke BS (2022). The Association Between Family History and Diverticulitis Recurrence: A Population-Based Study. Dis Colon Rectum, 66(2), 269-277.
  7. Allen-Brady K, Colletier KJ, Woller S, Eliason K, Uchida AM, Ro G, Newman M, Peterson KA (2022). Eosinophilic Gastritis and Enteritis Are Increased in Families With Eosinophilic Esophagitis. Am J Gastroenterol, 118(2), 263-268.
  8. Verrilli L, Johnstone E, Welt C, Allen-Brady K (2022). Primary ovarian insufficiency has strong familiality: results of a multigenerational genealogical study. Fertil Steril, 119(1), 128-134.
  9. Brockmeyer DL, Cheshier SH, Stevens J, Facelli JC, Rowe K, Heiss JD, Musolf A, Viskochil DH, Allen-Brady KL, Cannon-Albright LA (2022). A likely HOXC4 predisposition variant for Chiari malformations. J Neurosurg, 1-9.
  10. Schliep KC, Farland LV, Pollack AZ, Buck Louis G, Stanford JB, Allen-Brady K, Varner MW, Kah K, Peterson CM (2022). Endometriosis diagnosis, staging and typology and adverse pregnancy outcome history. Paediatr Perinat Epidemiol, 36(6), 771-781.
  11. Allen-Brady KL, Christensen MB, Sandberg AD, Pastuszak AW (2022). Significant familial clustering of Peyronie's disease in close and distant relatives. Andrology, 10(7), 1361-1367.
  12. Verrilli L, Johnstone E, Allen-Brady K, Welt C (2021). Shared genetics between nonobstructive azoospermia and primary ovarian insufficiency. F S Rev, 2(3), 204-213.
  13. Allen-Brady K, Chua JWF, Cuffolo R, Koch M, Sorrentino F, Cartwright R (2021). Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse. Int Urogynecol J.
  14. Peterson K, Clayton F, Qeadan F, Gorman D, Robson J, Allen-Brady K, Fang JC (2020). Esophageal Eosinophilia Is Common Among Relatives of Eosinophilic Esophagitis Patients. Clin Gastroenterol Hepatol, 20(5), e957-e963.
  15. Allen-Brady K, Norton PA, Hill AJ, Rowe K, Cannon-Albright LA (2020). Risk of pelvic organ prolapse treatment based on extended family history. Am J Obstet Gynecol, 223(1), 105.e1-105.e8.
  16. Byun J, Peterson CM, Backonja U, Taylor RN, Stanford JB, Allen-Brady KL, Smith KR, Louis GMB, Schliep KC (2020). Adiposity and Endometriosis Severity and Typology. J Minim Invasive Gynecol, 27(7), 1516-1523.
  17. Robson J, Korgenski K, Parsons K, McClain A, Barbagelata C, Allen-Brady K, Patel R, OGorman M, Peterson K, Guthery S (2019). Sensitivity and Specificity of Administrative Medical Coding for Pediatric Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr, 69(2), e49-e53.
  18. Dodson MW, Allen-Brady K, Brown LM, Elliott CG, Cannon-Albright LA (2018). Chronic Thromboembolic Pulmonary Hypertension Cases Cluster in Families. Chest, 155(2), 384-390.
  19. Hemmert R, Schliep KC, Willis S, Peterson CM, Louis GB, Allen-Brady K, Simonsen SE, Stanford JB, Byun J, Smith KR (2018). Modifiable life style factors and risk for incident endometriosis. Paediatr Perinat Epidemiol, 33(1), 19-25.
  20. Allen-Brady K, Rowe K, Cessna M, Lenherr S, Norton P (2018). Significant Linkage Evidence for Interstitial Cystitis/Painful Bladder Syndrome on Chromosome 3. J Urol, 199(1), 172-177.
  21. Allen-Brady K, Firszt R, Fang JC, Wong J, Smith KR, Peterson KA (2017). Population-based familial aggregation of eosinophilic esophagitis suggests a genetic contribution. J Allergy Clin Immunol, 140(4), 1138-1143.
  22. Wirostko BM, Curtin K, Ritch R, Thomas S, Allen-Brady K, Smith KR, Hageman GS, Allingham RR (2016). Risk for Exfoliation Syndrome in Women With Pelvic Organ Prolapse : A Utah Project on Exfoliation Syndrome (UPEXS) Study. JAMA Ophthalmol, 134(11), 1255-1262.
  23. Peterson K, Firszt R, Fang J, Wong J, Smith KR, Allen-Brady K (2016). Risk of autoimmunity in EoE and families - A population-based cohort study. Am J Gastroenterol, 111, 926-32.
  24. Morgan TK, Allen-Brady KL, Monson MA, Leclair CM, Sharp HT, Cannon-Albright LA (2016). Familiality analysis of provoked vestibulodynia treated by vestibulectomy supports genetic predisposition. Am J Obstet Gynecol, 214(5), 609.e1-7.
  25. Richter HE, Whitehead N, Arya L, Ridgeway B, Allen-Brady K, Norton P, Sung V, Shepherd JP, Komesu Y, Gaddis N, Fraser MO, Tan-Kim J, Meikle S, Page GP, Pelvic Floor Disorders Network (2014). Genetic contributions to urgency urinary incontinence in women. J Urol, 193(6), 2020-7.
  26. Allen-Brady K, Cannon-Albright LA, Farnham JM, Norton PA (2014). Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17. Am J Obstet Gynecol, 212(6), 771.e1-7.
  27. Allen-Brady K, Norton PA, Cannon-Albright L (2014). Risk of associated conditions in relatives of subjects with interstitial cystitis. Female Pelvic Med Reconstr Surg, 21(2), 93-8.
  28. Norton PA, Allen-Brady K, Wu J, Egger M, Cannon-Albright L (2014). Clinical characteristics of women with familial pelvic floor disorders. Int Urogynecol J, 26(3), 401-6.
  29. Lee S, Piccolo SR, Allen-Brady K (2014). Robust meta-analysis shows that glioma transcriptional subtyping complements traditional approaches. Cell Oncol (Dordr), 37(5), 317-29.
  30. Wu JM, Ward RM, Allen-Brady KL, Edwards TL, Norton PA, Hartmann KE, Hauser ER, Velez Edwards DR (2013). Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. Am J Obstet Gynecol, 208(5), 360-5.
  31. Norton PA, Allen-Brady K, Cannon-Albright LA (2013). The familiality of pelvic organ prolapse in the Utah Population Database. Int Urogynecol J, 24(3), 413-8.
  32. Kim SH, Lee S, Piccolo SR, Allen-Brady K, Park EJ, Chun JN, Kim TW, Cho NH, Kim IG, So I, Jeon JH (2012). Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1. Biochem Biophys Res Commun, 422(3), 436-41.
  33. Teerlink C, Farnham J, Allen-Brady K, Camp NJ, Thomas A, Leachman S, Cannon-Albright L (2012). A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q. Hum Genet, 131(1), 77-85.
  34. Allen-Brady K, Cannon-Albright L, Farnham JM, Teerlink C, Vierhout ME, van Kempen LCL, Kluivers KB, Norton PA (2011). Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. Obstet Gynecol, 118(6), 1345-1353.
  35. Allen-Brady K, Farnham J, Cannon-Albright L (2011). Strategies for selection of subjects for sequencing after detection of a linkage peak. BMC Proc, 5 Suppl 9, S77.
  36. Allen-Brady K, Cai G, Cannon D, Robison R, McMahon WM, Coon H, Buxbaum JD (2011). No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set. Autism Res, 4(4), 293-6.
  37. Lin WY, Camp NJ, Cannon-Albright LA, Allen-Brady K, Balasubramanian S, Reed MW, Hopper JL, Apicella C, Giles GG, Southey MC, Milne RL, Arias-Prez JI, Menndez-Rodrguez P, Bentez J, Grundmann M, Dubrowinskaja N, Park-Simon TW, Drk T, Garcia-Closas M, Figueroa J, Sherman M, Lissowska J, Easton DF, Dunning AM, Rajaraman P, Sigurdson AJ, Doody MM, Linet MS, Pharoah PD, Schmidt MK, Cox A (2011). A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet, 48(7), 477-84.
  38. Allen-Brady K, Farnham J, Cannon-Albright LA (2011). Strategies for selection of subjects for sequencing after detection of a linkage peak. BMC Proc, 5(Suppl 9), S77.
  39. Allen-Brady K, Camp NJ (2011). Genetic distance and markers used in linkage mapping. Methods Mol Biol, 713, 43-53.
  40. Krikov S, Price RC, Matney SA, Allen-Brady K, Facelli JC (2010). Enabling GeneHunter as a grid service: a case study for implementing analytical services in biomedical grids. Methods Inf Med, 50(4), 364-71.
  41. Allen-Brady K, Robison R, Cannon D, Varvil T, Villalobos M, Pingree C, Leppert MF, Miller J, McMahon WM, Coon H (2010). Genome-wide linkage in Utah autism pedigrees. Mol Psychiatry, 15(10), 1006-15.
  42. Coon H, Villalobos ME, Robison RJ, Camp NJ, Cannon DS, Allen-Brady K, Miller JS, McMahon WM (2010). Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees. Mol Autism, 1(1), 8.
  43. Allen-Brady K, Cannon D, Robison R, McMahon WM, Coon H (2010). A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families. Autism Res, 3(2), 47-52.
  44. Cannon DS, Miller JS, Robison RJ, Villalobos ME, Wahmhoff NK, Allen-Brady K, McMahon WM, Coon H (2010). Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders. Mol Autism, 1(1), 3.
  45. Piccolo SR, Abo RP, Allen-Brady K, Camp NJ, Knight S, Anderson JL, Horne BD (2009). Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study. BMC Proc, 3 Suppl 7, S46.
  46. Allen-Brady K, Miller J, Matsunami N, Stevens J, Block H, Farley M, Krasny L, Pingree C, Lainhart J, Leppert M, McMahon WM, Coon H (2009). A high-density SNP genome-wide linkage scan in a large autism extended pedigree. Mol Psychiatry, 14(6), 590-600.
  47. Allen-Brady K, Farnham JM, Camp NJ, Karlins E, Ostrander EA, Cannon-Albright LA (2009). No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees. BMC Res Notes, 2, 94.
  48. Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL, Humphreys MK, Dunning AM, Morrison J, Giles GG, Severi G, Baglietto L, English DR, Couch FJ, Olson JE, Wang X, Chang-Claude J, Flesch-Janys D, Abbas S, Salazar R, Mannermaa A, Kataja V, Kosma VM, Lindblom A, Margolin S, Heikkinen T, Kmpjrvi K, Aaltonen K, Nevanlinna H, Bogdanova N, Coinac I, Schrmann P, Drk T, Bartram CR, Schmutzler RK, Tchatchou S, Burwinkel B, Brauch H, Torres D, Hamann U, Justenhoven C, Ribas G, Arias JI, Benitez J, Bojesen SE, Nordestgaard BG, Flyger HL, Peto J, Fletcher O, Johnson N, Dos Santos Silva I, Fasching PA, Beckmann MW, Strick R, Ekici AB, Broeks A, Schmidt MK, van Leeuwen FE, Vant Veer LJ, Southey MC, Hopper JL, Apicella C, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Kristensen V, Grenaker Alnaes G, Hunter DJ, Kraft P, Cox DG, Hankinson SE, Seynaeve C, Vreeswijk MP, Tollenaar RA, Devilee P, Chanock S, Lissowska J, Brinton L, Peplonska B, Czene K, Hall P, Li Y, Liu J, Balasubramanian S, Rafii S, Reed MW, Pooley KA, Conroy D, Baynes C, Kang D, Yoo KY, Noh DY, Ahn SH, Shen CY, Wang HC, Yu JC, Wu PE, Anton-Culver H, Ziogoas A, Egan K, Newcomb P, Titus-Ernstoff L, Trentham Dietz A, Sigurdson AJ, Alexander BH, Bhatti P, Allen-Brady K, Cannon-Albright LA, Wong J, Australian Ovarian Cancer Study Group, Chenevix-Trench G, Spurdle AB, Beesley J, Pharoah PD, Easton DF, Garcia-Closas M, Breast Cancer Association Consortium (2009). Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev, 18(5), 1610-6.
  49. Allen-Brady K, Norton PA, Farnham JM, Teerlink C, Cannon-Albright LA (2009). Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21. Am J Hum Genet, 84(5), 678-82.
  50. Shephard ND, Abo R, Rigas SH, Frank B, Lin WY, Brock IW, Shippen A, Balasubramanian SP, Reed MW, Bartram CR, Meindl A, Schmutzler RK, Engel C, Burwinkel B, Cannon-Albright LA, Allen-Brady K, Camp NJ, Cox A (2009). A breast cancer risk haplotype in the caspase-8 gene. Cancer Res, 69(7), 2724-8.
  51. Krikov S, Price RC, Allen-Brady K, Cannon-Albright L, Facelli JC (2008). Enabling GeneHunter as a grid service: a case study for implementing analytical services for biomedical grids. AMIA Annu Symp Proc, 1014.
  52. Brune CW, Korvatska E, Allen-Brady K, Cook EH Jr, Dawson G, Devlin B, Estes A, Hennelly M, Hyman SL, McMahon WM, Munson J, Rodier PM, Schellenberg GD, Stodgell CJ, Coon H (2008). Heterogeneous association between engrailed-2 and autism in the CPEA network. Am J Med Genet B Neuropsychiatr Genet, 147B(2), 187-93.
  53. Thomas A, Camp NJ, Farnham JM, Allen-Brady K, Cannon-Albright LA (2008). Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays. Ann Hum Genet, 72(Pt 2), 279-87.
  54. Allen-Brady K, Miller J, Matsunami N, Stevens J, Block H, Farley M, Krasny L, Pingree C, Lainhart J, Leppert M, McMahon WM, Coon H (2008). The Value of Large Pedigrees for Chromosome Mapping in the Era of Dense Marker Sets. Int J Med Biol Front, 14(1/2), 9-24.
  55. Curtin K, Wong J, Allen-Brady K, Camp NJ (2007). PedGenie: meta genetic association testing in mixed family and case-control designs. BMC Bioinformatics, 8, 448.
  56. Easton DF, Deffenbaugh AM, Pruss D, Frye C, Wenstrup RJ, Allen-Brady K, Tavtigian SV, Monteiro AN, Iversen ES, Couch FJ, Goldgar DE (2007). A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes. Am J Hum Genet, 81(5), 873-83.
  57. Camp NJ, Farnham JM, Allen-Brady K, Cannon-Albright LA (2007). Statistical recombinant mapping in extended high-risk Utah pedigrees narrows the 8q24 prostate cancer locus to 2.0 Mb. Prostate, 67(13), 1456-64.
  58. Allen-Brady K (2007). Genetic polymorphisms and metastatic breast cancer survival. Future Oncol, 3(2), 155-8.
  59. Dupuis J, Albers K, Allen-Brady K, Cho K, Elston RC, Kappen HJ, Tang H, Thomas A, Thomson G, Tsung E, Yang Q, Zhang W, Zhao K, Zheng G, Ziegler JT (2007). Effect of linkage disequilibrium between markers in linkage and association analyses. Genet Epidemiol, 31 Suppl 1, S139-48.
  60. Allen-Brady K, Horne BD, Malhotra A, Teerlink C, Camp NJ, Thomas A (2007). Analysis of high-density single-nucleotide polymorphism data: three novel methods that control for linkage disequilibrium between markers in a linkage analysis. BMC Proc, 1 Suppl 1, S160.
  61. Curtin K, Wong J, Allen-Brady K, Camp NJ (2007). Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1. BMC Proc, 1 Suppl 1, S12.
  62. Allen BG, Allen-Brady K, Weeks DL (2006). Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev, 123(10), 719-29.
  63. Allen-Brady K, Cannon-Albright LA, Neuhausen SL, Camp NJ (2006). A role for XRCC4 in age at diagnosis and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 15(7), 1306-10.
  64. Allen-Brady K, Wong J, Camp NJ (2006). PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. BMC Bioinformatics, 7, 209.
  65. Allen-Brady K, Camp NJ, Ward JH, Cannon-Albright LA (2005). Lobular breast cancer: excess familiality observed in the Utah Population Database. Int J Cancer, 117(4), 655-61.
  66. Allen-Brady K, Camp NJ (2005). Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes. BMC Cancer, 5, 99.
  67. Allen-Brady K, Farnham JM, Weiler J, Camp NJ (2003). A cautionary note on the appropriateness of using a linkage resource for an association study. BMC Genet, 4 Suppl 1, S89.
  68. Beddhu S, Allen-Brady K, Cheung AK, Horne BD, Bair T, Muhlestein JB, Anderson JL (2002). Impact of renal failure on the risk of myocardial infarction and death. Kidney Int, 62(5), 1776-83.
  69. Allen KL, Miskulin D, Yan G, Dwyer JT, Frydrych A, Leung J, Poole D, and the Hemodialysis HEMO Study Group (2002). Association of nutritional and behavioral markers on the physical and mental health status in prevalent hemodialysis patients from the HEMO Study. J Ren Nutr, 12(3), 160-9.
  70. Allen KL, Gappmaier E (2001). Exercise Habits and Attitudes of Patients Undergoing Hemodialysis. Cardiopulm Phys Ther J, 12(1), 11-16.

Review

  1. Davies M, Jurynec MJ, Gomez-Alvarado F, Hu D, Feeley SE, Allen-Brady K, Tashjian RZ, Feeley BT (2022). Current cellular and molecular biology techniques for the orthopedic surgeon-scientist. [Review]. J Shoulder Elbow Surg, 32(1), e11-e22.
  2. Allen-Brady K, Bortolini MAT, Damaser MS (2022). Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review. [Review]. Int Urogynecol J, 33(7), 1765-1788.
  3. Deprest JA, Cartwright R, Dietz HP, Brito LGO, Koch M, Allen-Brady K, Manonai J, Weintraub AY, Chua JWF, Cuffolo R, Sorrentino F, Cattani L, Decoene J, Page AS, Weeg N, Varella Pereira GM, Mori da Cunha de Carvalho MGMC, Mackova K, Hympanova LH, Moalli P, Shynlova O, Alperin M, Bortolini MAT (2022). International Urogynecological Consultation (IUC): pathophysiology of pelvic organ prolapse (POP). [Review]. Int Urogynecol J, 33(7), 1699-1710.

Letter

  1. May Maestas M, Perry KD, Smith K, Firszt R, Allen-Brady K, Robson J, Joy E, Peterson K (2019). Food impactions in Eosinophilic esophagitis and acute exposures to fine particulate pollution. [Letter to the editor]. Allergy, 74(12), 2529-2530.