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In Kyoon Lyoo

In Kyoon Lyoo, MD, PhD, MMS

Languages spoken: English

Academic Information

Departments Primary - Psychiatry

Divisions: Adult Psychiatry

Academic Office Information

Education History

Graduate Training Harvard University-Massacusetts Institute of Technology
Seoul National University Graduate School
Professional Medical Seoul National University College of Medicine

Selected Publications

Journal Article

  1. Lee S, Kim J, Kim BJ, Kim RY, Ha E, Kim S, Hong SN, Lyoo IK, Kim DW (2022). Gray matter volume reduction in the emotional brain networks in adults with anosmia. J Neurosci Res, 100(6), 1321-1330.
  2. Joo Y, Lee S, Hwang J, Kim J, Cheon YH, Lee H, Kim S, Yurgelun-Todd DA, Renshaw PF, Yoon S, Lyoo IK (2022). Differential alterations in brain structural network organization during addiction between adolescents and adults. Psychol Med, 1-12.
  3. Ma J, Lyoo IK, Renshaw PF, Yurgelun-Todd DA (2022). Effect of cannabinoids on brain metabolites: A review of animal and human studies. Exp Clin Psychopharmacol.
  4. Jeong H, Yoon S, Sung YH, Kim J, Lyoo IK, Yurgelun-Todd DA, Renshaw PF (2021). Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res, 143, 215-221.
  5. Lee S, Kim TD, Kim RY, Joo Y, Chung YA, Lim SM, Lyoo IK, Kim J, Yoon S (2021). Hippocampal subregional alterations and verbal fluency in the early stage of type 2 diabetes mellitus. Eur J Neurosci, 54(10), 7550-7559.
  6. Ma J, Hong G, Ha E, Hong H, Kim J, Joo Y, Yoon S, Lyoo IK, Kim J (2021). Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress. Neurol Sci, 42(10), 4131-4138.
  7. Kim J, Yoon S, Lee S, Hong H, Ha E, Joo Y, Lee EH, Lyoo IK (2020). A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms. Nat Commun, 11(1), 1-12.
  8. Jeong H, Park S, Dager SR, Lim SM, Lee SL, Hong H, Ma J, Ha E, Hong YS, Kang I, Lee EH, Yoon S, Kim JE, Kim J, Lyoo IK (2019). Altered functional connectivity in the fear network of firefighters with repeated traumatic stress. Br J Psychiatry, 214(6), 347-53.
  9. Woo J, Kim JE, Im JJ, Lee J, Jeong HS, Park S, Jung SY, An H, Yoon S, Lim SM, Lee S, Ma J, Shin EY, Han YE, Kim B, Lee EH, Feng L, Chun H, Yoon BE, Kang I, Dager SR, Lyoo IK, Lee CJ (2018). Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning. Mol Psychiatry, 23(4), 1021-30.
  10. Yoon SJ, Cho HB, Kim JY, Lee DW, Kim GH, Hong YS, Moon SH, Park SW, Lee SH, Lee SJ, Bae SJ, Simonson DC, Lyoo IK (2017). Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus. Diabetologia, 60(7), 1207-17.
  11. Yoon S, Kim JE, Hwang J, Kang I, Jeon S, Im JJ, Kim BR, Lee S, Kim GH, Rhim H, Lim SM, Lyoo IK (2017). Recovery from posttraumatic stress requires dynamic and sequential shifts in amygdalar connectivities. Neuropsychopharmacology, 42(2), 454-61.
  12. Yoon S, Kim JE, Hwang J, Kim TS, Kan HJ, Namgung E, Ban S, Oh S, Yang J, Renshaw PF, Lyoo IK (2016). Effects of creatine monohydrate augmentation on brain metabolic and network outcome measures in women with major depressive disorder. Biol Psychiatry, 80(6), 439-47.
  13. Lyoo IK, Yoon S, Kim TS, Lim SM, Choi Y, Kim JE, Hwang J, Jeong HS, Cho HB, Chung YA, Renshaw PF (2015). Predisposition to and effects of methamphetamine use on the adolescent brain. Mol Psychiatry, 20(12), 1516-24.
  14. Lyoo IK, Yoon SJ, Jacobson AM, Hwang J, Musen G, Kim JE, Simonson DC, Bae S, Bolo N, Kim DJ, Weinger K, Lee JH, Ryan CM, Renshaw PF (2012). Prefrontal cortical deficits in type I diabetes mellitus: Brain correlates of comorbid depression. Arch Gen Psychiatry, 69(12), 1267-76.
  15. Lyoo IK, Yoon SJ, Kim TS, Hwang J, Kim JE, Won W, Bae S, Renshaw PF (2012). A randomized, double-blind, placebo-controlled oral creatine monohydrate augmentation trial for enhanced response to selective serotonin reuptake inhibitor in women with major depressive disorder. Am J Psychiatry, 169, 937-45.
  16. Lyoo IK, Kim JE, Yoon SJ, Hwang J, Bae S, Kim DJ (2011). The neurobiological role of the dorsolateral prefrontal cortex in recovery from trauma: longitudinal brain imaging study among survivors of the South Korean subway disaster. Arch Gen Psychiatry, 68(7), 701-13.
  17. Kim JE, Lyoo IK, Estes AM, Renshaw PF, Shaw DW, Friedman SD, Kim DJ, Yoon SJ, Hwang J, Dager SR (2010). Laterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder. Arch Gen Psychiatry, 67(11), 1187-97.
  18. Mollica RF, Lyoo IK, Chernoff MC, Bui HX, Lavelle J, Yoon SJ, Kim JE, Renshaw PF (2009). Brain structural abnormalities and mental health sequelae in South Vietnamese ex-political detainees who survived traumatic head injury and torture. Arch Gen Psychiatry.
  19. Lyoo IK, Yoon SJ, Musen G, Simonson DC, Weinger K, Bolo N, Ryan CM, Kim JE, Renshaw PF, Jacobson AM (2009). Altered prefrontal glutamate-glutamine-gamma-aminobutyric acid levels and relation to lowcognitive performance and depressive symptoms in type 1 diabetes mellitus. Arch Gen Psychiatry, 66(8), 878-87.
  20. Hwang J, Lyoo IK, Dager SR, Friedman SD, Oh JS, Lee JY, Kim SJ, Dunner DL, Renshaw PF (2006). Basal ganglia shape alterations in bipolar disorder. Am J Psychiatry, 163(2), 276-85.
  21. Lyoo IK, Kim MJ, Stoll AL, Demopulos CM, Parow AM, Dager SR, Friedman SD, Dunner DL, Renshaw PF (2004). Frontal lobe gray matter density decreases in bipolar I disorder. Biol Psychiatry.
  22. Lyoo IK, Kwon JS, Lee SJ, Han MH, Chang CG, Seo CS, Lee SI, Renshaw PF (2002). Decrease in genu of the corpus callosum in medication-naïve, early-onset dysthymia and depressive personality disorder. Biol Psychiatry.
  23. Kwon JS, Kim YM, Chang CG, Park BJ, Kim L, Yoon DJ, Han WS, Lee HJ, Lyoo IK (2000). Three-year follow-up of women with the sole diagnosis of depressive personality disorder: subsequent development of dysthymia and major depression. Am J Psychiatry, 157(12), 1966-72.
  24. Lyoo IK, Noam GG, Lee CK, Lee HK, Kennedy BP, Renshaw PF (1996). The corpus callosum and lateral ventricles in children with attention-deficit hyperactivity disorder: a brain magnetic resonance imaging study. Biol Psychiatry, 40(10), 1060-3.


  1. Lyoo IK, Renshaw PF (2002). Magnetic resonance spectroscopy: current and future applications in psychiatric research. [Review]. Biol Psychiatry, 51(3), 195-207.


  1. Woo J, Kim JE, Im JJ, Lee J, Jeong HS, Park S, Jung SY, An H, Yoon S, Lim SM, Lee S, Ma J, Shin EY, Han YE, Kim B, Lee EH, Feng L, Chun H, Yoon BE, Kang I, Dager SR, Lyoo IK, Lee CJ (2021). Correction: Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning. Mol Psychiatry (26(12), p. 7853). England.

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