Mario R. Capecchi

Mario R. Capecchi, PhD

Languages spoken: English

Academic Information

Departments Primary - Human Genetics , Adjunct - Oncological Sciences

Mario Capecchi, PhD, is a professor in the Department of Human Genetics and adjunct professor in the Department of Oncological Sciences at the University of Utah. He is an active participant in the Sarcoma Services Program at Huntsman Cancer Institute, and member of the Nuclear Control of Cell Growth and Differentiation Program.



Capecchi studies cancer models (experimental versions of cancer) recreated in mice. In 2007, Capecchi was awarded the Nobel Prize in Medicine/Physiology for his contributions to the development of "mouse knockout technology." He has a particular interest in the study of sarcomas and focuses on unraveling the function of Hox, associated with cancer.

Capecchi received a bachelor's degree from Antioch College, Ohio, and a PhD from Harvard University, Massachusetts.

Education History

Undergraduate Antioch College
 BS
Doctoral Training Harvard University
 PhD

Selected Publications

Journal Article

  1. Makki N, Capecchi M (2012). Cardiovascular defects in a mouse model of HOXA1 syndrome. Human molecular genetics, 21(1), 26-31.
  2. Haldar M, Hedberg ML, Hockin MF, Capecchi M (2009). A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer research, 69(8), 3657-64.
  3. Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi M (2010). Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell, 141(5), 775-85.
  4. Makki N, Capecchi M (2010). Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Developmental biology, 341(2), 499-509.
  5. Makki N, Capecchi M (2011). Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Developmental biology, 357(2), 295-304.
  6. Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi M (2013). Toward an understanding of the short bone phenotype associated with multiple osteochondromas. Journal of orthopaedic research, 31(4), 651-7.
  7. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi M (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.
  8. Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi M (2016). The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene, 35(38), 5021-32.
  9. Sangiorgi E, Capecchi M (2009). Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 106(17), 7101-6.
  10. Angus-Hill ML, Elbert KM, Hidalgo J, Capecchi M (2011). T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 108(12), 4914-9.
  11. Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi M (2013). Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer cell, 23(2), 215-27.
  12. Pozner A, Xu B, Palumbos S, Gee JM, Tvrdik P, Capecchi M (2015). Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Frontiers in molecular neuroscience, 8, 12.
  13. Capecchi M (2022). The origin and evolution of gene targeting. Developmental biology, 481, 179-187.
  14. Van Deren DA, De S, Xu B, Eschenbacher KM, Zhang S, Capecchi M (2022). Defining the Hoxb8 cell lineage during murine definitive hematopoiesis. Development (Cambridge, England), 149(8),
  15. Tränkner D, Boulet A, Peden E, Focht R, Van Deren D, Capecchi (2019). A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion. Cell reports, 29(4), 791-799.e3.
  16. Nagarajan N, Jones BW, West PJ, Marc RE, Capecchi M (2018). Corticostriatal circuit defects in Hoxb8 mutant mice. Molecular psychiatry, 23(9), 1868-1877.

Letter

  1. Haldar M, Karan G, Watanabe S, Guenther S, Braun T, Capecchi M (2014). Response: Contributions of the Myf5-independent lineage to myogenesis. Developmental cell, 31(5), 539-41.

Other

  1. Tränkner D, Boulet A, Peden E, Focht R, Van Deren D, Capecchi (2019). A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion. Cell reports, 29(4), 791-799.e3.
  2. Nam HS, Capecchi M (2020). Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life. Neural development, 15(1), 3.
  3. Nagarajan N, Jones BW, West PJ, Marc RE, Capecchi M (2018). Corticostriatal circuit defects in Hoxb8 mutant mice. Molecular psychiatry, 23(9), 1868-1877.
  4. Carroll LS, Capecchi M (2015). Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/ß-catenin signaling. Development (Cambridge, England), 142(23), 4056-67.
  5. Wu S, Wu Y, Zhang X, Capecchi M (2014). Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10678-83.
  6. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi M (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.