Mark Metzstein

Mark Metzstein, PhD

Languages spoken: English

Academic Information

Departments Primary - Human Genetics

Academic Office Information

markm@genetics.utah.edu

Research Interests

  • Drosophila
  • Drosophila melanogaster
  • Cytoplasmic Vesicles
  • Transport Vesicles
  • Drosophila tracheal development
  • Nonsense mediated m RNA decay

Education History

Postdoctoral Fellowship Stanford University School of Medicine, Department of Biochemistry, Laboratory of Dr. Mark A Krasnow
 Postdoctoral Fellow
Massachusetts Institute of Technology, Department of Biology
 Postdoctoral Training
Doctoral Training Massachusetts Institute of Technology, Department of Biology
 PhD
Robinson College, University of Cambridge
 BA

Selected Publications

Journal Article

  1. Nelson JO, Frster D, Frizzell KA, Luschnig S, Metzstein MM (2018). Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Genetics, 209(4), 1073-1084.
  2. Rosa JB, Metzstein MM, Ghabrial AS (2018). An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity. PLoS Genet, 14(1), e1007146.
  3. Nelson JO, Metzstein MM (2017). Reactivation Assay to Identify Direct Targets of the Nonsense-Mediated mRNA Decay Pathway in Drosophila. Methods Mol Biol, 1720, 205-211.
  4. Nelson JO, Moore KA, Chapin A, Hollien J, Metzstein MM (2016). Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability. Elife, 5.
  5. Nikolova LS, Metzstein MM (2015). Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Development, 142, 3964-3973.
  6. Jones TA, Nikolova LS, Schjelderup A, Metzstein MM (2014). Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells. Dev Biol, 390(1), 41-50.
  7. Chapin A, Hu H, Rynearson SG, Hollien J, Yandell M, Metzstein MM (2014). In Vivo Determination of Direct Targets of the Nonsense Mediated Decay Pathway in Drosophila. G3 (Bethesda), 4, 485-496.
  8. Jones TA, Metzstein MM (2013). Examination of Drosophila Larval Tracheal Terminal Cells by Light Microscopy. J Vis Exp, 77, e50496.
  9. Frizzell KA, Rynearson SG, Metzstein MM (2012). Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA, 18, 1475-1486.
  10. Ruiz OE, Nikolova LS, Metzstein MM (2012). Drosophila Zpr1 (Zinc Finger Protein 1) Is Required Downstream of Both EGFR And FGFR Signaling in Tracheal Subcellular Lumen Formation. PLoS One, 7(9), e45649.
  11. Jones TA, Metzstein MM (2011). A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. Genetics, 189, 153-164.
  12. Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest, 121(5), 1871-81.
  13. A Ashleigh Long, Cecon Mahapatra, E A Woodruff III, Jeff Rohrbough, Hung-Tat Leung, S Shino, L An, R W Doerge, Mark M Metzstein, William L Pak, Kendal Broadie (2010). The nonsense-mediated decay pathway is critical for maintaining synapse architecture and synaptic vesicle cycle efficacy. J Cell Sci, 123(19), 3303-3315.
  14. Metzstein MM, Krasnow M (2006). Functions of the Nonsense-Mediated RNA Decay Pathway in Drosophila Development. PLoS Genet, 2(12), 180.

Review

  1. Ghabrial A, Luschnig S, Metzstein MM, Krasnow MA (2003). Branching morphogenesis of the Drosophila tracheal system. [Review]. Annu Rev Cell Dev Biol, 19, 623-47.