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Mark Metzstein, PhD

Languages spoken: English

Academic Information

Departments Primary - Human Genetics

Education History

Undergraduate Robinson College, University of Cambridge
 BA
Doctoral Training Massachusetts Institute of Technology, Department of Biology
 PhD
Postdoctoral Training Massachusetts Institute of Technology, Department of Biology
 Postdoctoral Training
Postdoctoral Fellowship Stanford University School of Medicine, Department of Biochemistry, Laboratory of Dr. Mark A Krasnow
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Jones TA, Nikolova LS, Schjelderup A, Metzstein M (2014). Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells. Developmental biology, 390(1), 41-50.
  2. Nikolova LS, Metzstein M (2015). Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Development (Cambridge, England), 142, 3964-3973.
  3. Jones TA, Metzstein M (2011). A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. Genetics, 189, 153-164.
  4. A. Ashleigh Long, Cecon Mahapatra, E. A. Woodruff III, Jeff Rohrbough,Hung-Tat Leung,S. Shino, L. An, R. W. Doerge, Mark M. Metzstein,William L. Pak, Kendal Broadi (2010). The nonsense-mediated decay pathway is critical for maintaining synapse architecture and synaptic vesicle cycle efficacy. Journal of cell science, 123(19), 3303-3315.
  5. Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. The Journal of clinical investigation, 121(5), 1871-81.
  6. Frizzell KA, Rynearson SG, Metzstein M (2012). Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA (New York, N.Y.), 18, 1475-1486.
  7. Metzstein MM, Krasnow (2006). Functions of the Nonsense-Mediated RNA Decay Pathway in Drosophila Development. PLoS genetics, 2(12), 180.
  8. Ruiz OE, Nikolova LS, Metzstein M (2012). Drosophila Zpr1 (Zinc Finger Protein 1) Is Required Downstream of Both EGFR And FGFR Signaling in Tracheal Subcellular Lumen Formation. PloS one, 7(9), e45649. (Read full article)
  9. Jones TA, Metzstein M (2013). Examination of Drosophila Larval Tracheal Terminal Cells by Light Microscopy. Journal of visualized experiments, 77, e50496.
  10. Chapin A, Hu H, Rynearson SG, Hollien J, Yandell M, Metzstein MM (2014). In Vivo Determination of Direct Targets of the Nonsense Mediated Decay Pathway in Drosophila. G3 (Bethesda, Md.), 4, 485-496.
  11. Nelson JO, Förster D, Frizzell KA, Luschnig S, Metzstein M (2018). Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Genetics, 209(4), 1073-1084. (Read full article)
  12. Rosa JB, Metzstein MM, Ghabrial A (2018). An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity. PLoS genetics, 14(1), e1007146. (Read full article)
  13. Nelson JO, Moore KA, Chapin A, Hollien J, Metzstein M (2016). Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability. eLife, 5, (Read full article)
  14. Nelson JO, Metzstein M (2018). Reactivation Assay to Identify Direct Targets of the Nonsense-Mediated mRNA Decay Pathway in Drosophila. Methods in molecular biology (Clifton, N.J.), 1720, 205-211. (Read full article)

Review

  1. Ghabrial A, Luschnig S, Metzstein MM, Krasnow M (2003). Branching morphogenesis of the Drosophila tracheal system. Annual review of cell and developmental biology, 19, 623-47. (Read full article)