Mark N. Fluchel

Mark N. Fluchel, MD

Languages spoken: English, Spanish

Academic Information

Departments Adjunct - Pediatrics

Lab

Board Certification

  • American Board of Pediatrics (Sub: Pediatric Hematology-Oncology)

Dr. Fluchel received his medical degree from Vanderbilt University School of Medicine, completed his Pediatric residency at Seattle Children´s Hospital, and his Pediatric Hematology and Oncology Fellowship at the Children’s Hospital of Philadelphia.

He joined the faculty of the University of Utah in 2007, where he is currently an Associate Professor of Pediatrics in the Division of Pediatric Hematology and Oncology

Dr. Fluchel’s clinical interests include the treatment of all pediatric cancers and hematologic disorders, with an emphasis on neuroblastoma, hepatoblastoma, nephroblastoma, germ cell tumors, and the histiocytic disorders.

His primary research focuses on assessing the burden of care for families of pediatric oncology patients and developing methods to better serve patients from rural, immigrant and underserved communities. His research also includes studies designed to help physicians better understand the histiocytic disorders of Langerhans Cell Histiocytosis (LCH) and Hemophagocytic Lymphohistiocytosis (HLH).

Education History

Undergraduate Miami University
 BA
Professional Medical Vanderbilt University
 MD
Internship Seattle Children's Hospital
 Intern
Residency Seattle Children's Hospital
 Resident
Fellowship Children's Hospital of Philadelphia
 Fellow
Certification University of Utah
 Certificate
Graduate Training University of Utah
 MSCI

Selected Publications

Journal Article

  1. Tellen D. Bennett, MD, MS1, Mark Fluchel, MD2, Aimee O. Hersh, MD3,Kristen N. Hayward, MD, MS4, Adam L. Hersh, MD, PhD5, Thomas V. Brogan, MD6, Rajendu Srivastava, MD, MPH7, Bryan L. Stone, MD, MSCI7, E. Kent Korgenski, MT, MS8, Michael B. Mundorff, MBA, MHSA9, T. Charles Casper, PhD1, and Susan L. Bratton, MD, MPH1 (8/8/2012). Macrophage Activation Syndrome in Children with Systemic Lupus Erythematosus and Juvenile Idiopathic Arthritis. Arthritis Rheum.
  2. Staddon JH, Smock KJ, Schiffman JD, Fluchel MN, Engel ME, Weyrich AS, Campbell RA (2015). Pegasparaginase treatment alters thrombin generation by modulating the protein C and S system in acute lymphoblastic leukaemia/lymphoma. Blood Coagul Fibrinolysis, 26(7), 840-3. (Read full article)
  3. Eli L. Diamond, Omar Abdel-Wahab, Lynn Brody, Maria Arcila, Christian Bowers, Mark Fluchel (08/18/2016). Anakinra as efficacious therapy for intracranial Erdheim-Chester disease. Blood.
  4. Wu YP, Stenehjem DD, Linder LA, Yu B, Parsons BG, Mooney R, Fluchel MN (2018). Adherence to Oral Medications During Maintenance Therapy Among Children and Adolescents With Acute Lymphoblastic Leukemia: A Medication Refill Analysis. J Pediatr Oncol Nurs, 35(2), 86-93. (Read full article)
  5. Nagelhout ES, Linder L, Austin T, Parsons BG, Scott B, Gardner E, Spraker-Perlman H, Verma A, Fluchel M, Wu YP (12/5/2018). Social media use among parents and caregivers of a child with cancer. J Pediatr Oncol Nurs, 35(6), 399-405.
  6. Kirchhoff AC, Fluchel MN, Wright J, Ying J, Sweeney C, Bodson J, Stroup AM, Smith KR, Fraser A, Kinney AY (2014). Risk of hospitalization for survivors of childhood and adolescent cancer. Cancer Epidemiol Biomarkers Prev, 23(7), 1280-9. (Read full article)
  7. Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML (2015). The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet, 47(11), 1326-1333. (Read full article)
  8. Kirchhoff AC, Lyles CR, Fluchel M, Wright J, Leisenring W (2012). Limitations in health care access and utilization among long-term survivors of adolescent and young adult cancer. Cancer, 118(23), 5964-72. (Read full article)
  9. Joemy M Ramsay, Judy Y. Ou, Mark N. Fluchel, Anne C. Kirchhoff (Published). Respiratory Emergency Department Utilization from Diagnosis through Survivorship in Children, Adolescents, and Young Adults with Cancer. Cancer, 124(19), 3924-3933.
  10. Castillo L, Fluchel M, Dabezies A, Pieri D, Brockhorst N, Barr R (2001). Childhood cancer in Uruguay: 1992-1994. Incidence and mortality. Med Pediatr Oncol, 37(4), 400-4. (Read full article)
  11. Deneau M, Wallentine J, Guthery S, O'Gorman M, Bohnsack J, Fluchel M, Bezzant J, Pohl JF (09/13/10). Natural killer cell lymphoma in a pediatric patient with inflammatory bowel disease. Pediatrics, 126(4), e977-81.
  12. Sapna Kaul, Mark Fluchel, Holly Spraker-Perlman, Christopher Parmeter, Anne Kirchhoff (04/28/2016). Healthcare Experiences of Long-Term Survivors of Adolescent and Young Adult Cancer. Support Care Cancer, 24(6).
  13. Kirchhoff AC1, Montenegro RE, Warner EL, Wright J, Fluchel M, Stroup AM, Park ER, Kinney AY (06/15/2014). Childhood cancer survivors' primary care and follow-up experiences. Support Care Cancer, 22(6).
  14. Gina E. Nam, Echo L. Warner, Deborah K. Morreall, Anne C. Kirchoff, Anita Y. Kinney, Mark Fluchel (03/01/2016). Understanding Psychological Distress Among Pediatric Cancer Caregivers. Support Care Cancer.
  15. Lestini BJ, Goldsmith KC, Fluchel MN, Liu X, Chen NL, Goyal B, Pawel BR, Hogarty MD (2009). Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. Cancer Biol Ther, 8(16), 1587-95. (Read full article)
  16. Fluchel MN, Kirchhoff AC, Bodson J, Sweeney C, Edwards SL, Ding Q, Stoddard GJ, Kinney AY (2014). Geography and the burden of care in pediatric cancers. Pediatr Blood Cancer, 61(11), 1918-24. (Read full article)
  17. Zamora ER, Kaul S, Kirchhoff AC, Gwilliam V, Jimenez OA, Morreall DK, Montenegro RE, Kinney AY, Fluchel MN (2016). The impact of language barriers and immigration status on the care experience for Spanish-speaking caregivers of patients with pediatric cancer. Pediatr Blood Cancer, 63(12), 2173-2180. (Read full article)
  18. Smits-Seemann RR, Pettit J, Li H, Kirchhoff AC, Fluchel MN (2017). Infection-related mortality in Hispanic and non-Hispanic children with cancer.LID - 10.1002/pbc.26502 [doi]. Pediatr Blood Cancer, 64(9). (Read full article)
  19. Fluchel MN, Horsman JR, Furlong W, Castillo L, Alfonz Y, Barr RD (2008). Self and proxy-reported health status and health-related quality of life in survivors of childhood cancer in Uruguay. Pediatr Blood Cancer, 50(4), 838-43.
  20. Shirley Abraham, Mohamed Salama, Jeffrey Hancock, Jeffrey Jacobsen, Mark Fluchel (11/1/12). Congenital and childhood myeloproliferative disorders with eosinophilia responsive to imatinib. Pediatr Blood Cancer, 59(5), 4135-42.
  21. Kody R. Crowell, Raza A. Patel, Mark Fluchel, Amy Lowichik, Stacy Bryson, John F. Pohl (06/14/2013). Endoscopy in the Diagnosis of Intestinal Graft-Versus-Host Disease: Is Lower Endoscopy With Biopsy as Effective in Diagnosis as Upper Endoscopy Combined with Lower Endoscopy? Pediatr Blood Cancer, 60, 1798-1800.
  22. David Spencer Mangum, Anupam Verma, Cindy Weng, Xiaoming Sheng, Ryan Larsen, Anne C. Kirchhoff, Colleen Druzgal, Mark Fluchel (7/19/13). A Comparison of Central Lines in Pediatric Oncology Patients: Early Removal and Patient Centered Outcomes. Pediatr Blood Cancer.
  23. Abraham S, Salama M, Hancock J, Jacobsen J, Fluchel M (11/01//2012). Congenital and childhood myeloproliferative disorders with eosinophilia responsive to imatinib. Pediatr Blood Cancer, 59(5), 928-9.
  24. Botto LD, Flood T, Little J, Fluchel MN, Krikov S, Feldkamp ML, Wu Y, Goedken R, Puzhankara S, Romitti PA (2013). Cancer risk in children and adolescents with birth defects: a population-based cohort study. PLoS One, 8(7), e69077. (Read full article)
  25. Nam GE, Kaul S, Wu YP, Nelson RE, Wright J, Fluchel MN, Hacking CC, Kirchhoff AC (2015). A meta-analysis of body mass index of adolescent and adult survivors of pediatric acute lymphoblastic leukemia. J Cancer Surviv, 9(3), 412-21. (Read full article)
  26. Rochelle R. Smits-Seemann, Sapna Kaul, Aimee O. Hersh, Mark N. Fluchel, Kenneth Boucher, Anne C. Kirchhoff (09/29/2015). ReCAP: Gaps in Insurance Coverage for Pediatric Patients With Acute Lymphoblastic Leukemia. J Oncol Pract, 2, 175-176.
  27. Echo L. Warner, Anne C. Kirchhoff, PhD, MPH, Gina E. Nam, BS, BA, Mark Fluchel, MD (10/14/2014). The financial burden of pediatric cancer for patients and their families. J Oncol Pract.
  28. Sapna Kaul, PhD, Bree Barbeau, Jennifer Wright, MD, Mark Fluchel, MD, Anne C. Kirchoff, PhD, MPH and Richard E. Nelson, PhD (06/23/2015). Statewide Longitudinal Hospital Utilization and Charges for Childhood and Adolescent Cancer Patients. J Oncol Pract.
  29. Ou JY, Smits-Seemann RR, Kaul S, Fluchel MN, Sweeney C, Kirchhoff A (2017). Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample. Cancer epidemiology, 49, 216-224. (Read full article)
  30. Echo Warner, Mark Fluchel, Jennifer Wright, C. Sweeney, Kenneth M. Boucher, Alison Fraser, Ken R. Smith, Antoinette Stroup, Anita Y. Kinney, Anne Kirchhof (2014). A population-based study of childhood cancer survivors¿ body mass index. Journal of cancer epidemiology, 2014,
  31. Anne C. Kirchhoff, Karely Mann, Echo L. Warner, Heydon K. Kaddas, Douglas Fair, Mark Fluchel, Elizabeth D. Knackstedt, Deanna Kepk HPV Vaccination Knowledge, Intentions, and Practices among Caregivers of Childhood Cancer Survivors. Human vaccines & immunotherapeutics,
  32. Anne C. Kirchhoff, Karely Mann, Echo L. Warner, Heydon K. Kaddas, Douglas Fair, Mark Fluchel, Elizabeth D. Knackstedt, Deanna Kepk (2019). HPV Vaccination Knowledge, Intentions, and Practices among Caregivers of Childhood Cancer Survivors. Human vaccines & immunotherapeutics,
  33. Sapna Kaul, Kent Korgenski, Jian Ying, Christi F. Ng, Rochelle Smits-Seemann, Richard E. Nelson, Seth Andrews, Elizabeth Raetz, Mark Fluchel, Richard Lemons, Anne C. Kirchhof (2015). A retrospective analysis of treatment-related hospitalization costs of pediatric, adolescent, and young adult acute lymphoblastic leukemia. Cancer medicine,
  34. Salim Aljabari, Alfred Balch, Gitte Larsen, Mark Fluchel, Jennifer Workma (2019). Severe Sepsis-Associated Morbidity and Mortality Among Critically Ill Children with Cancer. Journal of pediatric intensive care,
  35. Scott Short, Mark Fluchel, Doug Barnhar Extrapleural Pneumonectomy for Advanced Pleuropulmonary Blastoma. Journal of pediatric surgery case reports,

Abstract

  1. Haralson M, Penner E, Fluchel M, DiMari S, Breyer M (1996). Determination of the collagen phenotype of rabbit cortical collecting duct cells in culture. [Abstract]. J Am Soc Nephrol, 7, A2541.
  2. Horsman, J, Fluchel M, Fulong, W, Castillo, L, Barr, (2000). Agreement of Health Utilities Index Scores among survivors of cancer in childhood, their parents and doctors in Uruguay.
  3. Liu X, Lin A, Dam V, Goldsmith KC, Fluchel M, Davis K, Pawel B, Karlsson A, Hogarty M (2006). A model of MycN-initiated neural cell oncogenesis shows a surprising predilection for complete suppression of MycN during progression.
  4. Wright J, Goldsmith KC*, Liu X, Lin A, Fluchel M, Hamilton A, Hogarty M (2006). Synthetic small molecule Bak-domain mimics potently induce apoptosis in NB cell lines.
  5. Horsman J, Fluchel M, Fulong W, Castillo L, Barr (2000). Agreement of Health Utilities Index Scores among survivors of cancer in childhood, their parents and doctors in Uruguay.
  6. P Romitti, T Flood, M Feldkamp, S Krikov, S Puzhankara, R Goedken, M Fluchel, J Little, L Bott (2010). Cancer Risk in Children with Birth Defects: A Longitudinal, Population-Based Assessment Among 2.7 Million Births.
  7. Warner EL, Mann K, Kaddas HK, Martel L, Pannier S, Knackstedt E, Fair D, Fluchel M, Kepka D, and Kirchhoff A (2019). Caregiver Intention To Restart Vaccinations After Childhood Cancer Treatment. Prev. Mar;28(3). 28(3),

Video/Film/CD/Web/Podcast

  1. Kathy Bolt (2012). Social Barriers Impact Care of Hispanic Children with Cancer.
  2. Maria Elena Neva (2012). Niños hispanos con cáncer en EE.UU.: el impacto de hablar español.
  3. Editor - Medical News Toda (2012). Care Of Children With Cancer Affected By Language Barriers, Immigration Status Of Hispanic Caregivershttp://www.medicalnewstoday.com/releases/252134.php.
  4. Dateline NB (2006). Dateline Medical Mysteries - Hemophagocytic Lymphohistiocytosis (HLH).