Martin H. Distel

Martin H. Distel, PhD

Languages spoken: English

Academic Information

Departments Primary - Pediatrics

Divisions: Hematology/Oncology

Education History

Fellowship University of California, San Diego
 Postdoctoral Fellow
Institute of Developmental Genetics, Helmholtz Center Munich/Technical University of Munich
 PhD
Graduate Training Technical University of Munich
 MSc
Technical University of Munich
 BSc

Selected Publications

Journal Article

  1. Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, vila Polo R, Cabrera-Prez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domnguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Dey-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antn J, Calzada-Hernndez J, Neth O, Viaud J, Nishikimi A, Dupr L, Boztug K (2023). Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. N Engl J Med, 389(6), 527-539. (Read full article)
  2. Sturtzel C, Grissenberger S, Bozatzi P, Scheuringer E, Wenninger-Weinzierl A, Zajec Z, Dernovek J, Pascoal S, Gehl V, Kutsch A, Granig A, Rifatbegovic F, Carre M, Lang A, Valtingojer I, Moll J, Ltsch D, Erhart F, Widhalm G, Surdez D, Delattre O, Andr N, Stampfl J, Tomai T, Taschner-Mandl S, Distel M (2023). Refined high-content imaging-based phenotypic drug screening in zebrafish xenografts. NPJ Precis Oncol, 7(1), 44. (Read full article)
  3. Eichhoff OM, Stoffel CI, Ksler J, Briker L, Turko P, Karsai G, Zila N, Paulitschke V, Cheng PF, Leitner A, Bileck A, Zamboni N, Irmisch A, Balazs Z, Tastanova A, Pascoal S, Johansen P, Wegmann R, Mena J, Othman A, Viswanathan VS, Wenzina J, Aloia A, Saltari A, Dzung A, TuPro Consortium, Krauthammer M, Schreiber SL, Hornemann T, Distel M, Snijder B, Dummer R, Levesque MP (2022). ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma. Cancer Res, 83(7), 1128-1146. (Read full article)
  4. Grissenberger S, Sturtzel C, Wenninger-Weinzierl A, Radic-Sarikas B, Scheuringer E, Bierbaumer L, Etienne V, Nmati F, Pascoal S, Ttzl M, Tomazou EM, Metzelder M, Putz EM, Decaudin D, Delattre O, Surdez D, Kovar H, Halbritter F, Distel M (2022). High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-X(L) inhibition against Ewing sarcoma. Cancer Lett, 554, 216028. (Read full article)
  5. Zajec, Dernovek J, Distel M, Gobec M, Tomai T (2022). Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma. Bioorg Chem, 131, 106311. (Read full article)
  6. Klughammer J, Romanovskaia D, Nemc A, Posautz A, Seid CA, Schuster LC, Keinath MC, Lugo Ramos JS, Kosack L, Evankow A, Printz D, Kirchberger S, Ergner B, Datlinger P, Fortelny N, Schmidl C, Farlik M, Skjrven K, Bergthaler A, Liedvogel M, Thaller D, Burger PA, Hermann M, Distel M, Distel DL, Kbber-Heiss A, Bock C (2023). Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species. Nat Commun, 14(1), 232. (Read full article)
  7. Schelch K, Eder S, Zitta B, Phimmachanh M, Johnson TG, Emminger D, Wenninger-Weinzierl A, Sturtzel C, Poplimont H, Ries A, Hoetzenecker K, Hoda MA, Berger W, Distel M, Dome B, Reid G, Grusch M (2022). YB-1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2. Mol Oncol. (Read full article)
  8. Gabler L, Jaunecker CN, Katz S, van Schoonhoven S, Englinger B, Pirker C, Mohr T, Vician P, Stojanovic M, Woitzuck V, Laemmerer A, Kirchhofer D, Mayr L, LaFranca M, Erhart F, Grissenberger S, Wenninger-Weinzierl A, Sturtzel C, Kiesel B, Lang A, Marian B, Grasl-Kraupp B, Distel M, Schler J, Gojo J, Grusch M, Spiegl-Kreinecker S, Donoghue DJ, Ltsch D, Berger W (2022). Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness. Acta Neuropathol Commun, 10(1), 65. (Read full article)
  9. Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, Velasco CD, Taylor JA, Terni B, Weinert T, Standfuss J, Cabernard CC, Llobet A, Steinmetz MO, Bausch AR, Distel M, Thorn-Seshold J, Akhmanova A, Thorn-Seshold O (2022). In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. J Am Chem Soc, 144(12), 5614-5628. (Read full article)
  10. Lichtenegger A, Mukherjee P, Zhu L, Morishita R, Tomita K, Oida D, Leskovar K, Abd El-Sadek I, Makita S, Kirchberger S, Distel M, Baumann B, Yasuno Y (2022). Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography. Biomed Opt Express, 13(4), 2202-2223. (Read full article)
  11. Zhang W, Scerbo P, Delagrange M, Candat V, Mayr V, Vriz S, Distel M, Ducos B, Bensimon D (2022). Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Commun Biol, 5(1), 113. (Read full article)
  12. Grissenberger S, Salzer B, Pascoal S, Wenninger-Weinzierl A, Lehner M, Distel M (2021). Preclinical testing of CAR T cells in zebrafish xenografts. Methods Cell Biol, 167, 133-147. (Read full article)
  13. Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Srensen J, Li J, Kubicek S (2021). An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. Mol Metab, 54, 101329. (Read full article)
  14. Andreana M, Sturtzel C, Spielvogel CP, Papp L, Leitgeb R, Drexler W, Distel M, Unterhuber A (2021). Toward Quantitative in vivo Label-Free Tracking of Lipid Distribution in a Zebrafish Cancer Model. Front Cell Dev Biol, 9, 675636. (Read full article)
  15. Okuda KS, Keyser MS, Gurevich DB, Sturtzel C, Mason EA, Paterson S, Chen H, Scott M, Condon ND, Martin P, Distel M, Hogan BM (2021). Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis. Elife, 10. (Read full article)
  16. Lmmle CA, Varady A, Mller TG, Sturtzel C, Riepl M, Mathes B, Eichhorst J, Sporbert A, Lehmann M, Krusslich HG, Distel M, Broichhagen J (2020). Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo. Chembiochem, 22(3), 548-556. (Read full article)
  17. Pascoal S, Grissenberger S, Scheuringer E, Fior R, Ferreira MG, Distel M (2020). Using Zebrafish Larvae as a Xenotransplantation Model to Study Ewing Sarcoma. Methods Mol Biol, 2226, 243-255. (Read full article)
  18. Sturtzel C, Hocking J, Kirchberger S, Distel M (2021). Studying the Tumor Microenvironment in Zebrafish. Adv Exp Med Biol, 1329, 69-92. (Read full article)
  19. Fernndez A, Straw A, Distel M, Leitgeb R, Baltuska A, Verhoef AJ (2020). Dynamic real-time subtraction of stray-light and background for multiphoton imaging. Biomed Opt Express, 12(1), 288-302. (Read full article)
  20. Wrobel JK, Najafi S, Ayhan S, Gatzweiler C, Krunic D, Ridinger J, Milde T, Westermann F, Peterziel H, Meder B, Distel M, Witt O, Oehme I (2020). Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts. Pharmaceuticals (Basel), 13(11). (Read full article)
  21. Haindl R, Duelk M, Gloor S, Dahdah J, Ojeda J, Sturtzel C, Deng S, Joyce Deloria A, Li Q, Liu M, Distel M, Drexler W, Leitgeb R (2020). Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source. Biomed Opt Express, 11(6), 3395-3406. (Read full article)
  22. Corallo D, Donadon M, Pantile M, Sidarovich V, Cocchi S, Ori M, De Sarlo M, Candiani S, Frasson C, Distel M, Quattrone A, Zanon C, Basso G, Tonini GP, Aveic S (2019). LIN28B increases neural crest cell migration and leads to transformation of trunk sympathoadrenal precursors. Cell Death Differ, 27(4), 1225-1242. (Read full article)
  23. Haindl R, Deloria AJ, Sturtzel C, Sattmann H, Rohringer W, Fischer B, Andreana M, Unterhuber A, Schwerte T, Distel M, Drexler W, Leitgeb R, Liu M (2020). Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae. Biomed Opt Express, 11(4), 2137-2151. (Read full article)
  24. Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M (2020). A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Cancers (Basel), 12(3). (Read full article)
  25. Shen J, Najafi S, Stble S, Fabian J, Koeneke E, Kolbinger FR, Wrobel JK, Meder B, Distel M, Heimburg T, Sippl W, Jung M, Peterziel H, Kranz D, Boutros M, Westermann F, Witt O, Oehme I (2018). A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. Cell Death Differ, 25(12), 2053-2070. (Read full article)
  26. Mayr V, Sturtzel C, Stadler M, Grissenberger S, Distel M (2018). Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish. Front Cell Dev Biol, 6, 111. (Read full article)
  27. Troll JV, Hamilton MK, Abel ML, Ganz J, Bates JM, Stephens WZ, Melancon E, van der Vaart M, Meijer AH, Distel M, Eisen JS, Guillemin K (2018). Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development, 145(4). (Read full article)
  28. Aichhorn S, Linhardt A, Halfmann A, Nadlinger M, Kirchberger S, Stadler M, Dillinger B, Distel M, Dohnal A, Teasdale I, Schfberger W (2017). A pH-sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier. Chemistry, 23(70), 17721-17726. (Read full article)
  29. Haindl R, Preisser S, Andreana M, Rohringer W, Sturtzel C, Distel M, Chen Z, Rank E, Fischer B, Drexler W, Liu M (2017). Dual modality reflection mode optical coherence and photoacoustic microscopy using an akinetic sensor. Opt Lett, 42(21), 4319-4322. (Read full article)
  30. Fernndez A, Grner-Nielsen L, Andreana M, Stadler M, Kirchberger S, Sturtzel C, Distel M, Zhu L, Kautek W, Leitgeb R, Baltuska A, Jespersen K, Verhoef A (2017). Optimizing pulse compressibility in completely all-fibered Ytterbium chirped pulse amplifiers for in vivo two photon laser scanning microscopy. Biomed Opt Express, 8(8), 3526-3537. (Read full article)
  31. Kainrath S, Stadler M, Reichhart E, Distel M, Janovjak H (2017). Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains. Angew Chem Int Ed Engl, 56(16), 4608-4611. (Read full article)
  32. Li J, Casteels T, Frogne T, Ingvorsen C, Honor C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Mjek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Srensen J, Kubicek S (2016). Artemisinins Target GABA(A) Receptor Signaling and Impair α Cell Identity. Cell, 168(1-2), 86-100.e15. (Read full article)
  33. Smidak R, Aradska J, Kirchberger S, Distel M, Sialana FJ, Wackerlig J, Mechtcheriakova D, Lubec G (2016). A detailed proteomic profiling of plasma membrane from zebrafish brain. Proteomics Clin Appl, 10(12), 1264-1268. (Read full article)
  34. Matsui H, Dorigo A, Buchberger A, Hocking JC, Distel M, Kster RW (2015). Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles. Dev Dyn, 244(12), 1574-80. (Read full article)
  35. Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Espn-Palazn R, Lawson ND, Dorsky R, Clements WK, Traver D (2015). Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development, 142(6), 1050-61. (Read full article)
  36. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Pankov D, MacRae C, Mork LA, Crump JG, Traver D (2014). Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J, 33(20), 2363-73. (Read full article)
  37. Alghisi E, Distel M, Malagola M, Anelli V, Santoriello C, Herwig L, Krudewig A, Henkel CV, Russo D, Mione MC (2013). Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the Notch pathway. Leukemia, 27(11), 2229-41. (Read full article)
  38. Xie X, Mathias JR, Smith MA, Walker SL, Teng Y, Distel M, Kster RW, Sirotkin HI, Saxena MT, Mumm JS (2012). Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner. BMC Biol, 10, 93. (Read full article)
  39. Ma R, Distel M, Den-Ben XL, Ntziachristos V, Razansky D (2012). Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography. Phys Med Biol, 57(22), 7227-37. (Read full article)
  40. Walker SL, Ariga J, Mathias JR, Coothankandaswamy V, Xie X, Distel M, Kster RW, Parsons MJ, Bhalla KN, Saxena MT, Mumm JS (2012). Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One, 7(1), e29916. (Read full article)
  41. Hoegler KJ, Distel M, Kster RW, Horne JH (2011). Targeting olfactory bulb neurons using combined in vivo electroporation and Gal4-based enhancer trap zebrafish lines. J Vis Exp, (54). (Read full article)
  42. Distel M, Jennifer C H, Kster RW (2011). In vivo cell biology using Gal4-mediated multicolor subcellular labeling in zebrafish. Commun Integr Biol, 4(3), 336-9. (Read full article)
  43. Wullimann MF, Mueller T, Distel M, Babaryka A, Grothe B, Kster RW (2011). The long adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis. Front Neuroanat, 5, 27. (Read full article)
  44. Santoriello C, Gennaro E, Anelli V, Distel M, Kelly A, Kster RW, Hurlstone A, Mione M (2010). Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS One, 5(12), e15170. (Read full article)
  45. Distel M, Hocking JC, Volkmann K, Kster RW (2010). The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo. J Cell Biol, 191(4), 875-90. (Read full article)
  46. Anelli V, Santoriello C, Distel M, Kster RW, Ciccarelli FD, Mione M (2010). Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Zebrafish, 6(4), 417-24. (Read full article)
  47. Distel M, Wullimann MF, Kster RW (2009). Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proc Natl Acad Sci U S A, 106(32), 13365-70. (Read full article)
  48. Nikolaou N, Watanabe-Asaka T, Gerety S, Distel M, Kster RW, Wilkinson DG (2009). Lunatic fringe promotes the lateral inhibition of neurogenesis. Development, 136(15), 2523-33. (Read full article)
  49. Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Flting J, Distel M, Kster RW, Schmid B, Haass C (2009). A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest, 119(5), 1382-95. (Read full article)
  50. Distel M, Kster RW (2007). In vivo time-lapse imaging of zebrafish embryonic development. Cold Spring Harb Protoc, 2007, pdb.prot4816. (Read full article)
  51. Distel M, Babaryka A, Kster RW (2006). Multicolor in vivo time-lapse imaging at cellular resolution by stereomicroscopy. Dev Dyn, 235(4), 1100-06. (Read full article)

Review

  1. Grnewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, Gonzlez-Gonzlez L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D (2020). Sarcoma treatment in the era of molecular medicine. [Review]. EMBO Mol Med, 12(11), e11131. (Read full article)
  2. Varady A, Distel M (2020). Non-neuromodulatory Optogenetic Tools in Zebrafish. [Review]. Front Cell Dev Biol, 8, 418. (Read full article)
  3. Kirchberger S, Sturtzel C, Pascoal S, Distel M (2017). Quo natas, Danio?-Recent Progress in Modeling Cancer in Zebrafish. [Review]. Front Oncol, 7, 186. (Read full article)
  4. Hocking JC, Distel M, Kster RW (2012). Studying cellular and subcellular dynamics in the developing zebrafish nervous system. [Review]. Exp Neurol, 242, 1-10. (Read full article)