Mary C. Beckerle, PhD

Academic Information

  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • 801-581-4485
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5360 (HCI Res North)
    Salt Lake City, UT 84112

Academic Bio

Mary Beckerle, PhD

Jon M. Huntsman Presidential Endowed Chair

CEO, Huntsman Cancer Institute at the University of Utah

Associate Vice President of Cancer Affairs, University of Utah Health

Distinguished Professor of Biology and Oncological Sciences

Mary Beckerle, PhD, has served as CEO of Huntsman Cancer Institute at the University of Utah since 2006. She is the associate vice president for cancer affairs at U of U Health, and she is a distinguished professor of biology and oncological sciences at the U of U. Beckerle joined the faculty of the University of Utah in 1986, and currently holds the Jon M. Huntsman Presidential Endowed Chair. She earned her PhD in molecular, cellular, and developmental biology from the University of Colorado at Boulder, where she was the recipient of a Danforth Fellowship, and completed post-doctoral research at the University of North Carolina at Chapel Hill.

Beckerle’s research has defined a novel molecular pathway that regulates cell motility, and her lab is currently focused on understanding the impact of this pathway on tumor progression, particularly in Ewing’s sarcoma. Her scientific work has been continuously funded by the National Institutes of Health (NIH) and the American Cancer Society for over 20 years. She guided graduate education at the University of Utah as the director of the Interdepartmental Graduate Program in Molecular Biology for two years. In addition, Beckerle developed the Multidisciplinary Cancer Research Training Program at Huntsman Cancer Institute at the University of Utah and served for several years as the principal investigator of the National Cancer Institute grant that supported this cancer-focused training initiative. Beckerle served as cancer center director and principal investigator of HCI’s Cancer Center Support Grant from 2006-2018, during which she led the process that resulted in Huntsman Cancer Institute being recognized as a Comprehensive Cancer Center, the highest recognition possible by the National Cancer Institute.

An active participant in national and international scientific affairs, Beckerle served as president of the American Society for Cell Biology (ASCB) in 2006. She has served on the NIH Advisory Committee to the Director, on the NCI Scientific Review Group Subcommittee A (Parent Committee) for Cancer Centers, as Chair of the American Cancer Society Council for Extramural Grants, and on the Coalition for Life Sciences Board of Directors.

Beckerle currently serves on the Medical Advisory Board of the Howard Hughes Medical Institute as well as the Scientific Advisory Boards of the National Center for Biological Sciences in India, the Mechanobiology Institute in Singapore, and several National Cancer Institute (NCI)-designated cancer centers. In 2013, she was elected to the Board of Directors of the American Association for Cancer Research. Beckerle serves as a member of the Board of Directors of Huntsman Corporation and Johnson & Johnson. In 2016, she was appointed to serve as a member of the National Cancer Moonshot Initiative Blue Ribbon Panel, a team charged with identifying strategies to best advance the scientific themes of Vice President Biden’s “cancer moonshot” initiative; Dr. Beckerle co-chaired the working group on Precision Prevention and Early Detection.

In 2000, Beckerle was appointed as a Guggenheim Fellow and a Rothschild-Yvette Mayent Award Scholar at the Curie Institute in Paris. She received the Utah Governor’s Medal for Science and Technology in 2001, the Sword of Hope Award from the American Cancer Society in 2004, and the Rosenblatt Prize for Excellence (the University of Utah’s highest honor) in 2007. Beckerle was elected as a Fellow of the American Academy of Arts and Sciences in 2008 and to the American Philosophical Society in 2017. In 2018, Beckerle received the Alfred G. Knudson Award in Cancer Genetics from the National Cancer Institute (NCI).

Selected Publications

Journal Article

  1. Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Pare PD, Fredberg JJ, Smith MA (2017). The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS ONE, 12(3), e0171728.
  2. Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild AH (2016 Mar). Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Mol Syst Biol, 12(3), 860.
  3. Fadul J, Bell R, Hoffman LM, Beckerle MC, Engel ME, Lessnick SL (2015 Mar). EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes Cancer, 6(3-4), 129-43.
  4. Stachowiak MR, Smith MA, Blankman E, Chapin LM, Balcioglu HE, Wang S, Beckerle MC, OShaughnessy B (2014 Dec 9). A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Proc Natl Acad Sci U S A, 111(49), 17528-33.
  5. Smith MA, Hoffman LM, Beckerle MC (2014 Oct). LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol, 24(10), 575-83.
  6. Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC (2014 Sep 15). Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell, 25(18), 2695-709.
  7. Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL (2014 Sep 1). Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res, 20(17), 4584-97.
  8. Valantine HA, Beckerle MC, Reed KL, Towner D, Zahniser NR (2014 Aug 27). Teaching corporate in college. Sci Transl Med, 6(251), 251fs33.
  9. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (2014 Mar 1). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng, 7(1), 73-85.
  10. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng, 7, 73-85.
  11. Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick SL (2013 Nov). A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol, 33(22), 4448-60.
  12. Wiles ET, Bell R, Thomas D, Beckerle M, Lessnick SL (2013 Nov). ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma. Genes Cancer, 4(11-12), 486-500.
  13. Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV (2013 Nov 1). Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. Cell Cycle, 12(21), 3377-89.
  14. Pronovost SM, Beckerle MC, Kadrmas JL (2013 Mar). Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS Genet, 9(3), e1003406.
  15. Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC (2013). LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS ONE, 8(8), e69378.
  16. Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC (2012 Nov 21). Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J, 103(10), 2082-92.
  17. Elias MC, Pronovost SM, Cahill KJ, Beckerle MC, Kadrmas JL (2012 Jul 1). A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. J Cell Sci, 125(Pt 13), 3185-94.
  18. Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC (2012 May). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell, 23(10), 1846-59.
  19. Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC (2012 Feb). The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes Cancer, 3(2), 102-16.
  20. Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL (2012). The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm. Front Oncol, 2, 2.
  21. Beckerle MC, Reed KL, Scott RP, Shafer MA, Towner D, Valantine HA, Zahniser NR (2011 Oct 12). Medical faculty development: a modern-day odyssey. Sci Transl Med, 3(104), 104cm31.
  22. Clark KA, Lesage-Horton H, Zhao C, Beckerle MC, Swank DM (2011 Aug). Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Am J Physiol Cell Physiol, 301(2), C373-82.
  23. Beckerle MC (2010 Nov 15). How cell biologists can contribute to improving cancer outcomes. Mol Biol Cell, 21(22), 3788-9.
  24. Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC (2010 Sep 14). A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell, 19(3), 365-76.
  25. Renfranz PJ, Blankman E, Beckerle MC (2010 Sep). The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Anat Rec (Hoboken), 293(9), 1455-69.
  26. Scaife CL, Shea J, Emerson L, Boucher K, Firpo MA, Beckerle MC, Mulvihill SJ (2010 Jun). Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. HPB (Oxford), 12(5), 352-8.
  27. Hervy M, Hoffman LM, Jensen CC, Smith M, Beckerle MC (2010 May 1). The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes Cancer, 1(5), 506-515.
  28. Lilly B, Clark KA, Yoshigi M, Pronovost S, Wu ML, Periasamy M, Chi M, Paul RJ, Yet SF, Beckerle MC (2010 Apr). Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Arterioscler Thromb Vasc Biol, 30(4), 694-701.
  29. Han HF, Beckerle MC (2009 May). The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell, 20(9), 2361-70.
  30. Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets L (2009 Mar). TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J, 23(3), 916-28.
  31. Hansen MD, Beckerle MC (2008 Jun 20). alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochem Biophys Res Commun, 371(1), 144-8.
  32. Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer R (2008 Jan). The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. J Exp Biol, 211(Pt 1), 15-23.
  33. Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC (2007 Aug). Characterization of RACK1 function in Drosophila development. Dev Dyn, 236(8), 2207-15.
  34. Clark KA, Bland JM, Beckerle MC (2007 Jun 15). The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci, 120(Pt 12), 2066-77.
  35. Pomies P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC (2007 May). The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell, 18(5), 1723-33.
  36. Hervy M, Hoffman L, Beckerle MC (2006 Oct). From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol, 18(5), 524-32.
  37. Takizawa N, Smith TC, Nebl T, Crowley JL, Palmieri SJ, Lifshitz LM, Ehrhardt AG, Hoffman LM, Beckerle MC, Luna EJ (2006 Jul 31). Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. J Cell Biol, 174(3), 447-58.
  38. Hansen MD, Beckerle MC (2006 Jun 9). Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. J Biol Chem, 281(23), 16178-88.
  39. Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle MC (2006 Feb 27). Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol, 172(5), 771-82.
  40. McKeown CR, Han HF, Beckerle MC (2006 Feb). Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1. Dev Dyn, 235(2), 530-8.
  41. Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005 Oct 24). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol, 171(2), 209-15.
  42. Norman KR, Fazzio RT, Mellem JE, Espelt MV, Strange K, Beckerle MC, Maricq AV (2005 Oct 7). The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell, 123(1), 119-32.
  43. Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA (2005 Oct). Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest, 115(10), 2716-30.
  44. Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle MC (2004 Dec 20). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol, 167(6), 1019-24.
  45. Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC (2004 Feb 20). The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem, 279(8), 6824-33.
  46. Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV, Somlyo AP (2003 Sep). LPP, a LIM protein highly expressed in smooth muscle. Am J Physiol Cell Physiol, 285(3), C674-85.
  47. Clark KA, McGrail M, Beckerle MC (2003 Jun). Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development, 130(12), 2611-21.
  48. Henderson JR, Pomies P, Auffray C, Beckerle MC (2003 Mar). ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. Cell Motil Cytoskeleton, 54(3), 254-65.
  49. Renfranz PJ, Siegrist SE, Stronach BE, Macalma T, Beckerle MC (2003 Feb 13). Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Gene, 305(1), 13-26.
  50. Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, Menzies AS, Goh KL, Jensen CC, Gertler FB, Fuchs E, Fassler R, Beckerle MC (2003 Jan). Targeted disruption of the murine zyxin gene. Mol Cell Biol, 23(1), 70-9.
  51. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (2003 Jan). Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell, 4(1), 107-18.
  52. Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (2002 Mar 15). Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem, 277(11), 9580-9.
  53. Henderson JR, Brown D, Richardson JA, Olson EN, Beckerle MC (2002 Jan). Expression of the gene encoding the LIM protein CRP2: a developmental profile. J Histochem Cytochem, 50(1), 107-11.
  54. Lilly B, Olson EN, Beckerle MC (2001 Dec 15). Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells. Dev Biol, 240(2), 531-47.
  55. Nix DA, Fradelizi J, Bockholt S, Menichi B, Louvard D, Friederich E, Beckerle MC (2001 Sep 14). Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J Biol Chem, 276(37), 34759-67.
  56. Pashmforoush M, Pomies P, Peterson KL, Kubalak S, Ross J Jr, Hefti A, Aebi U, Beckerle MC, Chien KR (2001 May). Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med, 7(5), 591-7.
  57. Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, White RL (2000 Oct 24). Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A, 97(22), 12085-90.
  58. Harper BD, Beckerle MC, Pomies P (2000 Aug 15). Fine mapping of the alpha-actinin binding site within cysteine-rich protein. Biochem J, 350 Pt 1, 269-74.
  59. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000 Jul 21). Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem, 275(29), 22503-11.
  60. Drees BE, Andrews KM, Beckerle MC (1999 Dec 27). Molecular dissection of zyxin function reveals its involvement in cell motility. J Cell Biol, 147(7), 1549-60.
  61. Pomies P, Macalma T, Beckerle MC (1999 Oct 8). Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. J Biol Chem, 274(41), 29242-50.
  62. Stronach BE, Renfranz PJ, Lilly B, Beckerle MC (1999 Jul). Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Mol Biol Cell, 10(7), 2329-42.
  63. Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC (1999 May 4). Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation. Biochemistry, 38(18), 5701-13.
  64. Henderson JR, Macalma T, Brown D, Richardson JA, Olson EN, Beckerle MC (1999 Mar). The LIM protein, CRP1, is a smooth muscle marker. Dev Dyn, 214(3), 229-38.
  65. Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G (1999 Jan 11). A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol, 144(1), 45-57.
  66. Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD (1999). LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. Gene Expr, 8(4), 207-17.
  67. Ahern-Djamali SM, Comer AR, Bachmann C, Kastenmeier AS, Reddy SK, Beckerle MC, Walter U, Hoffmann FM (1998 Aug). Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. Mol Biol Cell, 9(8), 2157-71.
  68. Schmeichel KL, Beckerle MC (1998 May 1). LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function. Biochem J, 331 ( Pt 3), 885-92.
  69. Yi J, Beckerle MC (1998 Apr 15). The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics, 49(2), 314-6.
  70. Schmeichel KL, Stronach BE, Beckerle MC (1998). Purification and assay of zyxin. Methods Enzymol, 298, 62-76.
  71. Louis HA, Pino JD, Schmeichel KL, Pomies P, Beckerle MC (1997 Oct 24). Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. J Biol Chem, 272(43), 27484-91.
  72. Pomies P, Louis HA, Beckerle MC (1997 Oct 6). CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. J Cell Biol, 139(1), 157-68.
  73. Nix DA, Beckerle MC (1997 Sep 8). Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol, 138(5), 1139-47.
  74. Golsteyn RM, Beckerle MC, Koay T, Friederich E (1997 Aug). Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes. J Cell Sci, 110 ( Pt 16), 1893-906.
  75. Schmeichel KL, Beckerle MC (1997 Feb). Molecular dissection of a LIM domain. Mol Biol Cell, 8(2), 219-30.
  76. Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC (1996 Dec 6). Molecular characterization of human zyxin. J Biol Chem, 271(49), 31470-8.
  77. Stronach BE, Siegrist SE, Beckerle MC (1996 Sep). Two muscle-specific LIM proteins in Drosophila. J Cell Biol, 134(5), 1179-95.
  78. Hobert O, Schilling JW, Beckerle MC, Ullrich A, Jallal B (1996 Apr 4). SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene, 12(7), 1577-81.
  79. Perez-Alvarado GC, Kosa JL, Louis HA, Beckerle MC, Winge DR, Summers MF (1996 Mar 22). Structure of the cysteine-rich intestinal protein, CRIP. J Mol Biol, 257(1), 153-74.
  80. Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (1995 Dec 1). The cysteine-rich protein family of highly related LIM domain proteins. J Biol Chem, 270(48), 28946-54.
  81. Schmeichel KL, Beckerle MC (1994 Oct 21). The LIM domain is a modular protein-binding interface. Cell, 79(2), 211-9.
  82. Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers MF (1994 Jun). Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat Struct Biol, 1(6), 388-98.
  83. Michelsen JW, Sewell AK, Louis HA, Olsen JI, Davis DR, Winge DR, Beckerle MC (1994 Apr 15). Mutational analysis of the metal sites in an LIM domain. J Biol Chem, 269(15), 11108-13.
  84. Kosa JL, Michelsen JW, Louis HA, Olsen JI, Davis DR, Beckerle MC, Winge DR (1994 Jan 18). Common metal ion coordination in LIM domain proteins. Biochemistry, 33(2), 468-77.
  85. Crawford AW, Pino JD, Beckerle MC (1994 Jan). Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. J Cell Biol, 124(1-2), 117-27.
  86. Bertagnolli ME, Locke SJ, Hensler ME, Bray PF, Beckerle MC (1993 Dec). Talin distribution and phosphorylation in thrombin-activated platelets. J Cell Sci, 106 ( Pt 4), 1189-99.
  87. Bertagnolli ME, Beckerle MC (1993 Jun). Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets. J Cell Biol, 121(6), 1329-42.
  88. Michelsen JW, Schmeichel KL, Beckerle MC, Winge DR (1993 May 15). The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A, 90(10), 4404-8.
  89. Sadler I, Crawford AW, Michelsen JW, Beckerle MC (1992 Dec). Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol, 119(6), 1573-87.
  90. Crawford AW, Michelsen JW, Beckerle MC (1992 Mar). An interaction between zyxin and alpha-actinin. J Cell Biol, 116(6), 1381-93.
  91. Crawford AW, Beckerle MC (1991 Mar 25). Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem, 266(9), 5847-53.
  92. Beckerle MC (1990 Jan). The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester. Cell Regul, 1(2), 227-36.
  93. Beckerle MC, Miller DE, Bertagnolli ME, Locke SJ (1989 Dec). Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets. J Cell Biol, 109(6 Pt 2), 3333-46.
  94. Drenckhahn D, Beckerle M, Burridge K, Otto J (1988 Aug). Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry. Eur J Cell Biol, 46(3), 513-22.
  95. Beckerle MC, Burridge K, DeMartino GN, Croall DE (1987 Nov 20). Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell, 51(4), 569-77.
  96. Beckerle MC (1986 Nov). Identification of a new protein localized at sites of cell-substrate adhesion. J Cell Biol, 103(5), 1679-87.
  97. Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K (1986 Apr 10-16). Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature, 320(6062), 531-3.
  98. Sealock R, Paschal B, Beckerle M, Burridge K (1986 Mar). Talin is a post-synaptic component of the rat neuromuscular junction. Exp Cell Res, 163(1), 143-50.
  99. Beckerle MC, OHalloran T, Burridge K (1986). Demonstration of a relationship between talin and P235, a major substrate of the calcium-dependent protease in platelets. J Cell Biochem, 30(3), 259-70.
  100. OHalloran T, Beckerle MC, Burridge K (1985 Oct 3-9). Identification of talin as a major cytoplasmic protein implicated in platelet activation. Nature, 317(6036), 449-51.
  101. Beckerle MC (1984 Jun). Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells. J Cell Biol, 98(6), 2126-32.
  102. Beckerle MC, Porter KR (1983 Feb). Analysis of the role of microtubules and actin in erythrophore intracellular motility. J Cell Biol, 96(2), 354-62.
  103. Porter KR, Beckerle MC, McNiven MA (1983). The Cytoplasmic Matrix. Mol Cell Biol, 2, 259-302.
  104. Beckerle MC, Porter KR (1982 Feb 25). Inhibitors of dynein activity block intracellular transport in erythrophores. Nature, 295(5851), 701-3.


  1. Kadrmas JL, Beckerle MC (2004 Nov). The LIM domain: from the cytoskeleton to the nucleus. [Review]. Nat Rev Mol Cell Biol, 5(11), 920-31.
  2. Renfranz PJ, Beckerle MC (2002 Feb). Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. [Review]. Curr Opin Cell Biol, 14(1), 88-103.
  3. Clark KA, McElhinny AS, Beckerle MC, Gregorio CC (2002). Striated muscle cytoarchitecture: an intricate web of form and function. [Review]. Annu Rev cell Dev Biol, 18, 637-706.
  4. Beckerle MC (1998 Dec 11). Spatial control of actin filament assembly: lessons from Listeria. [Review]. Cell, 95(6), 741-8.
  5. Beckerle MC (1997 Nov). Zyxin: zinc fingers at sites of cell adhesion. [Review]. BioEssays, 19(11), 949-57.
  6. Bertagnolli ME, Beckerle MC (1994 Apr 18). Regulated membrane-cytoskeleton linkages in platelets. [Review]. Ann N Y Acad Sci, 714, 88-100.
  7. Beckerle MC, Yeh RK (1990). Talin: role at sites of cell-substratum adhesion. [Review]. Cell Motil Cytoskeleton, 16(1), 7-13.

Edited Book

  1. Beckerle MC (Ed.) (2002). Cell Adhesion. Oxford University Press.

Book Chapter

  1. Drees BE, Beckerle MC (1999). Zyxin. In Thomas Kreis and Ronald Vale (Eds.), Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (pp. 95-98). Oxford University Press.
  2. Pomies P, Beckerle MC (1999). The cysteine-rich protein family. In Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins. Oxford University Press.
  3. Schmeichel KL, Beckerle MC, Crawford AW (1998). Blot Overlay Assay: A Method to Detect Protein-Protein Interactions. In Cell Biology: A Laboratory Handbook (2nd Edition, 4, pp. 441-449).
  4. Crawford, AW, and Beckerle, MC (). Blot overlay assay: a method to detect protein–protein interactions. In Cell biology. A laboratory handbook (pp. 301-308). New York London: Academic Press.
  5. Crawford AW, Beckerle MC (1989). Cell-substratum adhesion: Mechanism and Regulation. In George M. Malacinski (Ed.), Cytoplasmic Organization Systems. Primers in Developmental Biology, Vol. IV. New York: McGraw-Hill.
  6. Porter KR, Beckerle MC, McNiven MA (1983-01-01). A Mechanism for Intracellular Transport. In Grisolen, Guerri, Samson, Norton and Reinoso-Suarez (Eds.), Ramon and Cajal's Contribution to the Neurosciences.
  7. Byers HR, Fujiwara K, Beckerle MC, Porter KR (1980). Microtubule organization and function in chromatophores and scleroblasts in vitro and in situ. In DeBrabander and DeMey (Eds.), Microtubules and Microtubule Inhibitors. Elsevier/ North Holland, Amsterdam: Janssen Pharmaceutical Research Foundation.


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