Randall W. Burt, MD
- Departments: Internal Medicine - Professor Emeritus
- Divisions: Gastroenterology
- Cancer Center Programs: Cancer Control & Population Sciences
- National Board of Medical Examiners
- American Board of Internal Medicine (Sub: Gastroenterology)
- American Board of Internal Medicine (Internal Medicine)
Academic Office Information
Huntsman Cancer Institute
2000 Circle of Hope, Room: 5260
Salt Lake City, UT 84112
Randall Burt, MD, is senior director of Prevention and Outreach and Clinical Services at Huntsman Cancer Institute. He is also a professor in the Department of Medicine, Division of Gastroenterology, at the University of Utah School of Medicine. He holds the D. Keith Barnes, MD, and Ida May "Dotty" Barnes, RN, Presidential Endowed Chair in Medicine. In addition, he is director of the Familial Colon Cancer Clinic and co-director of the Family Cancer Assessment Clinic at Huntsman Cancer Institute. He is a member of the Cancer Control and Population Sciences Program.
Dr. Burt is a gastroenterologist with primary interest in familial risk and inherited syndromes of colorectal cancer. In past by Burt and members of his group, they demonstrated shown that inheritance is a critical determinant in colon cancer, possibly playing a role in up to a third of all cases. In 1987, a group led by Ray White, PhD and Burt, discovered the chromosomal location of the gene for a dangerous inherited colon cancer syndrome called familial adenomatous polyposis (FAP). Soon after, the sequence of the gene and mutations responsible for the syndrome were identified by this group. It soom became apparent that this gene was an early mutation in the large majority of colon cancers and premalignant adenomatous polyps. An important outcome of this research is that genetic testing soon became available to identify persons with the inherited syndrome. Burt looks for new gene mutations that cause predisposition to common colon cancers, by utelizing the Utah Population Data Base, a data base that combines the Utah Cancer Registry (a SEER registry) and the Utah genealogies. Large families (up to 20,000 persons) are available in this resource for gene discovery. As part of a large, randomized, controlled study, he researched the impact of diet on the occurrence of colon cancer, and now directs a chemoprevention study involving subjects with familial adenomatous polyposis. Dr. Burt also conducts research in each of the inherited colon cancer syndromes, including familial adenomatous polyposis, Lynch syndrome (hereditary nonpolyposis colorectal cancer), Peutz-Jegher disease, familial juvenile polyposis syndrome, Cowden syndrome, serrated polyposis syndrome (hyperplastic polyposis syndrome) and others. These studies involve clarifying the phenotype and the molecular-genetic aspects of these diseases.
Clinical care for persons with these syndromes, including genetic testing and endoscopy, is major part of Dr. Burt's academic practice. The determination of famial risk including appropriate risk stratification and screening, is also a part of both research and clinical care. Extensive use of the Utah Population Data Base is used in these investigations to precisely determine colon cancer risk in families without one of the known interited syndromes.
Burt received his medical degree from the University of Utah in 1974. He completed an internship and residency in internal medicine at Washington University and Barnes Hospital in St. Louis, Missouri, and completed a fellowship in gastroenterology at the University of Utah School of Medicine in 1979.
|Fellowship||University of Utah School of Medicine
|Professional Medical||University of Utah Hospital School of Medicine
|Undergraduate||University of Utah
- Tuohy TM, Rowe KG, Mineau GP, Pimentel R, Burt RW, Samadder NJ (2014). Risk of colorectal cancer and adenomas in the families of patients with adenomas: A population-based study in Utah. Cancer, 120(1), 35-42.
- Samadder NJ, Curtin K, Tuohy TM, Pappas L, Boucher K, Provenzale D, Rowe KG, Mineau GP, Smith K, Pimentel R, Kirchhoff AC, Burt RW (2014). Characteristics of missed or interval colorectal cancer and patient survival: a population-based study. Gastroenterology, 146(4), 950-60.
- Burt RW (2013). Colon cancer screening continues as pivotal to cancer prevention. J Natl Compr Canc Netw, 11(12), 1457-8.
- Burt RW (2012). Diagnosing Lynch syndrome: more light at the end of the tunnel. Cancer Prev Res (Phila), 5(4), 507-10.
- Knight S, Abo RP, Abel HJ, Neklason DW, Tuohy TM, Burt RW, Thomas A, Camp NJ (2012). Shared genomic segment analysis: the power to find rare disease variants. Ann Hum Genet, 76(6), 500-9.
- Neklason DW, Done MW, Sargent NR, Schwartz AG, Anton-Culver H, Griffin CA, Ahnen DJ, Schildkraut JM, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Burt RW (2011). Activating mutation in MET oncogene in familial colorectal cancer. BMC Cancer, 11, 424.
- Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB (2011). Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res, 21(5), 768-74.
- Taylor DP, Burt RW, Williams MS, Haug PJ, Cannon-Albright LA (2010). Population-based family history-specific risks for colorectal cancer: a constellation approach. Gastroenterology, 138(3), 877-85.
- Neklason DW, Tuohy TM, Stevens J, Otterud B, Baird L, Kerber RA, Samowitz WS, Kuwada SK, Leppert MF, Burt RW (2010). Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. J Med Genet, 47(10), 692-9.
- Jasperson KW, Tuohy TM, Neklason DW, Burt RW (2010). Hereditary and familial colon cancer. [Review]. Gastroenterology, 138(6), 2044-58.
- Tuohy TM, Done MW, Lewandowski MS, Shires PM, Saraiya DS, Huang SC, Neklason DW, Burt RW (2010). Large intron 14 rearrangement in APC results in splice defect and attenuated FAP. Hum Genet, 127(3), 359-69.