Douglas T. Carrell, PhD, HCLD

Chief, Division of Andrology

Research Interests

  • Genetics of Male Infertility
  • In Vitro Maturation of Oocytes and Follicles
  • Potential Causes and Solutions to Abnormal Embryo Development

Languages

  • English
  • Spanish

Academic Information

  • Departments: Human Genetics - Adjunct Professor, Obstetrics/Gynecology - Adjunct Assistant Professor, Surgery - Professor
  • Divisions: General OB/GYN, Urology

Academic Bio

Doug Carrell received his Ph.D. degree in reproductive physiology from the University of Utah in 1995, after receiving a M.S. degree in cellular and developmental biology from Brigham Young University. Dr. Carrell has worked in the area of research and treatment of human infertility for 40 years. Dr. Carrell is the clinical laboratory director of the In Vitro Fertilization (IVF) and Andrology laboratories at the University of Utah, and also directs a number of post-doctoral fellows, Ph.D. graduate students, and research personnel. Dr. Carrell is an international leader in the field genetic aspects of male infertility and early embryogenesis. He has authored more than 250 research papers and book chapters, and has edited 9 medical books related to infertility. Dr. Carrell is a frequent invited speaker at national and international medical and research meetings, and served as founding Co Editor-in-Chief of Andrology, the leading journal of male reproductive science and medicine. Dr. Carrell has served recently as president of the Society of Male Reproduction and Urology (SMRU) and the board of the American Society of Reproductive Medicine (ASRM). Dr. Carrell is married and has 5 children. In his free time, Dr. Carrell is an avid marathoner, having completed more than 260 marathons throughout the world and in locations as diverse as the Sahara desert, the Andes, and Antarctica.

Research Statement

Doug Carrell received his Ph.D. degree in reproductive physiology from the University of Utah in 1995, after receiving a M.S. degree in cellular and developmental biology from Brigham Young University. Dr. Carrell has worked in the area of research and treatment of human infertility for 35 years. Dr. Carrell is the clinical laboratory director of the In Vitro Fertilization (IVF) and Andrology laboratories at the University of Utah, and also directs a number of post-doctoral fellows, Ph.D. graduate students, and research personnel. Dr. Carrell is an international leader in the field genetic aspects of male infertility and early embryogenesis. He has authored more than 225 research papers and book chapters, and has edited 8 medical books related to infertility. Dr. Carrell is a frequent invited speaker at national and international medical and research meetings, and is the Co Editor-in-Chief of Andrology. Dr. Carrell is the current president of the Society of Male Reproduction and Urology (SMRU) and is on the board of the American Society of Reproductive Medicine (ASRM). Dr. Carrell is married and has 5 children. In his free time, Dr. Carrell is an avid marathoner, having completed more than 175 marathons throughout the world.

Education History

Type School Degree
Doctoral Training University of Utah
Ph.D.
Graduate Training Brigham Young University
Biology
M.S.
Undergraduate Brigham Young University
Zoology
B.S.

Selected Publications

Journal Article

  1. Krausz C, Riera-Escamilla A, Moreno-Mendoza D, Holleman K, Cioppi F, Algaba F, Pybus M, Friedrich C, Wyrwoll MJ, Casamonti E, Pietroforte S, Nagirnaja L, Lopes AM, Kliesch S, Pilatz A, Carrell DT, Conrad DF, Ars E, Ruiz-Casta E, Aston KI, Baarends WM, Tttelmann F (2020). Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men. (Epub ahead of print) Genet Med.
  2. James ER, Carrell DT, Aston KI, Jenkins TG, Yeste M, Salas-Huetos A (2020). The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction. Int J Mol Sci, 21(15).
  3. Salas-Huetos A, Maghsoumi-Norouzabad L, James ER, Carrell DT, Aston KI, Jenkins TG, Becerra-Toms N, Javid AZ, Abed R, Torres PJ, Luque EM, Ramrez ND, Martini AC, Salas-Salvad J (2020). Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta-analysis. (Epub ahead of print) Obes Rev.
  4. Santana VP, James ER, Miranda-Furtado CL, Souza MF, Pompeu CP, Esteves SC, Carrell DT, Aston KI, Jenkins TG, Reis RMD (2020). Differential DNA methylation pattern and sperm quality in men with varicocele. (Epub ahead of print) Fertil Steril.
  5. Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston KI (2020). NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure. PLoS Genet, 16(6), e1008756.
  6. Samuel R, Son J, Jenkins TG, Jafek A, Feng H, Gale BK, Carrell DT, Hotaling JM (2020). Microfluidic System for Rapid Isolation of Sperm From Microdissection TESE Specimens. Urology, 140, 70-76.
  7. Samuel R, Son J, Jenkins TG, Jafek A, Feng H, Gale BK, Carrell DT, Hotaling JM (2019). AUTHOR REPLY. Urology, 140, 75-76.
  8. Ibrahim Y, Einerson B, Carrell DT, Emery BR, Johnstone E (2020). The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates. (Epub ahead of print) Asian J Androl.
  9. Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ, DonorConnect, Kim R, Tharmalingam M, Matilionyte G, Lindskog C, Carrell DT, Mitchell RT, Goriely A, Hotaling JM, Cairns BR (2020). The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty. Cell Stem Cell, 26(2), 262-276.e4.
  10. Schisterman EF, Clemons T, Peterson CM, Johnstone E, Hammoud AO, Lamb D, Carrell DT, Perkins NJ, Sjaarda LA, Van Voorhis BJ, Ryan G, Summers K, Campbell B, Robins J, Chaney K, Mills JL, Mendola P, Chen Z, DeVilbiss EA, Mumford SL (2019). A Randomized Trial to Evaluate the Effects of Folic Acid and Zinc Supplementation on Male Fertility and Livebirth: Design and Baseline Characteristics. Am J Epidemiol, 189(1), 8-26.
  11. Schisterman EF, Sjaarda LA, Clemons T, Carrell DT, Perkins NJ, Johnstone E, Lamb D, Chaney K, Van Voorhis BJ, Ryan G, Summers K, Hotaling J, Robins J, Mills JL, Mendola P, Chen Z, DeVilbiss EA, Peterson CM, Mumford SL (2020). Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial. JAMA, 323(1), 35-48.
  12. Salas-Huetos A, James ER, Aston KI, Carrell DT, Jenkins TG, Yeste M (2019). The role of miRNAs in male human reproduction: a systematic review. Andrology, 8(1), 7-26.
  13. Jenkins TG, James ER, Aston KI, Salas-Huetos A, Pastuszak AW, Smith KR, Hanson HA, Hotaling JM, Carrell DT (2019). Age-associated sperm DNA methylation patterns do not directly persist trans-generationally. Epigenetics Chromatin, 12(1), 74.
  14. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT, Yeste M (2019). The Expression of miRNAs in Human Ovaries, Oocytes, Extracellular Vesicles, and Early Embryos: A Systematic Review. Cells, 8(12).
  15. Pollard SH, Cox KJ, Blackburn BE, Wilkins DG, Carrell DT, Stanford JB, Porucznik CA (2019). Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort. Reprod Toxicol, 90, 82-87.
  16. Lee AS, Rusch J, Lima AC, Usmani A, Huang N, Lepamets M, Vigh-Conrad KA, Worthington RE, Mgi R, Wu X, Aston KI, Atkinson JP, Carrell DT, Hess RA, OBryan MK, Conrad DF (2019). Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility. Nat Commun, 10(1), 4626.
  17. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT (2019). Diet and sperm quality: Nutrients, foods and dietary patterns. Reprod Biol, 19(3), 219-224.
  18. Garg D, Johnstone EB, Fair DB, Carrell DT, Berga S, Letourneau JM (2019). Oncofertility conundrum: discrepancy between anti-MĪ‹llerian hormone and mature oocyte yield in a peripubertal girl with Hodgkin lymphoma. J Assist Reprod Genet, 36(8), 1753-1756.
  19. Carrell DT (2019). The Sperm Epigenome: Implications for Assisted Reproductive Technologies. Adv Exp Med Biol, 1166, 47-56.
  20. Simon L, Emery B, Carrell DT (2019). Sperm DNA Fragmentation: Consequences for Reproduction. Adv Exp Med Biol, 1166, 87-105.
  21. Gannon JR, Emery BR, Jenkins TG, Carrell DT (2013). The sperm epigenome: implications for the embryo. Adv Exp Med Biol, 791, 53-66.
  22. GeSQ, Griffin J, Liu L, Aston KI, Simon L, Jenkins TG, Emery BR, Carrell DT (2013). Association of single nucleotide polymorphisms (SNPs) in Pygo2 coding gene with Idiopathic Oligozoospermia and azoospermia. Hereditas, 35(5), 616-622.
  23. Racowsky C, Carrell D (2012). Safety, Efficacy, and Complexities in the ART Laboratory. Semin Reprod Med, 30(3), 165-6.
  24. Aston KI, Carrell DT (2011). Emerging evidence for the role of genomic instability in male factor infertility. Syst Biol Reprod Med, 58(2), 71-80.
  25. Nanassy L, Liu L, Griffin J, Carrell DT (2010). The clinical utility of the protamine 1/protamine 2 ratio in sperm. Protein Pept Lett, 18(8), 772-7.
  26. Liu L, Milroy C, Peterson CM, Carrell DT (2011). Successful cryoloop vitrification and subsequent in vitro maturation of mouse preantral follicles. Syst Biol Reprod Med, 57(3), 149-53.
  27. Jenkins TG, Carrell DT (2010). The paternal epigenome and embryogenesis: poising mechanisms for development. Asian J Androl, 13(1), 76-80.
  28. Hammoud AO, Griffin J, Meikle AW, Gibson M, Peterson CM, Carrell DT (2010). Association of aromatase (TTTAn) repeat polymorphism length and the relationship between obesity and decreased sperm concentration. Hum Reprod, 25(12), 3146-51.
  29. Aston KI, Krausz C, Laface I, Ruiz-Castan E, Carrell DT (2010). Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod, 25(6), 1383-97.
  30. Platts AE, Lalancette C, Emery BR, Carrell DT, Krawetz SA (2010). Disease progression and solid tumor survival: a transcriptome decoherence model. Mol Cell Probes, 24(1), 53-60.
  31. Aston KI, Carrell DT (2009). Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. J Androl, 30(6), 711-25.
  32. Hammoud SS, Nix DA, Zhang H, Purwar J, Carrell DT, Cairns BR (2009). Distinctive chromatin in human sperm packages genes for embryo development. Nature, 460(7254), 473-8.
  33. Liu L, Aoki VW, Carrell DT (2008). Evaluation of the developmental competence and chromosomal compliment of mouse oocytes derived from in-vitro growth and maturation of preantral follicles. J Assist Reprod Genet, 25(2-3), 107-13.
  34. Emery BR, Miller RL, Carrell DT (2001). Hamster oocyte membrane potential and ion permeability vary with preantral cumulus cell attachment and developmental stage. BMC Dev Biol, 1, 14.

Book

  1. Schlegel PN, Fauser B, Carrell DT, Racowsky C (2013). Biennial Review of Infertility. (Vol. 3). New York: Springer.
  2. Carrell DT (2013). Paternal Influences on Human Reproductive Success. Cambridge: Cambridge University Press.
  3. Carrell DT, Aston KI (2013). Methods in Molecular Biology: Spermatogenesis: Methods and Protocols. New York: Humana Press.

Editorial

  1. Carrell DT, Simoni M (2019). Announcing the Sixth Andrology Award. Andrology, 8(1), 5-6.
  2. Carrell DT, Simoni M, Krausz C, Gerton GL (2019). Advancing the cause of improved male reproductive health. Andrology, 7(6), 761.
  3. Meistrich ML, Carrell DT (2012). Evolution of the Journal of Andrology and a bright future for Andrology. J Androl, 33(6), 1119-24.

Patent

  1. Carrell DT, Cairns B, Hammoud S (2019). Posing of the sperm for early embryogenesis.
  2. Gale BK, Carrell DT, Murphy K, Hotaling JM, Son J (2017). Tissue sample processing system and associated methods. App US20170306288A1. U.S. Patent No. Pending. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Carrell DT, Simon L (2015). Sperm separation devices and associated methods, May 19. U.S. Patent No. 9,034,161. Washington, D.C.:U.S. Patent and Trademark Office.
  4. Odell WD, Grover S, Caticha S, Carrell DT, Woods ML (2000). Control of Infectious Microorganisms by Modulation of Chorionic Gonadotropin-Related Protein Activity. U.S. Patent No. 6139839. Washington, D.C.:U.S. Patent and Trademark Office.