Hilary Coon, PhD

Research Interests

  • Suicide
  • Autism Spectrum Disorders
  • Statistical Genetics
  • Genetic Epidemiology
  • Child Psychiatry
  • Obesity
  • Pulmonary fibrosis
  • Nicotine Dependence

Languages

  • English

Academic Information

  • Departments: Biomedical Informatics - Adjunct Professor, Internal Medicine - Adjunct Professor, Psychiatry - Professor
  • Divisions: Adult Psychiatry, Epidemiology

Academic Office Information

  • Biomedical Polymers Research Bldg
    Psychiatry Genetics Laboratory
    20 S 2030 E, Room: 408
    Salt Lake City, UT 84112

Research Statement

Hilary Coon's primary research interests within the Department of Psychiatry include finding genes that lead to susceptibility to autism and, genetic risk factors for suicide, and the genetics of nicotine and alcohol addiction. Work to achieve these goals is accomplished through collaborations with national, and international collaborators, and locally through analyses of extended families ascertained through the Utah Population Data Base (UPDB). Gene findings may lead to better understanding of underlying mechanisms. Intermediate traits and co-morbid conditions associated with disease have also been a focus of Dr. Coon's research. Traits that are correlated with disease are often observed at increased rates also in clinically unaffected family members. These traits may indicate the presence of relatively common gene changes that, together with other genetic and environmental factors, contribute to increased risk of carrying a diagnosis. In addition, appearance of particular traits or co-morbid conditions in affected pedigree members and their clinically unaffected relatives may indicate particular genetic subtypes of disease present in the family. The study of these phenotypes within families may reveal susceptibility mutations that would otherwise not be detected. Pedigrees also offer a chance to study protective mechanisms in unaffected relatives, and environmental exposures that may be particularly important for genetically susceptible individuals. Interests outside the Psychiatry Department include the development and application of statistical methods to genetic and phenotypic data, cardiovascular genetics, genetics of obesity, and genetics of lung disorders. Dr. Coon is also interested in research ethics, and is a long time member of the University of Utah Institutional Review Board.

Education History

Type School Degree
Doctoral Training University of Colorado
Psychology/Behavioral Genetics
Ph.D.
Fellowship University of Colorado, Institute for Behavioral Genetics, Colorado Adoption Project
Biostatistics
Fellow
Graduate Training University of Colorado
Psychology/Behavioral Genetics
M.A.
Undergraduate University of Colorado
Mathematics
B.A.
Undergraduate University of Colorado
Music
B.A.

Selected Publications

Journal Article

  1. Das SC, Chen D, Callor WB, Christensen E, Coon H, Williams ME (2019). DiI-mediated analysis of presynaptic and postsynaptic structures in human postmortem brain tissue. J Comp Neurol, 527(18), 3087-3098.
  2. Shade J, Coon H, Docherty AR (2019). Ethical implications of using biobanks and population databases for genetic suicide research. Am J Med Genet B Neuropsychiatr Genet, 180(8), 601-608.
  3. Bilder DA, Esplin MS, Coon H, Burghardt P, Clark EAS, Fraser A, Smith KR, Worsham W, Chappelle K, Rayner T, Bakian AV (2020). Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder. J Autism Dev Disord, 49(11), 4572-4583.
  4. Kirby AV, Bakian AV, Zhang Y, Bilder DA, Keeshin BR, Coon H (2019). A 20-year study of suicide death in a statewide autism population. Autism Research, 12(4), 658-666.
  5. Nobre C, Gehlenborg N, Coon H, Lex A (2018). Lineage: Visualizing Multivariate Clinical Data in Genealogy Graphs. IEEE Trans Vis Comput Graph, 25(3), 1543-1558.
  6. An JY, Lin K, Zhu L, Werling DM, Dong S, Brand H, Wang HZ, Zhao X, Schwartz GB, Collins RL, Currall BB, Dastmalchi C, Dea J, Duhn C, Gilson MC, Klei L, Liang L, Markenscoff-Papadimitriou E, Pochareddy S, Ahituv N, Buxbaum JD, Coon H, Daly MJ, Kim YS, Marth GT, Neale BM, Quinlan AR, Rubenstein JL, Sestan N, State MW, Willsey AJ, Talkowski ME, Devlin B, Roeder K, Sanders SJ (2018). Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder. Science, 362(6420).
  7. Coon H, Darlington TM, DiBlasi E, Callor WB, Ferris E, Fraser A, Yu Z, William N, Das SC, Crowell SE, Chen D, Anderson JS, Klein M, Jerominski L, Cannon D, Shabalin A, Docherty A, Williams M, Smith KR, Keeshin B, Bakian AV, Christensen E, Li QS, Camp NJ, Gray D (2018). Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide. (Epub ahead of print) Mol Psychiatry.
  8. Werling DM, Brand H, An JY, Stone MR, Zhu L, Glessner JT, Collins RL, Dong S, Layer RM, Markenscoff-Papadimitriou E, Farrell A, Schwartz GB, Wang HZ, Currall BB, Zhao X, Dea J, Duhn C, Erdman CA, Gilson MC, Yadav R, Handsaker RE, Kashin S, Klei L, Mandell JD, Nowakowski TJ, Liu Y, Pochareddy S, Smith L, Walker MF, Waterman MJ, He X, Kriegstein AR, Rubenstein JL, Sestan N, McCarroll SA, Neale BM, Coon H, Willsey AJ, Buxbaum JD, Daly MJ, State MW, Quinlan AR, Marth GT, Roeder K, Devlin B, Talkowski ME, Sanders SJ (2018). An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. Nat Genet, 50(5), 727-736.
  9. Lin CY, Chang KW, Lin CY, Wu JY, Coon H, Huang PH, Ho HN, Akbarian S, Gau SS, Huang HS (2018). Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes. Sci Rep, 8(1), 4277.
  10. Waller RG, Darlington TM, Wei X, Madsen MJ, Thomas A, Curtin K, Coon H, Rajamanickam V, Musinsky J, Jayabalan D, Atanackovic D, Rajkumar SV, Kumar S, Slager S, Middha M, Galia P, Demangel D, Salama M, Joseph V, McKay J, Offit K, Klein RJ, Lipkin SM, Dumontet C, Vachon CM, Camp NJ (2018). Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk. PLoS Genet, 14(2), e1007111.
  11. Farley M, Cottle KJ, Bilder D, Viskochil J, Coon H, McMahon W (2017). Mid-life social outcomes for a population-based sample of adults with ASD. Autism Research, 11(1), 142-152.
  12. Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (May 22, 2017). Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism, 8(21).
  13. Figueroa KP, Coon H, Santos N, Velazquez L, Mederos LA, Pulst SM (2017). Genetic analysis of age at onset variation in spinocerebellar ataxia type 2. Neurol Genet, 3(3), e155.
  14. Weiner DJ, Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, Samocha KE, Goldstein JI, Okbay A, Bybjerg-Grauholm J, Werge T, Hougaard DM, Taylor J, iPSYCH-Broad Autism Group, Psychiatric Genomics Consortium Autism Group, Skuse D, Devlin B, Anney R, Sanders SJ, Bishop S, Mortensen PB, Brglum AD, Smith GD, Daly MJ, Robinson EB (May 15, 2017). Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet, May 15(10:1038).
  15. Woodbury-Smith M, Bilder DA, Morgan J, Jerominski L, Darlington T, Dyer T, Paterson AD, Coon H (2017). Combined genome-wide linkage and targeted association analysis of head circumference in autism spectrum disorder families. J Neurodev Disord, 9, 5.
  16. Christensen ED, Berger J, Alashari MM, Coon H, Robison C, Ho HT, Adams DR, Gahl WA, Smith KR, Opitz JM, Johnson DR (2017). Sudden infant death "syndrome"-Insights and future directions from a Utah population database analysis. Am J Med Genet A, 173(1), 177-182.
  17. Hu H, Coon H, Li M, Yandell M, Huff CD (2016). VARPRISM: incorporating variant prioritization in tests of de novo mutation association. Genome Medicine, 8(1), 91.
  18. McGlade E, Bakian A, Coon H, Yurgelun-Todd D, Callor WB, Byrd J, Gray D (2016). Male suspected suicide decedents in Utah: A comparison of Veterans and nonveterans. Compr Psychiatry, 69, 1-10.
  19. Jones KB, Cottle K, Bakian A, Farley M, Bilder D, Coon H, McMahon WM (2016). A description of medical conditions in adults with autism spectrum disorder: A follow-up of the 1980s Utah/UCLA Autism Epidemiologic Study. Autism, 20(5), 551-61.
  20. Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Mller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerstrm N, Scherbaum N, Schml C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munaf MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL (2016). Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet, 46(2), 151-69.
  21. Cannon DS, Medina TR, Mermelstein RJ, Hedeker D, Bakian AV, Coon H, Cook EH, Hamil C, Weiss RB (2016). CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res, 18(2), 196-203.
  22. Hasstedt SJ, Coon H, Xin Y, Adams TD, Hunt SC (2016). APOH interacts with FTO to predispose to healthy thinness. Hum Genet, 135(2), 201-7.
  23. Hollingshaus MS, Coon H, Crowell SE, Gray DD, Hanson HA, Pimentel R, Smith KR (2016). Differential Vulnerability to Early-Life Parental Death: The Moderating Effects of Family Suicide History on Risks for Major Depression and Substance Abuse in Later Life. Biodemography Soc Biol, 62(1), 105-25.
  24. Whitehouse AJ, Coon H, Miller J, Salisbury B, Bishop DV (2010). Narrowing the broader autism phenotype: a study using the Communication Checklist-Adult Version (CC-A). Autism, 14(6), 559-74.
  25. Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Blte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Sequeira AF, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Hallmayer J, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg GD, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Scherer SW, Sutcliffe JS, Betancur C (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466(7304), 368-72.
  26. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lnnqvist J, Nthen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet, 73(1), 49-62.
  27. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, ONeill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lnnqvist J, Peltonen L, ODonovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoga T, Helgason T (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet, 73(1), 34-48.
  28. Kronenberg F, Coon H, Ellison RC, Borecki I, Arnett DK, Province MA, Eckfeldt JH, Hopkins PN, Hunt SC (2002). Segregation analysis of HDL cholesterol in the NHLBI Family Heart Study and in Utah pedigrees. Eur J Hum Genet, 10(6), 367-74.

Other

  1. Bilder DA, Esplin MS, Coon H, Burghardt P, Clark EAS, Fraser A, Smith KR, Worsham W, Chappelle K, Rayner T, Bakian AV (2019). Correction to: Early Second Trimester Maternal Serum Steroid‑Related Biomarkers Associated with Autism Spectrum Disorder. J Autism Dev Disord (49(11), p. 4584). United States.