Elena Y. Enioutina, MD, PhD

Research Interests

  • Immunopharmacology
  • Medicine, Herbal
  • Myeloid Derived Suppressor Cells (MDSCs)
  • Neonatal Infections/Sepsis
  • Pharmacology
  • Vaccination
  • Chlamydia Infections

Languages

  • English
  • Russian

Academic Information

  • Departments: Pathology - Adjunct Assistant Professor, Pediatrics - Research Assistant Professor, Pharmaceutics and Pharmaceutical Chemistry - Adjunct Assistant Professor
  • Divisions: Microbiology and Immunology, Pediatric Clinical Pharmacology

Academic Office Information

  • 801-587-1916
  • Williams Building
    295 Chipeta Way, Room: 1S100
    Salt Lake City, UT 84108

Email: elena.enioutina@hsc.utah.edu

Academic Bio

Dr. Elena Yu Enioutina holds an M.D. degree in Preventive medicine and Ph.D. in medicine with specialization in pharmacology and toxicology. She has hands-on experience in immunopharmacology, pharmacology/toxicology, animal modeling as well as extensive academic research experience in immunology, vaccines, and immune senescence. Her long-standing interest in the prophylaxis of infectious diseases goes back to medical school years. Immune senescence and modulation of immune responses in aged animals by cholesterol lowering drugs was the topic of her Ph.D. work. Her current research involves the understanding of the relationship between the activity of cord blood myeloid derived suppressor cells and neonatal susceptibility to infections, and discovering therapeutic options aimed to improve immune responsiveness of newborns.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah School of Medicine
Pathology
Postdoctoral Fellow
Doctoral Training All Union Research Institute of Medicinal Plants (VILAR)
Pharmacology/Immunotoxicology
Ph.D.
Internship I.M. Sechenov First Moscow State Medical University
Preventive Medicine
Intern
Professional Medical I.M. Sechenov First Moscow Institute of Medicine
Medicine
M.D.
Undergraduate I.M. Sechenov First Moscow Institute of Medicine
B.A.

Global Impact

Education History

Type School Degree Country
Doctoral Training All Union Research Institute of Medicinal Plants (VILAR)
Pharmacology/Immunotoxicology
Ph.D. Russia
Internship I.M. Sechenov First Moscow State Medical University
Preventive Medicine
Intern Russia
Professional Medical I.M. Sechenov First Moscow Institute of Medicine
Medicine
M.D. Russia
Undergraduate I.M. Sechenov First Moscow Institute of Medicine
B.A. Russia

Selected Provider Publications

Journal Article

  1. Enioutina EY, Teng L, Fateeva TV, Brown JCS, Job KM, Bortnikova VV, Krepkova LV, Gubarev MI, Sherwin CMT (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. Expert Rev Clin Pharmacol, 10(11), 1203-1214.
    Global Impact: Global.

  2. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 4. Canada and United States. Expert Rev Clin Pharmacol, 9(12), 1597-1609.
    Global Impact: Global.

  3. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X, Di L, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 3. China and Japan. Expert Rev Clin Pharmacol, 9(9), 1225-33.
    Global Impact: Global.

  4. Sammons HM, Gubarev MI, Krepkova LV, Bortnikova VV, Corrick F, Job KM, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. Expert Rev Clin Pharmacol, 9(8), 1117-27.
    Global Impact: Global.

  5. Barnes J, McLachlan AJ, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. Expert Rev Clin Pharmacol, 9(7), 905-15.
    Global Impact: Global.

  6. Tataurova TA, Krepkova LV, Bortnikova VV, Kuznersov YuB, Enioutina EY aka Eniutina EIu (1988). Preclinical toxicological study of glyciram. Farmakol Toksikol, 51(6), 87-90.
    Global Impact: Russia.

Service

Date Role Description Country
09/01/2017 Reviewer AAPS 2017 meeting Global
11/24/2016 Moderator ASCPT webinar Global

Selected Publications

Journal Article

  1. Krepkova LV, Bortnikova VV, Babenko AN, Mizina PG, Mkhitarov VA, Job KM, Sherwin CM, Enioutina EY (2021). Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development. BMC Complement Med Ther, 21(1), 31.
  2. Enioutina EY, Job KM, Krepkova LV, Reed MD, Sherwin CM (2020). How can we improve the safe use of herbal medicine and other natural products? A clinical pharmacologist mission. Expert Rev Clin Pharmacol, 13(9), 935-944.
  3. Biltaji E, Enioutina EY, Yellepeddi V, Rower JE, Sherwin CMT, Ward RM, Lemons RS, Constance JE (2020). Supportive care medications coinciding with chemotherapy among children with hematologic malignancy. Leuk Lymphoma, 61(8), 1920-1931.
  4. Illamola SM, Amaeze OU, Krepkova LV, Birnbaum AK, Karanam A, Job KM, Bortnikova VV, Sherwin CMT, Enioutina EY (2020). Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know. Frontiers in Pharmacology, 10(1483).
  5. Balch A, Wilkes J, Thorell E, Pavia A, Sherwin CMT, Enioutina EY (2019). Changing trends in IVIG use in pediatric patients: A retrospective review of practices in a network of major USA pediatric hospitals. Int Immunopharmacol, 76, 105868.
  6. Wagstaff JS, Durrant RJ, Newman MG, Eason R, Ward RM, Sherwin CMT, Enioutina EY (2019). Antibiotic Treatment of Suspected and Confirmed Neonatal Sepsis Within 28 Days of Birth: A Retrospective Analysis. Front Pharmacol, 10, 1191.
  7. Enioutina EY, Teng L, Fateeva TV, Brown JCS, Job KM, Bortnikova VV, Krepkova LV, Gubarev MI, Sherwin CMT (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. Expert Rev Clin Pharmacol, 10(11), 1203-1214.
  8. Enioutina EY, Salis ER, Job KM, Gubarev MI, Krepkova LV, Sherwin CM (2017). Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide. Expert Rev Clin Pharmacol, 10(3), 327-338.
  9. Yu T, Enioutina EY, Brunner HI, Vinks AA, Sherwin CM (2017). Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. Clin Pharmacokinet, 56(2), 107-125.
  10. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 4. Canada and United States. Expert Rev Clin Pharmacol, 9(12), 1597-1609.
  11. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X, Di L, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 3. China and Japan. Expert Rev Clin Pharmacol, 9(9), 1225-33.
  12. Job KM, Olson J, Stockmann C, Constance JE, Enioutina EY, Rower JE, Linakis MW, Balch AH, Yu T, Liu X, Thorell EA, Sherwin CM (2016). Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections. Expert Rev Anti Infect Ther, 14(8), 731-46.
  13. Sammons HM, Gubarev MI, Krepkova LV, Bortnikova VV, Corrick F, Job KM, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. Expert Rev Clin Pharmacol, 9(8), 1117-27.
  14. Barnes J, McLachlan AJ, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. Expert Rev Clin Pharmacol, 9(7), 905-15.
  15. Enioutina EY, Constance JE, Stockmann C, Linakis MW, Yu T, Rower JE, Balch AH, Sherwin CM (2015). Pharmacokinetic considerations in the use of antivirals in neonates. Expet Opin Drug Metabol Toxicol, 11(12), 1861-78.
  16. Enioutina EY, Bareyan D, Daynes RA (2011). A role for immature myeloid cells in immune senescence. J Immunol, 186(2), 697-707.
  17. Enioutina EY, Bareyan D, Daynes RA (2009). TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses. J Immunol, 182(7), 4296-305.
  18. Enioutina EY, Visic DM, Daynes RA (2002). The induction of systemic and mucosal immunity to protein vaccines delivered through skin sites exposed to UVB. Vaccine, 20(16), 2116-30.
  19. Enioutina EY, Visic D, Daynes RA (2000). The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity. Vaccine, 18(24), 2753-67.
  20. Enioutina EY, Visic D, McGee ZA, Daynes RA (1999). The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine, 17(23-24), 3050-64.
  21. Tataurova TA, Krepkova LV, Bortnikova VV, Kuznersov YuB, Enioutina EY aka Eniutina EIu (1988). Preclinical toxicological study of glyciram. Farmakol Toksikol, 51(6), 87-90.

Editorial

  1. Enioutina EY, Job KM, Sherwin CMT (2020). Why we need to pay attention to toxicity associated with herbal medicines. 13(86(9)), 1793-1794.
  2. Biltaji E, Kumar SS, Enioutina EY, Sherwin CMT (2017). Can ad hoc analyses of clinical trials help personalize treatment decisions? 83(11), 2337-2338.

Abstract

  1. VV Bortnikova, LV Krepkiva, VVKarabaeva, GF Sidelnikova, PG Mizina, KM Job, CMT Sherwin, EY Enioutina (September 2019). Results of a Randomized Clinical Trial related to the Effectiveness of Flakozid, an Antiviral Drug of Herbal Origin. [Abstract].
  2. JS Wagstaff, MG Newman, EY Enioutina (September 2019). Empiric treatment of neonatal early-onset sepsis: a retrospective analysis of the University of Utah Hospital cases [Abstract].

Clinical Trials