Elena Y. Enioutina, MD, PhD

Research Interests

  • Immunopharmacology
  • Medicine, Herbal
  • Myeloid Derived Suppressor Cells (MDSCs)
  • Neonatal Infections/Sepsis
  • Pharmacology
  • Vaccination
  • Chlamydia Infections

Languages

  • English
  • Russian

Academic Information

  • Departments: Pathology - Adjunct Assistant Professor, Pediatrics - Research Assistant Professor, Pharmaceutics and Pharmaceutical Chemistry - Adjunct Assistant Professor
  • Divisions: Microbiology and Immunology, Pediatric Clinical Pharmacology

Academic Office Information

  • 801-587-1916
  • Williams Building
    295 Chipeta Way, Room: 1S100
    Salt Lake City, UT 84108

Email: elena.enioutina@hsc.utah.edu

Academic Bio

Dr. Elena Yu Enioutina holds an M.D. degree in Preventive medicine and Ph.D. in medicine with specialization in pharmacology and toxicology. She has hands-on experience in immunopharmacology, pharmacology/toxicology, animal modeling as well as extensive academic research experience in immunology, vaccines, and immune senescence. Her long-standing interest in the prophylaxis of infectious diseases goes back to medical school years. Immune senescence and modulation of immune responses in aged animals by cholesterol lowering drugs was the topic of her Ph.D. work. Her current research involves the understanding of the relationship between the activity of cord blood myeloid derived suppressor cells and neonatal susceptibility to infections, and discovering therapeutic options aimed to improve immune responsiveness of newborns.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah School of Medicine
Pathology
Postdoctoral Fellow
Doctoral Training All Union Research Institute of Medicinal Plants (VILAR)
Pharmacology/Immunotoxicology
Ph.D.
Internship I.M. Sechenov First Moscow State Medical University
Preventive Medicine
Intern
Professional Medical I.M. Sechenov First Moscow Institute of Medicine
Medicine
M.D.
Undergraduate I.M. Sechenov First Moscow Institute of Medicine
B.A.

Global Impact

Education History

Type School Degree Country
Doctoral Training All Union Research Institute of Medicinal Plants (VILAR)
Pharmacology/Immunotoxicology
Ph.D. Russia
Internship I.M. Sechenov First Moscow State Medical University
Preventive Medicine
Intern Russia
Professional Medical I.M. Sechenov First Moscow Institute of Medicine
Medicine
M.D. Russia
Undergraduate I.M. Sechenov First Moscow Institute of Medicine
B.A. Russia

Selected Provider Publications

Journal Article

  1. Enioutina EY, Myers EJ, Tvrdik P, Hoidal JR, Rogers SW, Gahring LC (2015). The nicotinic receptor Alpha7 impacts the mouse lung response to LPS through multiple mechanisms. PLoS ONE, 10(3), e0121128.
    Global Impact: Global.

  2. Tataurova TA, Krepkova LV, Bortnikova VV, Kuznersov YuB, Enioutina EY aka Eniutina EIu (1988). Preclinical toxicological study of glyciram. Farmakol Toksikol, 51(6), 87-90.
    Global Impact: Russia.

Review

  1. Enioutina EY, Teng L, Fateeva TV, Brown JCS, Job KM, Bortnikova VV, Krepkova LV, Gubarev MI, Sherwin CMT (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. [Review]. Expert Review of Clinical Pharmacology, 10(11), 1203-1214.
    Global Impact: Global.

  2. Barnes J, McLachlan AJ, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. [Review]. Expert Review of Clinical Pharmacology, 9(7), 905-15.
    Global Impact: Global.

  3. Sammons HM, Gubarev MI, Krepkova LV, Bortnikova VV, Corrick F, Job KM, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. [Review]. Expert Review of Clinical Pharmacology, 9(8), 1117-27.
    Global Impact: Global.

  4. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X, Di L, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 3. China and Japan. [Review]. Expert Review of Clinical Pharmacology, 9(9), 1225-33.
    Global Impact: Global.

  5. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 4. Canada and United States. [Review]. Expert Review of Clinical Pharmacology, 9(12), 1597-1609.
    Global Impact: Global.

Service

Date Role Description Country
09/01/1977 Student Board Member Russia
01/01/1985 Project Head "Anthology of All-Union Institute of Medicinal Plants" Russia
11/24/2016 Moderator ASCPT webinar Global
09/01/2017 Reviewer AAPS 2017 meeting Global

Career

Institution Description Country
Moscow Endocrine Plant, All-Union Pharmaceutical Industry Occupational Therapist (Summers) Russia
All Union Institute of Medicinal Plants, Laboratory of Toxicology and Adverse Drug Reactions Multiple Positions Russia

Selected Publications

Journal Article

  1. Feldkamp ML, Enioutina EY, Botto LD, Krikov S, Byrne JL, Geisler WM (2015). Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis. J Perinatol, 35(11), 930-4.
  2. Enioutina EY, Myers EJ, Tvrdik P, Hoidal JR, Rogers SW, Gahring LC (2015). The nicotinic receptor Alpha7 impacts the mouse lung response to LPS through multiple mechanisms. PLoS ONE, 10(3), e0121128.
  3. Gahring LC, Enioutina EY, Myers EJ, Spangrude GJ, Efimova OV, Kelley TW, Tvrdik P, Capecchi MR, Rogers SW (2013). Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. PLoS One, 8(3), e57481.
  4. Contreras YM, Yu X, Hale MA, Callaway CW, Bareyan D, McKnight RA, Joss-Moore LA, Enioutina EY, Lane RH (2011). Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats. Pediatr Res, 70(2), 123-9.
  5. Ahlem CN, Auci DL, Nicoletti F, Pieters R, Kennedy MR, Page TM, Reading CL, Enioutina EY, Frincke JM (2011). Pharmacology and immune modulating properties of 5-androstene-3beta,7beta,17beta-triol, a DHEA metabolite in the human metabolome. J Steroid Biochem Mol Biol, 126(3-5), 87-94.
  6. Wendorf JR, Ghartey-Tagoe EB, Williams SC, Enioutina E, Singh P, Cleary GW (2011). Transdermal delivery of macromolecules using solid-state biodegradable microstructures. Pharm Res, 28(1), 22-30.
  7. Enioutina EY, Bareyan D, Daynes RA (2011). A role for immature myeloid cells in immune senescence. J Immunol, 186(2), 697-707.
  8. Enioutina EY, Bareyan D, Daynes RA (2009). TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses. J Immunol, 182(7), 4296-305.
  9. Tataurova TA, Krepkova LV, Bortnikova VV, Kuznersov YuB, Enioutina EY aka Eniutina EIu (1988). Preclinical toxicological study of glyciram. Farmakol Toksikol, 51(6), 87-90.
  10. Alfred Balch, Jacob Wilkes, Emily Thorell, Andrew Pavia, Catherine Sherwin, Elena Enioutina (Submit Sin preparation). Changing IVIG use in Pediatric Patients: A retrospective review of practices in a network of major US Pediatric Hospitals. Int J Immunopharmacol.

Review

  1. Enioutina EY, Teng L, Fateeva TV, Brown JCS, Job KM, Bortnikova VV, Krepkova LV, Gubarev MI, Sherwin CMT (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. [Review]. Expert Review of Clinical Pharmacology, 10(11), 1203-1214.
  2. Enioutina EY, Salis ER, Job KM, Gubarev MI, Krepkova LV, Sherwin CM (2017). Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide. [Review]. Expert Review of Clinical Pharmacology, 10(3), 327-338.
  3. Yu T, Enioutina EY, Brunner HI, Vinks AA, Sherwin CM (2017). Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. [Review]. Clin Pharmacokinet, 56(2), 107-125.
  4. Barnes J, McLachlan AJ, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. [Review]. Expert Review of Clinical Pharmacology, 9(7), 905-15.
  5. Sammons HM, Gubarev MI, Krepkova LV, Bortnikova VV, Corrick F, Job KM, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. [Review]. Expert Review of Clinical Pharmacology, 9(8), 1117-27.
  6. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X, Di L, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 3. China and Japan. [Review]. Expert Review of Clinical Pharmacology, 9(9), 1225-33.
  7. Job KM, Olson J, Stockmann C, Constance JE, Enioutina EY, Rower JE, Linakis MW, Balch AH, Yu T, Liu X, Thorell EA, Sherwin CM (2016). Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections. [Review]. Expert Review of Anti-Infective Therapy, 14(8), 731-46.
  8. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 4. Canada and United States. [Review]. Expert Review of Clinical Pharmacology, 9(12), 1597-1609.
  9. Enioutina EY, Constance JE, Stockmann C, Linakis MW, Yu T, Rower JE, Balch AH, Sherwin CM (2015). Pharmacokinetic considerations in the use of antivirals in neonates. [Review]. Expert Opinion on Drug Metabolism and Toxicology, 11(12), 1861-78.

Editorial

  1. Biltaji E, Kumar SS, Enioutina EY, Sherwin CMT (2017). Can ad hoc analyses of clinical trials help personalize treatment decisions? Br J Clin Pharmacol, 83(11), 2337-2338.

Abstract

  1. Feldkamp ML, Enioutina EY, Byrne JLB, Bareyan D, Krikov S, Botto LD (2012). A pilot study of gastroschisis and biomarkers for chlamydia infection and inflammation [Abstract]. 39th Annual Meeting of the International Clearinghouse for Birth Defects Surveillance and Research, Ottawa, Canada.