Sihem Boudina, PhD


  • Arabic
  • English
  • French

Academic Information

  • Departments: Biochemistry - Adjunct Associate Professor, Internal Medicine - Adjunct Associate Professor, Nutrition and Integrative Physiology - Associate Professor, Surgery - Adjunct Assistant Professor
  • Divisions: Cardiothoracic Surgery, Endocrinology and Metabolism

Academic Office Information

  • 801-585-6833
  • George and Dolores Eccles Institute of Human Genetics
    Nutrition and Integrative Physiology
    15 N 2030 E, Room: 3410B
    Salt Lake City, UT 84112

Academic Bio

Sihem Boudina, PhD, is an Associate Professor in the Department of Nutrition and Integrative Physiology at the College of Health and an investigator at the Molecular Medicine Program at the University of Utah. Dr. Boudina's research is focused at understanding the pathogenesis of obesity and cardiovascular disease. Particularly, her lab has pioneered research of cardiac metabolism in diabetes and redox-regulation of energy expenditure.
Dr. Boudina received a bachelor's degree from the University of Science and technology in Algeria, and a PhD from Bordeaux 2 University in France. She then joined the lab of Dr. E. Dale Abel at the University of Utah for a post-doctoral training, after which she was recruited as a research Assistant Professor in the Division of Endocrinology. In 2010, Dr. Boudina became a faculty member in the Department of Nutrition and Integrative Physiology. She was promoted to Associate Professor and was awarded tenure in 2016. Dr. Boudina has earned several awards and fellowships from including awards from JDRF and AHA. She has been involved with mentoring students including under represented and minority students and has served in the EDI committee of the College of Health since 2018. She serves on several committees at the University of Utah and is a long-time grant reviewer for NIH. Dr. Boudina is nationally and internationally recognized for her pioneering work in cardiac metabolism and mitochondrial energetics.

Selected Publications

Journal Article

  1. Ghosh R, Vinod V, Symons JD, Boudina S (2020). Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging. Cells, 9(4).
  2. Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S (2018). Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Rep, 29(2), 270-282.e5.
  3. Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, OBrien KD, ORourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L (2020). Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop. Circulation, 140(14), 1205-1216.
  4. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brs LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019). Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv, 5(9), eaax8352.
  5. Pires KM, Torres NS, Buffolo M, Gunville R, Schaaf C, Davis K, Selzman CH, Gottlieb RA, Boudina S (2019). Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling. Antioxid Redox Signal, 31(6), 444-457.
  6. Ferhat M, Funai K, Boudina S (2018). Autophagy in Adipose Tissue Physiology and Pathophysiology. Antioxid Redox Signal, 31(6), 487-501.
  7. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, OConnell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL (2018). T cell-mediated regulation of the microbiota protects against obesity. Science, 365(6451).
  8. de Paula GSM, Wilieman M, Silva KR, Baptista LS, Boudina S, de Souza LL, Bento-Bernardes T, Asensi KD, Goldenberg RCDS, Pazos-Moura CC (2019). Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells. J Mol Endocrinol, 63(1), 93-102.
  9. Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, OConnell RM (2019). Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease. PLoS Genet, 15(2), e1007970.
  10. Park SK, La Salle DT, Cerbie J, Cho JM, Bledsoe A, Nelson A, Morgan DE, Richardson RS, Shiu YT, Boudina S, Trinity JD, Symons JD (2018). Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans. Am J Physiol Heart Circ Physiol, 316(1), H106-H112.
  11. Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S (2017). Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk. Cell Rep, 25(7), 1708-1717.e5.
  12. Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S (2018). Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Proc Natl Acad Sci U S A, 115(33), E7871-E7880.
  13. Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S (2017). Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. J Mol Cell Cardiol, 113, 39-50.
  14. Bharath LP, Cho JM, Park SK, Ruan T, Li Y, Mueller R, Bean T, Reese V, Richardson RS, Cai J, Sargsyan A, Pires K, Anandh Babu PV, Boudina S, Graham TE, Symons JD (2017). Endothelial Cell Autophagy Maintains Shear Stress-Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase. Arterioscler Thromb Vasc Biol, 37(9), 1646-1656.
  15. Ortega SP, Chouchani ET, Boudina S (2017). Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes. Adipocyte, 6(1), 56-61.
  16. Han YH, Buffolo M, Pires KM, Pei S, Scherer PE, Boudina S (2016). Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis. Diabetes, 65(9), 2639-51.
  17. Park H, Cho S, Han YH, Janat-Amsbury MM, Boudina S, Bae YH (2015). Combinatorial gene construct and non-viral delivery for anti-obesity in diet-induced obese mice. J Control Release, 207, 154-62.
  18. Boudina S, Graham TE (2014). Mitochondrial function/dysfunction in white adipose tissue. Exp Physiol, 99(9), 1168-78.
  19. Silva FJ, Holt DJ, Vargas V, Yockman J, Boudina S, Atkinson D, Grainger DW, Revelo MP, Sherman W, Bull DA, Patel AN (2014). Metabolically active human brown adipose tissue derived stem cells. Stem Cells, 32(2), 572-81.
  20. Pires KM, Ilkun O, Valente M, Boudina S (2014). Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice. Obesity (Silver Spring), 22(1), 178-87.
  21. Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S (2013). Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. J Mol Cell Cardiol, 64, 20-9.
  22. Ilkun O, Boudina S (2013). Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies. Curr Pharm Des, 19(27), 4806-17.
  23. Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel ED (2012). UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice. Diabetes, 61(12), 3260-9.
  24. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J (2012). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337(6090), 96-100.
  25. Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED (2012). Genetic loss of insulin receptors worsens cardiac efficiency in diabetes. J Mol Cell Cardiol, 52(5), 1019-26.
  26. Li Y, Wende AR, Nunthakungwan O, Huang Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T (2012). Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. FEBS J, 279(4), 599-611.
  27. Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ (2012). HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One, 7(8), e42118.
  28. Boudina S, Abel ED (2010). Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord, 11(1), 31-9.
  29. Singhal AK, Symons JD, Boudina S, Jaishy B, Shiu YT (2010). Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury. Vasc Dis Prev, 7, 1-14.
  30. S Boudina (2009). Clinical manifestation of diabetic cardiomyopathy. Heart Metab, 45(2009), 10-14.
  31. Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED (2009). Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res, 82(2), 351-60.
  32. Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED (2008). Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes, 57(11), 2924-32.
  33. Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP (2008). The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol, 295(1), H185-96.
  34. Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA (2008). Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med, 14(3-4), 98-108.
  35. Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R (2007). CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol, 293(5), H3201-9.
  36. ONeill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED (2007). A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab, 6(4), 294-306.
  37. Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED (2007). Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes, 56(10), 2457-66.
  38. Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J (2007). PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A, 104(39), 15466-71.
  39. Boudina S, Abel ED (2007). Diabetic cardiomyopathy revisited. Circulation, 115(25), 3213-23.
  40. Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mkel TP, Schneider MD (2007). Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab, 5(2), 129-42.
  41. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strmstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A (2006). Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol, 4(11), e369.
  42. Boudina S, Abel ED (2006). Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda), 21, 250-8.
  43. Boudina S, Sena S, ONeill BT, Tathireddy P, Young ME, Abel ED (2005). Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation, 112(17), 2686-95.
  44. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP (2005). PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol, 3(4), e101.
  45. Mazumder PK, ONeill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED (2004). Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes, 53(9), 2366-74.
  46. Dos Santos P, Laclau MN, Boudina S, Garlid KD (2004). Alterations of the bioenergetics systems of the cell in acute and chronic myocardial ischemia. Mol Cell Biochem, 256-257(1-2), 157-66.
  47. Dos Santos P, Kowaltowski AJ, Laclau MN, Seetharaman S, Paucek P, Boudina S, Thambo JB, Tariosse L, Garlid KD (2002). Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart. Am J Physiol Heart Circ Physiol, 283(1), H284-95.
  48. Ducret T, Boudina S, Sorin B, Vacher AM, Gourdou I, Liguoro D, Guerin J, Bresson-Bepoldin L, Vacher P (2002). Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells. Glia, 38(3), 200-14.
  49. Boudina S, Laclau MN, Tariosse L, Daret D, Gouverneur G, Bonoron-Adle S, Saks VA, Dos Santos P (2002). Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. Am J Physiol Heart Circ Physiol, 282(3), H821-31.
  50. Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adele S, Saks VA, Garlid KD, Dos Santos P (2001). Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. J Mol Cell Cardiol, 33(5), 947-56.


  1. Dodson MV, Boudina S, Albrecht E, Bucci L, Culver MF, Wei S, Bergen WG, Amaral AJ, Moustaid-Moussa N, Poulos S, Hausman GJ (2013). A long journey to effective obesity treatments: is there light at the end of the tunnel? [Review]. Exp Biol Med (Maywood), 238(5), 491-501.


  1. Sara Palacios-Ortega, Marcio Buffolo, Karla Maria Pires and Sihem Boudina (2017). Mitochondrial Stress: A Novel Thermogenic Pathway to Fight Obesity and Diabetes [Abstract]. Obesity and Adipose Tissue Biology (J4). Keystone Symposia. Keystone, Colorado, USA.