Samuel M. Brown, MD, MS

Languages

  • English
  • Russian
  • Spanish

Academic Information

  • Departments: Internal Medicine - Associate Professor
  • Divisions: Pulmonary

Board Certification

  • American Board of Internal Medicine (Sub: Critical Care Medicine)
  • American Board of Internal Medicine (Sub: Pulmonary Disease)

Academic Office Information

  • 801-507-6556
  • Intermountain Medical Center
    Shock Trauma ICU
    5121 Cottonwood Street
    Murray, UT 84107

Academic Bio

Samuel Brown, M.D., M.S., is an attending physician in the Shock Trauma ICU at Intermountain Medical Center and assistant professor of pulmonary and critical care at the University of Utah School of Medicine. Board certified in pulmonary and critical care medicine, and a testamur of the National Board of Echocardiography. His clinical interests include life-threatening infection (“sepsis”), acute lung injury, and the function of the heart and blood vessels during life-threatening illness.

Education History

Type School Degree
Fellowship University of Utah School of Medicine/SLC VA Hospital, Department of Anesthesia
Transthoracic Echocardiography
Fellow
Fellowship University of Utah
Pulmonary and Critical Care Medicine
Fellow
Graduate Training University of Utah
Clinical Investigation
M.S.
Residency Massachusetts General Hospital
Internal Medicine
Resident
Internship Massachusetts General Hospital
Internal Medicine
Intern
Professional Medical Harvard Medical School
Medicine
M.D.
Undergraduate Harvard College
Linguistics and Russian
A.B.

Global Impact

Service

Date Role Description Country
09/01/2020 Chair NHLBI CONNECTS Inpatient Master Protocol Subcommittee.  I chair this committee, which is responsible for the NHLBI master protocol among hospitalized patients with COVID-19. This includes both the master protocol itself and the writing and execution of "domain-specific appendices," which are specific platforms for comparison of sets of agents, The agents studied within the master protocol are focused on host-based therapies for COVID-19. Brazil

Selected Publications

Journal Article

  1. Han JH, Ginde AA, Brown SM, Baughman A, Collar EM, Ely EW, Gong MN, Hope AA, Hou PC, Hough CL, Iwashyna TJ, Jackson JC, Khan A, Orun OM, Patel MB, Raman R, Rice TW, Ringwood N, Semler MW, Shapiro NI, Talmor DS, Self WH, PETAL Network Investigators (2021). Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults. (Epub ahead of print) Chest.
  2. Beesley SJ, Sorensen J, Walkey AJ, Tonna JE, Lanspa MJ, Hirshberg E, Grissom CK, Horne BD, Burk R, Abraham TP, Paine R, Brown SM (2022). Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis. Crit Care Med, 49(4), e444-e453.
  3. Knox DB, Lanspa MJ, Brown SM, Peltan ID, Donohue MM, Puttgen A (2020). Decreased Observance of Stroke in the Population Associated With COVID-19 Related Distancing Measures. Neurohospitalist, 11(2), 137-140.
  4. Panebianco NL, Mayo PH, Arntfield RT, Brown SM, Diaz-Gomez J, Hernandez A, Koenig SJ, Noble V, Sekiguchi H, Subhiyah RG, Mulvagh S, Saric M, Troianos CA, Labovitz AJ (2021). Assessing Competence in Critical Care Echocardiography: Development and Initial Results of an Examination and Certification Processes. (Epub ahead of print) Crit Care Med.
  5. Douin DJ, Ward MJ, Lindsell CJ, Howell MP, Hough CL, Exline MC, Gong MN, Aboodi MS, Tenforde MW, Feldstein LR, Stubblefield WB, Steingrub JS, Prekker ME, Brown SM, Peltan ID, Khan A, Files DC, Gibbs KW, Rice TW, Casey JD, Hager DN, Qadir N, Henning DJ, Wilson JG, Patel MM, Self WH, Ginde AA (2021). ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis-March to June 2020. Crit Care Explor, 3(3), e0361.
  6. ACTIV-3TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, stergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD (2020). A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med, 384(10), 905-914.
  7. Brown SM, Beesley SJ, Stubben C, Wilson EL, Presson AP, Grissom C, Maguire C, Rondina MT, Hopkins RO (2020). Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study. J Intensive Care Med, 36(3), 262-270.
  8. Lanspa MJ, Cirulis MM, Wiley BM, Olsen TD, Wilson EL, Beesley SJ, Brown SM, Hirshberg EL, Grissom CK (2020). Right Ventricular Dysfunction in Early Sepsis and Septic Shock. Chest, 159(3), 1055-1063.
  9. Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW, VICTAS Investigators (2021). Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA, 325(8), 742-750.
  10. Fox ER, Shah M, Vinik R, Brown S, Buckel W, Webb B, Zarndt J, Evans M, Mesdaghi P, Imlay HN, Spivak ES (2021). Developing statewide remdesivir use criteria. (Epub ahead of print) Am J Health Syst Pharm.
  11. Fisher KA, Olson SM, Tenforde MW, Self WH, Wu M, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Prekker ME, Steingrub JS, Exline MC, Henning DJ, Wilson JG, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Talbot HK, Casey JD, Grijalva CG, Flannery B, Patel MM, Feldstein LR (2021). Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States. (Epub ahead of print) Influenza Other Respi Viruses.
  12. Tang Y, Brown SM, Sorensen J, Harley JB (2020). Physiology-Informed Real-Time Mean Arterial Blood Pressure Learning and Prediction for Septic Patients Receiving Norepinephrine. IEEE Trans Biomed Eng, 68(1), 181-191.
  13. Webb BJ, Peltan ID, Jensen P, Hoda D, Hunter B, Silver A, Starr N, Buckel W, Grisel N, Hummel E, Snow G, Morris D, Stenehjem E, Srivastava R, Brown SM (2020). Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study. Lancet Rheumatol, 2(12), e754-e763.
  14. Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE Jr, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM, National Heart Lung and Blood Institute PETAL Clinical Trials Network, Steingrub J, Smithline H, Tiru B, Tidswell M, Kozikowski L, Thornton-Thompson S, De Souza L, Hou P, Baron R, Massaro A, Aisiku I, Fredenburgh L, Seethala R, Johnsky L, Riker R, Seder D, May T, Baumann M, Eldridge A, Lord C, Shapiro N, Talmor D, OMara T, Kirk C, Harrison K, Kurt L, Schermerhorn M, Banner-Goodspeed V, Boyle K, Dubosh N, Filbin M, Hibbert K, Parry B, Lavin-Parsons K, Pulido N, Lilley B, Lodenstein C, Margolin J, Brait K, Jones A, Galbraith J, Peacock R, Nandi U, Wachs T, Matthay M, Liu K, Kangelaris K, Wang R, Calfee C, Yee K, Hendey G, Chang S, Lim G, Qadir N, Tam A, Beutler R, Levitt J, Wilson J, Rogers A, Vojnik R, Roque J, Albertson T, Chenoweth J, Adams J, Pearson S, Juarez M, Almasri E, Fayed M, Hughes A, Hillard S, Huebinger R, Wang H, Vidales E, Patel B, Ginde A, Moss M, Baduashvili A, McKeehan J, Finck L, Higgins C, Howell M, Douglas I, Haukoos J, Hiller T, Lyle C, Cupelo A, Caruso E, Camacho C, Gravitz S, Finigan J, Griesmer C, Park P, Hyzy R, Nelson K, McDonough K, Olbrich N, Williams M, Kapoor R, Nash J, Willig M, Ford H, Gardner-Gray J, Ramesh M, Moses M, Ng Gong M, Aboodi M, Asghar A, Amosu O, Torres M, Kaur S, Chen JT, Hope A, Lopez B, Rosales K, Young You J, Mosier J, Hypes C, Natt B, Borg B, Salvagio Campbell E, Hite RD, Hudock K, Cresie A, Alhasan F, Gomez-Arroyo J, Duggal A, Mehkri O, Hastings A, Sahoo D, Abi Fadel F, Gole S, Shaner V, Wimer A, Meli Y, King A, Terndrup T, Exline M, Pannu S, Robart E, Karow S, Hough C, Robinson B, Johnson N, Henning D, Campo M, Gundel S, Seghal S, Katsandres S, Dean S, Khan A, Krol O, Jouzestani M, Huynh P, Weissman A, Yealy D, Scholl D, Adams P, McVerry B, Huang D, Angus D, Schooler J, Moore S, Files C, Miller C, Gibbs K, LaRose M, Flores L, Koehler L, Morse C, Sanders J, Langford C, Nanney K, MdalaGausi M, Yeboah P, Morris P, Sturgill J, Seif S, Cassity E, Dhar S, de Wit M, Mason J, Goodwin A, Hall G, Grady A, Chamberlain A, Brown S, Bledsoe J, Leither L, Peltan I, Starr N, Fergus M, Aston V, Montgomery Q, Smith R, Merrill M, Brown K, Armbruster B, Harris E, Middleton E, Paine R, Johnson S, Barrios M, Eppensteiner J, Limkakeng A, McGowan L, Porter T, Bouffler A, Leahy JC, deBoisblanc B, Lammi M, Happel K, Lauto P, Self W, Casey J, Semler M, Collins S, Harrell F, Lindsell C, Rice T, Stubblefield W, Gray C, Johnson J, Roth M, Hays M, Torr D, Zakaria A, Schoenfeld D, Thompson T, Hayden D, Ringwood N, Oldmixon C, Ulysse C, Morse R, Muzikansky A, Fitzgerald L, Whitaker S, Lagakos A, Brower R, Reineck L, Aggarwal N, Bienstock K, Freemer M, Maclawiw M, Weinmann G, Morrison L, Gillespie M, Kryscio R, Brodie D, Zareba W, Rompalo A, Boeckh M, Parsons P, Christie J, Hall J, Horton N, Zoloth L, Dickert N, Diercks D (2021). Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA, 324(21), 2165-2176.
  15. Self WH, Tenforde MW, Stubblefield WB, Feldstein LR, Steingrub JS, Shapiro NI, Ginde AA, Prekker ME, Brown SM, Peltan ID, Gong MN, Aboodi MS, Khan A, Exline MC, Files DC, Gibbs KW, Lindsell CJ, Rice TW, Jones ID, Halasa N, Talbot HK, Grijalva CG, Casey JD, Hager DN, Qadir N, Henning DJ, Coughlin MM, Schiffer J, Semenova V, Li H, Thornburg NJ, Patel MM, CDC COVID-19 Response Team, IVY Network (2020). Decline in SARS-CoV-2 Antibodies After Mild Infection Among Frontline Health Care Personnel in a Multistate Hospital Network - 12 States, April-August 2020. MMWR Morb Mortal Wkly Rep, 69(47), 1762-1766.
  16. Cirulis MM, Dodson MW, Brown LM, Brown SM, Lahm T, Elliott G (2020). At the X-Roads of Sex and Genetics in Pulmonary Arterial Hypertension. Genes (Basel), 11(11).
  17. Brown SM, Peltan I, Kumar N, Leither L, Webb BJ, Starr N, Grissom CK, Buckel WR, Srivastava R, Butler AM, Groat D, Haaland B, Ying J, Harris E, Johnson S, Paine R 3rd, Greene T (2020). Hydroxychloroquine vs. Azithromycin for Hospitalized Patients with COVID-19 (HAHPS): Results of a Randomized, Active Comparator Trial. (Epub ahead of print) Ann Am Thorac Soc.
  18. Fisher KA, Olson SM, Tenforde MW, Feldstein LR, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Prekker ME, Steingrub JS, Exline MC, Henning DJ, Wilson JG, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Talbot HK, Casey JD, Grijalva CG, Flannery B, Patel MM, Self WH, IVY Network Investigators, CDC COVID-19 Response Team (2020). Telework Before Illness Onset Among Symptomatic Adults Aged ≥18 Years With and Without COVID-19 in 11 Outpatient Health Care Facilities - United States, July 2020. MMWR Morb Mortal Wkly Rep, 69(44), 1648-1653.
  19. Akhlaghi N, Needham DM, Bose S, Banner-Goodspeed VM, Beesley SJ, Dinglas VD, Groat D, Greene T, Hopkins RO, Jackson J, Mir-Kasimov M, Sevin CM, Wilson E, Brown SM (2020). Evaluating the association between unmet healthcare needs and subsequent clinical outcomes: protocol for the Addressing Post-Intensive Care Syndrome-01 (APICS-01) multicentre cohort study. BMJ Open, 10(10), e040830.
  20. Feldstein LR, Self WH, Ferdinands JM, Randolph AG, Aboodi M, Baughman AH, Brown SM, Exline MC, Files DC, Gibbs K, Ginde AA, Gong MN, Grijalva CG, Halasa N, Khan A, Lindsell CJ, Newhams M, Peltan ID, Prekker ME, Rice TW, Shapiro NI, Steingrub J, Talbot HK, Halloran ME, Patel M, Influenza Vaccine Effectiveness in the Critically Ill IVY Investigators and the Pediatric Intensive Care Influenza Vaccine Effectiveness PICFLU-VE Investigators (2020). Incorporating real-time influenza detection into the test-negative design for estimating influenza vaccine effectiveness: The real-time test-negative design (rtTND). (Epub ahead of print) Clin Infect Dis.
  21. Fisher KA, Tenforde MW, Feldstein LR, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Prekker ME, Steingrub JS, Exline MC, Henning DJ, Wilson JG, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Talbot HK, Casey JD, Grijalva CG, Flannery B, Patel MM, Self WH, IVY Network Investigators, CDC COVID-19 Response Team (2020). Community and Close Contact Exposures Associated with COVID-19 Among Symptomatic Adults ≥18 Years in 11 Outpatient Health Care Facilities - United States, July 2020. MMWR Morb Mortal Wkly Rep, 69(36), 1258-1264.
  22. Self WH, Tenforde MW, Stubblefield WB, Feldstein LR, Steingrub JS, Shapiro NI, Ginde AA, Prekker ME, Brown SM, Peltan ID, Gong MN, Aboodi MS, Khan A, Exline MC, Files DC, Gibbs KW, Lindsell CJ, Rice TW, Jones ID, Halasa N, Talbot HK, Grijalva CG, Casey JD, Hager DN, Qadir N, Henning DJ, Coughlin MM, Schiffer J, Semenova V, Li H, Thornburg NJ, Patel MM, CDC COVID-19 Response Team, IVY Network (2020). Seroprevalence of SARS-CoV-2 Among Frontline Health Care Personnel in a Multistate Hospital Network - 13 Academic Medical Centers, April-June 2020. MMWR Morb Mortal Wkly Rep, 69(35), 1221-1226.
  23. Casey JD, Johnson NJ, Semler MW, Collins SP, Aggarwal NR, Brower RG, Chang SY, Eppensteiner J, Filbin M, Gibbs KW, Ginde AA, Gong MN, Harrell F, Hayden DL, Hough CL, Khan A, Leither LM, Moss M, Oldmixon CF, Park PK, Reineck LA, Ringwood NJ, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Torr DK, Weissman A, Lindsell CJ, Rice TW, Thompson BT, Brown SM, Self WH (2020). Rationale and Design of ORCHID: A Randomized Placebo-controlled Clinical Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19. Ann Am Thorac Soc, 17(9), 1144-1153.
  24. Beesley SJ, Hirshberg EL, Wilson EL, Butler JM, Oniki TA, Kuttler KG, Orme JF, Hopkins RO, Brown SM (2020). Depression and Change in Caregiver Burden Among Family Members of Intensive Care Unit Survivors. Am J Crit Care, 29(5), 350-357.
  25. Brown SM, Peltan ID, Webb B, Kumar N, Starr N, Grissom C, Buckel WR, Srivastava R, Harris ES, Leither LM, Johnson SA, Paine R 3rd, Greene T (2020). Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial. Ann Am Thorac Soc, 17(8), 1008-1015.
  26. Tenforde MW, Kim SS, Lindsell CJ, Billig Rose E, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Steingrub JS, Smithline HA, Gong MN, Aboodi MS, Exline MC, Henning DJ, Wilson JG, Khan A, Qadir N, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Stubblefield WB, Patel MM, Self WH, Feldstein LR, IVY Network Investigators, CDC COVID-19 Response Team, IVY Network Investigators (2020). Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020. MMWR Morb Mortal Wkly Rep, 69(30), 993-998.
  27. Brunisholz KD, Knighton AJ, Webb B, Brown SM, Peltan ID, Stenehjem E, Knowlton K, Belnap TW, Quam J, Srivastava R, Intermountain Healthcare Research Guidance Council (2020). How Community-Based Health Systems Embrace Research During the COVID-19 Pandemic. Qual Manag Health Care, 29(3), 173-175.
  28. Peltan ID, Bledsoe JR, Brems D, McLean S, Murnin E, Brown SM (2020). Institution of an emergency department "swarming" care model and sepsis door-to-antibiotic time: A quasi-experimental retrospective analysis. PLoS ONE, 15(5), e0232794.
  29. Hirshberg EL, Butler J, Francis M, Davis FA, Lee D, Tavake-Pasi F, Napia E, Villalta J, Mukundente V, Coulter H, Stark L, Beesley SJ, Orme JF, Brown SM, Hopkins RO (2020). Persistence of patient and family experiences of critical illness. BMJ Open, 10(4), e035213.
  30. Beesley SJ, Egan E, Lanspa MJ, Wilson EL, Hirshberg EL, Grissom CK, Burk R, Brown SM (2020). Unanticipated critical findings on echocardiography in septic patients. Ultrasound J, 12(1), 12.
  31. Webb BJ, Subramanian A, Lopansri B, Goodman B, Jones PB, Ferraro J, Stenehjem E, Brown SM (2020). Antibiotic Exposure and Risk for Hospital-Associated Clostridioides difficile Infection. Antimicrob Agents Chemother, 64(4).
  32. Peltan ID, Poll JB, Guidry D, Brown SM, Beninati W (2019). Acceptability and Perceived Utility of Telemedical Consultation during Cardiac Arrest Resuscitation. A Multicenter Survey. Ann Am Thorac Soc, 17(3), 321-328.
  33. Novack V, Beitler JR, Yitshak-Sade M, Thompson BT, Schoenfeld DA, Rubenfeld G, Talmor D, Brown SM (2020). Alive and Ventilator Free: A Hierarchical, Composite Outcome for Clinical Trials in the Acute Respiratory Distress Syndrome. Crit Care Med, 48(2), 158-166.
  34. Lanspa MJ, Peltan ID, Jacobs JR, Sorensen JS, Carpenter L, Ferraro JP, Brown SM, Berry JG, Srivastava R, Grissom CK (2019). Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS. Crit Care, 23(1), 424.
  35. Hirshberg EL, Wilson EL, Stanfield V, Kuttler KG, Majercik S, Beesley SJ, Orme J, Hopkins RO, Brown SM (2019). Impact of Critical Illness on Resource Utilization: A Comparison of Use in the Year Before and After ICU Admission. Crit Care Med, 47(11), 1497-1504.
  36. Cirulis MM, Beesley SJ, Wilson EL, Stubben C, Olsen TD, Hirshberg EL, Smith LM, Lanspa MJ, Abraham TP, Grissom CK, Rondina MT, Brown SM (2019). The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study. Intensive Care Med Exp, 7(1), 57.
  37. Brown SM, Paine R 3rd, Lanspa M, Gong M (2019). Value beyond the P: The Case for Higher-Quality and Better-publicized Pilot and Feasibility Trials. Ann Am Thorac Soc, 16(10), 1230-1233.
  38. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.
  39. Wiegers SE, Ryan T, Arrighi JA, Brown SM, Canaday B, Damp JB, Diaz-Gomez JL, Figueredo VM, Garcia MJ, Gillam LD, Griffin BP, Kirkpatrick JN, Klarich KW, Lui GK, Maffett S, Naqvi TZ, Patel AR, Poulin MF, Rose GA, Swaminathan M (2019). 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): A Report of the ACC Competency Management Committee. Catheter Cardiovasc Interv, 94(3), 481-505.
  40. Brown SM, Bose S, Banner-Goodspeed V, Beesley SJ, Dinglas VD, Hopkins RO, Jackson JC, Mir-Kasimov M, Needham DM, Sevin CM, Addressing Post Intensive Care Syndrome 01 APICS-01 study team (2019). Approaches to Addressing Post-Intensive Care Syndrome among Intensive Care Unit Survivors. A Narrative Review. Ann Am Thorac Soc, 16(8), 947-956.
  41. Writing Committee Members, Wiegers SE, Ryan T, Arrighi JA, Brown SM, Canaday B, Damp JB, Diaz-Gomez JL, Figueredo VM, Garcia MJ, Gillam LD, Griffin BP, Kirkpatrick JN, Klarich KW, Lui GK, Maffett S, Naqvi TZ, Patel AR, Poulin MF, Rose GA, Swaminathan M, ACC Competency Management Committee, Arrighi JA, Mendes LA, Adams JE 3rd, Brush JE Jr, Dec GW Jr, Denktas A, Fernandes S, Freeman R, Hahn RT, Halperin JL, Housholder-Hughes SD, Khan SS, Klarich KW, Lin CH, Marine JE, McPherson JA, Niazi K, Ryan T, Solomon MA, Spicer RL, Tam M, Wang A, Weissman G, Weitz HH, Williams ES (2019). 2019 ACC/AHA/ASE Advanced Training Statement on Echocardiography (Revision of the 2003 ACC/AHA Clinical Competence Statement on Echocardiography): A Report of the ACC Competency Management Committee. J Am Soc Echocardiogr, 32(8), 919-943.
  42. Tang Y, Brown S, Sorensen J, Harley JB (2019). Reduced Rank Least Squares for Real-Time Short Term Estimation of Mean Arterial Blood Pressure in Septic Patients Receiving Norepinephrine. IEEE J Transl Eng Health Med, 7, 4100209.
  43. National Heart Lung and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC (2019). Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med, 380(21), 1997-2008.
  44. Brown SM, Grissom CK, Moss M, Rice TW, Schoenfeld D, Hou PC, Thompson BT, Brower RG, NIHNHLBI PETAL Network Collaborators (2016). Nonlinear Imputation of Pao2/Fio2 From Spo2/Fio2 Among Patients With Acute Respiratory Distress Syndrome. Chest, 150(2), 307-13.
  45. Godard S, Herry C, Westergaard P, Scales N, Brown S, Burns K, Mehta S, Jacono F, Kubelik D, Maziak DE, Marshall J, Martin C, Seely A (2015). Practice variation in spontaneous breathing trial performance and documentation. (Epub ahead of print) Can Respir J.
  46. Brown SM, Tate MQ, Jones JP, Kuttler KG, Lanspa MJ, Rondina MT, Grissom CK, Mathews VJ (2015). Coefficient of Variation of Coarsely Sampled Heart Rate is Associated With Early Vasopressor Independence in Severe Sepsis and Septic Shock. J Intensive Care Med, 30(7), 420-5.
  47. Walkey AJ, Pencina KM, Knox D, Kuttler KG, DAgostino RB Sr, Benjamin EJ, Brown SM (2015). Five-Year Risk of Mechanical Ventilation in Community-Dwelling Adults: The Framingham-Intermountain Anticipating Life Support Study. J Am Geriatr Soc, 63(10), 2082-8.
  48. Lanspa MJ, Pittman JE, Hirshberg EL, Wilson EL, Olsen T, Brown SM, Grissom CK (2015). Association of left ventricular longitudinal strain with central venous oxygen saturation and serum lactate in patients with early severe sepsis and septic shock. Crit Care, 19(1), 304.
  49. Knox DB, Lanspa MJ, Kuttler KG, Brewer SC, Brown SM (2015). Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med, 41(5), 814-22.
  50. Brown SM, Grissom CK, Rondina MT, Hoidal JR, Scholand MB, Wolff RK, Morris AH, Paine R 3rd, NIHNHLBI ARDS Network (2015). Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome. Exp Lung Res, 41(3), 155-62.
  51. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom CK (2015). Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. J Gerontol A Biol Sci Med Sci, 70(2), 225-31.
  52. Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR 3rd, Morris AH, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network (2015). Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med, 43(2), 288-95.
  53. Pratt CM, Hirshberg EL, Jones JP, Kuttler KG, Lanspa MJ, Wilson EL, Hopkins RO, Brown SM (2015). Long-term outcomes after severe shock. Shock, 43(2), 128-32.
  54. Brown SM, Tate Q, Jones JP, Knox DB, Kuttler KG, Lanspa M, Rondina MT, Grissom CK, Behera S, Mathews VJ, Morris A (2013). Initial fractal exponent of heart rate variability is associated with success of early resuscitation in patients with severe sepsis or septic shock: a prospective cohort study. J Crit Care, 28(6), 959-63.
  55. Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP, Intermountain Healthcare Intensive Medicine Clinical Program (2013). Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med, 188(1), 77-82.
  56. Brown SM, Lanspa MJ, Jones JP, Kuttler KG, Li Y, Carlson R, Miller RR 3rd, Hirshberg EL, Grissom CK, Morris AH (2013). Survival after shock requiring high-dose vasopressor therapy. Chest, 143(3), 664-671.
  57. Brown SM, Pittman J, Miller Iii RR, Horton KD, Markewitz B, Hirshberg E, Jones J, Grissom CK (2011). Right and left heart failure in severe H1N1 influenza A infection. Eur Respir J, 37(1), 112-8.

Edited Book

  1. Brown SM, Blaivas M, Hirshberg E, Kasal J, Pustavoitau A (Eds.) (2015). Comprehensive Critical Care Ultrasound. Chicago, IL: Society of Critical Care Medicine.

Commentary

  1. Brown SM, Paine R 3rd (2019). Asking Causal Questions of Observational Data: The Quest Continues. Ann Am Thorac Soc, 16(8), 977-979.

Case Report

  1. Winward J, Lyckholm L, Brown SM, Mokadem M (2020). Case of relapsing sulfasalazine-induced hypersensitivity syndrome upon re-exposure. BMJ Case Rep, 13(9), e235803.
  2. Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, OBrien EA, Ilstrup SJ, Christensen RD (2019). First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Transfusion, 59(10), 3089-3092.

Editorial

  1. Brown SM (2019). The number needed to mourn. Intensive Care Med, 45(8), 1154-1155.

Letter

  1. Tonna JE, Peltan I, Brown SM, Herrick JS, Keenan HT, University of Utah Mechanical Power Study Group (2020). Mechanical power and driving pressure as predictors of mortality among patients with ARDS. [Letter to the editor]. Intensive Care Med, 46(10), 1941-1943.
  2. Peltan ID, Brown SM, Hough CL (2019). In reply. [Letter to the editor]. Ann Emerg Med, 74(4), 607-608.
  3. Hirshberg EL, Lanspa MJ, Brown SM, Dean NC, Grissom CK (2019). The authors reply. [Letter to the editor]. Crit Care Med, 47(8), e724-e726.
  4. Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ, Shahul S, Brown SM (2018). The authors reply. [Letter to the editor]. Crit Care Med, 46(10), e1013-e1014.
  5. Brown SM (2007). Tiotropium in combination with placebo, salmeterol, or fluticasone salmeterol for chronic obstructive pulmonary disease: possible confounding effect of treatment withdrawal? [Letter to the editor]. Ann Intern Med, 147(12), 882; author reply 882-3.

Other

  1. Murray DD, Babiker AG, Baker JV, Barkauskas CE, Brown SM, Chang C, Davey VJ, Gelijns AC, Ginde AA, Grund B, Higgs E, Hudson F, Kan VL, Lane HC, Murray TA, Paredes R, Parmar MKB, Pett S, Phillips AN, Polizzotto MN, Reilly C, Sandkovsky U, Sharma S, Teitelbaum M, Thompson BT, Young BE, Neaton JD, Lundgren JD (2020). Design and implementation of the multi-arm, multi-stage Therapeutics for Inpatients with COVID-19 (TICO) platform master protocol: An Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) initiative. United States.

Patent

  1. Brown SM (2012). Apparatus, systems, and methods for accessing the airway with medical instruments without interruption of assisted respiration (licensed to ReddyPort, LLC). U.S. Patent No. WO2012100016 A1. Washington, D.C.:U.S. Patent and Trademark Office.