Samuel M. Brown, MD, MS


  • English
  • Russian
  • Spanish

Academic Information

  • Departments: Internal Medicine - Associate Professor
  • Divisions: Pulmonary

Board Certification

  • American Board of Internal Medicine (Sub: Critical Care Medicine)
  • American Board of Internal Medicine (Sub: Pulmonary Disease)

Academic Office Information

  • 801-507-6556
  • Intermountain Medical Center
    Shock Trauma ICU
    5121 Cottonwood Street
    Murray, UT 84107

Academic Bio

Samuel Brown, M.D., M.S., is an attending physician in the Shock Trauma ICU at Intermountain Medical Center and assistant professor of pulmonary and critical care at the University of Utah School of Medicine. Board certified in pulmonary and critical care medicine, and a testamur of the National Board of Echocardiography. His clinical interests include life-threatening infection (“sepsis”), acute lung injury, and the function of the heart and blood vessels during life-threatening illness.

Education History

Type School Degree
Fellowship University of Utah School of Medicine/SLC VA Hospital, Department of Anesthesia
Transthoracic Echocardiography
Fellowship University of Utah
Pulmonary and Critical Care Medicine
Graduate Training University of Utah
Clinical Investigation
Residency Massachusetts General Hospital
Internal Medicine
Internship Massachusetts General Hospital
Internal Medicine
Professional Medical Harvard Medical School
Undergraduate Harvard College
Linguistics and Russian

Selected Publications

Journal Article

  1. Brunisholz KD, Knighton AJ, Webb B, Brown SM, Peltan ID, Stenehjem E, Knowlton K, Belnap TW, Quam J, Srivastava R, Intermountain Healthcare Research Guidance Council (2020). How Community-Based Health Systems Embrace Research During the COVID-19 Pandemic. Qual Manag Health Care, 29(3), 173-175.
  2. Brown SM, Peltan ID, Webb B, Kumar N, Starr N, Grissom C, Buckel WR, Srivastava R, Harris ES, Leither L, Johnson SA, Paine R 3rd, Greene T (2020). Hydroxychloroquine vs. Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS): Protocol for a Pragmatic, Open Label, Active Comparator Trial. (Epub ahead of print) Ann Am Thorac Soc.
  3. Peltan ID, Bledsoe JR, Brems D, McLean S, Murnin E, Brown SM (2020). Institution of an emergency department "swarming" care model and sepsis door-to-antibiotic time: A quasi-experimental retrospective analysis. PLoS ONE, 15(5), e0232794.
  4. Hirshberg EL, Butler J, Francis M, Davis FA, Lee D, Tavake-Pasi F, Napia E, Villalta J, Mukundente V, Coulter H, Stark L, Beesley SJ, Orme JF, Brown SM, Hopkins RO (2020). Persistence of patient and family experiences of critical illness. BMJ Open, 10(4), e035213.
  5. Beesley SJ, Egan E, Lanspa MJ, Wilson EL, Hirshberg EL, Grissom CK, Burk R, Brown SM (2020). Unanticipated critical findings on echocardiography in septic patients. Ultrasound J, 12(1), 12.
  6. Webb BJ, Subramanian A, Lopansri B, Goodman B, Jones PB, Ferraro J, Stenehjem E, Brown SM (2020). Antibiotic Exposure and Risk for Hospital-Associated Clostridioides difficile Infection. Antimicrob Agents Chemother, 64(4).
  7. Peltan ID, Poll JB, Guidry D, Brown SM, Beninati W (2019). Acceptability and Perceived Utility of Telemedical Consultation during Cardiac Arrest Resuscitation. A Multicenter Survey. Ann Am Thorac Soc, 17(3), 321-328.
  8. Novack V, Beitler JR, Yitshak-Sade M, Thompson BT, Schoenfeld DA, Rubenfeld G, Talmor D, Brown SM (2021). Alive and Ventilator Free: A Hierarchical, Composite Outcome for Clinical Trials in the Acute Respiratory Distress Syndrome. Crit Care Med, 48(2), 158-166.
  9. Brown SM, Beesley SJ, Stubben C, Wilson EL, Presson AP, Grissom C, Maguire C, Rondina MT, Hopkins RO (2020). Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study. J Intensive Care Med, 885066619897604.
  10. Lanspa MJ, Peltan ID, Jacobs JR, Sorensen JS, Carpenter L, Ferraro JP, Brown SM, Berry JG, Srivastava R, Grissom CK (2019). Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS. Crit Care, 23(1), 424.
  11. Hirshberg EL, Wilson EL, Stanfield V, Kuttler KG, Majercik S, Beesley SJ, Orme J, Hopkins RO, Brown SM (2019). Impact of Critical Illness on Resource Utilization: A Comparison of Use in the Year Before and After ICU Admission. Crit Care Med, 47(11), 1497-1504.
  12. Cirulis MM, Beesley SJ, Wilson EL, Stubben C, Olsen TD, Hirshberg EL, Smith LM, Lanspa MJ, Abraham TP, Grissom CK, Rondina MT, Brown SM (2019). The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study. Intensive Care Med Exp, 7(1), 57.
  13. Brown SM, Paine R 3rd, Lanspa M, Gong M (2019). Value beyond the P: The Case for Higher-Quality and Better-publicized Pilot and Feasibility Trials. Ann Am Thorac Soc, 16(10), 1230-1233.
  14. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.
  15. Wiegers SE, Ryan T, Arrighi JA, Brown SM, Canaday B, Damp JB, Diaz-Gomez JL, Figueredo VM, Garcia MJ, Gillam LD, Griffin BP, Kirkpatrick JN, Klarich KW, Lui GK, Maffett S, Naqvi TZ, Patel AR, Poulin MF, Rose GA, Swaminathan M (2019). 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): A Report of the ACC Competency Management Committee. Catheter Cardiovasc Interv, 94(3), 481-505.
  16. Brown SM, Bose S, Banner-Goodspeed V, Beesley SJ, Dinglas VD, Hopkins RO, Jackson JC, Mir-Kasimov M, Needham DM, Sevin CM, Addressing Post Intensive Care Syndrome 01 APICS-01 study team (2019). Approaches to Addressing Post-Intensive Care Syndrome among Intensive Care Unit Survivors. A Narrative Review. Ann Am Thorac Soc, 16(8), 947-956.
  17. Writing Committee Members, Wiegers SE, Ryan T, Arrighi JA, Brown SM, Canaday B, Damp JB, Diaz-Gomez JL, Figueredo VM, Garcia MJ, Gillam LD, Griffin BP, Kirkpatrick JN, Klarich KW, Lui GK, Maffett S, Naqvi TZ, Patel AR, Poulin MF, Rose GA, Swaminathan M, ACC Competency Management Committee, Arrighi JA, Mendes LA, Adams JE 3rd, Brush JE Jr, Dec GW Jr, Denktas A, Fernandes S, Freeman R, Hahn RT, Halperin JL, Housholder-Hughes SD, Khan SS, Klarich KW, Lin CH, Marine JE, McPherson JA, Niazi K, Ryan T, Solomon MA, Spicer RL, Tam M, Wang A, Weissman G, Weitz HH, Williams ES (2019). 2019 ACC/AHA/ASE Advanced Training Statement on Echocardiography (Revision of the 2003 ACC/AHA Clinical Competence Statement on Echocardiography): A Report of the ACC Competency Management Committee. J Am Soc Echocardiogr, 32(8), 919-943.
  18. National Heart Lung and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC (2019). Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med, 380(21), 1997-2008.
  19. Brown SM, Grissom CK, Moss M, Rice TW, Schoenfeld D, Hou PC, Thompson BT, Brower RG (2016). Nonlinear Imputation of Pao2/Fio2 From Spo2/Fio2 Among Patients With Acute Respiratory Distress Syndrome. Chest, 150(2), 307-13.
  20. Brown SM, Tate MQ, Jones JP, Kuttler KG, Lanspa MJ, Rondina MT, Grissom CK, Mathews VJ (2015). Coefficient of Variation of Coarsely Sampled Heart Rate is Associated With Early Vasopressor Independence in Severe Sepsis and Septic Shock. J Intensive Care Med, 30(7), 420-5.
  21. Walkey AJ, Pencina KM, Knox D, Kuttler KG, DAgostino RB Sr, Benjamin EJ, Brown SM (2015). Five-Year Risk of Mechanical Ventilation in Community-Dwelling Adults: The Framingham-Intermountain Anticipating Life Support Study. J Am Geriatr Soc, 63(10), 2082-8.
  22. Lanspa MJ, Pittman JE, Hirshberg EL, Wilson EL, Olsen T, Brown SM, Grissom CK (2015). Association of left ventricular longitudinal strain with central venous oxygen saturation and serum lactate in patients with early severe sepsis and septic shock. Crit Care, 19(1), 304.
  23. Knox DB, Lanspa MJ, Kuttler KG, Brewer SC, Brown SM (2015). Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med, 41(5), 814-22.
  24. Brown SM, Grissom CK, Rondina MT, Hoidal JR, Scholand MB, Wolff RK, Morris AH, Paine R 3rd (2015). Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome. Exp Lung Res, 41(3), 155-62.
  25. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom CK (2015). Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. J Gerontol A Biol Sci Med Sci, 70(2), 225-31.
  26. Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR 3rd, Morris AH (2015). Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med, 43(2), 288-95.
  27. Pratt CM, Hirshberg EL, Jones JP, Kuttler KG, Lanspa MJ, Wilson EL, Hopkins RO, Brown SM (2015). Long-term outcomes after severe shock. Shock, 43(2), 128-32.
  28. Brown SM, Tate Q, Jones JP, Knox DB, Kuttler KG, Lanspa M, Rondina MT, Grissom CK, Behera S, Mathews VJ, Morris A (2013). Initial fractal exponent of heart rate variability is associated with success of early resuscitation in patients with severe sepsis or septic shock: a prospective cohort study. J Crit Care, 28(6), 959-63.
  29. Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP, Intermountain Healthcare Intensive Medicine Clinical Program (2013). Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med, 188(1), 77-82.
  30. Brown SM, Lanspa MJ, Jones JP, Kuttler KG, Li Y, Carlson R, Miller RR 3rd, Hirshberg EL, Grissom CK, Morris AH (2013). Survival after shock requiring high-dose vasopressor therapy. Chest, 143(3), 664-671.
  31. Brown SM, Pittman J, Miller Iii RR, Horton KD, Markewitz B, Hirshberg E, Jones J, Grissom CK (2011). Right and left heart failure in severe H1N1 influenza A infection. Eur Respir J, 37(1), 112-8.

Edited Book

  1. Brown SM, Blaivas M, Hirshberg E, Kasal J, Pustavoitau A (Eds.) (2015). Comprehensive Critical Care Ultrasound. Chicago, IL: Society of Critical Care Medicine.


  1. Brown SM, Paine R 3rd (2019). Asking Causal Questions of Observational Data: The Quest Continues. Ann Am Thorac Soc, 16(8), 977-979.

Case Report

  1. Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, OBrien EA, Ilstrup SJ, Christensen RD (2019). First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Transfusion, 59(10), 3089-3092.


  1. Brown SM (2019). The number needed to mourn. Intensive Care Med, 45(8), 1154-1155.


  1. Tonna JE, Peltan I, Brown SM, Herrick JS, Keenan HT, University of Utah Mechanical Power Study Group (2020). Mechanical power and driving pressure as predictors of mortality among patients with ARDS. [Letter to the editor]. Intensive Care Med.
  2. Peltan ID, Brown SM, Hough CL (2019). In reply. [Letter to the editor]. Ann Emerg Med, 74(4), 607-608.
  3. Hirshberg EL, Lanspa MJ, Brown SM, Dean NC, Grissom CK (2019). The authors reply. [Letter to the editor]. Crit Care Med, 47(8), e724-e726.
  4. Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ, Shahul S, Brown SM (2018). The authors reply. [Letter to the editor]. Crit Care Med, 46(10), e1013-e1014.
  5. Brown SM (2007). Tiotropium in combination with placebo, salmeterol, or fluticasone salmeterol for chronic obstructive pulmonary disease: possible confounding effect of treatment withdrawal? [Letter to the editor]. Ann Intern Med, 147(12), 882; author reply 882-3.


  1. Brown SM (2012). Apparatus, systems, and methods for accessing the airway with medical instruments without interruption of assisted respiration (licensed to ReddyPort, LLC). U.S. Patent No. WO2012100016 A1. Washington, D.C.:U.S. Patent and Trademark Office.