Kenneth I. Aston, PhD

Research Interests

  • Andrological Research

Languages

  • English

Academic Information

  • Departments: Surgery - Associate Professor
  • Divisions: Urology

Board Certification

  • American Board of Bioanalysis

Academic Office Information

  • 801-581-3740
  • Andrology & IVF Laboratories
    675 Arapeen Drive, Room: 3B110
    Salt Lake City, UT 84108

Academic Bio

Ki Aston completed his Ph.D. at Utah State University in 2007. For his dissertation research he evaluated factors associated with somatic cell nuclear transfer efficiency and nuclear reprogramming. He was involved in bovine nuclear transfer and was part of the first group to successfully clone an equine species. Upon completion of his graduate training, Ki joined the Andrology team at the University of Utah as a Post Doctoral Fellow in 2007, and in 2011 he received a faculty appointment with the Division of Urology. His research efforts here have focused on identifying genetic and epigenetic factors associated with male infertility. In addition, Ki is actively involved in expanding fertility preservation options at the University of Utah. In his free time, Ki loves spending time with his wife and four young children and enjoys almost any form of outdoor recreation.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah, Andrology and IVF Laboratories
Postdoctoral Fellow
Doctoral Training Utah State University
Animal Science: Reproductive Physiology
Ph.D.
Undergraduate Utah State University
Biology, minors in Chemistry and Spanish
B.S.
Undergraduate Utah State University
Biology, minors in Chemistry and Spanish

Selected Publications

Journal Article

  1. Patel DP, Jenkins TG, Aston KI, Guo J, Pastuszak AW, Hanson HA, Hotaling JM (2020). Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of "big data". (Epub ahead of print) Fertil Steril.
  2. Salas-Huetos A, James ER, Aston KI, Carrell DT, Jenkins TG, Yeste M (2019). The role of miRNAs in male human reproduction: a systematic review. Andrology, 8(1), 7-26.
  3. Jenkins TG, James ER, Aston KI, Salas-Huetos A, Pastuszak AW, Smith KR, Hanson HA, Hotaling JM, Carrell DT (2019). Age-associated sperm DNA methylation patterns do not directly persist trans-generationally. Epigenetics Chromatin, 12(1), 74.
  4. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT, Yeste M (2019). The Expression of miRNAs in Human Ovaries, Oocytes, Extracellular Vesicles, and Early Embryos: A Systematic Review. Cells, 8(12).
  5. Lee AS, Rusch J, Lima AC, Usmani A, Huang N, Lepamets M, Vigh-Conrad KA, Worthington RE, Mgi R, Wu X, Aston KI, Atkinson JP, Carrell DT, Hess RA, OBryan MK, Conrad DF (2019). Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility. Nat Commun, 10(1), 4626.
  6. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT (2019). Diet and sperm quality: Nutrients, foods and dietary patterns. Reprod Biol, 19(3), 219-224.
  7. Aston KI (2014). Genetic susceptibility to male infertility: news from genome-wide association studies. Andrology, 2(3), 315-21.
  8. Aston KI, Hunt SC, Susser E, Kimura M, Factor-Litvak P, Carrell D, Aviv A (2012). Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans. Mol Hum Reprod, 18(11), 517-22.
  9. Aston KI, Punj V, Liu L, Carrell DT (2012). Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis. Fertil Steril, 97(2), 285-92.
  10. Carrell DT, Aston KI (2011). Sperm genetic testing: clinical implications and use. AUA Updat Ser, 30, 129-136.
  11. Aston KI, Krausz C, Laface I, Ruiz-Castane E, Carrell DT (2010). Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod, 25(6), 1383-97.
  12. Aston KI, Carrell DT (2009). Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. J Androl, 30(6), 711-25.

Book Chapter

  1. Aston KI, Conrad DF (2013). A review of genome-wide approaches to study the genetic basis for spermatogenic defects. In Pharmag (927, pp. 397-410). United States.

Patent

  1. Carrell DT, Cairns BR, Jenkins TG, Aston KI (2019). Systems and methods for determining impact of age related changes in sperm epigenome on offspring phenotype. U.S. Patent No. Pending. Washington, D.C.:U.S. Patent and Trademark Office.