Amit N. Patel, MD

Research Interests

  • Transcatheter Aortic Valve Replacement (TAVI or TAVR)
  • Stem Cell Therapy Trials
  • Portable Perfusion for Organ Preservation
  • Endoscopic Vessel Harvesting
  • Robotic Delivery of Stem Cell Therapy
  • Sutureless Vascular Anastamosis
  • Minimally Invasive Cardiopulmonary Bypass and Leukofiltration
  • Postoperative Arrhythmia Management
  • Photo-Oxidation of Valve Tissue

Languages

  • English

Academic Information

  • Departments: Surgery - Adjunct Professor
  • Divisions: Cardiothoracic Surgery

Board Certification

  • American Board of Thoracic Surgery (Thoracic Surg)

Academic Office Information

  • 801-574-0515
  • School of Medicine
    Division of Cardiothoracic Surgery
    30 N 1900 E, Room: 3C 127
    Salt Lake City, UT 84132

Research Statement

1.IRB #0506137 "Autologous Progenitor Cell Therapy for Congestive Heart Failure Patients Undergoing Treatment with Coronary Artery Bypass Grafting (CABG) Surgery." - Open 2.IRB #0504126 "A phase I study using bone marrow derived progenitor cells" - Open 3.IRB #0502172 "Autologous Progenitor Cells for the Treatment of Heart Failure" - Open 4.IRB #099-108 "Esophagectomy: Is Stapled Better Than Hand-Sewn Anastamosis?" - Closed 5.IRB #001-143 "Use of Leukocyte Filters in Cardiac Surgery: Do They Shorten Hospital Stay?" - Closed 6.IRB #001-103 "Open Thoracic Trauma Database" - Closed 7.IRB #001-101 "Acute Re-Operative Heart Surgery Database" - Closed 8.IRB #001-102 "Lung Cancer Database" - Closed 9.IRB #002-104 "Analysis of Post-Op and Chronic Atrial Fibrillation in Cardiac Surgery Patients" - Closed 10.IRB #002-106 "Prospective Evaluation of The Syncrusä Internal Cardioversion System" - Closed 11.IRB #001-090 "Cost Analysis of Endoscopic Vein Harvesting versus Bridge Vein Harvest" - Closed

Academic Bio

Amit Patel, MD, MS, is an associate professor in the Division of Cardiothoracic Surgery at the University of Utah School of Medicine and Director of Clinical Regenerative Medicine and Tissue Engineering at the University of Utah. His clinical interests include heart surgery for coronary disease, valve repair and replacement, heart failure, aortic surgery and stent grafts. Dr. Patel utilizes ultra minimally invasive surgical approaches when possible. Thoracic interests include lung surgery. His interests in thoracic oncology include minimally invasive (VATS) lung resections and hyperthermic chemotherapy for mesothelioma.Dr. Patel’s research includes studies in stem cell and gene therapy- researching the effects of stem cell and gene transplantation in treating cardiomyopathy, limb ischemia(inadequate blood flow to the leg), and skin graft regeneration following burn injuries. Currently he is leading a number of trials using gene therapy and stem cells to treat heart failure-cardiomyopathy and limb ischemia. In addition to cardiac research his thoracic research includes cancer stem cell identification and destruction, as well as novel agents to selectively attack lung cancer, thoracic sarcoma, and metastatic diseases.

Education History

Type School Degree
Fellowship University of Pittsburgh
Cardiothoracic Surgery
Fellow
Residency Baylor University Medical Center
Surgery
Resident
Internship Baylor University Medical Center
Surgery
Intern
Professional Medical Case Western Reserve University
Medicine
M.D.
Graduate Training Youngstown State University
Immunophysiology
Master's
Undergraduate Youngstown State University
Biological Sciences
B.S.

Selected Publications

Journal Article

  1. Ravindra VM, Mazur MD, Kumpati GS, Park MS, Patel AN, Tandar A, Welt FG, Bull D, Couldwell WT, Taussky P (2015). Carotid artery stenosis in the setting of trans-catheter aortic valve replacement: Clinical and technical considerations of carotid stenting. World Neurosurg, 1878(15), 1230-1239.
  2. Wagner SC, Ichim TE, Ma H, Szmanski J, Perez JA, Lopez, Bogin V, Patel AN, Tandar A, Welt FG, Bull D, Couldwell WT, Taussky P (2015). Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique? J Transl Med, 13(340).
  3. Patel AN, Ince H, Mittal S, Turan G, Trehan N (2015). REVIVE Trial: Retrograde Delivery of Autologous Bone Marrow in Patients with Heart Failure. Cytotherapy, 16(4), S39.
  4. Chung ES, Miller L, Patel AN, Anderson RD, Mendelsohn FO, Traverse J, Silver KH, Shin J, Ewald G, Farr MJ, Anwaruddin S, Plat F, Fisher SJ, AuWerter AT, Pastore JM, Aras R, Penn MS (2015). Changes in ventricular remodeling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischemic heart failure patients: the STOP-HF randomized Phase II trial. Eur Heart J, pii, EHV254.
  5. Holt-Casper D, Theisen JM, Moreno A, Warren M, Silva F, Grainger DW, Bull DA, Patel AN (2015). Novel Xeno-free Human Heart Matrix-Derived Three-Dimensional Scaffolds. J Transl Med, (13), 194.
  6. Riordan NH, Madrigel M, Reneau J, Cupeiro KD, Jimnez N, Ruiz S, Sanchez N, Ichim TE, Silva F, Patel AN (2015). Scalable Efficient Expansion of Mesenchymal Stem Cells in Xeno Free Media using Commercially Available Reagents. J Transl Med, 17(6), S81.
  7. Nickel elution properties of contemporary interatrial shunt closure devices.Verma DR, Khan MF, Tandar A, Rajasekaran NS, Neuharth R, Patel AN, Muhlestein JB, Badger RS (2015). Nickel elution properties of contemporary interatrial shunt closure devices. J Invasive Cardiol, 27(2), 99-104.
  8. Induction of tumor inhibitory anti-angiogenic response through immunization with interferon Gamma primed placental endothelial cells: ValloVax.Ichim TE, Li S, Ma H, Yurova YV, Szymanski JS, Patel AN, Kesari S, Min WP, Wagner SC (2015). Induction of tumor inhibitory anti-angiogenic response through immunization with interferon Gamma primed placental endothelial cells: ValloVax. J Transl Med, 13(1), 90.
  9. Safety and efficacy of ixmyelocel-T: an expanded, autologous multi-cellular therapy, in dilated cardiomyopathy.Henry TD, Traverse JH, Hammon BL, East CA, Bruckner B, Remmers AE, Recker D, Bull DA, Patel AN (2014). Safety and efficacy of ixmyelocel-T: an expanded, autologous multi-cellular therapy, in dilated cardiomyopathy. Circ Res, 115(8), 730-7.
  10. Thrombosis of a descending thoracic aortic endovascular stent graft in a patient with factor V Leiden: case report.Kumpati GS, Patel AN, Bull DA (2014). Thrombosis of a descending thoracic aortic endovascular stent graft in a patient with factor V Leiden: case report. J Cardiothorac Surg, 9(1), 47.
  11. Kumpati GS, Gray R, Patel A, Bull DA (02/01/2014). Endovascular Repair of Acute Ascending Aortic Disruption via the Right Axillary Artery. Ann Thorac Surg, 97(2), 700-3.
  12. Metabolically active human brown adipose tissue derived stem cells.Silva FJ, Holt DJ, Vargas V, Yockman J, Boudina S, Atkinson D, Grainger DW, Revelo MP, Sherman W, Bull DA, Patel AN (2014). Metabolically active human brown adipose tissue derived stem cells. Stem Cells, 32(2), 572-81.
  13. Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?Ichim TE, Warbington T, Cristea O, Chin JL, Patel AN (2013). Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction? J Transl Med, 11, 139.
  14. Advances in cardiovascular cell therapy.Patel AN (2013). Advances in cardiovascular cell therapy. Cell Transplant, 22(3), 505.
  15. Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic.Bockeria L, Bogin V, Bockeria O, Le T, Alekyan B, Woods EJ, Brown AA, Ichim TE, Patel AN (2013). Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic. J Transl Med, 11, 56.
  16. Putative population of adipose-derived stem cells isolated from mediastinal tissue during cardiac surgery.Patel AN, Yockman J, Vargas V, Bull DA (2013). Putative population of adipose-derived stem cells isolated from mediastinal tissue during cardiac surgery. Cell Transplant, 22(3), 507-11.
  17. Safety and efficacy of autologous cell therapy in critical limb ischemia: a systematic review.Benoit E, ODonnell TF, Patel AN (2013). Safety and efficacy of autologous cell therapy in critical limb ischemia: a systematic review. Cell Transplant, 22(3), 545-62.
  18. In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium.Spadaccio C, Rainer A, De Marco F, Lusini M, Gallo P, Sedati P, Muda AO, De Porcellinis S, Gregorj C, Avvisati G, Trombetta M, Chello M, Covino E, Bull DA, Patel AN, Genovese JA (2013). In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium. Cell Transplant, 22(3), 493-503.
  19. Changes in the expression pattern of mesenchymal and pluripotent markers in human adipose-derived stem cells.Park E, Patel AN (2010). Changes in the expression pattern of mesenchymal and pluripotent markers in human adipose-derived stem cells. Cell Biol Int, 34(10), 979-84.
  20. Patel AN, Silva F (2008). Menstrual blood stromal cells: the potential for regenerative medicine. Regen Med, 3(4), 443-4.
  21. Electrostimulation induces cardiomyocyte predifferentiation of fibroblasts.Genovese JA, Spadaccio C, Langer J, Habe J, Jackson J, Patel AN (2008). Electrostimulation induces cardiomyocyte predifferentiation of fibroblasts. Biochem Biophys Res Commun, 370(3), 450-5.

Review

  1. Stem cell therapy for heart failure.Patel AN, Silva F, Winters AA (2015). Stem cell therapy for heart failure. [Review]. Heart Fail Clin, 11(2), 275-86.

Book Chapter

  1. Alvelo-Rivera M, Patel AN, Landreneau J (2015). Thoracoscopic First Rib Resection with Dorsal Sympathectomy. In Sugarbaker D, Bueno R, Colson YL, Jaklitsch MT, Krasna MJ, Mentzer SJ (Eds.), Adult Chest Surgery (Second, pp. 1161-1181). McGraw Hill.
  2. Urschel HC, Pool JJ, Patel AN (2015). Thoracic Outlet Syndromes. In Sugarbaker DJ, Bueno R, Colson YL, Jaklitsch MT, Krasna MJ, Mentzer SJ (Eds.), Adult Chest Surgery (Second, pp. 1151-1160). McGraw Hill Education.
  3. Patel AN (2015). Section IV: Allogeneic Alternatives to Autologous Bone Marrow: The MSC 12. Overview of MSCs. In Miller-Stem Cell and Gene Therapy for Cardiovascular Disease.
  4. Patel AN (2015). Section VIII: Methods of Delivery Retrograde and Epicardial. In Miller-Stem Cell and Gene Therapy for Cardiovascular Disease.
  5. Patel AN (2015). Section VI: Other Allogeneic Sources of Stem Cells 19. Umbilical Cord, Placenta, Endometrium. In Miller-Stem Cell and Gene Therapy for Cardiovascular Disease.

Abstract

  1. Mehta S, Silva F, Vargas V, Elabd, Crombie C, Patel AN (2015). Evaluation of stem cell populations isolated from adipose tissue using minimally manipulated techniques [Abstract]. Cytotherapy, 17(6), S73.
  2. Silva F, Holt D, Elabd C, Patel AN (2015). Tissue engineered brown adipocyte constructs [Abstract]. Cytotherapy, 17(6), S73.
  3. Patel AN, Atkinson D, Walker R, Bull DA (2015). Severe hypoxia retains stem cell properties of umbilical cord derived stem cells [Abstract]. Cytotherapy.
  4. J Tuma, A Carrasco, R Fernandez Vina, S Chirinos, C Cruz, AN Patel (April, 2014). Five Year follow-up of coronary sinus delivery of bone marrow cells for congestive heart failure [Abstract]. 16(4), S61-S62.
  5. Patel AN, Ince H, Mittal S, Turan G, Trehan N (2014). Retrograde Delivery of Autologous Concentrated Bone Marrow Cell Therapy for Patients with Congestive Heart Failure-Revive 1- A Prospective Randomized Study [Abstract]. Cytotherapy, 16(4), S39.
  6. Patel AN, Mittal S, Vina RF, Benetti F, Trehan N (2014). Long Term Follow-Up of Coronary Artery Bypass Grafting with Autologous Bone Marrow Cell Therapy [Abstract]. Cytotherapy.
  7. Johnston C, Silva F, Walker R, Warbington T, Patel AN (2014). Next Generation Xenogenic-Free Biologics/Reagents [Abstract]. Cytotherapy, 16(4), S105.
  8. Won YW, Silva F, Lim KS, Kim SW, Bull DA, Patel AN (2014). Cell Surface Engineering to Enhance Mesenchymal Stem Cell Migration Towards SDF-1 for Ischemic Tissue [Abstract]. Cytotherapy, 16(4), S80.
  9. Holt D, Theisen J, Silva F, Grainger D, Bull DA, Patel AN (2014). Highly Cellularizable Three-Dimensional Human-Heart Derived Scaffolds [Abstract]. Cytotherapy, 16(4), S91-S92.
  10. Bull DA, Vargas V, Silva F, Patel AN (2014). Novel Metabolically Active Human Renal Multi-Potent Cells [Abstract]. Cytotherapy, 16(4), S69-S70.
  11. Silva F, Holt D, Vargas V, Bull DA, Patel AN (2014). Human Metabolically Active Brown Adipose Tissue Derived Stem Cells [Abstract]. 16(4), S69.
  12. Tuma J, Silva F, Cottle N, Patel AN (2014). Targeted Mesenchymal Stem Cell Therapy for Chronic Obstructive Pulmonary Disease [Abstract].

Patent

  1. Silva F, Weinreb M, Patel AN, Bull DA (2015). BROWN FAT CELL COMPOSITIONS AND METHODS. U.S. Patent No. 20140370591. Washington, D.C.:U.S. Patent and Trademark Office.
  2. Patel AN (2015). NUTRACEUTICAL MODULATORS OF STEM CELL ACTIVITY. U.S. Patent No. 20150050259. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Patel AN (2014). NEUTRACEUTICAL FORMULATION FOR TREATMENT OF DIABETES. U.S. Patent No. 20140186466. Washington, D.C.:U.S. Patent and Trademark Office.
  4. Patel AN (2014). NEUTRACEUTICAL FORMULATION FOR TREATMENT OF DIABETES. U.S. Patent No. 20140186466. Washington, D.C.:U.S. Patent and Trademark Office.
  5. Patel AN (2014). NUTRACEUTICAL FORMULATION FOR TREATMENT OF ELEVATED CHOLESTEROL AND CARDIOVASCULAR DISEASE. U.S. Patent No. 20140314729. Washington, D.C.:U.S. Patent and Trademark Office.
  6. Patel AN, Marleau A (2013). NATURAL MEANS OF AUGMENTING ENDOGENOUS STEM CELL NUMBERS. U.S. Patent No. 20130177543. Washington, D.C.:U.S. Patent and Trademark Office.