Rodney Stewart, MPhil, PhD

Research Interests

  • Childhood Cancer
  • Embryology
  • Brain Tumors
  • Zebrafish
  • Neural Crest Development
  • Neuroblastoma

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Oncological Sciences - Associate Professor
  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • 801-587-5567
  • Huntsman Cancer Institute
    Dept. Oncological Sciences
    2000 Circle of Hope, Room: 3245
    Salt Lake City, UT 84112

Academic Bio

Rodney Stewart, PhD, is an Associate Professor in the Department of Oncological Sciences at the University of Utah and a Huntsman Cancer Institute (HCI) investigator. He is a member of the Cell Response and Regulation Program.

Stewart's research focuses on identifying genetic mechanisms and drugs that impact pediatric cancers of the nervous system. His research combines embryology and cancer biology approaches using zebrafish cancer models and human cancer cell lines to find conserved targets for treatment of pediatric brain tumors. He is also interested in the discovery of new therapeutic targets in melanoma and neuroblastoma.

Before joining HCI, Stewart was a research fellow in the Department of Pediatric Oncology at Harvard Medical School, Dana-Farber Cancer Institute, where he also served as an instructor in pediatric oncology. He earned a PhD from Yale University, New Haven, Connecticut.

Education History

Type School Degree
Undergraduate University of Melbourne
Genetics
B.Sc. (Hons)

Global Impact

Education History

Type School Degree Country
Undergraduate University of Melbourne
Genetics
B.Sc. (Hons) Australia

Selected Publications

Journal Article

  1. Sorrells S, Nik S, Casey M, Cameron RC, Truong H, Toruno C, Gulfo M, Lowe A, Jette C, Stewart RA, Bowman TV (2018). Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis.LID - dmm031583 [pii]LID - 10.1242/dmm.031583 [doi]. Dis Model Mech, 11(2).
  2. Casey MJ, Modzelewska K, Anderson D, Goodman J, Boer EF, Jimenez L, Grossman D, Stewart RA (2017). Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response.LID - 10.3791/55712 [doi]. J Vis Exp, (123).
  3. Modzelewska K, Boer EF, Mosbruger TL, Picard D, Anderson D, Miles RR, Kroll M, Oslund W, Pysher TJ, Schiffman JD, Jensen R, Jette CA, Huang A, Stewart RA (2016). MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells. Cell Rep, 17(5), 1255-1264.
  4. Jimenez L, Wang J, Morrison MA, Whatcott C, Soh KK, Warner S, Bearss D, Jette CA, Stewart RA (2016). Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis. Dis Model Mech, 9(4), 389-400.
  5. Boer EF, Jette CA, Stewart RA (2016). Neural Crest Migration and Survival Are Susceptible to Morpholino-Induced Artifacts. PLoS ONE, 11(12), e0167278.
  6. Morrison MA, Zimmerman MW, Look AT, Stewart RA (2016). Studying the peripheral sympathetic nervous system and neuroblastoma in zebrafish. Methods Cell Biol, 134, 97-138.
  7. Boer EF, Howell ED, Schilling TF, Jette CA, Stewart RA (2015). Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells. PLoS Genet, 11(1), e1004946.
  8. Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, Rodig SJ, Neuberg DS, Helman D, Feng H, Stewart RA, Wang W, George RE, Kanki JP, Look AT (2012). Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell, 21(3), 362-73.
  9. Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG (2010). Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell, 18(5), 750-62.

Review

  1. Casey MJ, Stewart RA (2017). Zebrafish as a model to study neuroblastoma development.LID - 10.1007/s00441-017-2702-0 [doi]. [Review]. Cell Tissue Res.