Mia Hashibe, PhD

Research Interests

  • Cancer Epidemiology
  • Head and Neck Cancers
  • Cancer Survivorship
  • Epidemiology, Molecular
  • Global Epidemiology
  • Genetic Susceptibility

Languages

  • English

Academic Information

  • Departments: Family & Preventive Medicine - Associate Professor, Population Health Sciences - Adjunct Associate Professor
  • Divisions: Health System Innovation and Research, Public Health
  • Cancer Center Programs: Cancer Control & Population Sciences

Academic Office Information

  • Huntsman Cancer Institute
    Cancer Control & Population Sciences
    2000 Circle of Hope
    Salt Lake City, UT 84112

Academic Bio

Dr. Hashibe is an Associate Professor in the Department of Family and Preventive Medicine at the University of Utah, a Huntsman Cancer Institute (HCI) investigator and Director of Research Facilitation and Integration for the Utah Cancer Registry. She is a member of the Cancer Control and Population Sciences Program at HCI.

She is interested in the molecular, global and cancer epidemiology of head and neck cancer, lung cancer, and gynecologic cancers. She is the Scientific Coordinator and one of the founding members of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (http://inhance.iarc.fr/). Her studies include a head and neck cancer genetics study, multicenter head and neck cancer case-control study in China (http://www.interchange.utah.edu/), a lung and head and neck cancer case-control study in Nepal, head and neck cancer risk prediction modeling, and a Cancer Survivors Cohort Study in Utah.

Before joining HCI, Hashibe was a scientist with the International Agency for Research on Cancer in Lyon, France. She earned both a master's and doctoral degree from the University of California Los Angeles.

Research Statement

My areas of expertise are on global and molecular cancer epidemiology and cancer survivorship. My research projects include a head and neck cancer exome sequencing project (NIDCR R01), a head and neck cancer study in Nepal (NCI supplemental grant) and the International Head and Neck Cancer Epidemiology Consortium (INHANCE; NCI R13). The goal of the exome-sequencing project is to identify head and neck cancer (HNC) susceptibility genes by exome sequencing familial HNC cases, then mutation screening 2,000 HNC cases and 2,000 controls. I am a founding member and Scientific Coordinator of the INHANCE consortium, and led the data pooling effort to create the core INHANCE database with grant funding from the NCI and NIDCR. The INHANCE consortium has published >52 research papers thus far based on this data. We have been developing risk prediction models based on this data to calculate individualized risk estimates for head and neck cancer (NCI R21).

We also initiated population-based cancer survivor studies for head and neck cancer, thyroid cancer, gynecologic cancers, lymphoma and colorectal cancer. We reported that obesity was a large contributor to the risk of long-term disease risks among testicular cancer survivors (NCI R03; Hashibe 2016). In the endometrial cancer pilot study, we have been analyzing long-term disease incidence and risks, and testing questionnaires on endometrial cancer survivors (NCI R21; Soisson 2018). The aim of the cancer survivor studies is to comprehensively assess disease risks among cancer survivors in comparison to a general population cohort. I designed these studies by leveraging the Utah Population Database, which is comparable to the Scandinavian databases, with linkage across multiple statewide databases.

Education History

Type School Degree
Postdoctoral Fellowship International Agency for Research on Cancer (IARC)
Postdoctoral Fellow
Doctoral Training UCLA School of Public Health, Department of Epidemiology
UCLA/USC Molecular Genetic Epidemiology Training Program
Ph.D.
Graduate Training UCLA School of Public Health, Department of Epidemiology
Epidemiology
M.P.H.
Undergraduate University of California, Los Angeles (UCLA)
Biology and Japanese
B.S.

Global Impact

Education History

Type School Degree Country
Postdoctoral Fellowship International Agency for Research on Cancer (IARC)
Postdoctoral Fellow France

Selected Publications

Journal Article

  1. Blackburn BE, Soisson S, Rowe K, Snyder J, Fraser A, Deshmukh V, Newman M, Smith K, Herget K, Kirchhoff AC, Kepka D, Werner TL, Gaffney D, Mooney K, Hashibe M (2019). Prognostic factors for rural endometrial cancer patients in a population-based cohort. BMC Public Health, 19(1), 921.
  2. Di Credico G, Edefonti V, Polesel J, Pauli F, Torelli N, Serraino D, Negri E, Luce D, Stucker I, Matsuo K, Brennan P, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Holcatova I, Ahrens W, Lagiou P, Simonato L, Richiardi L, Healy C, Kjaerheim K, Conway DI, Macfarlane TV, Thomson P, Agudo A, Znaor A, Boaventura Rios LF, Toporcov TN, Franceschi S, Herrero R, Muscat J, Olshan AF, Zevallos JP, La Vecchia C, Winn DM, Sturgis EM, Li G, Fabianova E, Lissowska J, Mates D, Rudnai P, Shangina O, Swiatkowska B, Moysich K, Zhang ZF, Morgenstern H, Levi F, Smith E, Lazarus P, Bosetti C, Garavello W, Kelsey K, McClean M, Ramroth H, Chen C, Schwartz SM, Vaughan TL, Zheng T, Menvielle G, Boccia S, Cadoni G, Hayes RB, Purdue M, Gillison M, Schantz S, Yu GP, Brenner H, DSouza G, Gross ND, Chuang SC, Boffetta P, Hashibe M, Lee YA, Dal Maso L (2019). Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncol, 94, 47-57.
  3. Gudgeon JM, Varner MW, Hashibe M, Williams MS (2019). Is immunohistochemistry-based screening for Lynch syndrome in endometrial cancer effective? The consent's the thing. Gynecol Oncol, 154(1), 131-137.
  4. Laviana AA, Hernandez A, Huang LC, Zhao Z, Koyama T, Conwill R, Hoffman K, Feurer ID, Goodman M, Hamilton AS, Wu XC, Paddock LE, Stroup A, Cooperberg MR, Hashibe M, ONeil BB, Kaplan SH, Greenfield S, Penson DF, Barocas DA (2019). Interpretation of domain scores on the expanded prostate cancer index composite: How does the domain score translate into functional outcomes? J Urol, 101097JU0000000000000392.
  5. Aylward A, Abdelaziz S, Hunt JP, Buchmann LO, Cannon RB, Lloyd S, Hitchcock Y, Hashibe M, Monroe MM (2019). Rates of Dysphagia-Related Diagnoses in Long-Term Survivors of Head and Neck Cancers. Otolaryngol Head Neck Surg, 194599819850154.
  6. Chen Y, Lee YA, Li S, Li Q, Chen CJ, Hsu WL, Lou PJ, Zhu C, Pan J, Shen H, Ma H, Cai L, He B, Wang Y, Zhou X, Ji Q, Zhou B, Wu W, Ma J, Kawakita D, Boffetta P, Zhang ZF, Dai M, Hashibe M (2019). Body mass index and the risk of head and neck cancer in the Chinese population. Cancer Epidemiol, 60, 208-215.
  7. Garvin JH, Herget KA, Hashibe M, Kirchhoff AC, Hawley CW, Bolton D, Sweeney C (2019). Linkage between Utah All Payers Claims Database and Central Cancer Registry. Health Serv Res, 54(3), 707-713.
  8. Vohra SN, Sapkota A, Lee MT, Pun CB, Thakur B, Siwakoti B, Wiesenfeld PL, Hashibe M, Dallal CM (2019). Reproductive and Hormonal Factors in Relation to Lung Cancer Among Nepali Women. Front Oncol, 9, 311.
  9. Millar MM, Kinney AY, Camp NJ, Cannon-Albright LA, Hashibe M, Penson DF, Kirchhoff AC, Neklason DW, Gilsenan AW, Dieck GS, Stroup AM, Edwards SL, Bateman C, Carter ME, Sweeney C (2018). Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Recruitment Efforts for Population-Based Studies. Am J Epidemiol, 188(5), 928-939.
  10. Hashim D, Genden E, Posner M, Hashibe M, Boffetta P (2020). Head and neck cancer prevention: from primary prevention to impact of clinicians on reducing burden. Ann Oncol, 30(5), 744-756.
  11. Khetan P, Boffetta P, Luce D, Stucker I, Curado MP, Menezes A, Wunsch-Filho V, Ahrens W, Lagiou P, Serraino D, Richiardi L, Kjaerheim K, Conway D, Thomson P, Muscat J, Mates D, Ramroth H, Menvielle G, Vaughan TL, Brenner H, Lee YA, La Vecchia C, Hashibe M, Hashim D (2020). Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. J Occup Environ Med, 61(5), 397-404.
  12. Hashibe M, Li Q, Chen CJ, Hsu WL, Lou PJ, Zhu C, Pan J, Shen H, Ma H, Cai L, He B, Wang Y, Zhou X, Ji Q, Zhou B, Wu W, Ma J, Boffetta P, Zhang ZF, Dai M, Lee YA (2019). Involuntary smoking and the risk of head and neck cancer in an East Asian population. Cancer Epidemiol, 59, 173-177.
  13. Lloyd S, Baraghoshi D, Tao R, Garrido-Laguna I, Gilcrease GW 3rd, Whisenant J, Weis JR, Scaife C, Pickron TB, Huang LC, Monroe MM, Abdelaziz S, Fraser AM, Smith KR, Deshmukh V, Newman M, Rowe KG, Snyder J, Samadder NJ, Hashibe M (2020). Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated With Decreased Overall Survival. Am J Clin Oncol, 42(4), 355-362.
  14. Hawkins ML, Blackburn BE, Rowe K, Snyder J, Deshmukh VG, Newman M, Fraser A, Smith K, Herget K, Ganz PA, Samadder NJ, Hashibe M (2019). Endocrine and Metabolic Diseases among Colorectal Cancer Survivors in a Population-Based Cohort. (Epub ahead of print) J Natl Cancer Inst.
  15. Kawakita D, Lee YA, Gren LH, Buys SS, La Vecchia C, Hashibe M (2019). Fiber intake and the risk of head and neck cancer in the prostate, lung, colorectal and ovarian (PLCO) cohort. (Epub ahead of print) Int J Cancer.
  16. Lee YA, Li S, Chen Y, Li Q, Chen CJ, Hsu WL, Lou PJ, Zhu C, Pan J, Shen H, Ma H, Cai L, He B, Wang Y, Zhou X, Ji Q, Zhou B, Wu W, Ma J, Boffetta P, Zhang ZF, Dai M, Hashibe M (2018). Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population. Head Neck, 41(1), 92-102.
  17. De Vito R, Lee YCA, Parpinel M, Serraino D, Olshan AF, Zevallos JP, Levi F, Zhang ZF, Morgenstern H, Garavello W, Kelsey K, McClean M, Schantz S, Yu GP, Boffetta P, Chuang SC, Hashibe M, La Vecchia C, Parmigiani G, Edefonti V (2020). Shared and Study-specific Dietary Patterns and Head and Neck Cancer Risk in an International Consortium. Epidemiology, 30(1), 93-102.
  18. Soisson S, Ganz PA, Gaffney D, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Hanson HA, Wu YP, Stanford J, Al-Sarray A, Werner TL, Setiawan VW, Hashibe M (2017). Long-term Cardiovascular Outcomes Among Endometrial Cancer Survivors in a Large, Population-Based Cohort Study. J Natl Cancer Inst, 110(12), 1342-1351.
  19. Gaffney DK, Hashibe M, Kepka D, Maurer KA, Werner TL (2018). Too many women are dying from cervix cancer: Problems and solutions. Gynecol Oncol, 151(3), 547-554.
  20. Leoncini E, Vukovic V, Cadoni G, Giraldi L, Pastorino R, Arzani D, Petrelli L, Wnsch-Filho V, Toporcov TN, Moyses RA, Matsuo K, Bosetti C, La Vecchia C, Serraino D, Simonato L, Merletti F, Boffetta P, Hashibe M, Lee YA, Boccia S (2018). Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. Eur J Epidemiol, 33(12), 1205-1218.
  21. Blackburn BE, Ganz PA, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Kim J, Kirchhoff AC, Porucznik C, Hanson H, Abraham D, Monroe M, Hashibe M (2018). Reproductive and gynecological complication risks among thyroid cancer survivors. J Cancer Surviv, 12(5), 702-711.
  22. Lee DJ, Barocas DA, Zhao Z, Huang LC, Resnick MJ, Koyoma T, Conwill R, McCollum D, Cooperberg MR, Goodman M, Greenfield S, Hamilton AS, Hashibe M, Kaplan SH, Paddock LE, Stroup AM, Wu XC, Penson DF, Hoffman KE (2018). Comparison of Patient-reported Outcomes After External Beam Radiation Therapy and Combined External Beam With Low-dose-rate Brachytherapy Boost in Men With Localized Prostate Cancer. Int J Radiat Oncol Biol Phys, 102(1), 116-126.
  23. Park J, Blackburn BE, Ganz PA, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Kirchhoff AC, Abraham D, Kim J, Monroe M, Hashibe M (2017). Risk Factors for Cardiovascular Disease Among Thyroid Cancer Survivors: Findings From the Utah Cancer Survivors Study. J Clin Endocrinol Metab, 103(7), 2468-2477.
  24. Voltzke KJ, Lee YA, Zhang ZF, Zevallos JP, Yu GP, Winn DM, Vaughan TL, Sturgis EM, Smith E, Schwartz SM, Schantz S, Muscat J, Morgenstern H, McClean M, Li G, Lazarus P, Kelsey K, Gillison M, Chen C, Boffetta P, Hashibe M, Olshan AF (2018). Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium. Cancer Causes Control, 29(7), 619-630.
  25. Tyson MD 2nd, Koyama T, Lee D, Hoffman KE, Resnick MJ, Wu XC, Cooperberg MR, Goodman M, Greenfield S, Hamilton AS, Hashibe M, Paddock LE, Stroup A, Chen V, Conwill R, McCollum D, Penson DF, Barocas DA (2018). Effect of Prostate Cancer Severity on Functional Outcomes After Localized Treatment: Comparative Effectiveness Analysis of Surgery and Radiation Study Results. Eur Urol, 74(1), 26-33.
  26. Park J, Blackburn BE, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Burt L, Werner T, Gaffney DK, Lopez AM, Mooney K, Hashibe M (2018). Rural-metropolitan disparities in ovarian cancer survival: a statewide population-based study. Ann Epidemiol, 28(6), 377-384.
  27. Avulova S, Zhao Z, Lee D, Huang LC, Koyama T, Hoffman KE, Conwill RM, Wu XC, Chen V, Cooperberg MR, Goodman M, Greenfield S, Hamilton AS, Hashibe M, Paddock LE, Stroup A, Resnick MJ, Penson DF, Barocas DA (2017). The Effect of Nerve Sparing Status on Sexual and Urinary Function: 3-Year Results from the CEASAR Study. J Urol, 199(5), 1202-1209.
  28. Hashibe M, Kirchhoff AC, Kepka D, Kim J, Millar M, Sweeney C, Herget K, Monroe M, Henry NL, Lopez AM, Mooney K (2018). Disparities in cancer survival and incidence by metropolitan versus rural residence in Utah. Cancer Med, 7(4), 1490-1497.
  29. Soisson S, Ganz PA, Gaffney D, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Hanson HA, Wu YP, Stanford J, Werner TL, Setiawan VW, Hashibe M (2017). Long-term, adverse genitourinary outcomes among endometrial cancer survivors in a large, population-based cohort study. Gynecol Oncol, 148(3), 499-506.
  30. Wu YP, Kohlmann W, Curtin K, Yu Z, Hanson HA, Hashibe M, Parsons BG, Wong J, Schiffman JD, Grossman D, Leachman SA (2017). Melanoma risk assessment based on relatives' age at diagnosis. Cancer Causes Control, 29(2), 193-199.
  31. Lee DJ, Barocas DA, Zhao Z, Huang LC, Koyama T, Resnick MJ, Conwill R, McCollum D, Cooperberg MR, Goodman M, Greenfield S, Hamilton AS, Hashibe M, Kaplan SH, Paddock LE, Stroup AM, Wu XC, Penson DF, Hoffman KE (2017). Contemporary prostate cancer radiation therapy in the United States: Patterns of care and compliance with quality measures. Pract Radiat Oncol, 8(5), 307-316.
  32. Blackburn BE, Ganz PA, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Kim J, Kirchhoff AC, Porucznik C, Hanson H, Monroe M, Hashibe M (2017). Aging-Related Disease Risks among Young Thyroid Cancer Survivors. Cancer Epidemiol Biomarkers Prev, 26(12), 1695-1704.
  33. Hashibe M, Siwakoti B, Wei M, Thakur BK, Pun CB, Shrestha BM, Burningham Z, Lee YC, Sapkota A (2011). Socioeconomic status and lung cancer risk in Nepal. Asian Pac J Cancer Prev, 12(4), 1083-8.