Martin McMahon, PhD

Languages

  • English

Academic Information

  • Departments: Dermatology - Professor, Oncological Sciences - Adjunct Professor

Academic Office Information

  • 801-213-5790
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 2725
    Salt Lake City, UT 84112

Academic Bio

Academic Bio

Martin McMahon, PhD

Cumming-Presidential Chair of Cancer Biology

Senior Director for Preclinical Translation

Co-Leader of the Experimental Therapeutics Program

Dr. Martin McMahon was awarded a Ph.D. from King’s College, University of London, for studies on the mechanism of interferon action conducted with Drs. Ian Kerr and George Stark at the Imperial Cancer Research Fund (London, UK) and Stanford University (Stanford, CA). In 1985, he joined J. Michael Bishop’s laboratory in the Hooper Foundation of the University of California, San Francisco (UCSF) as a post-doctoral fellow to study oncogenic protein kinases. In 1991, he established an independent research group at the DNAX Research Institute (now Merck Research Labs, Palo Alto, CA) working on RAF protein kinases. From 1991-1998, Dr. McMahon pioneered the use of a new class of conditional oncoproteins to dissect the corrupting events that lead normal cells to develop aberrant properties of lethal cancer. In 1998, he was recruited to the faculty of the Cancer Research Institute of the UCSF Helen Diller Family Comprehensive Cancer Center where he served as the Efim Guzik Distinguished Professor of Cancer Biology, Co-Leader of the Experimental Therapeutics Program and Director for Professional Education. In 2015, he joined the faculty of the Department of Dermatology and the Huntsman Cancer Institute of the University of Utah, as the Cumming-Presidential Professor of Cancer Biology and the Senior Director for Preclinical Translation.

Research: Dr. McMahon’s translational cancer research program focuses on the mechanisms underlying the development of metastatic melanoma, lung and thyroid cancer. Although these malignancies are derived from distinct cell types, they share a striking number of common genetic alterations especially activating mutations in KRAS, BRAF, PIK3CA or CTNNB1 (-catenin). In addition, many of these tumors display alterations in tumor suppressors such as CDKN2A, PTEN or TP53. To do this, Dr. McMahon’s laboratory works with cultured human cancer-derived cells and with genetically engineered mouse models of human cancer. Such model systems have demonstrated considerable value in the design and evaluation of new diagnostic, prognostic, and therapeutic tools to treat patients with cancer.

Teaching: Since establishing an independent research laboratory in 1991, Dr. McMahon has mentored over 50 undergraduates, graduate students, postdoctoral or clinical fellows in his lab, most of whom have gone on to successful careers either in academia or the private sector. As a UCSF faculty member, Dr. McMahon was a member of three graduate programs: Tetrad; Biomedical Sciences (BMS) and; Chemistry & Chemical Biology (CCB) and served as Co-Director of the BMS graduate program for five years. As a member of these graduate programs he participated in numerous qualifying exams and thesis committees and as a presenter or student mentor in Research-In-Progress, Project Proposal and Journal Club forums. In his own research lab at UCSF, he hosted over 30 rotation students and had six full-time thesis students, of whom four have graduated with the award of a Ph.D. Dr. McMahon participated in numerous graduate level courses at UCSF and served as course organizer for the yearly cancer elective, “Advanced Topics in Cancer Research” and lead-organizer of a yearly minicourse, “Principles and Implications of Oncogene Addiction”. These courses focused on cancer cell signaling, models of cancer, pharmacological inhibition of signaling pathways and regulation of the cell division cycle or apoptosis.

Service: Dr. McMahon has served on numerous study sections including the NIH Basic Mechanisms of Cancer Therapy (Ad hoc, Chartered Member and Chair, 2006-2015) and Basic Cancer Research (BCR)-1 of the Cancer Prevention and Research Institute of Texas (CPRIT, 2013-date). He has served on the editorial board of Molecular Cancer Research, Molecular and Cellular Biology and Pigment Cell & Melanoma Research. He has organized a number of international conferences including the 2000 Oncogene Meeting (Frederick, MD) and the 2015 Annual Congress of the Society for Melanoma Research (San Francisco, CA), an academic organization of which Dr. McMahon is the current President.

Education History

Type School Degree
Postdoctoral Fellowship G.W. Hooper Research Foundation, University of California, J. Michael Bishop PhD
Cancer, virology, genetics
Postdoctoral Fellow
Doctoral Training King's College, London - Ian M. Kerr, PhD (Research done at Stanford University and ICRF)
Biochemistry
Ph.D.
Undergraduate University of Glasgow - Roy H. Burdon PhD
Biochemistry
B.Sc. (Hons)

Global Impact

Education History

Type School Degree Country
Doctoral Training King's College, London - Ian M. Kerr, PhD (Research done at Stanford University and ICRF)
Biochemistry
Ph.D. United Kingdom
Undergraduate University of Glasgow - Roy H. Burdon PhD
Biochemistry
B.Sc. (Hons) United Kingdom

Selected Publications

Journal Article

  1. Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen SL (2019). AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis. (Epub ahead of print) Mol Cancer Res.
  2. Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M (2019). Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med, 25(4), 620-627.
  3. Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cave H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F (2018). Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. Am J Med Genet A, 176(12), 2924-2929.
  4. Mulcahy Levy JM, McMahon M (2018). Linking brain tumors and epileptic seizures. Nat Med, 24(11), 1638-1639.
  5. Gardner LJ, Ward M, Andtbacka RHI, Boucher KM, Bowen GM, Bowles TL, Cohen AL, Grossmann K, Hitchcock YJ, Holmen SL, Hyngstrom J, Khong H, McMahon M, Monroe MM, Ross CB, Suneja G, Wada D, Grossman D (2017). Risk factors for development of melanoma brain metastasis and disease progression: a single-center retrospective analysis. Melanoma Res, 27(5), 477-484.
  6. Gardner LJ, Ward M, Andtbacka RHI, Boucher KM, Bowen GM, Bowles TL, Cohen AL, Grossmann K, Hitchcock YJ, Holmen SL, Hyngstrom J, Khong H, McMahon M, Monroe MM, Ross CB, Suneja G, Wada D, Grossman D (10/01/2017). Risk factors for development of melanoma brain metastasis and disease progression: a single-center retrospective analysis. Melanoma Res, 5, 477-484.
  7. Silva JM, Deuker MM, Baguley BC, McMahon M (2017). PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation. Pigment Cell Melanoma Res, 30(3), 353-367.
  8. Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER (2017). BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.LID - 10.7554/eLife.20331 [doi]LID - e20331 [pii]. eLife, 6.
  9. Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, Truong AY, Nicolaides TP, McMahon M, Berger MS, Phillips JJ, James CD, Petritsch CK (2016). Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Oncotarget, 7(46), 75839-75853.
  10. Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA (2016). The state of melanoma: challenges and opportunities. Pigment Cell Melanoma Res, 29(4), 404-16.
  11. Deuker MM, McMahon M (2016). Rational targeting of BRAF and PI3-Kinase signaling for melanoma therapy. Mol Cell Oncol, 3(3), e1033095.
  12. van Veen JE, Pringle DR, McMahon M (2016). P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo. PLoS ONE, 11(6), e0157661.
  13. Green S, Trejo CL, McMahon M (2015). PIK3CA(H1047R) promotes the growth of lung tumors initiated by oncogenic KRAS(G12D). Cancer Res, 75(24), 5378-91.
  14. Green S, Trejo CL, McMahon M (2015). PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis. Cancer Res, 75(24), 5378-91.
  15. Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW, McMahon M, Holmen SL (2015). AKT1 Activation Promotes Development of Melanoma Metastases. Cell Rep, 13(5), 898-905.
  16. Shai A, Dankort D, Juan J, Green S, McMahon M (2015). TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res, 75(15), 3167-80.
  17. Shai A, Dankort D, Juan J, Green S, McMahon M (05/22/15). TP53 silencing bypasses growth arrest of BRAFV600E-induced lung tumor cells in a two-switch model of lung tumorigenesis. Cancer Res, 75(15), 3167-3180.
  18. Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA (2015). Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma. Nat Genet, 47(5), 486-95.
  19. Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson EA, Algazi A, Robinson E, Osman I, Munoz-Couselo E, Cortes J, Frederick DT, Cooper ZA, McMahon M, Marchetti A, Rosell R, Flaherty KT, Wargo JA, Bivona TG (2015). The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet, 47(3), 250-6.
  20. Deuker MM, Marsh Durban V, Phillips WA, McMahon M (2015). PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma. Cancer Discov, 5(2), 143-53.
  21. Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M (2015). mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell, 27(1), 41-56.
  22. Charles RP, Silva J, Iezza G, Phillips WA, McMahon M (2014). Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis. Mol Cancer Res, 12(7), 979-86.
  23. Juan J, Muraguchi T, Iezza G, Sears RC, McMahon M (2014). Diminished WNT -> beta-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes Dev, 28(6), 561-75.
  24. Silva JM, Bulman C, McMahon M (2014). BRAFV600E cooperates with PI3K signaling, independent of AKT, to regulate melanoma cell proliferation. Mol Cancer Res, 12(3), 447-63.
  25. Marsh Durban V, Deuker MM, Bosenberg MW, Phillips W, McMahon M (2013). Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. J Clin Invest, 123(12), 5104-18.
  26. Trejo CL, Green S, Marsh V, Collisson EA, Iezza G, Phillips WA, McMahon M (2013). Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. Cancer Res, 73(21), 6448-61.
  27. Das Thakur M, Salangsang F, Landman AS, Sellers WR, Pryer NK, Levesque MP, Dummer R, McMahon M, Stuart DD (2013). Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature, 494(7436), 251-5.
  28. Collisson EA, Trejo CL, Silva JM, Gu S, Korkola JE, Heiser LM, Charles RP, Rabinovich BA, Hann B, Dankort D, Spellman PT, Phillips WA, Gray JW, McMahon M (2012). A central role for RAF-->MEK-->ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discov, 2(8), 685-93.
  29. Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE Jr, You MJ, DePinho RA, McMahon M, Bosenberg M (2009). Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet, 41(5), 544-52.
  30. Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M (2007). A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev, 21(4), 379-84.

Review

  1. Holderfield M, Deuker MM, McCormick F, McMahon M (2014). Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. [Review]. Nat Rev Cancer, 14(7), 455-67.

Other

  1. Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M (2019). Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med (25(5), p. 861). United States.
  2. McMahon M (2015). Intermittent dosing in melanoma. Clin Adv Hematol Oncol (13(6), pp. 348-50). United States.