Paul A. Sigala, PhD

Research Interests

  • Malaria
  • Heme Metabolism
  • Organelle Structure and Function
  • Metabolic Adaptation


Lab Website


  • English
  • Spanish

Academic Information

  • Departments: Biochemistry - Assistant Professor

Academic Office Information

  • 801-587-4874
  • Emma Eccles Jones Medical Research Building
    15 N Medical Dr E, Room: 3532D
    Salt Lake City, UT

Education History

Type School Degree
Doctoral Training Stanford University
Undergraduate University of California, San Diego
Chemistry/Biochemistry, Spanish Literature
B.S., B.A.
Other Training Pontificia Universidad Católica de Chile
Academic Exchange: Spanish Literature
Postdoctoral Fellowship Washington University in St. Louis
Molecular Microbiology
Postdoctoral Fellow

Global Impact

Education History

Type School Degree Country
Other Training Pontificia Universidad Católica de Chile
Academic Exchange: Spanish Literature


Date Role Description Country
06/20/1999 Teacher U.S. Peace Corps Volunteer: Chemistry, HIV/AIDS, and computer education; Asankrangwa Secondary School, Ghana, West Africa Ghana

Selected Publications

Journal Article

  1. Goldberg DE, Sigala PA (2017). Plasmodium heme biosynthesis: To be or not to be essential? PLoS Pathog, 13(9), e1006511.
  2. Sigala PA, Morante K, Tsumoto K, Caaveiro JM, Goldberg DE (2016). In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis. Biochemistry, 55(34), 4836-49.
  3. Sigala PA, Ruben EA, Liu CW, Piccoli PM, Hohenstein EG, Martinez TJ, Schultz AJ, Herschlag D (2015). Determination of Hydrogen Bond Structure in Water versus Aprotic Environments To Test the Relationship Between Length and Stability. J Am Chem Soc, 137(17), 5730-40.
  4. Sigala PA, Crowley JR, Henderson JP, Goldberg DE (2015). Deconvoluting heme biosynthesis to target blood-stage malaria parasites.LID - 10.7554/eLife.09143 [doi]. Elife, 4.
  5. Ke H, Sigala PA, Miura K, Morrisey JM, Mather MW, Crowley JR, Henderson JP, Goldberg DE, Long CA, Vaidya AB (2014). The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages. J Biol Chem, 289(50), 34827-37.
  6. Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JM, Pybus B, Ringe D, Petsko GA, Boxer SG, Herschlag D (2013). Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site. Proc Natl Acad Sci U S A, 110(28), E2552-61.
  7. Fafarman AT, Sigala PA, Schwans JP, Fenn TD, Herschlag D, Boxer SG (2012). Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase. Proc Natl Acad Sci U S A, 109(6), E299-308.
  8. Sigala PA, Crowley JR, Hsieh S, Henderson JP, Goldberg DE (2012). Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum. J Biol Chem, 287(45), 37793-807.


  1. Sigala PA, Goldberg DE (2014). The peculiarities and paradoxes of Plasmodium heme metabolism. [Review]. Annu Rev Microbiol, 68, 259-78.