Jennifer A. Doherty, MS, PhD

Research Interests

  • Identifying Similarities and Differences in Epidemiologic and Genetic Risk Factors and Survival Across Subtypes of Ovarian Cancer
  • Identifying Factors Associated with Ovarian Cancer Survival Disparities by Race/Ethnicity
  • Characterizing Epidemiologic and Molecular Features of Ovarian Cancer in Diverse Populations
  • Evaluating the Utility of Biomarkers Such as Telomere Length and Methylation Markers for Risk Stratification for Lung Cancer

Languages

  • English

Academic Information

  • Departments: Obstetrics/Gynecology - Adjunct Associate Professor, Population Health Sciences - Associate Professor
  • Divisions: Cancer Population Science, Gynecologic Oncology

Academic Bio

Jennifer Anne Doherty, MS, PhD

Huntsman Cancer Institute Endowed Chair in Cancer Research

Executive Director, Utah Cancer Registry

Staff Investigator, Huntsman Cancer Institute

Dr. Doherty is an Associate Professor in the Department of Population Health Sciences at the University of Utah and a Huntsman Cancer Institute (HCI) Endowed Chair in Cancer Research. She is the Executive Director of the Utah Cancer Registry and the Principal Investigator of the Utah Surveillance, Epidemiology and End Results (SEER) site. Her NIH-funded research program focuses on the molecular and genetic epidemiology of ovarian and lung cancers. Dr. Doherty received her BS in Biology from Cornell University, an MS in Epidemiology from the University of Illinois at Chicago, and a PhD in Epidemiology from the University of Washington. After her post-doctoral fellowship, she joined the faculty at the Fred Hutchinson Cancer Research Center. In 2012, she moved to the Geisel School of Medicine at Dartmouth. She has been a member of the Huntsman Cancer Institute and the University of Utah since 2016, and is the Chair of the Utah Population Database Faculty Advisory Committee (FAC), and a member of the Pre-clinical Research Resource FAC. Dr. Doherty holds an affiliate investigator appointment at the Fred Hutchinson Cancer Research Center and an adjunct professor appointment with the Geisel School of Medicine at Dartmouth. She is a standing member of the NIH Cancer, Heart, and Sleep Panel B Study Section, and 2019-2020 Chair-Elect of the Steering Committee for the American Association for Cancer Research Molecular Epidemiology Working Group. She is dedicated to teaching and mentoring the next generation of team scientists.

Research Statement

Dr. Jennifer A. Doherty, MS, PhD, is a Huntsman Cancer Institute Endowed Chair and Associate Professor in the Department of Population Health Sciences, and Adjunct Associate Professor in the Department of Obstetrics and Gynecology at the University of Utah. She is also an Adjunct Associate Professor in the Department of Epidemiology at the Geisel School of Medicine at Dartmouth, and an Affiliate Investigator in the Program in Epidemiology at the FHCRC. She is the Executive Director of the Utah Cancer Registry (UCR) and PI of the Utah SEER site. She has an NIH-funded research program in molecular and genetic epidemiology of ovarian and lung cancers, leading transdisciplinary team science with national and international collaborations. Her ovarian cancer research focuses on characterizing molecular subtypes to understand risk, outcomes, and disparities. Her work in lung cancer centers on identifying biomarkers that predict the development of lung cancer in heavy smokers. She has experience with developing innovative, integrative training programs in epidemiology. With her strong foundation in molecular epidemiologic methods, experience leading large scale transdisciplinary team studies, and role as a HCI Staff Investigator, she mentors trainees to integrate molecular epidemiology and bioinformatics with laboratory and clinical research efforts.

Education History

Type School Degree
Postdoctoral Training Fred Hutchinson Cancer Research Center
Genetic and Molecular Epidemiology
Postdoctoral Training
Doctoral Training University of Washington
Epidemiology
Ph.D.
Certification University of Washington
Public Health Genetics
Certificate
Graduate Training University of Illinois at Chicago
Epidemiology
M.S.
Undergraduate Cornell University
Biology
B.S.

Selected Publications

Journal Article

  1. Bodelon C, Killian JK, Sampson JN, Anderson WF, Matsuno R, Brinton LA, Lissowska J, Anglesio MS, Bowtell DDL, Doherty JA, Ramus SJ, Talhouk A, Sherman ME, Wentzensen N (2019). Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity. Clin Cancer Res, 25(19), 5937-5946.
  2. Manichaikul A, Peres LC, Wang XQ, Barnard ME, Chyn D, Sheng X, Du Z, Tyrer J, Dennis J, Schwartz AG, Cote ML, Peters E, Moorman PG, Bondy M, Barnholtz-Sloan JS, Terry P, Alberg AJ, Bandera EV, Funkhouser E, Wu AH, Pearce CL, Pike M, Setiawan VW, Haiman CA, African American Breast Cancer Consortium AABC, African Ancestry Prostate Cancer Consortium AAPC, Palmer JR, LeMarchand L, Wilkens LR, Berchuck A, Doherty JA, Modugno F, Ness R, Moysich K, Karlan BY, Whittemore AS, McGuire V, Sieh W, Lawrenson K, Gayther S, Sellers TA, Pharoah P, Schildkraut JM, African American Cancer Epidemiology Study AACES and the Ovarian Cancer Association Consortium OCAC (2019). Identification of novel epithelial ovarian cancer loci in women of African ancestry. (Epub ahead of print) Int J Cancer.
  3. Palmer EL, Hassanpour S, Higgins J, Doherty JA, Onega T (2019). Building a tobacco user registry by extracting multiple smoking behaviors from clinical notes. BMC Med Informat Decis Making, 19(1), 141.
  4. Palmer EL, Higgins J, Hassanpour S, Sargent J, Robinson CM, Doherty JA, Onega T (2019). Assessing data availability and quality within an electronic health record system through external validation against an external clinical data source. BMC Med Informat Decis Making, 19(1), 143.
  5. Lawrenson K, Song F, Hazelett DJ, Kar SP, Tyrer J, Phelan CM, Corona RI, Rodrguez-Malav NI, Seo JH, Adler E, Coetzee SG, Segato F, Fonseca MAS, Amos CI, Carney ME, Chenevix-Trench G, Choi J, Doherty JA, Jia W, Jin GJ, Kim BG, Le ND, Lee J, Li L, Lim BK, Adenan NA, Mizuno M, Park B, Pearce CL, Shan K, Shi Y, Shu XO, Sieh W, Australian Ovarian Cancer Study Group, Thompson PJ, Wilkens LR, Wei Q, Woo YL, Yan L, Karlan BY, Freedman ML, Noushmehr H, Goode EL, Berchuck A, Sellers TA, Teo SH, Zheng W, Matsuo K, Park S, Chen K, Pharoah PDP, Gayther SA, Goodman MT (2019). Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women. Gynecol Oncol, 153(2), 343-355.
  6. Peres LC, Cushing-Haugen KL, Kbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA (2019). Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage. J Natl Cancer Inst, 111(1), 60-68.
  7. Grieshober L, Graw S, Barnett MJ, Thornquist MD, Goodman GE, Chen C, Koestler DC, Marsit CJ, Doherty JA (2018). Methylation-derived Neutrophil-to-Lymphocyte Ratio and Lung Cancer Risk in Heavy Smokers. Cancer Prev Res (Phila), 11(11), 727-734.
  8. Peres LC, Cushing-Haugen KL, Anglesio M, Wicklund K, Bentley R, Berchuck A, Kelemen LE, Nazeran TM, Gilks CB, Harris HR, Huntsman DG, Schildkraut JM, Rossing MA, Kbel M, Doherty JA (2018). Histotype classification of ovarian carcinoma: A comparison of approaches. Gynecol Oncol, 151(1), 53-60.
  9. Ji X, Boss Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickebller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnstrm H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI (2018). Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat Commun, 9(1), 3221.
  10. OMara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen MM, Cheng THT, Clarke CL, Clendenning M, Cook LS, Couch FJ, Cox A, Crous-Bous M, Czene K, Day F, Dennis J, Depreeuw J, Doherty JA, Drk T, Dowdy SC, Drst M, Ekici AB, Fasching PA, Fridley BL, Friedenreich CM, Fritschi L, Fung J, Garca-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison SE, Healey CS, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Marchand LL, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir R, Olsson H, Orlow I, Otton G, Palles C, Perry JRB, Peto J, Pooler L, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers PAW, Rbner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, VanDen Berg D, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HMJ, Winham SJ, Wolk A, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Pharoah PDP, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ (2018). Identification of nine new susceptibility loci for endometrial cancer. Nat Commun, 9(1), 3166.
  11. Doherty JA, Grieshober L, Houck JR, Barnett MJ, Tapsoba JD, Thornquist M, Wang CY, Goodman GE, Chen C (2018). Telomere Length and Lung Cancer Mortality among Heavy Smokers. Cancer Epidemiol Biomarkers Prev, 27(7), 829-837.
  12. Doherty JA, Grieshober L, Houck JR, Barnett MJ, De Dieu Tapsoba J, Thornquist MD, Wang CY, Goodman GE, Chen C (2018). Nested case-control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial. Br J Cancer, 118(11), 1513-1517.
  13. Harris HR, Babic A, Webb PM, Nagle CM, Jordan SJ, Risch HA, Rossing MA, Doherty JA, Goodman MT, Modugno F, Ness RB, Moysich KB, Kjaer SK, Hogdall E, Jensen A, Schildkraut JM, Berchuck A, Cramer DW, Bandera EV, Wentzensen N, Kotsopoulos J, Narod SA, Phelan CM, McLaughlin JR, Anton-Culver H, Ziogas A, Pearce CL, Wu AH, Terry KL (2018). Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev, 27(2), 174-182.
  14. Harrington LX, Way GP, Doherty JA, Greene CS (2018). Functional network community detection can disaggregate and filter multiple underlying pathways in enrichment analyses. Pac Symp Biocomput, 23, 157-167.
  15. eGTEx Project Collaborators Stranger BE, Brigham LE, Hasz R, Hunter M, Johns C, Johnson M, Kopen G, Leinweber WF, Lonsdale JT, McDonald A, Mestichelli B, Myer K, Roe B, Salvatore M, Shad S, Thomas JA, Walters G, Washington M, Wheeler J, Bridge J, Foster BA, Gillard BM, Karasik E, Kumar R, Miklos M, Moser MT, Jewell SD, Montroy RG, Rohrer DC, Valley DR, Davis DA, Mash DC, Gould SE, Guan P, Koester S, Little AR, Martin C, Moore HM, Rao A, Struewing JP, Volpi S, Hansen KD, Hickey PF, Rizzardi LF, Hou L, Liu Y, Molinie B, Park Y, Rinaldi N, Wang L, Van Wittenberghe N, Claussnitzer M, Gelfand ET, Li Q, Linder S, Zhang R, Smith KS, Tsang EK, Chen LS, Demanelis K, Doherty JA, Jasmine F, Kibriya MG, Jiang L, Lin S, Wang M, Jian R, Li X, Chan J, Bates D, Diegel M, Halow J, Haugen E, Johnson A, Kaul R, Lee K, Maurano MT, Nelson J, Neri FJ, Sandstrom R, Fernando MS, Linke C, Oliva M, Skol A, Wu F, Akey JM, Feinberg AP, Li JB, Pierce BL, Stamatoyannopoulos JA, Tang H, Ardlie KG, Kellis M, Snyder MP, Montgomery SB (2017). Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease. Nat Genet.
  16. Epidemiology Working Group Steering Committee, Ovarian Cancer Association Consortium Members of the EWG SC, in alphabetical order, Doherty JA, Jensen A, Kelemen LE, Pearce CL, Poole E, Schildkraut JM, Terry KL, Tworoger SS, Webb PM, Wentzensen N (2017). Current Gaps in Ovarian Cancer Epidemiology: The Need for New Population-Based Research. J Natl Cancer Inst, 109(10).
  17. Doherty JA, Peres LC, Wang C, Way GP, Greene CS, Schildkraut JM (2017). Challenges and Opportunities in Studying the Epidemiology of Ovarian Cancer Subtypes. Current Epidemiology Reports, 4(3), 211-220.
  18. Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, Dennis J, Pirie A, Riggan MJ, Chornokur G, Earp MA, Lyra PC Jr, Lee JM, Coetzee S, Beesley J, McGuffog L, Soucy P, Dicks E, Lee A, Barrowdale D, Lecarpentier J, Leslie G, Aalfs CM, Aben KKH, Adams M, Adlard J, Andrulis IL, Anton-Culver H, Antonenkova N, AOCS study group, Aravantinos G, Arnold N, Arun BK, Arver B, Azzollini J, Balmaa J, Banerjee SN, Barjhoux L, Barkardottir RB, Bean Y, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bermisheva M, Bernardini MQ, Birrer MJ, Bjorge L, Black A, Blankstein K, Blok MJ, Bodelon C, Bogdanova N, Bojesen A, Bonanni B, Borg, Bradbury AR, Brenton JD, Brewer C, Brinton L, Broberg P, Brooks-Wilson A, Bruinsma F, Brunet J, Buecher B, Butzow R, Buys SS, Caldes T, Caligo MA, Campbell I, Cannioto R, Carney ME, Cescon T, Chan SB, Chang-Claude J, Chanock S, Chen XQ, Chiew YE, Chiquette J, Chung WK, Claes KBM, Conner T, Cook LS, Cook J, Cramer DW, Cunningham JM, DAloisio AA, Daly MB, Damiola F, Damirovna SD, Dansonka-Mieszkowska A, Dao F, Davidson R, DeFazio A, Delnatte C, Doheny KF, Diez O, Ding YC, Doherty JA, Domchek SM, Dorfling CM, Drk T, Dossus L, Duran M, Drst M, Dworniczak B, Eccles D, Edwards T, Eeles R, Eilber U, Ejlertsen B, Ekici AB, Ellis S, Elvira M, EMBRACE Study, Eng KH, Engel C, Evans DG, Fasching PA, Ferguson S, Ferrer SF, Flanagan JM, Fogarty ZC, Fortner RT, Fostira F, Foulkes WD, Fountzilas G, Fridley BL, Friebel TM, Friedman E, Frost D, Ganz PA, Garber J, Garca MJ, Garcia-Barberan V, Gehrig A, GEMO Study Collaborators, Gentry-Maharaj A, Gerdes AM, Giles GG, Glasspool R, Glendon G, Godwin AK, Goldgar DE, Goranova T, Gore M, Greene MH, Gronwald J, Gruber S, Hahnen E, Haiman CA, Hkansson N, Hamann U, Hansen TVO, Harrington PA, Harris HR, Hauke J, HEBON Study, Hein A, Henderson A, Hildebrandt MAT, Hillemanns P, Hodgson S, Hgdall CK, Hgdall E, Hogervorst FBL, Holland H, Hooning MJ, Hosking K, Huang RY, Hulick PJ, Hung J, Hunter DJ, Huntsman DG, Huzarski T, Imyanitov EN, Isaacs C, Iversen ES, Izatt L, Izquierdo A, Jakubowska A, James P, Janavicius R, Jernetz M, Jensen A, Jensen UB, John EM, Johnatty S, Jones ME, Kannisto P, Karlan BY, Karnezis A, Kast K, KConFab Investigators, Kennedy CJ, Khusnutdinova E, Kiemeney LA, Kiiski JI, Kim SW, Kjaer SK, Kbel M, Kopperud RK, Kruse TA, Kupryjanczyk J, Kwong A, Laitman Y, Lambrechts D, Larraaga N, Larson MC, Lazaro C, Le ND, Le Marchand L, Lee JW, Lele SB, Leminen A, Leroux D, Lester J, Lesueur F, Levine DA, Liang D, Liebrich C, Lilyquist J, Lipworth L, Lissowska J, Lu KH, Lubinski J, Luccarini C, Lundvall L, Mai PL, Mendoza-Fandio G, Manoukian S, Massuger LFAG, May T, Mazoyer S, McAlpine JN, McGuire V, McLaughlin JR, McNeish I, Meijers-Heijboer H, Meindl A, Menon U, Mensenkamp AR, Merritt MA, Milne RL, Mitchell G, Modugno F, Moes-Sosnowska J, Moffitt M, Montagna M, Moysich KB, Mulligan AM, Musinsky J, Nathanson KL, Nedergaard L, Ness RB, Neuhausen SL, Nevanlinna H, Niederacher D, Nussbaum RL, Odunsi K, Olah E, Olopade OI, Olsson H, Olswold C, OMalley DM, Ong KR, Onland-Moret NC, OPAL study group, Orr N, Orsulic S, Osorio A, Palli D, Papi L, Park-Simon TW, Paul J, Pearce CL, Pedersen IS, Peeters PHM, Peissel B, Peixoto A, Pejovic T, Pelttari LM, Permuth JB, Peterlongo P, Pezzani L, Pfeiler G, Phillips KA, Piedmonte M, Pike MC, Piskorz AM, Poblete SR, Pocza T, Poole EM, Poppe B, Porteous ME, Prieur F, Prokofyeva D, Pugh E, Pujana MA, Pujol P, Radice P, Rantala J, Rappaport-Fuerhauser C, Rennert G, Rhiem K, Rice P, Richardson A, Robson M, Rodriguez GC, Rodrguez-Antona C, Romm J, Rookus MA, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Salvesen HB, Sandler DP, Schoemaker MJ, Senter L, Setiawan VW, Severi G, Sharma P, Shelford T, Siddiqui N, Side LE, Sieh W, Singer CF, Sobol H, Song H, Southey MC, Spurdle AB, Stadler Z, Steinemann D, Stoppa-Lyonnet D, Sucheston-Campbell LE, Sukiennicki G, Sutphen R, Sutter C, Swerdlow AJ, Szabo CI, Szafron L, T (2017). Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet, 49(5), 680-691.
  19. Dixon SC, Nagle CM, Wentzensen N, Trabert B, Beeghly-Fadiel A, Schildkraut JM, Moysich KB, deFazio A, Risch HA, Rossing MA, Doherty JA, Wicklund KG, Goodman MT, Modugno F, Ness RB, Edwards RP, Jensen A, Kjaer SK, Hogdall E, Berchuck A, Cramer DW, Terry KL, Poole EM, Bandera EV, Paddock LE, Anton-Culver H, Ziogas A, Menon U, Gayther SA, Ramus SJ, Gentry-Maharaj A, Pearce CL, Wu AH, Pike MC, Webb PM (2017). Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. Br J Cancer, 116(9), 1223-1228.
  20. Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumacher FR, Kote-Jarai Z, Lindstrom S, Witte JS, Fang S, Han J, Kraft P, Hunter DJ, Song F, Hung RJ, McKay J, Gruber SB, Chanock SJ, Risch A, Shen H, Haiman CA, Boardman L, Ulrich CM, Casey G, Peters U, Amin Al Olama A, Berchuck A, Berndt SI, Bezieau S, Brennan P, Brenner H, Brinton L, Caporaso N, Chan AT, Chang-Claude J, Christiani DC, Cunningham JM, Easton D, Eeles RA, Eisen T, Gala M, Gallinger SJ, Gayther SA, Goode EL, Grnberg H, Henderson BE, Houlston R, Joshi AD, Kry S, Landi MT, Le Marchand L, Muir K, Newcomb PA, Permuth-Wey J, Pharoah P, Phelan C, Potter JD, Ramus SJ, Risch H, Schildkraut J, Slattery ML, Song H, Wentzensen N, White E, Wiklund F, Zanke BW, Sellers TA, Zheng W, Chatterjee N, Amos CI, Doherty JA, GECCO and the GAME-ON Network CORECT, DRIVE, ELLIPSE, FOCI, and TRICL (2016). Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer, 139(12), 2655-2670.

Editorial

  1. Tworoger SS, Doherty JA (2017). Epidemiologic paradigms for progress in ovarian cancer research. Cancer Causes Control, 28(5), 361-364.

Video/Film/CD/Web/Podcast

  1. Way GP, Rudd JR, Wang C, Hamidi H, Fridley BL, Konecny G, Goode EL, Greene CS, Doherty JA (2016). Comprehensive cross-population analysis of high-grade serous ovarian cancer supports no more than three subtypes [Web]. bioRxiv. Available: http://dx.doi.org/10.1101/030239.