Patrice N. Mimche, PhD

Research Interests

  • Malaria Pathogenesis
  • Mechanisms of Organs Fibrogenesis

Languages

  • English

Academic Information

  • Departments: Pathology - Assistant Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-213-8504
  • Maxwell M. Wintrobe Research and Education Building
    26 N Medical Dr
    Salt Lake City, UT 84132

Email: patrice.mimche@path.utah.edu

Education History

Type School Degree
Postdoctoral Fellowship Emory University School of Medicine
Immunology and Infectious Diseases
Postdoctoral Fellow
Doctoral Training London School of Hygiene & Tropical Medicine/European Molecular Biology Laboratory
Biological Sciences
Ph.D.
Graduate Training University of Yaoundé I
Biochemistry
M.S.
Undergraduate University of Yaoundé I
Biochemistry
B.S.

Global Impact

Education History

Type School Degree Country
Doctoral Training London School of Hygiene & Tropical Medicine/European Molecular Biology Laboratory
Biological Sciences
Ph.D. United Kingdom
Graduate Training University of Yaoundé I
Biochemistry
M.S. Cameroon
Undergraduate University of Yaoundé I
Biochemistry
B.S. Cameroon

Selected Publications

Journal Article

  1. Darling TK, Mimche PN, Bray C, Umaru B, Brady LM, Stone C, Eboumbou Moukoko CE, Lane TE, Ayong LS, Lamb TJ (2020). EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog, 16(1), e1008261.
  2. Darling TK, Schenk MP, Zhou CC, Maloba FM, Mimche PN, Gibbins JM, Jobe SM, Lamb TJ (2019). Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria. Blood Adv, 4(1), 1-8.
  3. Mimche SM, Lee CM, Liu KH, Mimche PN, Harvey RD, Murphy TJ, Nyagode BA, Jones DP, Lamb TJ, Morgan ET (2019). A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice. Malaria Journal.
  4. Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb TJ (2018). EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Sci Rep, 8(1), 2532.
  5. Qiu Y, Ahn B, Sakurai Y, Hansen CE, Tran R, Mimche PN, Mannino RG, Ciciliano JC, Lamb TJ, Joiner CH, Ofori-Acquah SF, Lam WA (2018). Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease. Nat Biomed Eng, 2, 453-463.
  6. Mimche PN, Brady LM, Bray CF, Lee CM, Thapa M, King TP, Quicke K, McDermott CD, Mimche SM, Grakoui A, Morgan ET, Lamb TJ (2015). The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Hepatology, 62(3), 900-14.
  7. Mimche PN, Brady LM, Keeton S, Fenne DS, King TP, Quicke KM, Hudson LE, Lamb TJ (2015). Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation. PLoS ONE, 10(9), e0138835.
  8. Ali IM, Evehe MS, Netongo PM, Atogho-Tiedeu B, Akindeh-Nji M, Ngora H, Domkam IK, Diakite M, Baldip K, Ranford-Cartwright L, Mimche PN, Lamb T, Mbacham WF (2014). Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon. Pathog Glob Health, 108(7), 323-33.
  9. Mimche PN, Thompson E, Taramelli D, Vivas L (2012). Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages. J Antimicrob Chemother, 67(8), 1895-904.
  10. Mbacham WF, Evehe MS, Netongo PM, Ateh IA, Mimche PN, Ajua A, Nji AM, Irenee D, Echouffo-Tcheugui JB, Tawe B, Hallett R, Roper C, Targett G, Greenwood B (2010). Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. Malaria Journal, 9, 34.
  11. Mbacham WF, Evehe MS, Netongo PM, Ali IM, Nfor EM, Akaragwe A, Mimche PN, Nji A, Djoko CF, Tawe B, Gawa B, Asongna T, Toh GB, Atogho-Tieudeu B, Nge N, Ebeng E, Mokube AJ, Kuaban C, Bickii J, Penlap V, Titanji VP, Njikam N (2009). Mutations within folate metabolizing genes of Plasmodium falciparum in Cameroon. Afr J Biotechnol, 8(19), 4749-54.
  12. Mbacham WF, Mimche PN, Netongo PM, Evehe MS, Nji A, Amunom I, Daily J, Makoge V, Laserson K, Yong SM, Lomah N, Enyong P, Titanji VP, Wirth DF (2008). Limited variation of the 5’cis- control region of the transmission blocking vaccine candidate Pfs25 amid great genetic diversity of Plasmodium falciparum in Cameroon. Afr J Biotechnol, 7(5), 523-33.

Review

  1. Mimche PN, Taramelli D, Vivas L (2011). The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. [Review]. Malaria Journal, 10 Suppl 1, S10.