Brian D. Evavold, PhD

Chief, Division of Microbiology and Immunology

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Pathology - Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-585-9689
  • Emma Eccles Jones Research Building
    15 North Medical Drive East, Room: 4280A
    Salt Lake City, UT 84112

Email: u6010849@utah.edu

Research Statement

My research centers on how antigen recognition by T cells determines cell phenotype, fate, and outcome of the adaptive immune response. Understanding the mechanisms driving T cell activation provides novel insight into the basis of autoimmune disease and effective response to infections.

Education History

Type School Degree
Postdoctoral Fellowship Washington University
T Cell Responses to Altered Peptide Ligands
Postdoctoral Fellow
Doctoral Training University of Chicago
T Cell Responses
Ph.D.
Undergraduate St. Olaf College
Chemistry, Biology
B.A.

Global Impact

Presentations

Description Country
Evavold BD. T cell response to Altered peptide ligands. Autumn British Transplantation Society Meeting, London, England, United Kingdom United Kingdom
Evavold BD. Altered peptide ligands for the T cell receptor. Cardiff University-Immunology Seminar Series, Cardiff, Wales, United Kingdom United Kingdom
Evavold BD. Variant peptide ligands for the TCR. Immunology Seminar Series, King’s College London, London, England, United Kingdom United Kingdom
Evavold BD. Affinity of myelin specific T cells. 5th Aegean Autoimmune Conference, Crete, Greece Greece
Evavold BD. 2D T cell affinity of myelin reactive T cells. Department of Microbiology Seminar Series, University of British Columbia, Vancouver, British Columbia, Canada Canada
Evavold BD. 2D affinity of CD4+ T cells. Cardiff University, London, Wales, United Kingdom United Kingdom
Evavold BD. Frequency and affinity of CD4+ Tregs. University of Edinburgh, Edinburgh, Scotland, United Kingdom United Kingdom
Evavold BD. 2D frequency and affinity of myelin specific Tregs. Stochastic, statistical and computational approaches to Immunology, Edinburgh, Scotland, United Kingdom United Kingdom
Evavold BD. Affinity of myelin specific. 6th Aegean Autoimmune Conference, Corfu, Greece Greece
Evavold BD. Frequency and 2D affinity of CD4 T cells. Lausanne Cancer Institute, Lausanne, Switzerland Switzerland
Evavold BD. 2D affinity of CD4 T cells. MRC Immunology Seminar, Mill Hill, London, United Kingdom United Kingdom
Evavold BD. T cell activation; the force awakens. Bridge Gaps & Crossroads Symposium, student invited speaker, University of Vienna, Vienna, Austria Austria

Selected Publications

Journal Article

  1. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML (2019). A Critical Insulin TCR Contact Residue Selects High Affinity and Pathogenic Insulin Specific T Cells. (Epub ahead of print) Diabetes.
  2. Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold BD (2019). A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery. (Epub ahead of print) Diabetes.
  3. Spear TT, Evavold BD, Baker BM, Nishimura MI (2019). Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy. Cancer Immunol Immunother, 68(11), 1881-1889.
  4. Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok WW (2019). Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes. Sci Adv, 5(8), eaaw9336.
  5. Shwetank, Frost EL, Mockus TE, Ren HM, Toprak M, Lauver MD, Netherby-Winslow CS, Jin G, Cosby JM, Evavold BD, Lukacher AE (2019). PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis. Front Immunol, 10, 783.
  6. Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez RJ, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold BD, Zhu C, Chen W, Lou J (2019). Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Mol Cell, 73(5), 1015-1027.e7.
  7. Hong J, Ge C, Jothikumar P, Yuan Z, Liu B, Bai K, Li K, Rittase W, Shinzawa M, Zhang Y, Palin A, Love P, Yu X, Salaita K, Evavold BD, Singer A, Zhu C (2018). A TCR mechanotransduction signaling loop induces negative selection in the thymus. Nat Immunol, 19(12), 1379-1390.
  8. Kolawole EM, Andargachew R, Liu B, Jacobs JR, Evavold BD (2018). 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes. Front Immunol, 9, 2348.
  9. DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT (2017). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science, 361(6407).

Patent

  1. Allen PM, Sloan-Lancaster J, Evavold BD (1994). Anergy of T cells using partial agonist peptides.