Keke C. Fairfax, PhD

Languages

  • English

Academic Information

  • Departments: Pathology - Assistant Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-581-5980
  • Emma Eccles Jones Medical Research Building
    15 N Medical Dr E
    Salt Lake City, UT

Email: keke.fairfax@path.utah.edu

Research Statement

IL-4 and immuno-modulation are hallmarks of parasitic infections, my laboratory broadly focuses on using the helminth parasite Schistosoma mansoni as a tool to understand both, the consequences of IL-4 induced immuno-modulation, and the complex interplay between B, T and stromal cells necessary to develop an optimal T and B cell memory response Under this umbrella we currently have three main projects: 1) Understanding the immunological implications of maternal schistosomiasis; 2) Dissecting the role of IL-4 in shaping the cellular environment of peripheral lymph nodes during homeostasis and antigenic challenge; 3) Delineating the mechanistic role of hepatic macrophages in helminth-induced protection from metabolic diseases.

Education History

Type School Degree
Postdoctoral Fellowship Washington University in St. Louis
UNCF/MERCK Fellowship
Postdoctoral Fellow
Fellowship Trudeau Institute
Postdoctoral Research Associate
Doctoral Training Yale University
Microbiology
Ph.D.
Undergraduate University of Chicago
Biology
B.A.

Selected Publications

Journal Article

  1. Cortes-Selva D, Ready A, Gibbs L, Rajwa B, Fairfax KC (). IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response. Eur J Immunol, 49(3), 428-442.
  2. Cortes-Selva D, Elvington AF, Ready A, Rajwa B, Pearce EJ, Randolph GJ, Fairfax KC (2018). Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype. Front Immunol, 9, 2580.
  3. Wang F, Johnson RL, DeSmet ML, Snyder PW, Fairfax KC, Fleet JC (2017 Jun 1). Vitamin D Receptor-Dependent Signaling Protects Mice From Dextran Sulfate Sodium-Induced Colitis. Endocrinology, 158(6), 1951-1963.
  4. Dwyer DF, Barrett NA, Austen KF (2016 Jul). Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol, 17(7), 878-87.
  5. Everts B, Tussiwand R, Dreesen L, Fairfax KC, Huang SC, Smith AM, ONeill CM, Lam WY, Edelson BT, Urban JF Jr, Murphy KM, Pearce EJ (2016 Jan 11). Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12. J Exp Med, 213(1), 35-51.
  6. Fairfax KC, Everts B, Amiel E, Smith AM, Schramm G, Haas H, Randolph GJ, Taylor JJ, Pearce EJ (2015 Apr 1). IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism. J Immunol, 194(7), 2999-3010.
  7. Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK, Gilfillan S, Colonna M (2015 Mar). Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol, 16(3), 306-17.
  8. Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C (2014 Nov 1). Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. J Immunol, 193(9), 4485-96.
  9. Fairfax KC, Harrison LM, Cappello M (2014 Nov). Molecular cloning and characterization of a nematode polyprotein antigen/allergen from the human and animal hookworm Ancylostoma ceylanicum. Mol Biochem Parasitol, 198(1), 37-44.
  10. Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ (2014 Jul 28). Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med, 211(8), 1525-31.
  11. Fairfax KC, Everts B, Smith AM, Pearce EJ (2013 Oct 15). Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection. J Immunol, 191(8), 4202-10.
  12. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S (2013 Jun). The transcriptional landscape of alphabeta T cell differentiation. Nat Immunol, 14(6), 619-32.
  13. Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR, Maayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ (2012 Nov). Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol, 13(11), 1118-28.
  14. Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M (2012 Sep). Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol, 13(9), 888-99.
  15. Fairfax KC, Amiel E, King IL, Freitas TC, Mohrs M, Pearce EJ (2012 Jan). IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog, 8(1), e1002490.
  16. Fairfax KC, Vermeire JJ, Harrison LM, Bungiro RD, Grant W, Husain SZ, Cappello M (2009 Dec). Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum. Int J Parasitol, 39(14), 1561-71.
  17. Vinatzer BA, Teitzel GM, Lee MW, Jelenska J, Hotton S, Fairfax K, Jenrette J, Greenberg JT (2006 Oct). The type III effector repertoire of Pseudomonas syringae pv. syringae B728a and its role in survival and disease on host and non-host plants. Mol Microbiol, 62(1), 26-44.

Review

  1. Fairfax K, Nascimento M, Huang SC, Everts B, Pearce EJ (2012 Nov). Th2 responses in schistosomiasis. [Review]. Semin Immunopathol, 34(6), 863-71.