Hans R. Haecker, MD, PhD

Languages

  • English

Academic Information

  • Departments: Pathology - Professor
  • Divisions: Microbiology and Immunology

Board Certification

  • Bavarian State Medical Association (Sub: Microbiology and Infection Epidemiology)

Email: hans.haecker@path.utah.edu

Education History

Type School Degree
Postdoctoral Fellowship University of California, San Diego School of Medicine
Pharmacology
Postdoctoral Fellow
Doctoral Training Technical University of Munich
Medical Microbiology and Immunology
Ph.D.
Residency University of Ulm
Hematology/Oncology
Resident
Professional Medical University of Ulm
Medicine
M.D.

Global Impact

Education History

Type School Degree Country
Doctoral Training Technical University of Munich
Medical Microbiology and Immunology
Ph.D. Germany
Residency University of Ulm
Hematology/Oncology
Resident Germany
Professional Medical University of Ulm
Medicine
M.D. Germany

Selected Publications

Journal Article

  1. Kuriakose J, Redecke V, Guy C, Zhou J, Wu R, Ippagunta SK, Tillman H, Walker PD, Vogel P, Hcker H (2019). Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis.LID - 10.1172/JCI125116 [doi]LID - 125116 [pii]. J Clin Invest, 130.
  2. Pollock JA, Sharma N, Ippagunta SK, Redecke V, Hcker H, Katzenellenbogen JA (2018). Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure-Activity Relationships Governing Pan- and Selective Signaling Inhibitors. ChemMedChem, 13(20), 2208-2216.
  3. Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Hcker H (2018). Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.LID - eaaq1077 [pii]LID - 10.1126/scisignal.aaq1077 [doi]. Sci Signal, 11(543).
  4. Leithner A, Renkawitz J, De Vries I, Hauschild R, Hcker H, Sixt M (2018). Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration. Eur J Immunol, 48(6), 1074-1077.
  5. Yang CH, Wang Y, Sims M, Cai C, He P, Hcker H, Yue J, Cheng J, Boop FA, Pfeffer LM (2017). MicroRNA203a suppresses glioma tumorigenesis through an ATM-dependent interferon response pathway. Oncotarget, 8(68), 112980-112991.
  6. Di Ceglie I, van den Akker GG, Ascone G, Ten Harkel B, Hcker H, van de Loo FA, Koenders MI, van der Kraan PM, de Vries TJ, Vogl T, Roth J, van Lent PL (2017). Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology. J Leukoc Biol, 101(4), 957-966.
  7. Penkert RR, Jones BG, Hcker H, Partridge JF, Hurwitz JL (2017). Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines. Cytokine, 91, 1-5.
  8. Grajkowska LT, Ceribelli M, Lau CM, Warren ME, Tiniakou I, Nakandakari Higa S, Bunin A, Hcker H, Mirny LA, Staudt LM, Reizis B (2017). Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification. Immunity, 46(1), 65-77.
  9. Ippagunta SK, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, Redecke V, Hcker H (2016). Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Proc Natl Acad Sci U S A, 113(41), E6162-E6171.
  10. Kaewborisuth C, Zanin M, Hcker H, Webby RJ, Lekcharoensuk P (2016). G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology. Virol J, 13, 127.
  11. Redecke V, Chaturvedi V, Kuriakose J, Hcker H (2016). SHARPIN controls the development of regulatory T cells. Immunology, 148(2), 216-26.
  12. Bunin A, Sisirak V, Ghosh HS, Grajkowska LT, Hou ZE, Miron M, Yang C, Ceribelli M, Uetani N, Chaperot L, Plumas J, Hendriks W, Tremblay ML, Hcker H, Staudt LM, Green PH, Bhagat G, Reizis B (2015). Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells. Immunity, 43(2), 277-88.
  13. Wache C, Klein M, Ostergaard C, Angele B, Hcker H, Pfister HW, Pruenster M, Sperandio M, Leanderson T, Roth J, Vogl T, Koedel U (2015). Myeloid-related protein 14 promotes inflammation and injury in meningitis. J Infect Dis, 212(2), 247-57.
  14. Tawaratsumida K, Phan V, Hrincius ER, High AA, Webby R, Redecke V, Hcker H (2014). Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor. J Virol, 88(16), 9038-48.
  15. Schwab L, Goroncy L, Palaniyandi S, Gautam S, Triantafyllopoulou A, Mocsai A, Reichardt W, Karlsson FJ, Radhakrishnan SV, Hanke K, Schmitt-Graeff A, Freudenberg M, von Loewenich FD, Wolf P, Leonhardt F, Baxan N, Pfeifer D, Schmah O, Schonle A, Martin SF, Mertelsmann R, Duyster J, Finke J, Prinz M, Henneke P, Hcker H, Hildebrandt GC, Hcker G, Zeiser R (2014). Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med, 20(6), 648-54.
  16. Klein M, Brouwer MC, Angele B, Geldhoff M, Marquez G, Varona R, Hcker G, Schmetzer H, Hcker H, Hammerschmidt S, van der Ende A, Pfister HW, van de Beek D, Koedel U (2014). Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis. PLoS ONE, 9(4), e93057.
  17. Redecke V, Wu R, Zhou J, Finkelstein D, Chaturvedi V, High AA, Hcker H (2013). Hematopoietic progenitor cell lines with myeloid and lymphoid potential. Nat Methods, 10(8), 795-803.
  18. Gautam S, Kirschnek S, Gentle IE, Kopiniok C, Henneke P, Hcker H, Malleret L, Belaaouaj A, Hcker G (2013). Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-beta (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation. Cell Death Differ, 20(8), 1068-79.
  19. Hohne C, Wenzel M, Angele B, Hammerschmidt S, Hcker H, Klein M, Bierhaus A, Sperandio M, Pfister HW, Koedel U (2013). High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis. Brain, 136(Pt 6), 1746-59.
  20. LeMessurier KS, Hcker H, Chi L, Tuomanen E, Redecke V (2013). Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung. PLoS Pathog, 9(11), e1003727.
  21. Hcker H, Chi L, Rehg JE, Redecke V (2012). NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKalpha activation. J Immunol, 188(9), 4602-10.
  22. Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Hcker H, Hcker G (2011). Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa. Cell Death Differ, 18(11), 1805-14.
  23. Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Hcker H (2011). A20-binding inhibitor of NF-kappaB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein beta activation and protects from inflammatory disease. Proc Natl Acad Sci U S A, 108(44), E998-1006.
  24. Stempin CC, Chi L, Giraldo-Vela JP, High AA, Hcker H, Redecke V (2011). The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-kappaB activation. J Biol Chem, 286(43), 37147-57.
  25. Garrison SP, Thornton JA, Hcker H, Webby R, Rehg JE, Parganas E, Zambetti GP, Tuomanen EI (2010). The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. PLoS Pathog, 6(12), e1001240.
  26. LeMessurier K, Hcker H, Tuomanen E, Redecke V (2010). Inhibition of T cells provides protection against early invasive pneumococcal disease. Infect Immun, 78(12), 5287-94.
  27. Woehrl B, Klein M, Rupprecht T, Schmetzer H, Angele B, Hcker H, Hcker G, Pfister HW, Koedel U (2010). CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis. J Infect Dis, 202(9), 1389-96.
  28. Koedel U, Frankenberg T, Kirschnek S, Obermaier B, Hcker H, Paul R, Hcker G (2009). Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. PLoS Pathog, 5(5), e1000461.
  29. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Hcker H, Karin M, Vignali DA (2008). Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A, 105(51), 20197-202.
  30. Into T, Inomata M, Nakashima M, Shibata K, Hcker H, Matsushita K (2008). Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol, 28(4), 1338-47.
  31. Frankenberg T, Kirschnek S, Hcker H, Hcker G (2008). Phagocytosis-induced apoptosis of macrophages is linked to uptake, killing and degradation of bacteria. Eur J Immunol, 38(1), 204-15.
  32. El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Watowich SS, Hcker H, Foxwell BM, Murray PJ (2007). Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol, 179(11), 7215-9.
  33. Wang GG, Calvo KR, Pasillas MP, Sykes DB, Hcker H, Kamps MP (2006). Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods, 3(4), 287-93.
  34. Hcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Hcker G, Mann M, Karin M (2006). Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature, 439(7073), 204-7.
  35. Kirschnek S, Ying S, Fischer SF, Hcker H, Villunger A, Hochrein H, Hcker G (2005). Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim. J Immunol, 174(2), 671-9.
  36. Amir RE, Hcker H, Karin M, Ciechanover A (2004). Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene, 23(14), 2540-7.
  37. Redecke V, Hcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E (2004). Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol, 172(5), 2739-43.
  38. Seegmuller I, Hcker H, Wagner H (2003). IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism. Eur J Immunol, 33(2), 428-33.
  39. Hcker H, Furmann C, Wagner H, Hcker G (2002). Caspase-9/-3 activation and apoptosis are induced in mouse macrophages upon ingestion and digestion of Escherichia coli bacteria. J Immunol, 169(6), 3172-9.
  40. Ahmad-Nejad P, Hcker H, Rutz M, Bauer S, Vabulas RM, Wagner H (2002). Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol, 32(7), 1958-68.
  41. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hcker H, Wagner H (2001). Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem, 276(33), 31332-9.
  42. Bauer S, Kirschning CJ, Hcker H, Redecke V, Hausmann S, Akira S, Wagner H, Lipford GB (2001). Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A, 98(16), 9237-42.
  43. Hcker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H (2000). Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med, 192(4), 595-600.
  44. Vabulas RM, Pircher H, Lipford GB, Hcker H, Wagner H (2000). CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J Immunol, 164(5), 2372-8.
  45. Schrezenmeier H, Hildebrand A, Rojewski M, Hcker H, Heimpel H, Raghavachar A (2000). Paroxysmal nocturnal haemoglobinuria: a replacement of haematopoietic tissue? Acta Haematol, 103(1), 41-8.
  46. Hcker H, Mischak H, Hacker G, Eser S, Prenzel N, Ullrich A, Wagner H (1999). Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells. EMBO J, 18(24), 6973-82.
  47. Hcker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, Wagner H (1998). CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J, 17(21), 6230-40.
  48. Sparwasser T, Miethke T, Lipford G, Erdmann A, Hcker H, Heeg K, Wagner H (1997). Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol, 27(7), 1671-9.
  49. Sparwasser T, Miethke T, Lipford G, Borschert K, Hcker H, Heeg K, Wagner H (1997). Bacterial DNA causes septic shock. Nature, 386(6623), 336-7.
  50. del Val M, Hengel H, Hcker H, Hartlaub U, Ruppert T, Lucin P, Koszinowski UH (1992). Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. J Exp Med, 176(3), 729-38.

Review

  1. Hcker H, Tseng PH, Karin M (2011). Expanding TRAF function: TRAF3 as a tri-faced immune regulator. [Review]. Nat Rev Immunol, 11(7), 457-68.
  2. Hcker H, Karin M (2006). Regulation and function of IKK and IKK-related kinases. [Review]. Sci STKE, 2006(357), re13.
  3. Hcker H, Karin M (2002). Is NF-kappaB2/p100 a direct activator of programmed cell death? [Review]. Cancer Cell, 2(6), 431-3.
  4. Hcker G, Redecke V, Hcker H (2002). Activation of the immune system by bacterial CpG-DNA. [Review]. Immunology, 105(3), 245-51.
  5. Wagner H, Hcker H, Lipford GB (2000). Immunostimulatory DNA sequences help to eradicate intracellular pathogens. [Review]. Springer Semin Immunopathol, 22(1-2), 147-52.
  6. Hcker H (2000). Signal transduction pathways activated by CpG-DNA. [Review]. Curr Top Microbiol Immunol, 247, 77-92.
  7. Wagner H, Lipford GB, Hcker H (2000). The role of immunostimulatory CpG-DNA in septic shock. [Review]. Springer Semin Immunopathol, 22(1-2), 167-71.
  8. Heeg K, Sparwasser T, Lipford GB, Hcker H, Zimmermann S, Wagner H (1998). Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. [Review]. Eur J Clin Microbiol Infect Dis, 17(7), 464-9.

Book Chapter

  1. Hcker H, Karin M (2006). Regulation of IKK. In Handbook of Transcription Factor NF-kappaB (pp. 25-51). CRC Press.