Maria Bettini, PhD
- Departments: Pathology - Associate Professor
- Divisions: Microbiology and Immunology
Dr. Maria Bettini’s work has focused on understanding immunotolerance pathways and their dysregulation in autoimmunity. Dr. Bettini utilizes cutting edge genetic approaches to create systems that advance our knowledge of tissue targeted autoimmunity. Her work has uncovered several pathways that are important in suppression of autoimmune responses, which have therapeutic potential. More recently, Dr. Bettini has made significant advancement in our understanding of regulatory T cell function in autoimmunity and the signaling pathways that modulate Treg functional profile. Her current work is aimed at harnessing this knowledge to improve current cell based therapies for treatment of autoimmune disorders.
The focus of my research is mechanisms of tolerance and their failure in autoimmunity, with primary interest in type 1 diabetes. Our approach is built upon a combination of innovative mouse models of T cell biology and autoimmunity, including mouse and human single T cell receptor retrogenic mice.
Current projects investigate the role of T cell receptor antigen specificity and affinity in function of pathogenic and regulatory T cells in autoimmunity.
|Post Graduate Training||St. Jude Children’s Research Hospital
|Post Graduate Training||Emory University
|Doctoral Training||Emory University
Immunology and Molecular Pathogenesis
|Undergraduate||East Tennessee State University
Biology, concentration Biochemistry
- Kong Y, Jing Y, Bettini M (2019). Generation of T cell receptor retrogenic mice. Curr Protoc Immunol.
- Sprouse ML, Scavuzzo MA, Blum S, Shevchenko I, Lee T, Makedonas G, Borowiak M, Bettini ML, Bettini M (2018). High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity. JCI Insight.
- Sprouse ML, Shevchenko I, Scavuzzo MA, Joseph F, Lee T, Blum S, Borowiak M, Bettini ML, Bettini M (2018). Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity. J Immunol.