Matthew L. Bettini, PhD


Lab Website


  • English

Academic Information

  • Departments: Pathology - Associate Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-213-8560
  • Emma Eccles Jones Medical Research Building
    15 N Medical Dr E
    Salt Lake City, UT


Education History

Type School Degree
Research Fellow St. Jude Children's Research Hospital
Immunology and Autoimmunity
Postdoctoral Research Fellow
Doctoral Training Emory University
Immunology and Molecular Pathogenesis
Graduate Training Georgia State University
Undergraduate Furman University

Selected Publications

Journal Article

  1. Andrew G Ramstead, Jared A Wallace, Soh-Hyun Lee, Kaylyn M Bauer, William W Tang, Bettini ML, H Atakan Ekiz, June L Round, Jared Rutter, Ryan M OConnell (2020). Mitochondrial Pyruvate Carrier 1 (MPC1) promotes peripheral T cell homeostasis through metabolic regulation of thymic development. Cell Rep.
  2. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML (2019). A Critical Insulin TCR Contact Residue Selects High Affinity and Pathogenic Insulin Specific T Cells. Diabetes.
  3. Shrestha AK, Bettini ML, Menon RT, Gopal VYN, Huang S, Edwards DP, Pammi M, Barrios R, Shivanna B (2019). Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice. Am J Physiol Lung Cell Mol Physiol, 316(1), L229-L244.
  4. Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE (2018). Critical Role for the Microbiota in CX3CR1(+) Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity, 49(1), 151-163.e5.
  5. Sprouse ML, Shevchenko I, Scavuzzo MA, Joseph F, Lee T, Blum S, Borowiak M, Bettini ML, Bettini (2018). Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity. J Immunol, 200(3), 909-914.
  6. Lee T, Sprouse ML, Banerjee P, Bettini, Bettini ML (2017). Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells. J Immunol, 199(7), 2270-2278.
  7. Bettini ML, Chou PC, Guy CS, Lee T, Vignali KM, Vignali DAA (2017 Sep 1). Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development. J Immunol, 199(5), 1555-1560.
  8. Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA (2014). Membrane association of the CD3epsilon signaling domain is required for optimal T cell development and function. J Immunol, 193(1), 258-67.
  9. Bettini ML, Bettini, Nakayama M, Guy CS, Vignali DA (2013 Oct). Generation of T cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer. Nat Protoc, 8(10), 1837-40.
  10. Bettini ML, Pan F, Bettini, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM, Vignali DA (2012 May 25). Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity, 36(5), 717-30.


  1. Bettini ML, Bettini (2017). Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex. [Review]. Front Endocrinol (Lausanne), 8, 351.
  2. Bettini ML, Bettini, Vignali DA (2012). T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. [Review]. Immunology, 136(3), 265-72.