Julia Brasch, PhD

Academic Information

  • Departments: Biochemistry - Assistant Professor

Education History

Type School Degree
Graduate Training Gottfried Wilhelm Leibniz University of Hannover
Biochemistry, Biophysics and Structural Biology
Ph.D.
Undergraduate Gottfried Wilhelm Leibniz University of Hannover
Biochemistry
B.S., M.S.

Selected Publications

Journal Article

  1. Brasch J, Goodman KM, Noble AJ, Rapp M, Mannepalli S, Bahna F, Dandey VP, Bepler T, Berger B, Maniatis T, Potter CS, Carragher B, Honig B, Shapiro L (2019). Visualization of clustered protocadherin neuronal self-recognition complexes. Nature, 569(7755), 280-283.
  2. Zeiske T, Baburajendran N, Kaczynska A, Brasch J, Palmer AG 3rd, Shapiro L, Honig B, Mann RS (2018). Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites. Cell Rep, 24(9), 2221-2230.
  3. Brasch J, Katsamba PS, Harrison OJ, Ahlsn G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L (2017). Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior. Cell Rep, 23(6), 1840-1852.
  4. Evangelista F, Roth AJ, Prisayanh P, Temple BR, Li N, Qian Y, Culton DA, Liu Z, Harrison OJ, Brasch J, Honig B, Shapiro L, Diaz LA (2018). Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. J Autoimmun, 89, 171-185.
  5. Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A (2017). Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Proc Natl Acad Sci U S A, 114(42), 11163-11168.
  6. Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A (2017). Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2. J Biol Chem, 292(27), 11586-11598.
  7. Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L (2016). Structural basis of adhesive binding by desmocollins and desmogleins. Proc Natl Acad Sci U S A, 113(26), 7160-5.
  8. Vendome J, Felsovalyi K, Song H, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B (2014). Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc Natl Acad Sci U S A, 111(40), E4175-84.
  9. Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L (2012). Nectin ectodomain structures reveal a canonical adhesive interface. Nat Struct Mol Biol, 19(9), 906-15.
  10. Brasch J, Harrison OJ, Honig B, Shapiro L (2012). Thinking outside the cell: how cadherins drive adhesion. Trends Cell Biol, 22(6), 299-310.
  11. Liu Q, Dahmane T, Zhang Z, Assur Z, Brasch J, Shapiro L, Mancia F, Hendrickson WA (2012). Structures from anomalous diffraction of native biological macromolecules. Science, 336(6084), 1033-7.
  12. Brasch J, Harrison OJ, Ahlsen G, Liu Q, Shapiro L (2011). Crystal structure of the ligand binding domain of netrin G2. J Mol Biol, 414(5), 723-34.
  13. Brasch J, Harrison OJ, Ahlsen G, Carnally SM, Henderson RM, Honig B, Shapiro L (2011). Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. J Mol Biol, 408(1), 57-73.
  14. Harrison OJ, Jin X, Hong S, Bahna F, Ahlsen G, Brasch J, Wu Y, Vendome J, Felsovalyi K, Hampton CM, Troyanovsky RB, Ben-Shaul A, Frank J, Troyanovsky SM, Shapiro L, Honig B (2010). The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19(2), 244-56.
  15. Harrison OJ, Bahna F, Katsamba PS, Jin X, Brasch J, Vendome J, Ahlsen G, Carroll KJ, Price SR, Honig B, Shapiro L (2010). Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol, 17(3), 348-57.
  16. Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L (2010). T-cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol, 17(3), 339-47.
  17. Koehnke J, Jin X, Trbovic N, Katsamba PS, Brasch J, Ahlsen G, Scheiffele P, Honig B, Palmer AG 3rd, Shapiro L (2007). Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure, 16(3), 410-21.