Jennifer A. Sinnott, PhD

Academic Information

  • Departments: Internal Medicine - Research Assistant Professor, Pediatrics - Adjunct Assistant Professor
  • Divisions: Epidemiology

Selected Publications

Journal Article

  1. Ahearn TU, Peisch S, Pettersson A, Ebot EM, Zhou CK, Graff RE, Sinnott JA, Fazli L, Judson GL, Bismar TA, Rider JR, Gerke T, Chan JM, Fiorentino M, Flavin R, Sesso HD, Finn S, Giovannucci EL, Gleave M, Loda M, Li Z, Pollak M, Mucci LA, Transdisciplinary Prostate Cancer Partnership ToPCaP (2018). Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease. Carcinogenesis, 39(12), 1431-1437.
  2. Sinnott JA, Brumberg K, Wilson KM, Ebot EM, Giovannucci EL, Mucci LA, Rider JR (2018). Differential Gene Expression in Prostate Tissue According to Ejaculation Frequency. Eur Urol, 74(5), 545-548.
  3. Sinnott JA, Cai F, Yu S, Hejblum BP, Hong C, Kohane IS, Liao KP (2017). PheProb: probabilistic phenotyping using diagnosis codes to improve power for genetic association studies. J Am Med Inform Assoc, 25(10), 1359-1365.
  4. Sinnott JA, Cai T (2018). Pathway aggregation for survival prediction via multiple kernel learning. Stat Med, 37(16), 2501-2515.
  5. Felix AS, Sinnott JA, Vetter MH, Rhoades J, Cohn DE, Backes FJ, Sherman ME, Suarez AA (2018). Detection of endometrial cancer cells in the fallopian tube lumen is associated with adverse prognostic factors and reduced survival. Gynecol Oncol, 150(1), 38-43.
  6. Neykov M, Hejblum BP, Sinnott JA (2016). Kernel machine score test for pathway analysis in the presence of semi-competing risks. Stat Methods Med Res, 27(4), 1099-1114.
  7. Shisler R, Sinnott JA, Wang V, Hebert C, Salani R, Felix AS (2017). Life after endometrial cancer: A systematic review of patient-reported outcomes. Gynecol Oncol, 148(2), 403-413.
  8. Ebot EM, Gerke T, Labb DP, Sinnott JA, Zadra G, Rider JR, Tyekucheva S, Wilson KM, Kelly RS, Shui IM, Loda M, Kantoff PW, Finn S, Vander Heiden MG, Brown M, Giovannucci EL, Mucci LA (2017). Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer. Cancer, 123(21), 4130-4138.
  9. Sinnott JA, Peisch SF, Tyekucheva S, Gerke T, Lis R, Rider JR, Fiorentino M, Stampfer MJ, Mucci LA, Loda M, Penney KL (2016). Prognostic Utility of a New mRNA Expression Signature of Gleason Score. Clin Cancer Res, 23(1), 81-87.
  10. Markt SC, Nuttall E, Turman C, Sinnott J, Rimm EB, Ecsedy E, Unger RH, Fall K, Finn S, Jensen MK, Rider JR, Kraft P, Mucci LA (2016). Sniffing out significant "Pee values": genome wide association study of asparagus anosmia. BMJ, 355, i6071.
  11. Kelly RS, Sinnott JA, Rider JR, Ebot EM, Gerke T, Bowden M, Pettersson A, Loda M, Sesso HD, Kantoff PW, Martin NE, Giovannucci EL, Tyekucheva S, Heiden MV, Mucci LA (2016). The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study. Cancer Metab, 4, 22.
  12. Rider JR, Wilson KM, Sinnott JA, Kelly RS, Mucci LA, Giovannucci EL (2016). Ejaculation Frequency and Risk of Prostate Cancer: Updated Results with an Additional Decade of Follow-up. Eur Urol, 70(6), 974-982.
  13. Sinnott JA, Cai T (2016). Inference for survival prediction under the regularized Cox model. Biostatistics, 17(4), 692-707.
  14. Stopsack KH, Gerke TA, Sinnott JA, Penney KL, Tyekucheva S, Sesso HD, Andersson SO, Andrn O, Cerhan JR, Giovannucci EL, Mucci LA, Rider JR (2016). Cholesterol Metabolism and Prostate Cancer Lethality. Cancer Res, 76(16), 4785-90.
  15. Lu D, Sinnott JA, Valdimarsdttir U, Fang F, Gerke T, Tyekucheva S, Fiorentino M, Lambe M, Sesso HD, Sweeney CJ, Wilson KM, Giovannucci EL, Loda M, Mucci LA, Fall K (2015). Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer. Clin Cancer Res, 22(3), 765-772.
  16. Martin NE, Gerke T, Sinnott JA, Stack EC, Andrn O, Andersson SO, Johansson JE, Fiorentino M, Finn S, Fedele G, Stampfer M, Kantoff PW, Mucci LA, Loda M (2015). Measuring PI3K Activation: Clinicopathologic, Immunohistochemical, and RNA Expression Analysis in Prostate Cancer. Mol Cancer Res, 13(10), 1431-40.
  17. Rider JR, Fiorentino M, Kelly R, Gerke T, Jordahl K, Sinnott JA, Giovannucci EL, Loda M, Mucci LA, Finn S, Transdisciplinary Prostate Cancer Partnership ToPCaP (2015). Tumor expression of adiponectin receptor 2 and lethal prostate cancer. Carcinogenesis, 36(6), 639-47.
  18. Sinnott JA, Rider JR, Carlsson J, Gerke T, Tyekucheva S, Penney KL, Sesso HD, Loda M, Fall K, Stampfer MJ, Mucci LA, Pawitan Y, Andersson SO, Andrn O (2015). Molecular differences in transition zone and peripheral zone prostate tumors. Carcinogenesis, 36(6), 632-8.
  19. Penney KL, Sinnott JA, Tyekucheva S, Gerke T, Shui IM, Kraft P, Sesso HD, Freedman ML, Loda M, Mucci LA, Stampfer MJ (2014). Association of prostate cancer risk variants with gene expression in normal and tumor tissue. Cancer Epidemiol Biomarkers Prev, 24(1), 255-60.
  20. Sinnott JA, Dai W, Liao KP, Shaw SY, Ananthakrishnan AN, Gainer VS, Karlson EW, Churchill S, Szolovits P, Murphy S, Kohane I, Plenge R, Cai T (2014). Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records. Hum Genet, 133(11), 1369-82.
  21. Flavin R, Pettersson A, Hendrickson WK, Fiorentino M, Finn S, Kunz L, Judson GL, Lis R, Bailey D, Fiore C, Nuttall E, Martin NE, Stack E, Penney KL, Rider JR, Sinnott J, Sweeney C, Sesso HD, Fall K, Giovannucci E, Kantoff P, Stampfer M, Loda M, Mucci LA (2014). SPINK1 protein expression and prostate cancer progression. Clin Cancer Res, 20(18), 4904-11.
  22. Sinnott JA, Cai T (2013). Omnibus risk assessment via accelerated failure time kernel machine modeling. Biometrics, 69(4), 861-73.
  23. Zu K, Martin NE, Fiorentino M, Flavin R, Lis RT, Sinnott JA, Finn S, Penney KL, Ma J, Fazli L, Gleave ME, Bismar TA, Stampfer MJ, Pollak MN, Loda M, Mucci LA, Giovannucci E (2013). Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study. Cancer Epidemiol Biomarkers Prev, 22(11), 1984-93.
  24. Penney KL, Stampfer MJ, Jahn JL, Sinnott JA, Flavin R, Rider JR, Finn S, Giovannucci E, Sesso HD, Loda M, Mucci LA, Fiorentino M (2013). Gleason grade progression is uncommon. Cancer Res, 73(16), 5163-8.
  25. Sinnott JA, Kraft P (2011). Artifact due to differential error when cases and controls are imputed from different platforms. Hum Genet, 131(1), 111-9.
  26. Penney KL, Sinnott JA, Fall K, Pawitan Y, Hoshida Y, Kraft P, Stark JR, Fiorentino M, Perner S, Finn S, Calza S, Flavin R, Freedman ML, Setlur S, Sesso HD, Andersson SO, Martin N, Kantoff PW, Johansson JE, Adami HO, Rubin MA, Loda M, Golub TR, Andrn O, Stampfer MJ, Mucci LA (2011). mRNA expression signature of Gleason grade predicts lethal prostate cancer. J Clin Oncol, 29(17), 2391-6.
  27. Penney KL, Pyne S, Schumacher FR, Sinnott JA, Mucci LA, Kraft PL, Ma J, Oh WK, Kurth T, Kantoff PW, Giovannucci EL, Stampfer MJ, Hunter DJ, Freedman ML (2010). Genome-wide association study of prostate cancer mortality. Cancer Epidemiol Biomarkers Prev, 19(11), 2869-76.
  28. Fiorentino M, Judson G, Penney K, Flavin R, Stark J, Fiore C, Fall K, Martin N, Ma J, Sinnott J, Giovannucci E, Stampfer M, Sesso HD, Kantoff PW, Finn S, Loda M, Mucci L (2010). Immunohistochemical expression of BRCA1 and lethal prostate cancer. Cancer Res, 70(8), 3136-9.
  29. Stark JR, Perner S, Stampfer MJ, Sinnott JA, Finn S, Eisenstein AS, Ma J, Fiorentino M, Kurth T, Loda M, Giovannucci EL, Rubin MA, Mucci LA (2009). Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3? J Clin Oncol, 27(21), 3459-64.
  30. Stark JR, Wiklund F, Grnberg H, Schumacher F, Sinnott JA, Stampfer MJ, Mucci LA, Kraft P (2009). Toll-like receptor signaling pathway variants and prostate cancer mortality. Cancer Epidemiol Biomarkers Prev, 18(6), 1859-63.


  1. Rider JR, Wilson KM, Sinnott JA, Kelly RS, Mucci LA, Giovannucci EL (2016). Reply to Herney Andrés García-Perdomo and Ramiro Manzano Nunez's Letter to the Editor Re: Jennifer R. Rider, Kathryn M. Wilson, Jennifer M. Sinnott, Rachel S. Kelly, Lorelei A. Mucci, Edward L. Giovannucci. Ejaculation Frequency and Risk of Prostate Cancer: Updated Results with an Additional Decade of Follow-up. Eur Urol 2016;70:974-82: Looking Deeper: P-hacking and Some Other Bias. [Letter to the editor]. Eur Urol, 70(6), e156-e157.