Mary C. Beckerle

Mary C. Beckerle, PhD

Academic Information

Departments Adjunct - Oncological Sciences

Lab

Mary C. Beckerle, PhD

Jon M. Huntsman Presidential Endowed Chair

CEO, Huntsman Cancer Institute at the University of Utah

Associate Vice President of Cancer Affairs, University of Utah Health

Distinguished Professor of Biology and Oncological Sciences

Mary C. Beckerle, PhD, has served as CEO of Huntsman Cancer Institute (HCI) at the University of Utah (U of U) since 2006. She is the associate vice president for cancer affairs at U of U Health, and she is a distinguished professor of biology and oncological sciences at the U of U. Beckerle joined the faculty of the U of U in 1986, and currently holds the Jon M. Huntsman Presidential Endowed Chair. She earned her PhD in molecular, cellular, and developmental biology from the University of Colorado at Boulder, where she was the recipient of a Danforth Fellowship, and completed post-doctoral research at the University of North Carolina at Chapel Hill.

Beckerle’s research has defined a novel molecular pathway that regulates mechanotransduction and cell motility, and her lab has contributed to understanding the impact of this pathway on tumor progression, particularly in Ewing’s sarcoma. Her scientific work has been continuously funded by the National Institutes of Health (NIH) and the American Cancer Society for over 30 years. She guided graduate education at the U of U as the director of the Interdepartmental Graduate Program in Molecular Biology for two years. In addition, Beckerle developed the Multidisciplinary Cancer Research Training Program at HCI and served for several years as the principal investigator of the National Cancer Institute (NCI) grant that supported this cancer-focused training initiative. Beckerle served as cancer center director and principal investigator of HCI’s Cancer Center Support Grant from 2006-2018, during which she led the process that resulted in HCI being designated as a Comprehensive Cancer Center, the highest recognition possible by the NCI.

An active participant in national and international scientific affairs, Beckerle served as president of the American Society for Cell Biology in 2006. She has served on the NIH Advisory Committee to the Director, on the NCI Scientific Review Group Subcommittee A (Parent Committee) for Cancer Centers, as Chair of the American Cancer Society Council for Extramural Grants, on the Coalition for Life Sciences Board of Directors, and the Board of the Mechanobiology Institute in Singapore. In 2013, she was elected to the Board of Directors of the American Association for Cancer Research.

Beckerle currently serves on the Medical Advisory Board of the Howard Hughes Medical Institute, the Management Board of the National Centre for Biological Sciences in India, and the External Advisory Boards of several NCI-designated comprehensive cancer centers. Beckerle is a member of the Board of Directors of Huntsman Corporation and Johnson & Johnson. In 2016, she was appointed to the National Cancer Moonshot Initiative Blue Ribbon Panel, a team charged with identifying strategies to best advance the scientific themes of Vice President Biden’s “cancer moonshot” initiative; she co-chaired the working group on Precision Prevention and Early Detection. In 2018, the American Academy of Arts and Sciences appointed Dr. Beckerle to the Advisory Committee on Science, Engineering, and Technology. She is also a member of NCI’s Board of Scientific Advisors since 2018.

In 2000, Beckerle was appointed as a Guggenheim Fellow and a Rothschild-Yvette Mayent Award Scholar at the Curie Institute in Paris. She received the Utah Governor’s Medal for Science and Technology in 2001, the Sword of Hope Award from the American Cancer Society in 2004, and the Rosenblatt Prize for Excellence (the University of Utah’s highest honor) in 2007. Beckerle was elected as a Fellow of the American Academy of Arts and Sciences in 2008 and to the American Philosophical Society in 2017. In 2018, Beckerle received the Alfred G. Knudson Award in Cancer Genetics from NCI. In 2021, Beckerle was elected as a Fellow of the American Association for Cancer Research Academy and as a member of the National Academy of Sciences.

Selected Publications

Journal Article

  1. Hansen MD, Beckerle MC (2008). alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochem Biophys Res Commun, 371(1), 144-8.
  2. Schmeichel KL, Beckerle MC (1998). LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function. Biochem J, 331 ( Pt 3), 885-92.
  3. Harper BD, Beckerle MC, Pomies P (2000). Fine mapping of the alpha-actinin binding site within cysteine-rich protein. Biochem J, 350 Pt 1, 269-74.
  4. Kosa JL, Michelsen JW, Louis HA, Olsen JI, Davis DR, Beckerle MC, Winge DR (1994). Common metal ion coordination in LIM domain proteins. Biochemistry, 33(2), 468-77.
  5. Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC (1999). Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation. Biochemistry, 38(18), 5701-13.
  6. Beckerle MC (1990). The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester. Cell Regul, 1(2), 227-36.
  7. Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC (2012). Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J, 103(10), 2082-92.
  8. Henderson JR, Macalma T, Brown D, Richardson JA, Olson EN, Beckerle MC (1999). The LIM protein, CRP1, is a smooth muscle marker. Dev Dyn, 214(3), 229-38.
  9. McKeown CR, Han HF, Beckerle MC (2006). Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1. Dev Dyn, 235(2), 530-8.
  10. Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC (2007). Characterization of RACK1 function in Drosophila development. Dev Dyn, 236(8), 2207-15.
  11. Hervy M, Hoffman L, Beckerle MC (2006). From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol, 18(5), 524-32.
  12. Schmeichel KL, Beckerle MC (1997). Molecular dissection of a LIM domain. Mol Biol Cell, 8(2), 219-30.
  13. Ahern-Djamali SM, Comer AR, Bachmann C, Kastenmeier AS, Reddy SK, Beckerle MC, Walter U, Hoffmann FM (1998). Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. Mol Biol Cell, 9(8), 2157-71.
  14. Stronach BE, Renfranz PJ, Lilly B, Beckerle MC (1999). Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Mol Biol Cell, 10(7), 2329-42.
  15. Pomies P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC (2007). The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell, 18(5), 1723-33.
  16. Han HF, Beckerle MC (2009). The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell, 20(9), 2361-70.
  17. Beckerle MC (2010). How cell biologists can contribute to improving cancer outcomes. Mol Biol Cell, 21(22), 3788-9.
  18. Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC (2012). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell, 23(10), 1846-59.
  19. Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC (2014). Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell, 25(18), 2695-709.
  20. Hoffman L, Jensen CC, Yoshigi M, Beckerle (2017). Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1. Molecular biology of the cell, 28(20), 2661-2675.
  21. Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore T (1999). LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. Gene expression, 8(4), 207-17.
  22. Beckerle MC, Burridge K, DeMartino GN, Croall D (1987). Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell, 51(4), 569-77.
  23. Schmeichel KL, Beckerle M (1994). The LIM domain is a modular protein-binding interface. Cell, 79(2), 211-9.
  24. Norman KR, Fazzio RT, Mellem JE, Espelt MV, Strange K, Beckerle MC, Maricq A (2005). The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell, 123(1), 119-32.
  25. Henderson JR, Pomies P, Auffray C, Beckerle M (2003). ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. Cell motility and the cytoskeleton, 54(3), 254-65.
  26. Lilly B, Olson EN, Beckerle M (2001). Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells. Developmental biology, 240(2), 531-47.
  27. Clark KA, McGrail M, Beckerle M (2003). Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development (Cambridge, England), 130(12), 2611-21.
  28. Drenckhahn D, Beckerle M, Burridge K, Otto (1988). Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry. European journal of cell biology, 46(3), 513-22.
  29. Sealock R, Paschal B, Beckerle M, Burridge (1986). Talin is a post-synaptic component of the rat neuromuscular junction. Experimental cell research, 163(1), 143-50.
  30. Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets (2009). TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB journal, 23(3), 916-28.
  31. Renfranz PJ, Siegrist SE, Stronach BE, Macalma T, Beckerle M (2003). Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Gene, 305(1), 13-26.
  32. Yi J, Beckerle M (1998). The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics, 49(2), 314-6.
  33. Crawford AW, Beckerle M (1991). Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. The Journal of biological chemistry, 266(9), 5847-53.
  34. Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle M (1995). The cysteine-rich protein family of highly related LIM domain proteins. The Journal of biological chemistry, 270(48), 28946-54.
  35. Michelsen JW, Sewell AK, Louis HA, Olsen JI, Davis DR, Winge DR, Beckerle M (1994). Mutational analysis of the metal sites in an LIM domain. The Journal of biological chemistry, 269(15), 11108-13.
  36. Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle M (1996). Molecular characterization of human zyxin. The Journal of biological chemistry, 271(49), 31470-8.
  37. Louis HA, Pino JD, Schmeichel KL, Pomies P, Beckerle M (1997). Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. The Journal of biological chemistry, 272(43), 27484-91.
  38. Pomies P, Macalma T, Beckerle M (1999). Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. The Journal of biological chemistry, 274(41), 29242-50.
  39. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn R (2000). Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. The Journal of biological chemistry, 275(29), 22503-11.
  40. Nix DA, Fradelizi J, Bockholt S, Menichi B, Louvard D, Friederich E, Beckerle M (2001). Targeting of zyxin to sites of actin membrane interaction and to the nucleus. The Journal of biological chemistry, 276(37), 34759-67.
  41. Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle M (2002). Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. The Journal of biological chemistry, 277(11), 9580-9.
  42. Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle M (2004). The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. The Journal of biological chemistry, 279(8), 6824-33.
  43. Hansen MD, Beckerle M (2006). Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. The Journal of biological chemistry, 281(23), 16178-88.
  44. Sadler I, Crawford AW, Michelsen JW, Beckerle M (1992). Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. The Journal of cell biology, 119(6), 1573-87.
  45. Crawford AW, Michelsen JW, Beckerle M (1992). An interaction between zyxin and alpha-actinin. The Journal of cell biology, 116(6), 1381-93.
  46. Beckerle MC, Miller DE, Bertagnolli ME, Locke S (1989). Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets. The Journal of cell biology, 109(6 Pt 2), 3333-46.
  47. Beckerle M (1986). Identification of a new protein localized at sites of cell-substrate adhesion. The Journal of cell biology, 103(5), 1679-87.
  48. Beckerle M (1984). Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells. The Journal of cell biology, 98(6), 2126-32.
  49. Beckerle MC, Porter K (1983). Analysis of the role of microtubules and actin in erythrophore intracellular motility. The Journal of cell biology, 96(2), 354-62.
  50. Crawford AW, Pino JD, Beckerle M (1994). Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. The Journal of cell biology, 124(1-2), 117-27.
  51. Bertagnolli ME, Beckerle M (1993). Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets. The Journal of cell biology, 121(6), 1329-42.
  52. Stronach BE, Siegrist SE, Beckerle M (1996). Two muscle-specific LIM proteins in Drosophila. The Journal of cell biology, 134(5), 1179-95.
  53. Nix DA, Beckerle M (1997). Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. The Journal of cell biology, 138(5), 1139-47.
  54. Pomies P, Louis HA, Beckerle M (1997). CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. The Journal of cell biology, 139(1), 157-68.
  55. Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun (1999). A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. The Journal of cell biology, 144(1), 45-57.
  56. Drees BE, Andrews KM, Beckerle M (1999). Molecular dissection of zyxin function reveals its involvement in cell motility. The Journal of cell biology, 147(7), 1549-60.
  57. Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle M (2004). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. The Journal of cell biology, 167(6), 1019-24.
  58. Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle M (2005). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. The Journal of cell biology, 171(2), 209-15.
  59. Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle M (2006). Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. The Journal of cell biology, 172(5), 771-82.
  60. Takizawa N, Smith TC, Nebl T, Crowley JL, Palmieri SJ, Lifshitz LM, Ehrhardt AG, Hoffman LM, Beckerle MC, Luna E (2006). Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. The Journal of cell biology, 174(3), 447-58.
  61. Beckerle MC, O'Halloran T, Burridge (1986). Demonstration of a relationship between talin and P235, a major substrate of the calcium-dependent protease in platelets. Journal of cellular biochemistry, 30(3), 259-70.
  62. Bertagnolli ME, Locke SJ, Hensler ME, Bray PF, Beckerle M (1993). Talin distribution and phosphorylation in thrombin-activated platelets. Journal of cell science, 106 ( Pt 4), 1189-99.
  63. Golsteyn RM, Beckerle MC, Koay T, Friederich (1997). Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes. Journal of cell science, 110 ( Pt 16), 1893-906.
  64. Clark KA, Bland JM, Beckerle M (2007). The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. Journal of cell science, 120(Pt 12), 2066-77.
  65. Elias MC, Pronovost SM, Cahill KJ, Beckerle MC, Kadrmas J (2012). A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. Journal of cell science, 125(Pt 13), 3185-94.
  66. Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman M (2005). Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. The Journal of clinical investigation, 115(10), 2716-30.
  67. Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer (2008). The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. The Journal of experimental biology, 211(Pt 1), 15-23.
  68. Henderson JR, Brown D, Richardson JA, Olson EN, Beckerle M (2002). Expression of the gene encoding the LIM protein CRP2: a developmental profile. The journal of histochemistry and cytochemistry, 50(1), 107-11.
  69. Perez-Alvarado GC, Kosa JL, Louis HA, Beckerle MC, Winge DR, Summers M (1996). Structure of the cysteine-rich intestinal protein, CRIP. Journal of molecular biology, 257(1), 153-74.
  70. Schmeichel KL, Stronach BE, Beckerle M (1998). Purification and assay of zyxin. Methods in enzymology, 298, 62-76.
  71. Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, Menzies AS, Goh KL, Jensen CC, Gertler FB, Fuchs E, Fassler R, Beckerle M (2003). Targeted disruption of the murine zyxin gene. Molecular and cellular biology, 23(1), 70-9.
  72. Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick S (2013). A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Molecular and cellular biology, 33(22), 4448-60.
  73. Porter KR, Beckerle MC, McNiven M (1983). The Cytoplasmic Matrix. Molecular and cellular biology, 2, 259-302.
  74. Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge (1986). Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature, 320(6062), 531-3.
  75. O'Halloran T, Beckerle MC, Burridge (1985). Identification of talin as a major cytoplasmic protein implicated in platelet activation. Nature, 317(6036), 449-51.
  76. Beckerle MC, Porter K (1982). Inhibitors of dynein activity block intracellular transport in erythrophores. Nature, 295(5851), 701-3.
  77. Hobert O, Schilling JW, Beckerle MC, Ullrich A, Jallal (1996). SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene, 12(7), 1577-81.
  78. Michelsen JW, Schmeichel KL, Beckerle MC, Winge D (1993). The LIM motif defines a specific zinc-binding protein domain. Proceedings of the National Academy of Sciences of the United States of America, 90(10), 4404-8.
  79. Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, White R (2000). Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proceedings of the National Academy of Sciences of the United States of America, 97(22), 12085-90.
  80. Stachowiak MR, Smith MA, Blankman E, Chapin LM, Balcioglu HE, Wang S, Beckerle MC, O'Shaughnessy (2014). A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17528-33.
  81. Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers M (1994). Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nature structural biology, 1(6), 388-98.
  82. Lilly B, Clark KA, Yoshigi M, Pronovost S, Wu ML, Periasamy M, Chi M, Paul RJ, Yet SF, Beckerle M (2010). Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Arteriosclerosis, thrombosis, and vascular biology, 30(4), 694-701.
  83. Pashmforoush M, Pomies P, Peterson KL, Kubalak S, Ross J Jr, Hefti A, Aebi U, Beckerle MC, Chien K (2001). Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nature medicine, 7(5), 591-7.
  84. Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick S (2014). Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clinical cancer research, 20(17), 4584-97.
  85. Smith MA, Hoffman LM, Beckerle M (2014). LIM proteins in actin cytoskeleton mechanoresponse. Trends in cell biology, 24(10), 575-83.
  86. Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV, Somlyo A (2003). LPP, a LIM protein highly expressed in smooth muscle. American journal of physiology. Cell physiology, 285(3), C674-85.
  87. Clark KA, Lesage-Horton H, Zhao C, Beckerle MC, Swank D (2011). Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. American journal of physiology. Cell physiology, 301(2), C373-82.
  88. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz R (2003). Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Developmental cell, 4(1), 107-18.
  89. Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle M (2010). A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Developmental cell, 19(3), 365-76.
  90. Pishas KI, Drenberg CD, Taslim C, Theisen ER, Johnson KM, Saund RS, Pop IL, Crompton BD, Lawlor ER, Tirode F, Mora J, Delattre O, Beckerle MC, Callen DF, Sharma S, Lessnick S (2018). Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response. Molecular cancer therapeutics, 17(9), 1902-1916.
  91. Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin A (2013). Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. Cell cycle (Georgetown, Tex.), 12(21), 3377-89.
  92. Pronovost SM, Beckerle MC, Kadrmas J (2013). Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS genetics, 9(3), e1003406.
  93. Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild A (2016). Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Molecular systems biology, 12(3), 860.
  94. Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle M (2013). LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PloS one, 8(8), e69378.
  95. Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Pare PD, Fredberg JJ, Smith M (2017). The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PloS one, 12(3), e0171728.
  96. Renfranz PJ, Blankman E, Beckerle M (2010). The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Anatomical record (Hoboken, N.J., 293(9), 1455-69.
  97. Scaife CL, Shea J, Emerson L, Boucher K, Firpo MA, Beckerle MC, Mulvihill S (2010). Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. HPB, 12(5), 352-8.
  98. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu Y (2014). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cellular and molecular bioengineering, 7(1), 73-85.
  99. Beckerle MC, Reed KL, Scott RP, Shafer MA, Towner D, Valantine HA, Zahniser N (2011). Medical faculty development: a modern-day odyssey. Science translational medicine, 3(104), 104cm31.
  100. Valantine HA, Beckerle MC, Reed KL, Towner D, Zahniser N (2014). Teaching corporate in college. Science translational medicine, 6(251), 251fs33.
  101. Hervy M, Hoffman LM, Jensen CC, Smith M, Beckerle M (2010). The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes & cancer, 1(5), 506-515.
  102. Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle M (2012). The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes & cancer, 3(2), 102-16.
  103. Wiles ET, Bell R, Thomas D, Beckerle M, Lessnick S (2013). ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma. Genes & cancer, 4(11-12), 486-500.
  104. Fadul J, Bell R, Hoffman LM, Beckerle MC, Engel ME, Lessnick S (2015). EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes & cancer, 6(3-4), 129-43.
  105. Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall R (2012). The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm. Frontiers in oncology, 2, 2.

Review

  1. Bertagnolli ME, Beckerle MC (1994). Regulated membrane-cytoskeleton linkages in platelets. [Review]. Ann N Y Acad Sci, 714, 88-100.
  2. Beckerle MC (1997). Zyxin: zinc fingers at sites of cell adhesion. [Review]. Bioessays, 19, (11), 949-57.
  3. Renfranz PJ, Beckerle MC (2002). Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. [Review]. Curr Opin Cell Biol, 14, (1), 88-103.
  4. Beckerle M (1998). Spatial control of actin filament assembly: lessons from Listeria. Cell, 95(6), 741-8.
  5. Beckerle MC, Yeh R (1990). Talin: role at sites of cell-substratum adhesion. Cell motility and the cytoskeleton, 16(1), 7-13.
  6. Clark KA, McElhinny AS, Beckerle MC, Gregorio C (2002). Striated muscle cytoarchitecture: an intricate web of form and function. Annual review of cell and developmental biology, 18, 637-706.
  7. Kadrmas JL, Beckerle M (2004). The LIM domain: from the cytoskeleton to the nucleus. Nature reviews. Molecular cell biology, 5(11), 920-31.

Edited Book

  1. Beckerle M (2002). Cell Adhesion.

Book Chapter

  1. Byers HR, Fujiwara K, Beckerle MC, Porter K (1980). Microtubule organization and function in chromatophores and scleroblasts in vitro and in situ.
  2. Porter KR, Beckerle MC, McNiven M (1983). A Mechanism for Intracellular Transport.
  3. Crawford AW, Beckerle M (1989). Cell-substratum adhesion: Mechanism and Regulation.
  4. Schmeichel KL, Beckerle MC, Crawford A (1998). Blot Overlay Assay: A Method to Detect Protein-Protein Interactions. 4, 441-449.
  5. Pomies P, Beckerle M (1999). The cysteine-rich protein family.
  6. Drees BE, Beckerle M (1999). Zyxin. 95-98.
  7. Crawford, AW, and Beckerle, M (1994). Blot overlay assay: a method to detect protein'protein interactions. 301-308.
  8. Porter KR, Beckerle M, McNiven M (1983). The cytoplasmic matrix. Spatial Organization of Eukaryotic Cells – A Symposium in Honor of K. R. Porter. 2, 259-302.

Report

  1. Fradelizi J, Friederich E, Beckerle MC, Golsteyn RM (1999). Quantitative measurement of proteins by western blotting with Cy5-coupled secondary antibodies. (0736-6205 (Print)| 0736-6205 (Linking)). UNITED STATES.

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