Julie L. Kadrmas

Julie L. Kadrmas, PhD

Languages spoken: English

Academic Information

Departments Primary - Oncological Sciences

Julie Kadrmas, Ph.D. is an investigator in the Cell Response and Regulation Program at the Huntsman Cancer Institute. Her group is interested in understanding regulatory mechanisms controlling cell adhesion and migration, with implications for how cancer cells gain the capacity to leave the site of a primary tumor and migrate during metastasis. Through the examination of normal developmental processes in the fruit fly Drosophila melanogaster, they characterize the functions of the integrin family of transmembrane receptors in regulating cell attachment and movement. Of particular interest is a molecular scaffolding protein called PINCH, which physically associates with integrins, as well as several additional PINCH protein partners that impinge upon distinct signaling cascades. Their work will provide a molecular understanding of how protein-protein interactions mediated by molecular scaffolds such as PINCH, integrate signals between multiple pathways to coordinate complex biological processes like cell adhesion and migration.

Education History

Undergraduate Bowling Green State University
 BS
Doctoral Training Duke University
 PhD
Fellowship Duke University, National Institutes of Health
 Fellow
Postdoctoral Fellowship University of Utah, Department of Chemistry
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC (2007). Characterization of RACK1 function in Drosophila development. Dev Dyn, 236(8), 2207-15.
  2. Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle M (2004). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. The Journal of cell biology, 167(6), 1019-24.
  3. Elias MC , Pronovost SM, Cahill KJ, Beckerle MC and Kadrmas J (2012). A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. Journal of cell science, 125, 3185-3194.
  4. Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Buchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot JL, Paus T, Smolka MN, Spanagel R, O'Reilly PF, Laitinen J, Veijola JM, Feng J, Desrivieres S, Jarvelin MR, Schumann G, Rothenfluh (2015). Rsu1 regulates ethanol consumption in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America, 112(30), E4085-93.
  5. Wang Y, Antunes M, Anderson AE, Kadrmas JL, Jacinto A, Galko M (2015). Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis. Current biology, 25(17), 2215-27.
  6. Yoshigi M, Pronovost SM, Kadrmas J (2013). Interactions by 2D Gel Electrophoresis Overlap (iGEO): a novel high fidelity approach to identify constituents of protein complexes. Proteome science, 11(1), 21.
  7. Pronovost SM, Beckerle MC, Kadrmas J (2013). Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS genetics, 9(3), e1003406.
  8. Clark KA, Kadrmas J (2013). Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. Cytoskeleton (Hoboken, N.J.), 70(6), 304-16.
  9. Kadrmas JL, Beckerle MC, Yoshigi (2020). Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha. Scientific reports, 10(1), 19303.

Review

  1. Kadrmas JL, Beckerle M (2004). The LIM domain: from the cytoskeleton to the nucleus. Nature reviews. Molecular cell biology, 5(11), 920-31.