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John E. Greenlee, MD

Titles: Executive Vice-Chair, Department of Neurology, Vice-Chair of Education, Department of Neurology

Languages spoken: English

Academic Information

Departments: Neurology - Professor Emeritus

Divisions: Neuroimmunology

Academic Office Information

john.greenlee@hsc.utah.edu

Board Certification

  • American Board of Psychiatry & Neurology (Neurology)
  • National Board of Medical Examiners

Research Interests

  • Central Nervous System Infections
  • Leukoencephalopathy, Progressive Multifocal
  • Cerebrovascular Disorders
  • Remote effects of malignancy on the nervous system
  • Papovavirus Infections
  • Viral Oncogenesis

John E. Greenlee, MD, is professor of neurology and former interim department chair. His areas of specialty are central nervous system infections, autoimmune disorders of the central nervous system, and stroke. Dr. Greenlee was one of the first individuals to recognize the role of the immune response in causing central nervous system injury in patients with cancer.

Education History

Fellowship Johns Hopkins University
Neurology/Neurovirology
Fellow
Chief Resident University of Virginia Hospitals
Neurology
Chief Resident
Residency University of Virginia Hospitals
Neurology
Assistant Resident
Residency University of Virginia Hospitals (Internal Medicine)
Assistant Resident
Internship University of Virginia Hospitals
Internal Medicine
Intern
Fellowship University of Rochester School of Medicine
Pathology
Student Fellow
Professional Medical University of Rochester
Medicine
M.D.
Undergraduate Columbia School of General Studies
Pre-Medicine
Undergraduate Freie Universitat Berlin
Undergraduate Hamilton College
Languages
B.A.

Selected Publications

  1. Galli JR, Austin SD, Greenlee JE, Clardy SL (2018). Stiff person syndrome with Anti-GAD65 antibodies within the national veterans affairs health administration. Muscle Nerve, 58(6), 801-804.
  2. Wilson MR, ODonovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL (2018). Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. JAMA Neurol, 75(8), 947-955.
  3. Williams JP, Carlson NG, Greenlee JE (2018). Antibodies in Autoimmune Human Neurological Disease: Pathogenesis and Immunopathology. Semin Neurol, 38(3), 267-277.
  4. Greenlee JE, Clawson, SA, Hill KE, Wood B, Liu SC, Clardy SL, Carlson NG (2018). Interaction of Normal and Antineuronal IgGs with Neurons in Rat Brain Slice Cultures: Comparison of IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, and Production of Neuronal Death. Neurology [Abstract]. 90(15 Supp P2), 403.
  5. Greenlee JE, Clawson SA, Hill KE, Wood B, Liu SC, Clardy, SL, Carlson, NG (2018). Interaction of Normal and Antineuronal IgGs with neurons in Rat Brain Slice Cultures: Comparison of IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, and Production of Neuronal  Death.   [Abstract]. 90 (15)(Suppl P. 2), 403.
  6. Abenroth DC, Smith AG, Greenlee JE, Austin SD, Clardy SL (2017). Lambert-Eaton myasthenic syndrome: Epidemiology and therapeutic response in the national veterans affairs population. Muscle Nerve, 56(3), 421-426.
  7. Liu S, Hill K, Wood B, Clawsom S, Clardy S, Carlson N, Greenlee J (2017). FcyRI (CD64) Receptors are Widely Expressed on CNS Neurons and are Required for Neuronal IgG Binding and Uptake:  Implications for Antibody-Mediated Neuronal Injury.  [Abstract].
  8. McKasson M, Clardy SL, Clawson SA, Hill KE, Wood B, Carlson N, Bromberg M, Greenlee JE (2016). Voltage-gated calcium channel autoimmune cerebellar degeneration: Case and study of cytotoxicity. Neurol Neuroimmunol Neuroinflamm, 3(3), e222.
  9. Greenlee J, Clawson S, Wood B, Hill K, Clardy C, Carlson N (2016). Neuronal Uptake of Paraneoplastic IgG Autoantibodies Reactive with Intracellular Antigens Requires the Fc Portion of the IgG Molecule and Can Be Blocked by Normal IgG. [Abstract].
  10. Liu SC, Hill KE, Clawson SA, Wood B, Clardy SL, Carlson NG, Greenlee JE (2016). FcyRI (DC64) Fc Receptors are Expressed on CNS Neurons:  A Potential Mechanism for Neuronal Immunoglobulin Uptake and Antibody-Mediated Neuronal Injury. [Abstract].
  11. Greenlee J, Clawson S, Wood, B, Hill K, Clardy S, Carlson N (2016). Neuronal Uptake of Paraneoplastic IgG Autoantibodies Reactive With Intracellular Antigens Requires the Fc Portion of the IgG Molecule and Can be Blocked by Normal IgG.  2016 Annual Meeting, American Academy of Neurology. [Abstract]. 86:16(Supp p. 5), 295.
  12. Liu, S, Hill KE, Clawson SA, Wood B, Clardy SL, Carlson NG, Greenlee JE (2016). FcyRI (CD64) Fc Receptors are Expressed on CNS Neurons:  A Potential Mechanism for Neuronal Immunoglobulin Uptake and Antibody-Mediated Neuronal Injury.  2016 Annual Meeting,  American Neurological Association. [Abstract]. 80(Suppl 20), M158.
  13. Clawson SA, Hill KE, Wood B, Clardy SL, Carlson NG, Greenlee JE (09/28/2015). Intracellular update of immunoglubulin G antibodies is common among CNS neurons and requires the Fc portion of the IgG molecule. Presented at the 140th Annual Meeting of the American Neurological Assocation [Abstract]. Ann Neurol, 78((Supplment 19)), S76.
  14. Heiry M, Afra P, Matsuo F, Greenlee JE, Clardy SL (2015). Improvement of GAD65-associated autoimmune epilepsy with testosterone replacement therapy. Neurol Neuroimmunol Neuroinflamm, 2(5), e142.
  15. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Carlson NG (2015). Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One, 10(4), e0123446.
  16. Greenlee JE, Clawson SA, Hill KE, Wood B, Tsunda I, Carlson NG (04/17/2015). Anti-Yo Antibody Interaction with its intracellular target antigen leads to targeted Purkinje Cell death rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One, 10(4), e0123446.
  17. Greenlee JE, Clawson SA, Hill KA, Wood B, Clardy SL, Carlson NG (11/1/2014). Anti-Yo antibody, associated with paraneoplastic cerebellar degeneration, specifically produces Purkinje cell death by binding to the 62 kDa intracellular Yo antigen. Presented at Annual Meeting of the International Society for Neuroimmunology, Mainz, Germany [Abstract]. J Neuroimmunology, 275, 36-37.
  18. Greenlee JE (2014). The equine encephalitides. Handb Clin Neurol, 123, 417-32.
  19. Greenlee JE (2013). Treatment of paraneoplastic cerebellar degeneration. Curr Treat Options Neurol, 15(2), 185-200.
  20. Greenlee JE (2012). Encephalitis and postinfectious encephalitis. Continuum (Minneap Minn), 18(6 Infectious Disease), 1271-89.

Global Impact

Education History

Type School Degree
Undergraduate Freie Universitat Berlin