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Jeanne M. Frederick, Ph.D.

Languages spoken: English

Academic Information

Departments: Ophthalmology/Visual Sciences - Research Associate Professor

Academic Office Information

Research Statement

I have performed retina histology since 1982, first studying ultrastructural contacts of dopaminergic amacrine/interplexiform and glycinergic AII amacrine cells in freshly-acquired (<2 hr postmortem) human donor eyes. At the University of Utah, we have been first to show: a) mutant GHL-rhodopsin on a null background aggregates and is retained in the endoplasmic reticulum, identified by calnexin colabeling, where it initiates an unfolded protein response (2001); b) guanylate cyclases 1 & 2 participate in transport of photoreceptor peripheral membrane proteins (2007); c) lutein- and zeaxanthin-binding proteins, as well as lipase C, are expressed in neurons of the primate retina (2004-11); d) heterotrimeric kinesin-2 is required for photoreceptor connecting cilium and axoneme formation/maintenance (2014); e) ARL3 regulates transport of acylated and prenylated proteins to photoreceptor outer segments; and f) INPP5E participates in axoneme formation that is required for photoreceptor disc morphogenesis (2021). Future studies are directed at elucidating protein function in healthy photoreceptors, and reasons for dysfunction in the disease state.

Education History

Postdoctoral Fellowship Baylor College of Medicine
Retinal Development
Postdoctoral Fellow
Doctoral Training University of Wisconsin-Madison
Anatomy/Developmental Biology
Undergraduate Marquette University