Wesley I. Sundquist

Wesley I. Sundquist, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Academic Office Information

wes@biochem.utah.edu

Lab

Research Interests

  • Viral Egress
  • HIV
  • Structural Biology
  • Immunity
  • ESCRT Pathway
  • Cytokinesis
  • Protein Design

Wesley Sundquist, PhD, is Samuels Professor and Co-Chair of the Department of Biochemistry at the University of Utah. He is also a member of the Cell Response and Regulation Program at Huntsman Cancer Institute.

Sundquist received a bachelor's degree from Carleton College, Minnesota, and a PhD from the Massachusetts Institute of Technology. His honors and awards include election to the American Academy of Arts and Sciences and the National Academy of Sciences

Research Statement

The Sundquist lab studies the cellular, molecular and structural biology of retroviruses, particularly HIV, and the roles of the ESCRT pathway in cell division and the abscission checkpoint. Major projects in our lab include studies of: 1) ESCRT pathway functions and regulation in cell division and cancer, 2) HIV budding, 3) HIV capsid structure, function and restriction, particularly by the TRIM5α system, 4) AAV egress, and 5) Designed enveloped protein nanoparticles. Our approaches include NMR, EM, crystallographic and computational studies of viral complexes, identification and biochemical analyses of the interactions between viral components and their cellular partners, and genetic analyses of viral and cellular protein functions.

Education History

Postdoctoral Fellowship MRC Laboratory of Molecular Biology
 Postdoctoral Fellow
Doctoral Training Massachusetts Institute of Technology, MA
 PhD
Undergraduate Carleton College, Northfield, MN
 BA

Selected Publications

Journal Article

  1. Paine EL, Skalicky JJ, Whitby FG, Mackay DR, Ullman KS, Hill CP, Sundquist WI (2023). The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission. Elife, 12e, 84515.
  2. Wenzel DM, Mackay DR, Skalicky JJ, Paine EL, Miller MS, Ullman KS, Sundquist WI (2022). Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. Elife, 11(e), 77779.
  3. Rheinemann L, Downhour DM, Davenport KA, McKeown AN, Sundquist WI, Elde NC (2022). Recurrent evolution of an inhibitor of ESCRT-dependent virus budding and LINE-1 retrotransposition in primates. Curr Biol, 32(7), 1511-1522.e6. (Read full article)
  4. Rheinemann L, Downhour DM, Bredbenner K, Mercenne G, Davenport KA, Schmitt PT, Necessary CR, McCullough J, Schmitt AP, Simon SM, Sundquist WI, Elde NC (2021). RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis. Cell, 184(21), 5419-5431.e16. (Read full article)
  5. Strohacker LD, Mackay DR, Whitney MA, Couldwells GC, Sundquist WI, Ullman KS (2021). Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing. Elife, 10. (Read full article)
  6. Rheinemann L, Thompson T, Mercenne G, Paine EL, Peterson FC, Volkman BF, Alam SL, Alian A, Sundquist WI (2021). Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J Biol Chem, 297(2), 100975. (Read full article)
  7. Huttunen M, Samolej J, Evans RJ, Yakimovich A, White IJ, Kriston-Vizi J, Martin-Serrano J, Sundquist WI, Frickel EM, Mercer J (2021). Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress. Life Sci Alliance, 4(8), e202000910. (Read full article)
  8. Christensen DE, Ganser-Pornillos BK, Johnson JS, Pornillos O, Sundquist WI (2020). Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. Science, 370(6513), eabc8420. (Read full article)
  9. Link JO, Rhee MS, Tse WC, Zheng J, Somoza JR, Rowe W, Begley R, Chiu A, Mulato A, Hansen D, Singer E, Tsai LK, Bam RA, Chou CH, Canales E, Brizgys G, Zhang JR, Li J, Graupe M, Morganelli P, Liu Q, Wu Q, Halcomb RL, Saito RD, Schroeder SD, Lazerwith SE, Bondy S, Jin D, Hung M, Novikov N, Liu X, Villaseor AG, Cannizzaro CE, Hu EY, Anderson RL, Appleby TC, Lu B, Mwangi J, Liclican A, Niedziela-Majka A, Papalia GA, Wong MH, Leavitt SA, Xu Y, Koditek D, Stepan GJ, Yu H, Pagratis N, Clancy S, Ahmadyar S, Cai TZ, Sellers S, Wolckenhauer SA, Ling J, Callebaut C, Margot N, Ram RR, Liu YP, Hyland R, Sinclair GI, Ruane PJ, Crofoot GE, McDonald CK, Brainard DM, Lad L, Swaminathan S, Sundquist WI, Sakowicz R, Chester AE, Lee WE, Daar ES, Yant SR, Cihlar T (2020). Clinical targeting of HIV capsid protein with a long-acting small molecule. Nature, 584(7822), 614-618. (Read full article)
  10. Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR 3rd, Iwasa JH, Vershinin MD, Sundquist WI, Frost A (2020). Membrane constriction and thinning by sequential ESCRT-III polymerization. Nat Struct Mol Biol, 27(4), 392-399. (Read full article)
  11. Han H, Schubert HL, McCullough J, Monroe N, Purdy MD, Yeager M, Sundquist WI, Hill CP (2019). Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J Biol Chem, 295(2), 435-443. (Read full article)
  12. Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO (2019). A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model. Nat Med, 25(9), 1377-1384. (Read full article)
  13. Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP (2019). Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife, 8, e44071. (Read full article)
  14. Sadler JB, Wenzel D, Williams LK, Guindo-Martnez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J (2018). A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instabilityDOI: 10.1073/pnas.1805504115. Proc Natl Acad Sci U S A, 115(38), E8900-E8908.
  15. Wagner JM, Christensen DE, Bhattacharya A, Dawidziak DM, Roganowicz MD, Wan Y, Pumroy RA, Demeler B, Ivanov DN, Ganser-Pornillos BK, Sundquist WI, Pornillos O (2018). General model for retroviral capsid pattern recognition by TRIM5 Proteins. J Virol, 92(4). (Read full article)
  16. Han H, Monroe N, Sundquist WI, Shen PS, Hill CP (2017). The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. Elife, 6, 510-25. (Read full article)
  17. Monroe N, Han H, Shen PS, Sundquist WI, Hill CP (2017). Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife, 6, e24487. (Read full article)
  18. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A (2017). LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A, 114(11), E2166-E2175. (Read full article)
  19. Votteler J, Ogohara C, Yi S, Hsia Y, Nattermann U, Belnap DM, King NP, Sundquist WI (2016). Designed proteins induce the formation of nanocage-containing extracellular vesicles. Nature, 540(7632), 292-295. (Read full article)
  20. Li YL, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI (2016). Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids. Elife, 5, e16269. (Read full article)
  21. Wagner JM, Roganowicz MD, Skorupka K, Alam SL, Christensen D, Doss G, Wan Y, Frank GA, Ganser-Pornillos BK, Sundquist WI, Pornillos O (2016). Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α. Elife, 5, e16309. (Read full article)
  22. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A (2015). Structure and membrane remodeling activity of ESCRT-III helical polymers. Science, 350(6267), 1548-51. (Read full article)
  23. Caballe A, Wenzel DM, Agromayor M, Alam SL, Skalicky JJ, Kloc M, Carlton JG, Labrador L, Sundquist WI, Martin-Serrano J (2015). ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. Elife, 4, e06547. (Read full article)
  24. Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP (2015). Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). J Biol Chem, 290(21), 13490-9. (Read full article)
  25. Mercenne G, Alam SL, Arii J, Lalonde MS, Sundquist WI (2015). Angiomotin functions in HIV-1 assembly and budding. Elife, 4, e03778. (Read full article)
  26. Sanchez JG, Okreglicka K, Chandrasekaran V, Welker JM, Sundquist WI, Pornillos O (2014). The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl Acad Sci U S A, 111(7), 2494-9. (Read full article)
  27. Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP (2014). The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol, 426(3), 510-25. (Read full article)
  28. Sandrin V, Sundquist WI (2013). ESCRT requirements for EIAV budding. Retrovirology, 10, 104. (Read full article)
  29. Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW (2013). Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrob Agents Chemother, 57(10), 4622-31. (Read full article)
  30. Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist WI, Schoehn G, Weissenhorn W (2013). ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol, 15(2), 213-26. (Read full article)
  31. Skalicky JJ, Arii J, Wenzel DM, Stubblefield WM, Katsuyama A, Uter NT, Bajorek M, Myszka DG, Sundquist WI (2012). Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem, 287(52), 43910-26. (Read full article)
  32. Dowlatshahi DP, Sandrin V, Vivona S, Shaler TA, Kaiser SE, Melandri F, Sundquist WI, Kopito RR (2012). ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding. Dev Cell, 23(6), 1247-54. (Read full article)
  33. Morita E, Arii J, Christensen D, Votteler J, Sundquist WI (2012). Attenuated protein expression vectors for use in siRNA rescue experiments. Biotechniques, (0), 1-5. (Read full article)
  34. Lemke CT, Titolo S, von Schwedler U, Goudreau N, Mercier JF, Wardrop E, Faucher AM, Coulombe R, Banik SS, Fader L, Gagnon A, Kawai SH, Rancourt J, Tremblay M, Yoakim C, Simoneau B, Archambault J, Sundquist WI, Mason SW (2012). Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein. J Virol, 86(12), 6643-55. (Read full article)
  35. Jger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, DOrso I, Fernandes J, Fahey M, Mahon C, ODonoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ (2011). Global landscape of HIV-human protein complexes. Nature, 481(7381), 365-70. (Read full article)
  36. Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI (2011). Activation of the retroviral budding factor ALIX. J Virol, 85(17), 9222-6. (Read full article)
  37. Morita E, Sandrin V, McCullough J, Katsuyama A, Baci Hamilton I, Sundquist WI (2011). ESCRT-III protein requirements for HIV-1 budding. Cell Host Microbe, 9(3), 235-242. (Read full article)
  38. Ganser-Pornillos BK, Chandrasekaran V, Pornillos O, Sodroski JG, Sundquist WI, Yeager M (2011). Hexagonal assembly of a restricting TRIM5alpha protein. Proc Natl Acad Sci U S A, 108(2), 534-9. (Read full article)
  39. Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP (2011). Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. J Virol, 85(1), 632-7. (Read full article)
  40. Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP (2011). Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding. PLoS One, 6(12), e27466. (Read full article)
  41. Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP (2010). Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc Natl Acad Sci U S A, 107(42), 17951-6. (Read full article)
  42. Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK, Sundquist WI (2010). Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A, 107(29), 12889-94. (Read full article)
  43. Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI (2009). Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol, 16(7), 754-62. (Read full article)
  44. Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M (2009). X-ray structures of the hexameric building block of the HIV capsid. Cell, 137(7), 1282-92. (Read full article)
  45. Bajorek M, Morita E, Skalicky JJ, Morham SG, Babst M, Sundquist WI (2009). Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell, 20(5), 1360-73. (Read full article)
  46. Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP (2008). Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol, 384(4), 878-95. (Read full article)
  47. Langelier CR, Sandrin V, Eckert DM, Christensen DE, Chandrasekaran V, Alam SL, Aiken C, Olsen JC, Kar AK, Sodroski JG, Sundquist WI (2008). Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. J Virol, 82(23), 11682-94. (Read full article)
  48. Kieffer C, Skalicky JJ, Morita E, De Domenico I, Ward DM, Kaplan J, Sundquist WI (2008). Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell, 15(1), 62-73. (Read full article)
  49. McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP (2008). ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A, 105(22), 7687-91. (Read full article)
  50. Chung HY, Morita E, von Schwedler U, Mller B, Krusslich HG, Sundquist WI (2008). NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol, 82(10), 4884-97. (Read full article)
  51. Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen GJ (2008). Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol, 377(2), 364-77. (Read full article)
  52. Zhai Q, Fisher RD, Chung HY, Myszka DG, Sundquist WI, Hill CP (2008). Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV. Nat Struct Mol Biol, 15(1), 43-9. (Read full article)
  53. Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP (2007). Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J Mol Biol, 373(2), 355-66. (Read full article)
  54. Stuchell-Brereton MD, Skalicky JJ, Kieffer C, Karren MA, Ghaffarian S, Sundquist WI (2007). ESCRT-III recognition by VPS4 ATPases. Nature, 449(7163), 740-4. (Read full article)
  55. Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI (2007). Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J, 26(19), 4215-27. (Read full article)
  56. Neil SJ, Sandrin V, Sundquist WI, Bieniasz PD (2007). An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe, 2(3), 193-203. (Read full article)
  57. Morita E, Sandrin V, Alam SL, Eckert DM, Gygi SP, Sundquist WI (2007). Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe, 2(1), 41-53. (Read full article)
  58. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J (2007). The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell, 18(7), 2569-78. (Read full article)
  59. Higa MM, Alam SL, Sundquist WI, Ullman KS (2007). Molecular characterization of the Ran-binding zinc finger domain of Nup153. J Biol Chem, 282(23), 17090-100. (Read full article)
  60. Wright ER, Schooler JB, Ding HJ, Kieffer C, Fillmore C, Sundquist WI, Jensen GJ (2007). Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells. EMBO J, 26(8), 2218-26. (Read full article)
  61. Fisher RD, Chung HY, Zhai Q, Robinson H, Sundquist WI, Hill CP (2007). Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell, 128(5), 841-52. (Read full article)
  62. Arrigoni R, Alam SL, Wamstad JA, Bardwell VJ, Sundquist WI, Schreiber-Agus N (2006). The Polycomb-associated protein Rybp is a ubiquitin binding protein. FEBS Lett, 580(26), 6233-41. (Read full article)
  63. Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI (2006). Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat Struct Mol Biol, 13(11), 1029-30. (Read full article)
  64. Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI (2006). Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol, 80(19), 9465-80. (Read full article)
  65. Kelly BN, Howard BR, Wang H, Robinson H, Sundquist WI, Hill CP (2006). Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278). Biochemistry, 45(38), 11257-66. (Read full article)
  66. Stremlau M, Perron M, Lee M, Li Y, Song B, Javanbakht H, Diaz-Griffero F, Anderson DJ, Sundquist WI, Sodroski J (2006). Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A, 103(14), 5514-9. (Read full article)
  67. Scott A, Chung HY, Gonciarz-Swiatek M, Hill GC, Whitby FG, Gaspar J, Holton JM, Viswanathan R, Ghaffarian S, Hill CP, Sundquist WI (2005). Structural and mechanistic studies of VPS4 proteins. EMBO J, 24(20), 3658-69. (Read full article)
  68. Scott A, Gaspar J, Stuchell-Brereton MD, Alam SL, Skalicky JJ, Sundquist WI (2005). Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. Proc Natl Acad Sci U S A, 102(39), 13813-8. (Read full article)
  69. Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (2005). The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem, 280(11), 10548-55. (Read full article)
  70. Schmitt AP, Leser GP, Morita E, Sundquist WI, Lamb RA (2005). Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus. J Virol, 79(5), 2988-97. (Read full article)
  71. Benjamin J, Ganser-Pornillos BK, Tivol WF, Sundquist WI, Jensen GJ (2005). Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography. J Mol Biol, 346(2), 577-88. (Read full article)
  72. Stuchell MD, Garrus JE, Mller B, Stray KM, Ghaffarian S, McKinnon R, Krusslich HG, Morham SG, Sundquist WI (2004). The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem, 279(34), 36059-71. (Read full article)
  73. Hatziioannou T, Cowan S, Von Schwedler UK, Sundquist WI, Bieniasz PD (2004). Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid. J Virol, 78(11), 6005-12. (Read full article)
  74. Alam SL, Sun J, Payne M, Welch BD, Blake BK, Davis DR, Meyer HH, Emr SD, Sundquist WI (2004). Ubiquitin interactions of NZF zinc fingers. EMBO J, 23(7), 1411-21. (Read full article)
  75. Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP (2004). Ubiquitin recognition by the human TSG101 protein. Mol Cell, 13(6), 783-9. (Read full article)
  76. Ganser-Pornillos BK, von Schwedler UK, Stray KM, Aiken C, Sundquist WI (2004). Assembly properties of the human immunodeficiency virus type 1 CA protein. J Virol, 78(5), 2545-52. (Read full article)
  77. von Schwedler UK, Stuchell M, Mller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Krusslich HG, Kaplan J, Morham SG, Sundquist WI (2003). The protein network of HIV budding. Cell, 114(6), 701-13. (Read full article)
  78. Pornillos O, Higginson DS, Stray KM, Fisher RD, Garrus JE, Payne M, He GP, Wang HE, Morham SG, Sundquist WI (2003). HIV Gag mimics the Tsg101-recruiting activity of the human HRS protein. J Cell Biol, 162(3), 425-34. (Read full article)
  79. Fisher RD, Wang B, Alam SL, Higginson DS, Robinson H, Sundquist WI, Hill CP (2003). Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem, 278(31), 28976-84. (Read full article)
  80. Ganser BK, Cheng A, Sundquist WI, Yeager M (2003). Three-dimensional structure of the M-MuLV CA protein on a lipid monolayer: a general model for retroviral capsid assembly. EMBO J, 22(12), 2886-92. (Read full article)
  81. Howard BR, Vajdos FF, Li S, Sundquist WI, Hill CP (2003). Structural insights into the catalytic mechanism of cyclophilin A. Nat Struct Biol, 10(6), 475-81. (Read full article)
  82. Wang B, Alam SL, Meyer HH, Payne M, Stemmler TL, Davis DR, Sundquist WI (2003). Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem, 278(22), 20225-34. (Read full article)
  83. von Schwedler UK, Stray KM, Garrus JE, Sundquist WI (2003). Functional surfaces of the human immunodeficiency virus type 1 capsid protein. J Virol, 77(9), 5439-50. (Read full article)
  84. Pornillos O, Alam SL, Davis DR, Sundquist WI (2002). Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nat Struct Biol, 9(11), 812-7. (Read full article)
  85. Forshey BM, von Schwedler U, Sundquist WI, Aiken C (2002). Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. J Virol, 76(11), 5667-77. (Read full article)
  86. Pornillos O, Alam SL, Rich RL, Myszka DG, Davis DR, Sundquist WI (2002). Structure and functional interactions of the Tsg101 UEV domain. EMBO J, 21(10), 2397-406. (Read full article)
  87. Bosco DA, Eisenmesser EZ, Pochapsky S, Sundquist WI, Kern D (2002). Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proc Natl Acad Sci U S A, 99(8), 5247-52. (Read full article)
  88. Jenkins Y, Pornillos O, Rich RL, Myszka DG, Sundquist WI, Malim MH (2001). Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr and p6(Gag). J Virol, 75(21), 10537-42. (Read full article)
  89. Garrus JE, von Schwedler UK, Pornillos OW, Morham SG, Zavitz KH, Wang HE, Wettstein DA, Stray KM, Ct M, Rich RL, Myszka DG, Sundquist WI (2001). Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell, 107(1), 55-65. (Read full article)
  90. Li S, Hill CP, Sundquist WI, Finch JT (2000). Image reconstructions of helical assemblies of the HIV-1 CA protein. Nature, 407(6802), 409-13. (Read full article)
  91. Ganser BK, Li S, Klishko VY, Finch JT, Sundquist WI (1999). Assembly and analysis of conical models for the HIV-1 core. Science, 283(5398), 80-3. (Read full article)
  92. Worthylake DK, Wang H, Yoo S, Sundquist WI, Hill CP (1999). Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr, 55(Pt 1), 85-92. (Read full article)
  93. von Schwedler UK, Stemmler TL, Klishko VY, Li S, Albertine KH, Davis DR, Sundquist WI (1998). Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly. EMBO J, 17(6), 1555-68. (Read full article)
  94. Vajdos FF, Yoo S, Houseweart M, Sundquist WI, Hill CP (1997). Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein. Protein Sci, 6(11), 2297-307. (Read full article)
  95. Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP (1997). Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science, 278(5339), 849-53. (Read full article)
  96. Yoo S, Myszka DG, Yeh C, McMurray M, Hill CP, Sundquist WI (1997). Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J Mol Biol, 269(5), 780-95. (Read full article)
  97. Gamble TR, Vajdos FF, Yoo S, Worthylake DK, Houseweart M, Sundquist WI, Hill CP (1996). Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. Cell, 87(7), 1285-94. (Read full article)
  98. Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF (1996). Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses. J Mol Biol, 264(5), 1117-31. (Read full article)
  99. Massiah MA, Worthylake D, Christensen AM, Sundquist WI, Hill CP, Summers MF (1996). Comparison of the NMR and X-ray structures of the HIV-1 matrix protein: evidence for conformational changes during viral assembly. Protein Sci, 5(12), 2391-8. (Read full article)
  100. Gitti RK, Lee BM, Walker J, Summers MF, Yoo S, Sundquist WI (1996). Structure of the amino-terminal core domain of the HIV-1 capsid protein. Science, 273(5272), 231-5. (Read full article)
  101. Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI (1996). Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly. Proc Natl Acad Sci U S A, 93(7), 3099-104. (Read full article)
  102. Massiah MA, Starich MR, Paschall C, Summers MF, Christensen AM, Sundquist WI (1994). Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein. J Mol Biol, 244(2), 198-223. (Read full article)
  103. Sundquist WI, Heaphy S (1993). Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA. Proc Natl Acad Sci U S A, 90(8), 3393-7. (Read full article)
  104. Ren T, Bancroft DP, Sundquist WI, Keck M, Masschelein A, Lippar SJ (1993). Synthesis, Characterization, DNA Binding Properties, and Solution Thermochromism of Platinum (II) Complexes of the Ethidium Cation: Altered Regioselectivity in a DNA-Promoted Reaction. J Am Chem Soc, 115(24), 11341-52.
  105. Hollis LS, Sundquist WI, Burstyn JN, Heiger-Bernays WJ, Bellon SF, Ahmed KJ, Amundsen AR, Stern EW, Lippard SJ (1991). Mechanistic studies of a novel class of trisubstituted platinum(II) antitumor agents. Cancer Res, 51(7), 1866-75. (Read full article)
  106. Sundquist WI, Bancroft DP, Lippard SJ (1990). Synthesis, Characterization, and Biological Activity of cis-Diammineplatinum(II) Complexes of the DNA Intercalators 9-Aminoacridine and Chloroquine. J Am Chem Soc, 112(4), 1590-6.
  107. Sundquist WI, Klug A (1989). Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature, 342(6251), 825-9. (Read full article)
  108. Hollis LS, Miller AV, Amundsen AR, Stern EW, Sundquist WI, Toney J, Burstyn JN, Heiger W, Lippard SJ (08/01/1989). Chemical and biological studies of new platinum antitumor agents. J Inorg Biochem, 36(3-4), 151-372.
  109. Bowler BE, Ahmed KJ, Sundquist WI, Hollis LS, Whang EE, Lippard SJ (1989). Synthesis, Characterization, and DNA Binding Properties of (1,2-Diaminoethane)-platinum(II) Complexes Linked to the DNA Intercalator Acridine Orange by Trimethylene and Hexamethylene Chains. J Am Chem Soc, 111(4), 1299-306.
  110. Sundquist WI, Bancroft DP, Chassot L, Lippard SJ (1988). DNA promotes the reaction of cis-diamminedichloroplatinum(II) with the exocyclic amino groups of ethidium bromide. J Am Chem Soc, 110(25), 8559–8560.
  111. Sundquist WI, Lippard SJ, Stollar BD (1987). Monoclonal antibodies to DNA modified with cis- or trans-diamminedichloroplatinum(II). Proc Natl Acad Sci U S A, 84(23), 8225-9. (Read full article)
  112. Sundquist WI, Ahmed, KJ, Hollis LS, Lippard SJ (1987). Solvolysis reactions of cis- and trans-diamminedichloroplatinum(II) in dimethyl sulfoxide. Structural characterization and DNA binding of trans-bis(ammine)chloro(DMSO)platinum(1+). Inorg Chem, 26(10), 1524-8.
  113. Sundquist WI, Lippard SJ, Stollar BD (1986). Binding of cis- and trans-diamminedichloroplatinum(II) to deoxyribonucleic acid exposes nucleosides as measured immunochemically with anti-nucleoside antibodies. Biochemistry, 25(7), 1520-4. (Read full article)
  114. Kempe T, Sundquist WI, Chow F, Hu SL (1985). Chemical and enzymatic biotin-labeling of oligodeoxyribonucleotides. Nucleic Acids Res, 13(1), 45-57. (Read full article)
  115. Kempe T, Kent SB, Chow F, Peterson SM, Sundquist WI, LItalien JJ, Harbrecht D, Plunkett D, DeLorbe WJ (1985). Multiple-copy genes: production and modification of monomeric peptides from large multimeric fusion proteins. Gene, 39(2-3), 239-45. (Read full article)
  116. Kempe T, Chow F, Sundquist WI, Nardi TJ, Paulson B, Peterson SM (1982). Selective 2'-benzoylation at the cis 2',3'-diols of protected ribonucleosides. New solid phase synthesis of RNA and DNA-RNA mixtures. Nucleic Acids Res, 10(21), 6695-714. (Read full article)

Review

  1. Swanstrom R, Sundquist WI (2021). Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro. [Review]. Viruses, 13(11). (Read full article)
  2. McCullough J, Frost A, Sundquist WI (2018). Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. [Review]. Annu Rev Cell Dev Biol, 34, 85-109. (Read full article)
  3. Votteler J, Sundquist WI (2013). Virus budding and the ESCRT pathway. [Review]. Cell Host Microbe, 14(3), 232-41. (Read full article)
  4. McCullough J, Colf LA, Sundquist WI (2013). Membrane fission reactions of the mammalian ESCRT pathway. [Review]. Annu Rev Biochem, 82, 663-92. (Read full article)
  5. Sundquist WI, Krusslich HG (2012). HIV-1 assembly, budding, and maturation. [Review]. Cold Spring Harb Perspect Med, 2(7), a006924. (Read full article)
  6. Ganser-Pornillos BK, Yeager M, Sundquist WI (2008). The structural biology of HIV assembly. [Review]. Curr Opin Struct Biol, 18(2), 203-17. (Read full article)
  7. Morita E, Sundquist WI (2004). Retrovirus budding. [Review]. Annu Rev Cell Dev Biol, 20, 395-425. (Read full article)
  8. Pornillos O, Garrus JE, Sundquist WI (2002). Mechanisms of enveloped RNA virus budding. [Review]. Trends Cell Biol, 12(12), 569-79. (Read full article)
  9. Li S, Ganser B, Hill CP, Finch JT, Sundquist WI (2001). Structural Models for the HIV-1 Capsid. [Review]. Virus Res, 77(2), 97-99.
  10. Sundquist WI (1991). The Structures of Telomeric DNA. [Review]. Nucleic Acids Mol Biol, 5, 1-24.
  11. Sundquist WI, Lippard SJ (1990). The Coordination Chemistry of Platinum Anticancer Drugs and Related Compounds with DNA. [Review]. Coord Chem Rev, 100th Vol Celebration Issue, 293-322.

Commentary

  1. Sundquist WI, Matthews RC (2016). Staff scientists in the workforce. http://www.asbmb.org/asbmbtoday/201610/PublicAffairs. 15(9), 32-3.
  2. Sundquist WI, Corb B (2016). Creating a robust research enterprise. http://www.asbmb.org/asbmbtoday/201609/PublicAffairs/. 15(8), 35.
  3. McCullough J, Sundquist WI (2014). Putting a finger in the ring. Nat Struct Mol Biol, 21(12), 1025-7. (Read full article)
  4. Sundquist WI (2011). Commentary on “The protein network of HIV budding”. Yegor Voronin (Ed.), HIV: 30 years in 30 weeks. Web.
  5. Alam SL, Sundquist WI (2007). Structural biology: ESCRT service. Nature, 447(7147), 921-2. (Read full article)
  6. Nogales E, Sundquist WI (2007). Macromolecular Assemblages: focusing in on complexity. Curr Opin Struct Biol, 17(2), 205-8.
  7. Alam SL, Sundquist WI (2006). Two new structures of Ub-receptor complexes. U2. Nat Struct Mol Biol, 13(3), 186-8. (Read full article)
  8. Gu Y, Sundquist WI (2003). Good to CU. Nature, 424(6944), 21-2. (Read full article)
  9. Sundquist WI (1993). Conducting the G Quartet. Curr Biol, 3(12), 893-5.

Editorial

  1. Rey FA, Sundquist WI (2013). Macromolecular assemblies. Curr Opin Struct Biol, 23(2), 224-8. (Read full article)
  2. Sundquist WI, Krug RM (2012). Assemble, replicate, remodel and evade. Curr Opin Virol, 2(2), 111-4. (Read full article)
  3. Rey FA, Sundquist WI (2011). Macromolecular assemblages. Curr Opin Struct Biol, 21(2), 221-2. (Read full article)

Other

  1. McCullough J, Sundquist WI (2020). Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes. Curr Biol (30(23), pp. R1425-R1428). England. (Read full article)
  2. Schaller MD, McDowell G, Porter A, Shippen D, Friedman KL, Gentry MS, Serio TR, Sundquist WI (2017). What's in a name? Elife (6). England. (Read full article)
  3. Sundquist WI, Ullman KS (2015). An ESCRT to seal the envelope. Science (6241(348), pp. 1314-1315).
  4. Pickett CL, Corb BW, Matthews CR, Sundquist WI, Berg JM (2015). Toward a sustainable biomedical research enterprise: Finding consensus and implementing recommendations. Proc Natl Acad Sci U S A (112(35), pp. 10832-6). United States. (Read full article)
  5. Lalonde MS, Sundquist WI (2012). How HIV finds the door. Proc Natl Acad Sci U S A (109(46), pp. 18631-2). United States. (Read full article)
  6. Sundquist WI (1996). Tattle tales. Nat Struct Biol (3(1), pp. 8-11). United States. (Read full article)