Frank G. Whitby, PhD

Languages spoken: English, French

Academic Information

Departments: Biochemistry - Research Associate Professor

Academic Office Information

frankw@biochem.utah.edu

(801) 918-8493

Biomedical Polymers Research Bldg
Biochemistry
20 S 2030 E, Room: 3600B
Salt Lake City, UT 84112

Education History

Postdoctoral Fellowship University of Utah
Biochemistry 		Postdoctoral Fellow
Postdoctoral Fellowship University of California
Pharmaceutical Chemistry 		Postdoctoral Fellow
Doctoral Training Rice University
Biochemistry & Cell Biology 		Ph.D.
Undergraduate University of Denver
Chemistry 		B.S.

Selected Publications

  1. Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP (2015). FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs. Mol Cell, 60(2), 294-306.
  2. David J Kemble, Laura L McCullough, Frank G Whitby, Tim Formosa, Christopher P Hill (In Press). FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifshttp://dx.doi.org/10.1016/j.molcel.2015.09.008. Mol Cell, 60, 1-13.
  3. Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS (2015). Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets. Protein Sci, 24(4), 446-63.
  4. VanderLinden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP (2015). Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell, 57(5), 901-11.
  5. Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP (2014). The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol, 426(3), 510-25.
  6. Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP (2013). Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT. J Biol Chem, 288(15), 10188-94.
  7. Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W (2011). UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci, 14(7), 874-80.
  8. Bracken CD, Neighbor AM, Lamlenn KK, Thomas GC, Schubert HL, Whitby FG, Howard BR (2011). Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G. BMC Struct Biol, 11, 23.
  9. Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS (2010). Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance. J Virol, 84(21), 11235-44.
  10. Sadre-Bazzaz K, Whitby FG, Robinson H, Formosa T, Hill CP (2010). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening. Mol Cell, 37(5), 728-35.
  11. Stadtmueller BM, Ferrell K, Whitby FG, Heroux A, Robinson H, Myszka DG, Hill CP (2010). Structural models for interactions between the 20S proteasome and its PAN/19S activators. J Biol Chem, 285(1), 13-7.
  12. Schroepfer GJ Jr, Ruan B, Wilson WK, Whitby FG, Xiong Q (2001). Practical Screening Method for the Detection of Genetic Disorders of Sterol Metabolism. U.S. Patent No. WIPO Patent Application WO/2001/092893, Publication Number 2001/092893. Washington, D.C.:U.S. Patent and Trademark Office.