Colin K. Grissom

Colin K. Grissom, MD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions:

Academic Office Information

u0031381@utah.edu

Colin K. Grissom, MD, is the Co-Medical Director of the Shock Trauma Intensive Care Unit and Director of Critical Care Echocardiography at Intermountain Medical Center. Dr. Grissom supervises critical care fellows, internal medicine residents, emergency medicine residents, and transitional interns in the care of critically ill medical and surgical patients. Dr. Grissom was the leader in bringing critical care ultrasound and echocardiography to the bedside in this multidisciplinary 24-bed intensive care unit. He was the recipient of a University of Utah Department of Medicine Teaching Award in 2006.

Research Statement

<p>Colin K. Grissom, MD, is a clinical researcher with over 100 publications listed in PubMed. His primary areas of interest are clinical research on mechanical ventilation, the acute respiratory distress syndrome, sepsis, and applications of echocardiography and ultrasound to critically ill patients. He is the Principal Investigator for the Utah Center of the NIH/NHLBI Preventiona and Early Treatment of Acute Lung Injury (PETAL) clinical trials network. Other research intersts include high altitude illness, avalanche victim physiology, and hypothermia.</p>

Education History

Fellowship University of Utah School of Medicine, Department of Anesthesiology and Cardiology
 Fellow
University of Utah Hospital
 Fellow
Residency University of Washington
 Resident
Yale University School of Medicine
 MD
Undergraduate Yale University
 BA

Selected Publications

Journal Article

  1. Olsen GH, Gee PM, Wolfe D, Winberg C, Carpenter L, Jones C, Jacobs JR, Leither L, Peltan ID, Singer SJ, Asch SM, Grissom CK, Srivastava R, Knighton AJ (2023). Awakening and breathing coordination: A mixed-methods analysis of determinants of implementation. Ann Am Thorac Soc.
  2. Grissom CK, Lanspa MJ, Groat D, Jacobs JR, Carpenter L, Kuttler KG, Leither L, Peltan ID, Brown SM, Srivastava R (2023). Implementation of Lung-Protective Ventilation in Patients With Acute Respiratory Failure. Crit Care Med.
  3. Graham JD, Grissom CK (2023). From Pac-Man to UltraMan. Crit Care Med, 51(3), 415-418.
  4. National Heart Lung and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, Hough CL, Huang W, Iwashyna TJ, Jones AE, Khan A, Lai P, Liu KD, Miller CD, Oldmixon K, Park PK, Rice TW, Ringwood N, Semler MW, Steingrub JS, Talmor D, Thompson BT, Yealy DM, Self WH (2023). Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med, 388(6), 499-510.
  5. Morris AH, Horvat C, Stagg B, Grainger DW, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas FO, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Suchyta M, Pearl JE, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar S, Bernard GR, Thompson BT, Brower R, Truwit J, Steingrub J, Hiten RD, Willson DF, Zimmerman JJ, Nadkarni V, Randolph AG, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Moore FA, Evans RS, Sorenson DK, Wong A, Boland MV, Dere WH, Crandall A, Facelli J, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Ely EW, Pickering BW, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Pinsky MR, James B, Berwick DM (2022). Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy. J Am Med Inform Assoc, 30(1), 178-194.
  6. Campbell RA, Manne BK, Banerjee M, Middleton EA, Ajanel A, Schwertz H, Denorme F, Stubben C, Montenont E, Saperstein S, Page L, Tolley ND, Lim DL, Brown SM, Grissom CK, Sborov DW, Krishnan A, Rondina MT (2022). IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. J Clin Invest, 132(23).
  7. Peltan ID, Knighton AJ, Barney BJ, Wolfe D, Jacobs JR, Klippel C, Allen L, Lanspa MJ, Leither LM, Brown SM, Srivastava R, Grissom CK (2022). Delivery of Lung Protective Ventilation for Acute Respiratory Distress Syndrome: A Hybrid Implementation-Effectiveness Trial. Ann Am Thorac Soc.
  8. Knighton AJ, Kuttler KG, Ranade-Kharkar P, Allen L, Throne T, Jacobs JR, Carpenter L, Winberg C, Johnson K, Shrestha N, Ferraro JP, Wolfe D, Peltan ID, Srivastava R, Grissom CK (2022). An alert tool to promote lung protective ventilation for possible acute respiratory distress syndrome. JAMIA Open, 5(2), ooac050.
  9. Tonna JE, Peltan ID, Brown SM, Grissom CK, Presson AP, Herrick JS, Vasques F, Keenan HT (2021). Positive End-Expiratory Pressure and Respiratory Rate Modify the Association of Mechanical Power and Driving Pressure With Mortality Among Patients With Acute Respiratory Distress Syndrome. Crit Care Explor, 3(12), e0583.
  10. Carlton EF, Ice E, Barbaro RP, Kampuis L, Moss M, Angus DC, Banner-Goodspeed VM, Ginde AA, Gong MN, Grissom CK, Hou PC, Huang DT, Hough CTL, Talmor DS, Thompson BT, Yealy DM, Couper MP, Iwashyna TJ, NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL Network (2021). Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome. J Crit Care, 64, 160-164.
  11. Morris AH, Stagg B, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas F, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar SS, Bernard GR, Taylor Thompson B, Brower R, Truwit JD, Steingrub J, Duncan Hite R, Willson DF, Zimmerman JJ, Nadkarni VM, Randolph A, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Scott Evans R, Sorenson DK, Wong A, Boland MV, Grainger DW, Dere WH, Crandall AS, Facelli JC, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Wesley Ely E, Gajic O, Pickering B, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Angus D, Pinsky MR, James B, Berwick D (2020). Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc, 28(6), 1330-1344.
  12. Luks AM, Grissom CK (2021). Return to High Altitude After Recovery from Coronavirus Disease 2019. High Alt Med Biol, 22(2), 119-127.
  13. Beesley SJ, Sorensen J, Walkey AJ, Tonna JE, Lanspa MJ, Hirshberg E, Grissom CK, Horne BD, Burk R, Abraham TP, Paine R, Brown SM (2022). Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis. Crit Care Med, 49(4), e444-e453.
  14. Brown SM, Beesley SJ, Stubben C, Wilson EL, Presson AP, Grissom C, Maguire C, Rondina MT, Hopkins RO (2020). Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study. J Intensive Care Med, 36(3), 262-270.
  15. Lanspa MJ, Cirulis MM, Wiley BM, Olsen TD, Wilson EL, Beesley SJ, Brown SM, Hirshberg EL, Grissom CK (2020). Right Ventricular Dysfunction in Early Sepsis and Septic Shock. Chest, 159(3), 1055-1063.
  16. Brown SM, Peltan I, Kumar N, Leither L, Webb BJ, Starr N, Grissom CK, Buckel WR, Srivastava R, Butler AM, Groat D, Haaland B, Ying J, Harris E, Johnson S, Paine R 3rd, Greene T (2020). Hydroxychloroquine vs. Azithromycin for Hospitalized Patients with COVID-19 (HAHPS): Results of a Randomized, Active Comparator Trial. Ann Am Thorac Soc.
  17. Allen L, Knighton AJ, Brunisholz KD, Wolfe D, Kean J, Belnap TW, Grissom C, Srivastava R (2020). Increasing Adherence to Evidence-Based Care Using Root Cause Analysis. Qual Manag Health Care, 29(4), 282-284.
  18. Brown SM, Peltan ID, Webb B, Kumar N, Starr N, Grissom C, Buckel WR, Srivastava R, Harris ES, Leither LM, Johnson SA, Paine R 3rd, Greene T (2020). Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial. Ann Am Thorac Soc, 17(8), 1008-1015.
  19. Luks AM, Freer L, Grissom CK, McIntosh SE, Schoene RB, Swenson ER, Hackett PH (2020). COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. High Alt Med Biol, 21(2), 192-193.
  20. Beesley SJ, Egan E, Lanspa MJ, Wilson EL, Hirshberg EL, Grissom CK, Burk R, Brown SM (2020). Unanticipated critical findings on echocardiography in septic patients. Ultrasound J, 12(1), 12.
  21. Allen L, Knighton AJ, Wolfe D, Belnap T, Brunisholz KD, Carmichael H, Allen T, Peltan I, Grissom C, Srivastava R (2020). Implementing Evidence-Based Clinical Practice in the Critical Care Setting. Qual Manag Health Care, 29(2), 123-125.
  22. McIntosh SE, Little CE, Seibert TD, Polukoff NE, Grissom CK (2019). Avalanche airbag post-burial active deflation - The ability to create an air pocket to delay asphyxiation and prolong survival. Resuscitation, 146, 155-160.
  23. Knighton AJ, Kean J, Wolfe D, Allen L, Jacobs J, Carpenter L, Winberg C, Berry JG, Peltan ID, Grissom CK, Srivastava R (2020). Multi-factorial barriers and facilitators to high adherence to lung-protective ventilation using a computerized protocol: a mixed methods study. Implement Sci Commun, 1(1), 67.
  24. Lanspa MJ, Peltan ID, Jacobs JR, Sorensen JS, Carpenter L, Ferraro JP, Brown SM, Berry JG, Srivastava R, Grissom CK (2019). Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS. Crit Care, 23(1), 424.
  25. Blagev DP, Harris D, Dunn AC, Guidry DW, Grissom CK, Lanspa MJ (2019). Clinical presentation, treatment, and short-term outcomes of lung injury associated with e-cigarettes or vaping: a prospective observational cohort study. Lancet, 394(10214), 2073-2083.
  26. Lipman GS, Gaudio FG, Eifling KP, Ellis MA, Otten EM, Grissom CK (2019). Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Heat Illness: 2019 Update. Wilderness Environ Med, 30(4S), S33-S46.
  27. Luks AM, Auerbach PS, Freer L, Grissom CK, Keyes LE, McIntosh SE, Rodway GW, Schoene RB, Zafren K, Hackett PH (2019). Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update. Wilderness Environ Med, 30(4S), S3-S18.
  28. McIntosh SE, Freer L, Grissom CK, Auerbach PS, Rodway GW, Cochran A, Giesbrecht GG, McDevitt M, Imray CH, Johnson EL, Pandey P, Dow J, Hackett PH (2019). Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update. Wilderness Environ Med, 30(4S), S19-S32.
  29. Dow J, Giesbrecht GG, Danzl DF, Brugger H, Sagalyn EB, Walpoth B, Auerbach PS, McIntosh SE, Nmethy M, McDevitt M, Schoene RB, Rodway GW, Hackett PH, Zafren K, Bennett BL, Grissom CK (2019). Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update. Wilderness Environ Med, 30(4S), S47-S69.
  30. Cirulis MM, Beesley SJ, Wilson EL, Stubben C, Olsen TD, Hirshberg EL, Smith LM, Lanspa MJ, Abraham TP, Grissom CK, Rondina MT, Brown SM (2019). The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study. Intensive Care Med Exp, 7(1), 57.
  31. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.
  32. McIntosh SE, Brant-Zawadzki G, Milliner BH, Christensen ED, Nyberg AA, Grissom CK, Olivares CR, Kim HS, Tremper B (2019). Cause of Death in Utah Avalanche Fatalities, 2006-2007 through 2017-2018 Winter Seasons. Wilderness Environ Med, 30(2), 191-194.
  33. National Heart Lung and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC (2019). Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med, 380(21), 1997-2008.
  34. Mor-Cohen R, Zucker M, Grissom C, Brown SM, Seligsohn U, Campbell RA, Blair AM, Rondina MT (2019). The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients. J Thromb Thrombolysis, 47(2), 186-191.
  35. Morales-Ortz J, Rondina MT, Brown SM, Grissom C, Washington AV (2018). High Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-Like Transcript (TLT)-1 Are Associated With Acute Respiratory Distress Syndrome. Clin Appl Thromb Hemost, 24(7), 1122-1127.
  36. Luks AM, Grissom C, Freer L, Hackett P (2016). Medication Use Among Mount Everest Climbers: Practice and Attitudes. High Alt Med Biol, 17(4), 315-322.

Letter

  1. Lanspa MJ, Cirulis MM, Wiley BM, Olsen TD, Wilson EL, Beesley SM, Brown SM, Hirshberg EL, Grissom CK (2021). Response. [Letter to the editor]. Chest, 160(3), e319-e320.
  2. Lanspa MJ, Olsen TD, Wilson EL, Beesley SM, Brown SM, Hirshberg EL, Grissom CK, Cirulis MM, Wiley BM (2021). Response. [Letter to the editor]. Chest, 159(4), 1685-1686.
  3. McIntosh SE, Little CE, Seibert TD, Polukoff NE, Grissom CK (2020). Reply to: Reconsidering the air pocket around mouth and nose as a positive outcome predictor in completely buried avalanche victims. [Letter to the editor]. Resuscitation, 152, 210-211.
  4. McIntosh SE, Hemphill M, McDevitt MC, Gurung TY, Ghale M, Knott JR, Thapa GB, Basnyat B, Dow J, Weber DC, Grissom CK (2019). In Reply to Dr Bennett. [Letter to the editor]. Wilderness Environ Med, 30(3), 334-335.
  5. Hirshberg EL, Lanspa MJ, Brown SM, Dean NC, Grissom CK (2019). The authors reply. [Letter to the editor]. Crit Care Med, 47(8), e724-e726.
  6. Brillhart A, McIntosh S, Dow J, Grissom C (2016). In response to Epidemiology of Search and Rescue in Baxter State Park: Dangers of Descent and Fatigue. [Letter to the editor]. Wilderness Environ Med, 27(2), 344-5.

Other

  1. Horne BD, Bledsoe JR, Muhlestein JB, May HT, Peltan ID, Webb BJ, Carlquist JF, Bennett ST, Rea S, Bair TL, Grissom CK, Knight S, Ronnow BS, Le VT, Stenehjem E, Woller SC, Knowlton KU, Anderson JL (2022). Association of the Intermountain Risk Score with major adverse health events in patients positive for COVID-19: an observational evaluation of a US cohort. BMJ Open (12(3), pp. e053864). England.