Elena Y. Enioutina

Elena Y. Enioutina, MD, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Molecular Pharmaceutics , Primary - Pediatrics , Adjunct - Pathology

Divisions: Clinical Pharmacology

Dr. Elena Yu Enioutina holds an M.D. degree in Pediatric Preventive Medicine and a Ph.D. in medicine with a specialization in pharmacology and toxicology. She has hands-on experience in immunopharmacology, pharmacology/toxicology, and animal modeling, as well as extensive academic research experience in immunology, vaccines, and immune senescence. Her long-standing interest in the prophylaxis of infectious diseases goes back to her medical school years. Immune senescence and modulation of immune responses in aged animals by cholesterol-lowering drugs was the topic of her Ph.D. work.

Her current research is mainly focused on phytodrugs dietary supplements: 1) their safety and efficacy, 2) potentiation of conventional drug toxicity by concomitant use with phytodrugs, 3) use of phytodrugs by special patient populations, and 4) use of phytodrugs as an alternative/complementary treatment to conventional antibiotics. She is a Principal Investigator in several clinical trials examining the pharmacokinetics and efficacy of herbal and other natural products. Additionally, Dr. Enioutina is interested in evaluating intravenous immunoglobulins' efficacy in pediatric patients with neurological disorders. She continues her work aimed at optimizing the treatment of neonatal sepsis.

Education History

Undergraduate I.M. Sechenov First Moscow Institute of Medicine
 BA
Professional Medical I.M. Sechenov First Moscow Institute of Medicine
 MD
Internship I.M. Sechenov First Moscow State Medical University
 Intern
Doctoral Training All Union Research Institute of Medicinal Plants (VILAR)
 PhD
Postdoctoral Fellowship University of Utah School of Medicine
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Yu T, Enioutina EY, Brunner HI, Vinks AA, Sherwin C (2017). Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. Clinical pharmacokinetics, 56(2), 107-125.
  2. Enioutina EY, Bareyan D, Daynes R (2009). TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses. Journal of immunology (Baltimore, Md., 182(7), 4296-305.
  3. Enioutina EY, Bareyan D, Daynes R (2011). A role for immature myeloid cells in immune senescence. Journal of immunology (Baltimore, Md., 186(2), 697-707.
  4. Enioutina EY, Visic D, McGee ZA, Daynes R (1999). The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine, 17(23-24), 3050-64.
  5. Enioutina EY, Visic D, Daynes R (2000). The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity. Vaccine, 18(24), 2753-67.
  6. Balch A, Wilkes J, Thorell E, Pavia A, Sherwin CMT, Enioutina E (2019). Changing trends in IVIG use in pediatric patients: A retrospective review of practices in a network of major USA pediatric hospitals. International immunopharmacology, 76, 105868.
  7. Job KM, Olson J, Stockmann C, Constance JE, Enioutina EY, Rower JE, Linakis MW, Balch AH, Yu T, Liu X, Thorell EA, Sherwin C (2016). Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections. Expert review of anti-infective therapy, 14(8), 731-46.
  8. Barnes J, McLachlan AJ, Sherwin CM, Enioutina E (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. Expert review of clinical pharmacology, 9(7), 905-15.
  9. Sammons HM, Gubarev MI, Krepkova LV, Bortnikova VV, Corrick F, Job KM, Sherwin CM, Enioutina E (2016). Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. Expert review of clinical pharmacology, 9(8), 1117-27.
  10. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X, Di L, Sherwin CM, Enioutina E (2016). Herbal medicines: challenges in the modern world. Part 3. China and Japan. Expert review of clinical pharmacology, 9(9), 1225-33.
  11. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina E (2016). Herbal medicines: challenges in the modern world. Part 4. Canada and United States. Expert review of clinical pharmacology, 9(12), 1597-1609.
  12. Enioutina EY, Salis ER, Job KM, Gubarev MI, Krepkova LV, Sherwin C (2017). Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide. Expert review of clinical pharmacology, 10(3), 327-338.
  13. Enioutina EY, Teng L, Fateeva TV, Brown JCS, Job KM, Bortnikova VV, Krepkova LV, Gubarev MI, Sherwin CM (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. Expert review of clinical pharmacology, 10(11), 1203-1214.
  14. Enioutina EY, Job KM, Krepkova LV, Reed MD, Sherwin C (2020). How can we improve the safe use of herbal medicine and other natural products? A clinical pharmacologist mission. Expert review of clinical pharmacology, 13(9), 935-944.
  15. Illamola SM, Amaeze OU, Krepkova LV, Birnbaum AK, Karanam A, Job KM, Bortnikova VV, Sherwin CMT, Enioutina E (2020). Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know. Frontiers in pharmacology, 10(1483),
  16. Krepkova LV, Bortnikova VV, Babenko AN, Mizina PG, Mkhitarov VA, Job KM, Sherwin CM, Enioutina E (2021). Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development. BMC complementary medicine and therapies, 21(1), 31.
  17. Wagstaff JS,Durrant RJ,Newman MG,Eason R,Ward RM,Sherwin CMT,Enioutina E (2019). Antibiotic treatment of suspected and confirmed neonatal sepsis within 28 days of birth: A retrospective analysis. Frontiers in pharmacology, 10,
  18. Gubarev MI,Enioutina EY,Taylor JL,Visic DM,Daynes R (1998). Plant-derived glycoalkaloids protect mice against lethal infection with Salmonella typhimurium. Journal of immunology (Baltimore, Md., 12(2), 79-88.
  19. Krepkova LV, Babenko AN, Lemyaseva SV, Saybel OL, Sherwin CM, Enioutina E (2023). Modulation of Hepatic Functions by Chicory (Cichorium intybus L.) Extract: Preclinical Study in Rats. Pharmaceuticals (Basel, Switzerland), 16(10),
  20. Han X, Vollmer D, Enioutina E (2023). Immunomodulatory Effects of Modified Bovine Colostrum, Whey, and Their Combination with Other Natural Products: Effects on Human Peripheral Blood Mononuclear Cells. Current therapeutic research, clinical and experimental, 99, 100720.
  21. Constance JE, McFarland MM, Casucci T, Deininger MW, Enioutina EY, Job K, Lemons RS, Lim CS, Ward RM, Yellepeddi V, Watt K (2023). Mapping the Evidence for Opioid-Mediated Changes in Malignancy and Chemotherapeutic Efficacy: Protocol for a Scoping Review. JMIR research protocols, 12, e38167.
  22. Jain M, Anand A, Sharma N, Shamim MA, Enioutina E (2024). Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis. Nutrients, 16(20),
  23. Enioutina EY, Keddington RJ, Hauck KG, Chavez A, Clifford JJ, Cao TA, Smith B, Job KM, Balch (2024). Results of a Pilot Trial Assessing the Effects of Proper Oral Hygiene and a Probiotic Dietary Supplement on Oral Health in Volunteers with Oral Malodor. Microorganisms, 12(9),
  24. Feldkamp ML, Baum-Jones E, Enioutina EY, Krikov S, Kamath (2024). Association Between Self-Reported Infections and Seropositivity Among Pregnant Women With Gastroschisis: A Case Control Study, With Emphasis on Chlamydia trachomatis. Birth defects research, 116(9), e2400.
  25. Han X, Vollmer D, Yan X, Zhang Y, Zang M, Zhang C, Sherwin CM, Enioutina E (2024). Immunomodulatory Effects of Modified Colostrum, Whey, and Their Combination With Other Natural Products: Effects on Natural Killer Cells. Current therapeutic research, clinical and experimental, 101, 100750.
  26. Babenko AN, Krepkova LV, Borovkova MV, Kuzina OS, Mkhitarov VA, Job KM, Enioutina E (2024). Effects of Chicory (Cichorium intybus L.) Extract on Male Rat Reproductive System, Pregnancy and Offspring Development. Pharmaceuticals (Basel, Switzerland), 17(6),

Review

  1. Krepkova LV, Babenko AN, Saybel' OL, Lupanova IA, Kuzina OS, Job KM, Sherwin CM, Enioutina E (2021). Valuable Hepatoprotective Plants - How Can We Optimize Waste Free Uses of Such Highly Versatile Resources?. Frontiers in pharmacology, 12, 738504.
  2. Job KM, Roberts JK, Enioutina EY, Illamola SM, Kumar SS, Rashid J, Ward RM, Fukuda T, Sherbotie J, Sherwin C (2021). Treatment optimization of maintenance immunosuppressive agents in pediatric renal transplant recipients. Expert opinion on drug metabolism & toxicology, 17(7), 747-765.
  3. Sayre CL,Yellepeddi VK,Job KM,Krepkova LV,Sherwin CMT,Enioutina E (2023). Current use of complementary and conventional medicine for treatment of pediatric patients with gastrointestinal disorders. Frontiers in pharmacology, 14,
  4. Hudson RE,Job KM,Sayre CL,Krepkova LV,Sherwin CM,Enioutina E (2022). Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children. Frontiers in pharmacology, 13,
  5. Jain M, Stitt G, Son L, Enioutina E (2023). Probiotics and Their Bioproducts: A Promising Approach for Targeting Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus. Microorganisms, 11(10),
  6. Hudson RE, Metz TD, Ward RM, McKnite AM, Enioutina EY, Sherwin CM, Watt KM, Job K (2023). Drug exposure during pregnancy: Current understanding and approaches to measure maternal-fetal drug exposure. Frontiers in pharmacology, 14, 1111601.

Conference Proceedings

  1. Jonathan E. Buckendorf, Elena Y. Enioutin (2022). Virtual Laboratory Resources for Medical Microbiology Course.

Editorial

  1. Enioutina EY, Job KM, Sherwin CM (2020). Why we need to pay attention to toxicity associated with herbal medicines. 13(86(9)), 1793-1794.

Abstract

  1. JS Wagstaff, RM Eason, M Newman, CMT Sherwin, EY Enioutin (2018). Characterization and treatments of neonatal late-onset sepsis: a retrospective analysis of the University of Utah Hospital cases.