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Penelope J. Brockie, PhD

Languages spoken: English

Academic Information

Departments Primary - Neurobiology

Education History

Undergraduate Monash University
 BSc (Hons)
Doctoral Training University of Utah
 PhD

Selected Publications

Journal Article

  1. Lei N, Mellem JE, Brockie PJ, Madsen DM, Maricq AV (2017). NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength. Neuron, 96(6), 1303-1316.e6.
  2. Hoerndli FJ, Wang R, Mellem JE, Kallarackal A, Brockie PJ, Thacker C, Madsen DM, Maricq AV (2015). Neuronal Activity and CaMKII Regulate Kinesin-Mediated Transport of Synaptic AMPARs. Neuron, 86(2), 457-74.
  3. Hoerndli FJ, Maxfield DA, Brockie PJ, Mellem JE, Jensen E, Wang R, Madsen DM, Maricq AV (2013). Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron, 80(6), 1421-37.
  4. Brockie PJ, Jensen M, Mellem JE, Jensen E, Yamasaki T, Wang R, Maxfield D, Thacker C, Hoerndli F, Dunn PJ, Tomita S, Madsen DM, Maricq AV (2013). Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Neuron, 80(1), 129-42.
  5. Wang R, Mellem JE, Jensen M, Brockie PJ, Walker CS, Hoerndli FJ, Hauth L, Madsen DM, Maricq AV (2012). The SOL-2/Neto auxiliary protein modulates the function of AMPA-subtype ionotropic glutamate receptors. Neuron, 75(5), 838-50.
  6. Brockie PJ, Maricq AV (2010). In a pickle: is cornichon just relish or part of the main dish? Neuron, 68(6), 1017-9.
  7. Wang R, Walker CS, Brockie PJ, Francis MM, Mellem JE, Madsen DM, Maricq AV (2008). Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function. Neuron, 59(6), 997-1008.
  8. Mellem JE, Brockie PJ, Zheng Y, Madsen DM, Maricq AV (2002). Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans. Neuron, 36(5), 933-44.
  9. Brockie PJ, Mellem JE, Hills T, Madsen DM, Maricq AV (2001). The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion. Neuron, 31(4), 617-30.
  10. Zheng Y, Brockie PJ, Mellem JE, Madsen DM, Maricq AV (1999). Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor. Neuron, 24(2), 347-61.
  11. Jensen M, Hoerndli FJ, Brockie PJ, Wang R, Johnson E, Maxfield D, Francis MM, Madsen DM, Maricq AV (2012). Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell, 149(1), 173-87.
  12. Brockie PJ, Maricq AV (2006). Building a synapse: genetic analysis of glutamatergic neurotransmission. Biochem Soc Trans, 34(Pt 1), 64-7.
  13. Hills T, Brockie PJ, Maricq AV (2004). Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J Neurosci, 24(5), 1217-25.
  14. Brockie PJ, Madsen DM, Zheng Y, Mellem J, Maricq AV (2001). Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. J Neurosci, 21(5), 1510-22.
  15. Zheng Y, Mellem JE, Brockie PJ, Madsen DM, Maricq AV (2004). SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans. Nature, 427(6973), 451-7.
  16. Walker CS, Brockie PJ, Madsen DM, Francis MM, Zheng Y, Koduri S, Mellem JE, Strutz-Seebohm N, Maricq AV (2006). Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins. Proc Natl Acad Sci U S A, 103(28), 10781-6.
  17. Walker CS, Francis MM, Brockie PJ, Madsen DM, Zheng Y, Maricq AV (2006). Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Proc Natl Acad Sci U S A, 103(28), 10787-92.
  18. Zheng Y, Brockie PJ, Mellem JE, Madsen DM, Walker CS, Francis MM, Maricq AV (2006). SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans. Proc Natl Acad Sci U S A, 103(4), 1100-5.
  19. Walker CS, Jensen S, Ellison M, Matta JA, Lee WY, Imperial JS, Duclos N, Brockie PJ, Madsen DM, Isaac JT, Olivera B, Maricq AV (2009). A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr Biol, 19(11), 900-8.
  20. Kano T, Brockie PJ, Sassa T, Fujimoto H, Kawahara Y, Iino Y, Mellem JE, Madsen DM, Hosono R, Maricq AV (2008). Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors. Curr Biol, 18(13), 1010-5.
  21. Mellem JE, Brockie PJ, Madsen DM, Maricq AV (2008). Action potentials contribute to neuronal signaling in C. elegans. Nat Neurosci, 11(8), 865-7.
  22. Brockie PJ, Maricq AV (2003). Ionotropic glutamate receptors in Caenorhabditis elegans. Neurosignals, 12(3), 108-25.
  23. Brockie PJ, Maricq AV (2006). Ionotropic glutamate receptors: genetics, behavior and electrophysiology. WormBook, 1-16.
  24. Hoerndli FJ, Brockie PJ, Wang R, Mellem JE, Kallarackal A, Doser RL, Pierce DM, Madsen DM, Maricq A (2022). MAPK signaling and a mobile scaffold complex regulate AMPA receptor transport to modulate synaptic strength. Cell reports, 38(13), 110577.
  25. Goodell DJ, Whitby FG, Mellem JE, Lei N, Brockie PJ, Maricq AJ, Eckert DM, Hill CP, Madsen DM, Maricq A (2024). Mechanistic and structural studies reveal NRAP-1-dependent coincident activation of NMDARs. Cell reports, 43(2), 113694.

Editorial

  1. Jensen M, Brockie PJ, Maricq AV (2012). Wnt signaling regulates experience-dependent synaptic plasticity in the adult nervous system. Cell Cycle, 11(14), 2585-6.