Karim Khader

Karim Khader, PhD, MStat, MS

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine , Adjunct - Population Health Sciences

Divisions: Epidemiology

Karim Khader's research areas of interest are the advancing of statistical methodology and the use of mathematical models and computer simulations to understand the behavior of complex systems. These two general interests are complementary to one another; mathematical modeling and computer simulation represent a data-generating process which can be analyzed through the use of various statistical methodologies, while advances in statistical methodologies are needed to inform and parameterize computer simulations as the data-generating processes become increasingly complex. He has pursued these interests across multiple domains of study with a particular focus on transmission and infection due to antimicrobial resistant organisms in healthcare facilities, particularly with respect to understanding how to improve patient outcomes by reducing rates of healthcare-associated infections and gaining deeper insights into the key factors that result in infection.

Education History

Postdoctoral Fellowship Division of Epidemiology, University of Utah
 Postdoctoral Fellow
University of Utah
 PhD
Graduate Training University of Utah
 MStat
University of Rhode Island
 MS
Undergraduate University of Utah
 BS

Selected Publications

Journal Article

  1. Nelson Chang NC, Leecaster M, Fridkin S, Dube W, Katz M, Polgreen P, Roghmann MC, Khader K, Li L, Dumyati G, Tsay R, Lynfield R, Mahoehney JP, Nadle J, Hutson J, Pierce R, Zhang A, Wilson C, Haroldsen C, Mulvey D, Reddy SC, Stone ND, Slayton RB, Thompson ND, Stratford K, Samore M, Visnovsky LD (2023). Assessing Pathogen Transmission Opportunities: Variation in Nursing Home Staff-Resident Interactions. J Am Med Dir Assoc, 24(5), 735.e1-735.e9. (Read full article)
  2. Britt NS, Khader K, He T, Willson TM, Effiong A, Timbrook TT, Potter EM, Lodise TP (2022). Examining the clinical impact of rapid multiplex polymerase chain reaction-based diagnostic testing for bloodstream infections in a national cohort of the Veterans Health Administration. Pharmacotherapy, 43(1), 24-34. (Read full article)
  3. Jones M, Khader K, Branch-Elliman W (2022). Estimated Impact of the US COVID-19 Vaccination Campaign-Getting to 94% of Deaths Prevented. JAMA Netw Open, 5(7), e2220391. (Read full article)
  4. Livorsi DJ, Chorazy ML, Schweizer ML, Balkenende EC, Blevins A, Nair R, Samore M, Nelson RE, Khader K, Perencevich EN (2018). A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States. Antimicrob Resist Infect Control, 7(1).
  5. Thomas A, Khader K, Redd A, Leecaster M, Zhang Y, Jones M, Greene T, Samore M (2018). Extended models for nosocomial infection: parameter estimation and model selection. Math Med Biol, 35(suppl_1), 29-49. (Read full article)
  6. Perencevich EN, Harris AD, Pfeiffer CD, Rubin MA, Hill JN, Baracco GJ, Evans ME, Klutts JS, Streit JA, Nelson RE, Khader K, Reisinger HS (2018). Establishing a Research Agenda for Preventing Transmission of Multidrug-Resistant Organisms in Acute-Care Settings in the Veterans Health Administration. Infect Control Hosp Epidemiol, 39(2), 189-195.
  7. McDanel J, Schweizer M, Crabb V, Nelson R, Samore M, Khader K, Blevins AE, Diekema D, Chiang HY, Nair R, Perencevich E (2017). Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review. Infect Control Hosp Epidemiol, 38(10), 1209-1215.
  8. Nelson RE, Slayton RB, Stevens V, Jones M, Khader K, Rubin MA, Jernigan JA, Samore M (2017). Attributable Mortality of Healthcare-Associated Infections Due to Multidrug-Resistant Gram-Negative Bacteria and Methicillin-Resistant Staphylococcus Aureus. Infect Control Hosp Epidemiol, 38(07), 1-9.
  9. Toth DJA, Khader K, Slayton RB, Kallen AJ, Gundlapalli AV, OHagan JJ, Fiore AE, Rubin MA, Jernigan JA, Samore MH (2017). The potential for interventions in a long-term acute care hospital to reduce transmission of carbapenem-resistant enterobacteriaceae in affiliated healthcare facilities. Clin Infect Dis.
  10. Stevens VW, Nelson RE, Schwab-Daugherty EM, Khader K, Jones MM, Brown KA, Greene T, Croft LD, Neuhauser M, Glassman P, Goetz MB, Samore MH, Rubin MA (2017). Comparative effectiveness of vancomycin and metronidazole for the prevention of recurrence and death in patients with clostridium difficile infection. JAMA Intern Med.
  11. Nelson R, Deka R, Khader K, Stevens V, Schweizer M, Rubin M (2017). Dynamic transmission models for economic analysis applied to healthcare associated infections: A review of the literature. Am J Infect Control.
  12. Khader K, Thomas A, Huskins WC, Leecaster M, Zhang Y, Greene T, Redd A, Samore MH (2017). A dynamic transmission model to evaluate the effectiveness of infection control strategies. Open Forum Infect Dis.
  13. Chiang HY, Perencevich EN, Nair R, Nelson RE, Samore M, Khdaer K, Chorazy ML, Herwaldt LA, Blevins A, Ward MA, Schweizer ML (2017). Incidence and outcomes associated with infections caused by vancomycin-resistant enterococci in the united states: systematic literature review and meta-analysis. Infect Control Hosp Epidemiol.
  14. Nelson R, Schweizer M, Perencevich E, Nelson S, Khader K, Chiang H, Chorazy M, Blevins A, Ward M, Samore M (2016). Costs and mortality associated with healthcare-associated multi-drug resistant Acinetobacter infections. Infect Control Hosp Epidemiol.
  15. Toth D, Tanner W, Khader K, Gundlapalli A (2016). Estimates of the risk of a large or long-lasting outbreak of Middle East respiratory syndrome (MERS) after an importation outside the Arabian Peninsula. Epidemics.
  16. Nelson RE, Jones M, Leecaster M, Samore MH, Ray W, Huttner A, Huttner B, Khader K, Stevens VW, Gerding D, Schweizer ML, Rubin MA (2016). An Economic Analysis of Strategies to Control Clostridium Difficile Transmission and Infection Using an Agent-Based Simulation Model. PLoS One.
  17. Nelson RE, Samore MH, Khader K, Jones M, Stevens V, Evans ME, Schweizer ML, Perencevich EL, Rubin MA (2016). Economic analysis of Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. Am J Prev Med.
  18. Slayton R, Toth D, Lee B, Tanner W, Bartsch S, Khader K, Wong K, Brown K, McKinnell J, Ray W, Miller L, Rubin M, Kim D, Adler F, Cao C, Avery L, Stone N, Kallen A, Samore M, Huang S, Fridkin S, Jernigan J (2015). Vital Signs: Estimated effects of a coordinated approach for action to reduce antibiotic-resistant infections in health care facilities — United States. MMWR Morb Mortal Wkly Rep.
  19. Toth D, Gudlapalli A, Khader K, Pettey W, Rubin M, Adler F, Samore M (2015). Estimates of outbreak risk from new introductions of Ebola with immediate and delayed transmission control. Emerg Infect Dis.
  20. Nelson R, Nelson S, Khader K, Perencevich E, Schweizer M, Rubin M, Graves N, Harbarth S, Stevens V, Samore M (2015). The magnitude of time-dependent bias in the estimation of excess length of stay attributable to healthcare-associated infections. Infect Control Hosp Epidemiol.
  21. Stevens V, Khader K, Nelson R, Jones M, Rubin M, Brown K, Evans M, Greene T, Slade E, Samore M (2015). Excess length of stay attributable to clostridium difficile infection (CDI) in the acute care setting: A multistate model. Infect Control Hosp Epidemiol.
  22. Thomas A, Redd A, Khader K, Leecaster M, Greene T, Samore M (2015). Efficient parameter estimation for models of healthcare-associated pathogen transmission in discrete and continuous time. Math Med Biol, 32(1), 79-98. (Read full article)
  23. Khader K, Leecaster M, Greene T, Samore M, Thomas A (2014). Improved hidden Markov model for nosocomial infections. Math Med Biol, 31(4), 338-52. (Read full article)
  24. Jones M, Nielson C, Gupta K, Khader K, Evans M (2014). Collateral benefit of screening patients for methicillin-resistant Staphylococcus aureus at hospital admission: Isolation of patients with multidrug-resistant gram-negative bacteria. Am J Infect Control.
  25. Fridkin S, Baggs J, Fagan R, Magill S, Pollack L, Malpiedi P, Slayton R, Khader K, Rubin M, Jones M, Samore M, Dumyati G, Dodds-Ashley E, Meek J, Yousey-Hindes K, Jernigan J, Shehab N, Herrera R, McDonald C, Schneider A, Srinivasan A (2014). Vital Signs: Improving antibiotic use among hospitalized patients. MMWR Morb Mortal Wkly Rep.
  26. Rubin MA, Jones M, Leecaster M, Khader K, Ray W, Huttner A, Huttner B, Toth D, Sablay T, Borotkanics RJ, Gerding DN, Samore MH (2013). A simulation-based assessment of strategies to control Clostridium difficile transmission and infection. PLoS One, 8(11), e80671. (Read full article)