Lawrence J. Cook, PhD

Languages spoken: English

Academic Information

Departments: Pediatrics - Professor, Family & Preventive Medicine - Adjunct Associate Professor

Divisions: Pediatric Critical Care, Public Health

Academic Office Information

larry.cook@hsc.utah.edu

Research Interests

  • Probabilistic Linkage
  • Databases
  • Analysis of Missing Data
  • Research Design
  • Epidemiologic Research Design
  • Experimental Design, Outcomes Research
  • Research Methodology
  • Injury in Children
  • Injury Prevention
  • Traumatic Brain Injury
  • Motor Vehicles

Dr. Lawrence Cook is a Professor in Pediatric Critical Care. He has more than two decades of experience with probabilistic linkage theory and its application. He is the PI of the Utah Crash Outcome Data Evaluation System (CODES) and led the CODES Technical Assistance Center where he was responsible for assisting with the design and evaluation of linkage models for all states in the CODES Data Network. He was also responsible for conducting multi-state analyses and developed a General Use Model for combining linked crash and hospital data from multiple states.

Dr. Cook provides leadership for data coordination and analysis activities for projects at the University of Utah Data Coordinating Center (DCC). He is the PI of the Guthy-Jackson Charitable Foundation-funded CIRCLES study, which created a longitudinal registry and biorepository of patients with Neuromyelitis Optical Spectrum Disorders (NMOSD). He is the PI of the DCC for the CARE4Kids study, which aims to develop a clinical decision rule to identify early to middle adolescents at risk for developing persistent post concussive symptoms.

Dr. Cook serves as a faculty statistician for the Pediatric Emergency Care Applied Research Network (PECARN) where he oversees DCC activities for a variety of projects including the PECARN Registry and the PEDScreen and C-Spine prediction rule studies.

Education History

Doctoral Training Utah State University, Department of Mathematics and Statistics
 Ph.D.
Other Training Johns Hopkins Bloomberg School of Public Health, Summer Institute of Epidemiology & Biostatistics
Principles and Practice of Injury Prevention
Graduate Training University of Utah, Department of Mathematics
Statistics 		M.Stat
Undergraduate University of Utah
Mathematics 		B.S.

Selected Publications

  1. Oertel FC, Zimmermann HG, Motamedi S, Chien C, Aktas O, Albrecht P, Ringelstein M, Dcunha A, Pandit L, Martinez-Lapiscina EH, Sanchez-Dalmau B, Villoslada P, Palace J, Roca-Fernndez A, Leite MI, Sharma SM, Leocani L, Pisa M, Radaelli M, Lana-Peixoto MA, Fontenelle MA, Havla J, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Marignier R, Cobo-Calvo A, Asgari N, Jacob A, Huda S, Mao-Draayer Y, Green AJ, Kenney R, Yeaman MR, Smith TJ, Cook L, Brandt AU, Paul F, Petzold A (2023). Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry.
  2. Gholizadeh S, Exuzides A, Lewis KE, Palmer C, Waltz M, Rose JW, Jolley AM, Behne JM, Behne MK, Blaschke TF, Smith TJ, Sinnott J, Cook LJ, Yeaman MR, Guthy-Jackson Charitable Foundation CIRCLES Study Group (2022). Clinical and epidemiological correlates of treatment change in patients with NMOSD: insights from the CIRCLES cohort. J Neurol.
  3. Delgado-Corcoran C, Wawrzynski SE, Flaherty B, Kirkland B, Bodily S, Moore D, Cook LJ, Olson LM (2022). Extracorporeal membrane oxygenation and paediatric palliative care in an ICU. Cardiol Young, 1-7.
  4. Benedetti MH, Humphries KD, Codden R, Sagar S, Kufera JA, Cook LJ, Norris J, Stamatiadis N, Vesselinov R, Zhu M (2022). Age-based variability in the association between restraint use and injury type and severity in multi-occupant crashes. Ann Epidemiol, 76, 114-120.e2.
  5. Carlson KF, Gilbert TA, DeFrancesco S, Wright DA, Shen X, Cook LJ (2022). Accuracy of behavioral health variables in Oregon national violent death reporting system data: a linked cohort study. Inj Epidemiol, 9(1), 29.
  6. Sagar S, Stamatiadis N, Codden R, Benedetti M, Cook L, Zhu M (2022). Socioeconomic and Demographic Factors Effect in Association with Driver's Medical Services after Crashes. Int J Environ Res Public Health, 19(15).
  7. Wells JM, Rodean J, Cook L, Sills MR, Neuman MI, Kornblith AE, Jain S, Hirsch AW, Goyal MK, Fleegler EW, DeLaroche AM, Aronson PL, Leonard JC (2022). Injury-Related Pediatric Emergency Department Visits in the First Year of COVID-19. Pediatrics, 150.
  8. Dorsey BF, Kamimura A, Cook LJ, Kadish HA, Cook HK, Kang A, Nguyen JBT, Holsti M (2022). Communication Gaps Between Providers and Caregivers of Patients in a Pediatric Emergency Department. J Patient Exp, 9, 23743735221112223.
  9. Chaiyachati BH, Wood JN, Carter C, Lindberg DM, Chun TH, Cook LJ, Alpern ER, PECARN Registry Study Group and PECARN Child Abuse Special Interest Group (2022). Emergency Department Child Abuse Evaluations During COVID-19: A Multicenter Study. Pediatrics, 150(1).
  10. Oertel FC, Sotirchos ES, Zimmermann HG, Motamedi S, Specovius S, Asseyer ES, Chien C, Cook L, Vasileiou E, Filippatou A, Calabresi PA, Saidha S, Pandit L, DCunha A, Outteryck O, Zphir H, Pittock S, Flanagan EP, Bhatti MT, Rommer PS, Bsteh G, Zrzavy T, Kuempfel T, Aktas O, Ringelstein M, Albrecht P, Ayzenberg I, Pakeerathan T, Knier B, Aly L, Asgari N, Soelberg K, Marignier R, Tilikete CF, Calvo AC, Villoslada P, Sanchez-Dalmau B, Martinez-Lapiscina EH, Llufriu S, Green AJ, Yeaman MR, Smith TJ, Brandt AU, Chen J, Paul F, Havla J, with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group (2022). Longitudinal retinal changes in MOGAD. Ann Neurol, 92, 476-485.
  11. Balamuth F, Scott HF, Weiss SL, Webb M, Chamberlain JM, Bajaj L, Depinet H, Grundmeier RW, Campos D, Deakyne Davies SJ, Simon NJ, Cook LJ, Alpern ER, Pediatric Emergency Care Applied Research Network PECARN PED Screen and PECARN Registry Study Groups (2022). Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Third International Consensus Definitions for Sepsis and Septic Shock Definitions in the Pediatric Emergency Department. JAMA Pediatr, 176, 672-678.
  12. Delgado-Corcoran C, Wawrzynski SE, Mansfield KJ, Flaherty B, DeCourcey DD, Moore D, Cook LJ, Ullrich CK, Olson LM (2022). An Automatic Pediatric Palliative Care Consultation for Children Supported on Extracorporeal Membrane Oxygenation: A Survey of Perceived Benefits and Barriers. J Palliat Med, 25, 952-957.
  13. Goyal MK, Drendel AL, Chamberlain JM, Wheeler J, Olsen C, Grundmeier RW, Cook L, Bajaj L, Babcock L, Zorc JJ, Johnson T, Alpern ER, Pediatric Emergency Care Applied Research Network PECARN Registry Study Group (2021). Racial/Ethnic Differences in ED Opioid Prescriptions for Long Bone Fractures: Trends Over Time. Pediatrics, 148(5).
  14. Lu A, Zimmermann HG, Specovius S, Motamedi S, Chien C, Bereuter C, Lana-Peixoto MA, Fontenelle MA, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, DCunha A, Kim HJ, Hyun JW, Jung SK, Leocani L, Pisa M, Radaelli M, Siritho S, May EF, Tongco C, De Sze J, Senger T, Palace J, Roca-Fernndez A, Leite MI, Sharma SM, Stiebel-Kalish H, Asgari N, Soelberg KK, Martinez-Lapiscina EH, Havla J, Mao-Draayer Y, Rimler Z, Reid A, Marignier R, Cobo-Calvo A, Altintas A, Tanriverdi U, Yildirim R, Aktas O, Ringelstein M, Albrecht P, Tavares IM, Bichuetti DB, Jacob A, Huda S, Soto de Castillo I, Petzold A, Green AJ, Yeaman MR, Smith TJ, Cook L, Paul F, Brandt AU, Oertel FC, GJCF International Clinical Consortium for NMOSD (2021). Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry, 93, 188-195.
  15. Curry AE, Pfeiffer MR, Metzger KB, Carey ME, Cook LJ (2021). Development of the integrated New Jersey Safety and Health Outcomes (NJ-SHO) data warehouse: catalysing advancements in injury prevention research. Inj Prev, 27(5), 472-478.
  16. Oertel FC, Specovius S, Zimmermann HG, Chien C, Motamedi S, Bereuter C, Cook L, Lana Peixoto MA, Fontanelle MA, Kim HJ, Hyun JW, Palace J, Roca-Fernandez A, Leite MI, Sharma S, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, DCunha A, Aktas O, Ringelstein M, Albrecht P, May E, Tongco C, Leocani L, Pisa M, Radaelli M, Martinez-Lapiscina EH, Stiebel-Kalish H, Siritho S, de Seze J, Senger T, Havla J, Marignier R, Calvo AC, Bichuetti D, Tavares IM, Asgari N, Soelberg K, Altintas A, Yildirim R, Tanriverdi U, Jacob A, Huda S, Rimler Z, Reid A, Mao-Draayer Y, Soto de Castillo I, Petzold A, Green AJ, Yeaman MR, Smith T, Brandt AU, Paul F (2021). Retinal Optical Coherence Tomography in Neuromyelitis Optica. Neurol Neuroimmunol Neuroinflamm, 8(6).
  17. Goyal MK, Chamberlain JM, Webb M, Grundmeier RW, Johnson TJ, Lorch SA, Zorc JJ, Alessandrini E, Bajaj L, Cook L, Alpern ER, Pediatric Emergency Care Applied Research Network PECARN (2020). Racial and ethnic disparities in the delayed diagnosis of appendicitis among children. Acad Emerg Med, 28(9), 949-956.
  18. Delgado-Corcoran C, Bennett EE, Bodily SA, Wawrzynski SE, Green D, Moore D, Cook LJ, Olson LM (2021). Prevalence of specialised palliative care consultation for eligible children within a paediatric cardiac ICU. Cardiol Young, 31(9), 1458-1464.
  19. Ashraf AJ, Gilbert TA, Holmer HK, Cook LJ, Carlson KF (2021). Receipt of Concurrent VA and Non-VA Opioid and Sedative-Hypnotic Prescriptions Among Post-9/11 Veterans With Traumatic Brain Injury. J Head Trauma Rehabil, 36(5), 364-373.
  20. Exuzides A, Sheinson D, Sidiropoulos P, Magrini F, Gholizadeh S, Surinach A, Cook L, Meyer CS, Yeaman M (2021). Burden and cost of comorbidities in patients with neuromyelitis optica spectrum disorder. J Neurol Sci, 427, 117530.
  21. Exuzides A, Sheinson D, Sidiropoulos P, Gholizadeh S, Magrini F, Surinach A, Cook L, Meyer CS, Yeaman MR (2021). The costs of care from a US claims database in patients with neuromyelitis optica spectrum disorder. J Neurol Sci, 427, 117553.
  22. Kamins J, Richards R, Barney BJ, Locandro C, Pacchia CF, Charles AC, Cook LJ, Gioia G, Giza CC, Blume HK (2021). Evaluation of Posttraumatic Headache Phenotype and Recovery Time After Youth Concussion. JAMA Netw Open, 4(3), e211312.
  23. Rosenbaum PE, Locandro C, Chrisman SPD, Choe MC, Richards R, Pacchia C, Cook LJ, Rivara FP, Gioia GA, Giza CC (2020). Characteristics of Pediatric Mild Traumatic Brain Injury and Recovery in a Concussion Clinic Population. JAMA Netw Open, 3(11), e2021463.
  24. Specovius S, Zimmermann HG, Oertel FC, Chien C, Bereuter C, Cook LJ, Lana Peixoto MA, Fontenelle MA, Kim HJ, Hyun JW, Jung SK, Palace J, Roca-Fernandez A, Diaz AR, Leite MI, Sharma SM, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, Dcunha A, Aktas O, Ringelstein M, Albrecht P, May E, Tongco C, Leocani L, Pisa M, Radaelli M, Martinez-Lapiscina EH, Stiebel-Kalish H, Hellmann M, Lotan I, Siritho S, de Seze J, Senger T, Havla J, Marignier R, Tilikete C, Cobo Calvo A, Bichuetti DB, Tavares IM, Asgari N, Soelberg K, Altintas A, Yildirim R, Tanriverdi U, Jacob A, Huda S, Rimler Z, Reid A, Mao-Draayer Y, de Castillo IS, Yeaman MR, Smith TJ, Brandt AU, Paul F, GJCF International Clinical Consortium for NMOSD (2020). Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO). BMJ Open, 10(10), e035397.
  25. Brousseau DC, Alpern ER, Chamberlain JM, Ellison AM, Bajaj L, Cohen DM, Hariharan S, Cook LJ, Harding M, Panepinto J, Pediatric Emergency Care Applied Research Network PECARN (2020). A Multiyear Cross-sectional Study of Guideline Adherence for the Timeliness of Opioid Administration in Children With Sickle Cell Pain Crisis. Ann Emerg Med, 76(3S), S6-S11.
  26. Yandamuri SS, Jiang R, Sharma A, Cotzomi E, Zografou C, Ma AK, Alvey JS, Cook LJ, Smith TJ, Yeaman MR, OConnor KC, Guthy-Jackson Charitable Foundation CIRCLES Study Group (2020). High-throughput investigation of molecular and cellular biomarkers in NMOSD. Neurol Neuroimmunol Neuroinflamm, 7(5).
  27. Govindarajan P, Shiboski S, Grimes B, Cook LJ, Ghilarducci D, Meng T, Trickey AW (2019). Effect of Acute Stroke Care Regionalization on Intravenous Alteplase Use in Two Urban Counties. Prehosp Emerg Care, 24(4), 505-514.
  28. Fujihara K, Cook LJ (2020). Neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease: current topics. Curr Opin Neurol, 33(3), 300-308.
  29. Mealy MA, Kozachik SL, Cook LJ, Totonis L, Salazar RA, Allen JK, Nolan MT, Smith TJ, Levy M (2020). Scrambler therapy improves pain in neuromyelitis optica: A randomized controlled trial. Neurology, 94(18), e1900-e1907.
  30. Delgado-Corcoran C, Wawrzynski SE, Bennett EE, Green D, Bodily S, Moore D, Cook LJ, Olson LM (2020). Palliative Care in Children With Heart Disease Treated in an ICU. Pediatr Crit Care Med, 21(5), 423-429.
  31. Johnson MD, Zorc JJ, Nelson DS, Casper TC, Cook LJ, Finkelstein Y, Babcock L, Bajaj L, Chamberlain JM, Grundmeier RW, Webb M, Alpern ER, Pediatric Emergency Care Applied Research Network PECARN (2020). Intravenous Magnesium in Asthma Pharmacotherapy: Variability in Use in the PECARN Registry. J Pediatr, 220, 165-174.e2.
  32. Goyal MK, Johnson TJ, Chamberlain JM, Cook L, Webb M, Drendel AL, Alessandrini E, Bajaj L, Lorch S, Grundmeier RW, Alpern ER, PEDIATRIC EMERGENCY CARE APPLIED RESEARCH NETWORK PECARN (2020). Racial and Ethnic Differences in Emergency Department Pain Management of Children With Fractures. Pediatrics, 145(5).
  33. Cook LJ, Rose JW, Alvey JS, Jolley AM, Kuhn R, Marron B, Pederson M, Enriquez R, Yearley J, McKechnie S, Han MH, Tomczak AJ, Levy M, Mealy MA, Coleman J, Bennett JL, Johnson R, Barnes-Garcia M, Traboulsee AL, Carruthers RL, Lee LE, Schubert JJ, McMullen K, Kister I, Rimler Z, Reid A, Sicotte NL, Planchon SM, Cohen JA, Ivancic D, Sedlak JL, Sand IK, Repovic P, Amezcua L, Pruitt A, Amundson E, Chitnis T, Mullin DS, Klawiter EC, Russo AW, Riley CS, Onomichi KB, Levine L, Nelson KE, Nealon NM, Engel C, Kruse-Hoyer M, Marcille M, Tornes L, Rumpf A, Greer A, Kenneally Behne M, Rodriguez RR, Behne DW, Blackway DW, Coords B, Blaschke TF, Sheard J, Smith TJ, Behne JM, Yeaman MR, Guthy-Jackson Charitable Foundation International Clinical Consortium GJCFICC (2019). Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD. Neurol Neuroimmunol Neuroinflamm, 6(5), e583.
  34. Beekman J, Keisler A, Pedraza O, Haramura M, Gianella-Borradori A, Katz E, Ratchford JN, Barron G, Cook LJ, Behne JM, Blaschke TF, Smith TJ, Yeaman MR (2019). Neuromyelitis optica spectrum disorder: Patient experience and quality of life. Neurol Neuroimmunol Neuroinflamm, 6(4), e580.
  35. Alghnam S, Bell TM, Cook LJ, Alqahtani F, Castillo R (2019). Maternal and child health after injuries: a two-year follow-up of a nationally representative sample. Public Health, 168, 76-82.
  36. Curry AE, Pfeiffer MR, Carey ME, Cook LJ (2019). Catalyzing traffic safety advancements via data linkage: Development of the New Jersey Safety and Health Outcomes (NJ-SHO) data warehouse. Traffic Inj Prev, 20(sup2), S151-S155.
  37. Olson LM, Campbell KA, Cook L, Keenan HT (2018). Social history: A qualitative analysis of child abuse pediatricians' consultation notes. Child Abuse Negl, 86, 267-277.
  38. Olsen CS, Thomas AM, Cook LJ (2013). Hospital charges associated with motorcycle crash factors: a quantile regression analysis. Inj Prev, 20(4), 276-80.
  39. Campbell KA, Cook LJ, LaFleur BJ, Keenan HT (2010). Household, family, and child risk factors after an investigation for suspected child maltreatment: a missed opportunity for prevention. Arch Pediatr Adolesc Med, 164(10), 943-9.
  40. Edelman LS, Cook LJ, Saffle JR (2010). Burn injury in Utah: demographic and geographic risks. J Burn Care Res, 31(3), 375-84.