Karen Curtin

Karen Curtin, PhD, MStat

Languages spoken: Modern Greek, Spanish, English

Academic Information

Departments Adjunct - Ophthalmology & Visual Sciences

Lab

Karen Curtin (Ph.D., M.Stat.) is an Associate Professor in the Department of Internal Medicine, Division of Epidemiology and adjunct Associate Professor in Ophthalmology and Visual Sciences at the University of Utah School of Medicine and the John A. Moran Eye Center. Dr. Curtin serves as Interim Director of the Utah Population Database (UPDB), a unique shared resource housed at the University of Utah's Huntsman Cancer Institute where she is affiliated with Pedigree and Population Resource, the group that administers and supports research using the database. She is a Co-Investigator with the Steele Center for Translational Medicine at the Moran Eye Center and is adjunct faculty in the Division of Public Health where she serves on the Master of Biostatistics committee. Through her many affiliations Dr. Curtin, a genetic epidemiologist and population-based scientist, collaborates widely with investigators across the University of Utah Health Sciences Center, Huntsman Cancer Institute, Intermountain Healthcare, and other academic institutions. Dr. Curtin is a Huntsman Cancer Institute investigator and member of the Cancer Control and Population Sciences program, with a keen interest in the interaction of genetic, environmental, and molecular risk factors in the development of cancer and predisposing conditions.

Her wide array of research interests and experience in research infrastructure and project development have resulted several in cross-disciplinary collaborations. Focused on preventive and translational research, she is currently investigating mammographic breast density in relation to interval breast cancer and endocrine therapy-induced changes in breast density in a statewide cohort of women. Dr. Curtin is conducting population-based research to elucidate the genetic underpinnings of myeloid disorders and malignancies utilizing multigenerational, high-risk pedigrees unique to Utah. She established ongoing and productive collaborations with renowned translational and clinical investigators in age-related macular degeneration and exfoliation syndrome/glaucoma and associated comorbidities. She continues to pursue population-based investigations in gastrointestinal cancers with colleagues at the University of Utah and Mayo Clinic, and previously partnered with College of Pharmacy and Intermountain Healthcare to investigate a statewide cohort of amphetamine-type stimulant users to examine future incidence of Parkinson's disease.

Dr. Curtin received her PhD in biomedical informatics with an emphasis in genetic epidemiology from the University of Utah, where she was awarded the John D. Morgan Fellowship Award in Biomedical Informatics. Following post-doctoral training in molecular and risk factor epidemiology at Utah, Dr. Curtin received a faculty appointment in the Department of Internal Medicine. Prior to pursuing an academic career, she was a Master's level biostatistician on several large, population-based cancer studies. A prolific and extensively published researcher, Dr. Curtin is principal investigator of several internally and externally funded studies. She was invited to speak at the prestigious Lindberg Society Symposium at the 2018 World Ophthalmology Congress and recently received an award from the BrightFocus(R) Foundation's National Glaucoma Research Program to study prognostic factors and predictive markers of progression to exfoliation glaucoma in exfoliation syndrome.

Research Statement

As a cancer and genetic epidemiologist I serve as the Interim Director of Pedigree & Population Resource, the group that maintains the Utah Population Database (UPDB), a shared resource at the Huntsman Cancer Institute (HCI). For nearly 40 years, the UPDB has been a cornerstone of support for genetic and risk factor research into many cancer-related phenotypes. Currently, more than 290 active projects are supported by the UPDB resource. In addition to pursuing my own research interests in colorectal and breast cancer, I collaborate with investigators across the University of Utah Health Sciences Center to facilitate research using the UPDB which includes cancer registry information, vital records, and medical records for ~11 million individuals of whom many link to genealogy records. I am an HCI investigator and actively participate in the Cancer Control and Population Sciences program, with a keen interest in the interaction of genetic and environmental risk factors in the development of cancers, including syndromic constellations of cancers, using the unique research resources available in Utah. My experience in research infrastructure and project development have resulted in several highly productive collaborations within HCI and the University of Utah School of Medicine. As my publications demonstrate, I possess the skills to collaborate successfully on a project to identify determine the relationship between Li-Fraumeni Syndrome (LFS) and Leiomyosarcoma (LMS), including TP53 genotype-phenotype correlation to investigate the hypothesis that LMS risk in the population is significantly higher in LFS patients. I have both the academic training and experience in development of methods and approaches to assess genetic, familial, and population-level risk factors in the development of multifactorial diseases such as syndromic cancers that cluster in pedigrees

Education History

Undergraduate University of Utah, College of Business
 BS
Graduate Training University of Utah, College of Social and Behavioral Sciences
 MStat
Doctoral Training University of Utah School of Medicine, Clinical and Translational Track: Genetic Epidemiology
 PhD

Selected Publications

Journal Article

  1. Curtin K, Iles MM, Camp N (2009). Identifying rarer genetic variants for common complex diseases: diseased versus neutral discovery panels. Annals of human genetics, 73(1), 54-60.
  2. Samadder NJ, Smith KR, Mineau GP, Pimentel R, Wong J, Boucher K, Pappas L, Singh H, Ahnen D, Burt RW, Curtin (2015). Familial colorectal cancer risk by subsite of primary cancer: a population-based study in Utah. Alimentary pharmacology & therapeutics, 41(6), 573-80.
  3. Slattery ML, Curtin K, Wolff RK, Herrick JS, Caan BJ, Samowitz (2010). Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes. Cancer causes & control, 21(8), 1237-45.
  4. Makar KW, Poole EM, Resler AJ, Seufert B, Curtin K, Kleinstein SE, Duggan D, Kulmacz RJ, Hsu L, Whitton J, Carlson CS, Rimorin CF, Caan BJ, Baron JA, Potter JD, Slattery ML, Ulrich C (2013). COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. Cancer causes & control, 24(12), 2059-75.
  5. Rogers CR, Blackburn BE, Huntington M, Curtin K, Thorpe RJ Jr, Rowe K, Snyder J, Deshmukh V, Newman M, Fraser A, Smith K, Hashibe (2020). Rural-urban disparities in colorectal cancer survival and risk among men in Utah: a statewide population-based study. Cancer causes & control, 31(3), 241-253.
  6. Slager SL, Lanasa MC, Marti GE, Achenbach SJ, Camp NJ, Abbasi F, Kay NE, Vachon CM, Cerhan JR, Johnston JB, Call TG, Rabe KG, Kleinstern G, Boddicker NJ, Norman AD, Parikh SA, Leis JF, Banerji V, Brander DM, Glenn M, Ferrajoli A, Curtin K, Braggio E, Shanafelt TD, McMaster ML, Weinberg JB, Hanson CA, Caporaso N (2021). Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families. Blood, 137(15), 2046-2056.
  7. Curtin K, Fleckenstein AE, Keeshin BR, Yurgelun-Todd DA, Renshaw PF, Smith KR, Hanson G (2018). Increased risk of diseases of the basal ganglia and cerebellum in patients with a history of attention-deficit/hyperactivity disorder. Neuropsychopharmacology, 43(13), 2548-2555.
  8. Curtin K, Bigler J, Slattery ML, Caan B, Potter JD, Ulrich C (2004). MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer. Cancer epidemiology, biomarkers & prevention, 13(2), 285-92.
  9. Curtin K, Lin WY, George R, Katory M, Shorto J, Cannon-Albright LA, Bishop DT, Cox A, Camp NJ, Colorectal Cancer Study Group (2009). Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21. Cancer epidemiology, biomarkers & prevention, 18(2), 616-21.
  10. Curtin K, Lin WY, George R, Katory M, Shorto J, Cannon-Albright LA, Smith G, Bishop DT, Cox A, Camp NJ, Colorectal Cancer Study Group (2009). Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis. Cancer epidemiology, biomarkers & prevention, 18(9), 2476-84.
  11. Curtin K, Samowitz WS, Wolff RK, Ulrich CM, Caan BJ, Potter JD, Slattery M (2009). Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. Cancer epidemiology, biomarkers & prevention, 18(12), 3384-8.
  12. Rand KA, Song C, Dean E, Serie DJ, Curtin K, Sheng X, Hu D, Huff CA, Bernal-Mizrachi L, Tomasson MH, Ailawadhi S, Singhal S, Pawlish K, Peters ES, Bock CH, Stram A, Van Den Berg DJ, Edlund CK, Conti DV, Zimmerman T, Hwang AE, Huntsman S, Graff J, Nooka A, Kong Y, Pregja SL, Berndt SI, Blot WJ, Carpten J, Casey G, Chu L, Diver WR, Stevens VL, Lieber MR, Goodman PJ, Hennis AJ, Hsing AW, Mehta J, Kittles RA, Kolb S, Klein EA, Leske C, Murphy AB, Nemesure B, Neslund-Dudas C, Strom SS, Vij R, Rybicki BA, Stanford JL, Signorello LB, Witte JS, Ambrosone CB, Bhatti P, John EM, Bernstein L, Zheng W, Olshan AF, Hu JJ, Ziegler RG, Nyante SJ, Bandera EV, Birmann BM, Ingles SA, Press MF, Atanackovic D, Glenn MJ, Cannon-Albright LA, Jones B, Tricot G, Martin TG, Kumar SK, Wolf JL, Deming Halverson SL, Rothman N, Brooks-Wilson AR, Rajkumar SV, Kolonel LN, Chanock SJ, Slager SL, Severson RK, Janakiraman N, Terebelo HR, Brown EE, De Roos AJ, Mohrbacher AF, Colditz GA, Giles GG, Spinelli JJ, Chiu BC, Munshi NC, Anderson KC, Levy J, Zonder JA, Orlowski RZ, Lonial S, Camp NJ, Vachon CM, Ziv E, Stram DO, Hazelett DJ, Haiman CA, Cozen (2016). A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer epidemiology, biomarkers & prevention, 25(12), 1609-1618.
  13. Curtin K, Cannon-Albright LA, VanDerslice J, Yu Z, Herget KA, Thota R, Neklason D (2019). Associations of Tobacco and Alcohol Use with Risk of Neuroendocrine Tumors of the Small Intestine in Utah. Cancer epidemiology, biomarkers & prevention, 28(12), 1998-2004.
  14. Machiela MJ, Lan Q, Slager SL, Vermeulen RC, Teras LR, Camp NJ, Cerhan JR, Spinelli JJ, Wang SS, Nieters A, Vijai J, Yeager M, Wang Z, Ghesquières H, McKay J, Conde L, de Bakker PI, Cox DG, Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Giles GG, Melbye M, Gu J, Jackson RD, Kane E, Purdue MP, Vajdic CM, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SM, Witzig TE, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami HO, Roos G, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot T, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Turner J, Southey MC, Clavel J, Virtamo J, Weinstein S, Riboli E, Vineis P, Kaaks R, Boeing H, Tjønneland A, Angelucci E, Di Lollo S, Rais M, De Vivo I, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Liang L, Park JH, Chung CC, Weisenburger DD, Fraumeni JF Jr, Salles G, Glenn M, Cannon-Albright L, Curtin K, Wu X, Smedby KE, de Sanjose S, Skibola CF, Berndt SI, Birmann BM, Chanock SJ, Rothman (2016). Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Human molecular genetics, 25(8), 1663-76.
  15. Waller RG, Klein RJ, Vijai J, McKay JD, Clay-Gilmour A, Wei X, Madsen MJ, Sborov DW, Curtin K, Slager SL, Offit K, Vachon CM, Lipkin SM, Dumontet C, Camp N (2021). Sequencing at lymphoid neoplasm susceptibility loci maps six myeloma risk genes. Human molecular genetics, 30(12), 1142-1153.
  16. Berndt SI, Skibola CF, Joseph V, Camp NJ, Nieters A, Wang Z, Cozen W, Monnereau A, Wang SS, Kelly RS, Lan Q, Teras LR, Chatterjee N, Chung CC, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Armstrong BK, Cocco P, Zhang Y, Severi G, Zeleniuch-Jacquotte A, Lawrence C, Burdette L, Yuenger J, Hutchinson A, Jacobs KB, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Wang AH, Smedby KE, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Jones B, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Holly EA, Smith MT, Jackson RD, Tinker LF, Benavente Y, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Rabe KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Lanasa MC, Spector LG, Leis JF, Cunningham JM, Weinberg JB, Morrison VA, Caporaso NE, Norman AD, Linet MS, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Giles GG, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Offit K, Zelenetz A, Klein RJ, Spinelli JJ, Bertrand KA, Laden F, Giovannucci E, Kraft P, Kricker A, Turner J, Vajdic CM, Ennas MG, Ferri GM, Miligi L, Liang L, Sampson J, Crouch S, Park JH, North KE, Cox A, Snowden JA, Wright J, Carracedo A, Lopez-Otin C, Bea S, Salaverria I, Martin-Garcia D, Campo E, Fraumeni JF Jr, de Sanjose S, Hjalgrim H, Cerhan JR, Chanock SJ, Rothman N, Slager S (2013). Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nature genetics, 45(8), 868-76.
  17. Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP Jr, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Bailey JNC, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe SI, Kazama S, Zarnowski T, Inoue K, Irkec M, Coca-Prados M, Sugiyama K, Järvelä I, Schlottmann P, Lerner SF, Lamari H, Nilgün Y, Bikbov M, Park KH, Cha SC, Yamashiro K, Zenteno JC, Jonas JB, Kumar RS, Perera SA, Chan ASY, Kobakhidze N, George R, Vijaya L, Do T, Edward DP, de Juan Marcos L, Pakravan M, Moghimi S, Ideta R, Bach-Holm D, Kappelgaard P, Wirostko B, Thomas S, Gaston D, Bedard K, Greer WL, Yang Z, Chen X, Huang L, Sang J, Jia H, Jia L, Qiao C, Zhang H, Liu X, Zhao B, Wang YX, Xu L, Leruez S, Reynier P, Chichua G, Tabagari S, Uebe S, Zenkel M, Berner D, Mossböck G, Weisschuh N, Hoja U, Welge-Luessen UC, Mardin C, Founti P, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Ghosh A, Shetty R, Porporato N, Saravanan V, Venkatesh R, Shivkumar C, Kalpana N, Sarangapani S, Kanavi MR, Beni AN, Yazdani S, Lashay A, Naderifar H, Khatibi N, Fea A, Lavia C, Dallorto L, Rolle T, Frezzotti P, Paoli D, Salvi E, Manunta P, Mori Y, Miyata K, Higashide T, Chihara E, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Miyake M, Gotoh N, Matsuda F, Yoshimura N, Ikeda Y, Ueno M, Sotozono C, Jeoung JW, Sagong M, Park KH, Ahn J, Cruz-Aguilar M, Ezzouhairi SM, Rafei A, Chong YF, Ng XY, Goh SR, Chen Y, Yong VHK, Khan MI, Olawoye OO, Ashaye AO, Ugbede I, Onakoya A, Kizor-Akaraiwe N, Teekhasaenee C, Suwan Y, Supakontanasan W, Okeke S, Uche NJ, Asimadu I, Ayub H, Akhtar F, Kosior-Jarecka E, Lukasik U, Lischinsky I, Castro V, Grossmann RP, Sunaric Megevand G, Roy S, Dervan E, Silke E, Rao A, Sahay P, Fornero P, Cuello O, Sivori D, Zompa T, Mills RA, Souzeau E, Mitchell P, Wang JJ, Hewitt AW, Coote M, Crowston JG, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Kazakbaeva G, Fayzrakhmanov R, Al-Obeidan SA, Owaidhah O, Aljasim LA, Chowbay B, Foo JN, Soh RQ, Sim KS, Xie Z, Cheong AWO, Mok SQ, Soo HM, Chen XY, Peh SQ, Heng KK, Husain R, Ho SL, Hillmer AM, Cheng CY, Escudero-Domínguez FA, González-Sarmiento R, Martinon-Torres F, Salas A, Pathanapitoon K, Hansapinyo L, Wanichwecharugruang B, Kitnarong N, Sakuntabhai A, Nguyn HX, Nguyn GTT, Nguyn TV, Zenz W, Binder A, Klobassa DS, Hibberd ML, Davila S, Herms S, Nöthen MM, Moebus S, Rautenbach RM, Ziskind A, Carmichael TR, Ramsay M, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Fernández-Vega Cueto L, Oguz Ç, Tamcelik N, Atalay E, Batu B, Aktas D, Kas'm B, Wilson MR, Coleman AL, Liu Y, Challa P, Herndon L, Kuchtey RW, Kuchtey J, Curtin K, Chaya CJ, Crandall A, Zangwill LM, Wong TY, Nakano M, Kinoshita S, den Hollander AI, Vesti E, Fingert JH, Lee RK, Sit AJ, Shingleton BJ, Wang N, Cusi D, Qamar R, Kraft P, Pericak-Vance MA, Raychaudhuri S, Heegaard S, Kivelä T, Reis A, Kruse FE, Weinreb RN, Pasquale LR, Haines JL, Thorsteinsdottir U, Jonasson F, Allingham RR, Milea D, Ritch R, Kubota T, Tashiro K, Vithana EN, Micheal S, Topouzis F, Craig JE, Dubina M, Sundaresan P, Stefansson K, Wiggs JL, Pasutto F, Khor C (2017). Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nature genetics, 49(7), 993-1004.
  18. Kohli DR, Smith KR, Wong J, Yu Z, Boucher K, Faigel DO, Pannala R, Burt RW, Curtin K, Samadder N (2019). Familial pancreatic cancer risk: a population-based study in Utah. Journal of gastroenterology, 54(12), 1106-1112.
  19. Slattery ML, Wolff RK, Herrick JS, Curtin K, Caan BJ, Samowitz (2010). Alcohol consumption and rectal tumor mutations and epigenetic changes. Diseases of the colon and rectum, 53(8), 1182-9.
  20. Samadder NJ, Smith KR, Wong J, Hanson H, Boucher K, Burt RW, Charlton M, Byrne KR, Gallegos-Orozco JF, Koptiuch C, Curtin (2016). Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah. Digestive diseases and sciences, 61(12), 3627-3632.
  21. Jewel Samadder N, Valentine JF, Guthery S, Singh H, Bernstein CN, Wan Y, Wong J, Boucher K, Pappas L, Rowe K, Bronner M, Ulrich CM, Burt RW, Curtin K, Smith K (2017). Colorectal Cancer in Inflammatory Bowel Diseases: A Population-Based Study in Utah. Digestive diseases and sciences, 62(8), 2126-2132.
  22. Affolter K, Gligorich K, Samadder NJ, Samowitz WS, Curtin (2017). Feasibility of Large-Scale Identification of Sessile Serrated Polyp Patients Using Electronic Records: A Utah Study. Digestive diseases and sciences, 62(6), 1455-1463.
  23. Curtin K, Fleckenstein AE, Robison RJ, Crookston MJ, Smith KR, Hanson G (2015). Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: a population-based assessment. Drug and alcohol dependence, 146, 30-8.
  24. Samadder NJ, Curtin K, Tuohy TM, Pappas L, Boucher K, Provenzale D, Rowe KG, Mineau GP, Smith K, Pimentel R, Kirchhoff AC, Burt R (2014). Characteristics of missed or interval colorectal cancer and patient survival: a population-based study. Gastroenterology, 146(4), 950-60.
  25. Samadder NJ, Curtin K, Tuohy TM, Rowe KG, Mineau GP, Smith KR, Pimentel R, Wong J, Boucher K, Burt R (2014). Increased risk of colorectal neoplasia among family members of patients with colorectal cancer: a population-based study in Utah. Gastroenterology, 147(4), 814-821.e5; quiz e15-6.
  26. Din L, Sheikh M, Kosaraju N, Smedby KE, Bernatsky S, Berndt SI, Skibola CF, Nieters A, Wang S, McKay JD, Cocco P, Maynadié M, Foretová L, Staines A, Mack TM, de Sanjosé S, Vyse TJ, Padyukov L, Monnereau A, Arslan AA, Moore A, Brooks-Wilson AR, Novak AJ, Glimelius B, Birmann BM, Link BK, Stewart C, Vajdic CM, Haioun C, Magnani C, Conti DV, Cox DG, Casabonne D, Albanes D, Kane E, Roman E, Muzi G, Salles G, Giles GG, Adami HO, Ghesquières H, De Vivo I, Clavel J, Cerhan JR, Spinelli JJ, Hofmann J, Vijai J, Curtin K, Costenbader KH, Onel K, Offit K, Teras LR, Morton L, Conde L, Miligi L, Melbye M, Ennas MG, Liebow M, Purdue MP, Glenn M, Southey MC, Din M, Rothman N, Camp NJ, Wong Doo N, Becker N, Pradhan N, Bracci PM, Boffetta P, Vineis P, Brennan P, Kraft P, Lan Q, Severson RK, Vermeulen RCH, Milne RL, Kaaks R, Travis RC, Weinstein SJ, Chanock SJ, Ansell SM, Slager SL, Zheng T, Zhang Y, Benavente Y, Taub Z, Madireddy L, Gourraud PA, Oksenberg JR, Cozen W, Hjalgrim H, Khankhanian (2019). Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes. Genetic epidemiology, 43(7), 844-863.
  27. Curtin K, Samowitz WS, Wolff RK, Herrick J, Caan BJ, Slattery M (2009). Somatic alterations, metabolizing genes and smoking in rectal cancer. International journal of cancer, 125(1), 158-64.
  28. Curtin K, Smith KR, Fraser A, Pimentel R, Kohlmann W, Schiffman J (2013). Familial risk of childhood cancer and tumors in the Li-Fraumeni spectrum in the Utah Population Database: implications for genetic evaluation in pediatric practice. International journal of cancer, 133(10), 2444-53.
  29. Duensing I, Anderson MB, Meeks HD, Curtin K, Gililland J (2019). Patients with Type-1 Diabetes Are at Greater Risk of Periprosthetic Joint Infection: A Population-Based, Retrospective, Cohort Study. The Journal of bone and joint surgery. American volume, 101(20), 1860-1867.
  30. Samadder NJ, Smith KR, Wong J, Burt RW, Curtin (2020). Colorectal cancer in the setting of pregnancy and familial risk. International journal of colorectal disease, 35(8), 1559-1566.
  31. Orb Q, Curtin K, Oakley GM, Wong J, Meier J, Orlandi RR, Alt J (2016). Familial risk of pediatric chronic rhinosinusitis. The Laryngoscope, 126(3), 739-45.
  32. Padia R, Curtin K, Peterson K, Orlandi RR, Alt (2016). Eosinophilic esophagitis strongly linked to chronic rhinosinusitis. The Laryngoscope, 126(6), 1279-83.
  33. Padia R, Alt JA, Curtin K, Muntz HR, Orlandi RR, Berger J, Meier J (2017). Familial link of otitis media requiring tympanostomy tubes. The Laryngoscope, 127(4), 962-966.
  34. Curtin K, Samowitz WS, Ulrich CM, Wolff RK, Herrick JS, Caan BJ, Slattery M (2011). Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. Nutrition and cancer, 63(3), 357-66.
  35. Wirostko B, Allingham R, Wong J, Curtin (2018). Utah Project on Exfoliation Syndrome (UPEXS): Insight Into Systemic Diseases Associated With Exfoliation Syndrome. Journal of glaucoma, 27 Suppl 1, S75-S77.
  36. Neklason DW, VanDerslice J, Curtin K, Cannon-Albright L (2016). Evidence for a heritable contribution to neuroendocrine tumors of the small intestine. Endocrine-related cancer, 23(2), 93-100.
  37. Curtin K, Theilen LH, Fraser A, Smith KR, Varner MW, Hageman G (2019). Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life. Hypertension in pregnancy, 38(3), 141-148.
  38. Curtin K, Wolff RK, Herrick JS, Abo R, Slattery M (2010). Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor. BMC medical genetics, 11, 170.
  39. Samadder NJ, Curtin K, Wong J, Tuohy TM, Mineau GP, Smith KR, Pimentel R, Pappas L, Boucher K, Garrido-Laguna I, Provenzale D, Burt R (2014). Epidemiology and familial risk of synchronous and metachronous colorectal cancer: a population-based study in Utah. Clinical gastroenterology and hepatology, 12(12), 2078-84.e1-2.
  40. Samadder NJ, Smith KR, Hanson H, Pimentel R, Wong J, Boucher K, Ahnen D, Singh H, Ulrich CM, Burt RW, Curtin (2015). Increased Risk of Colorectal Cancer Among Family Members of All Ages, Regardless of Age of Index Case at Diagnosis. Clinical gastroenterology and hepatology, 13(13), 2305-11.e1-2.
  41. Samadder NJ, Curtin K, Pappas L, Boucher K, Mineau GP, Smith K, Fraser A, Wan Y, Provenzale D, Kinney AY, Ulrich C, Burt R (2016). Risk of Incident Colorectal Cancer and Death After Colonoscopy: A Population-based Study in Utah. Clinical gastroenterology and hepatology, 14(2), 279-86.e1-2.
  42. Samadder NJ, Neklason D, Snow A, Samowitz W, Cessna MH, Rowe K, Sandhu I, Boucher K, Pappas L, Smith KR, Wong J, Curtin K, Provenzale D, Burt R (2019). Clinical and Molecular Features of Post-Colonoscopy Colorectal Cancers. Clinical gastroenterology and hepatology, 17(13), 2731-2739.e2.
  43. Samadder NJ, Valentine JF, Guthery S, Singh H, Bernstein CN, Leighton JA, Wan Y, Wong J, Boucher K, Pappas L, Rowe K, Burt RW, Curtin K, Smith K (2019). Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. Clinical gastroenterology and hepatology, 17(9), 1807-1813.e1.
  44. Liu AY, Scherer D, Poole E, Potter JD, Curtin K, Makar K, Slattery ML, Caan BJ, Ulrich C (2013). Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. Molecular nutrition & food research, 57(4), 721-34.
  45. Venkatramani R, Spector LG, Georgieff M, Tomlinson G, Krailo M, Malogolowkin M, Kohlmann W, Curtin K, Fonstad RK, Schiffman J (2014). Congenital abnormalities and hepatoblastoma: a report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB). American journal of medical genetics. Part A, 164A(9), 2250-5.
  46. VanDerslice J, Taddie MC, Curtin K, Miller C, Yu Z, Hemmert R, Cannon-Albright LA, Neklason D (2020). Early life exposures associated with risk of small intestinal neuroendocrine tumors. PloS one, 15(4), e0231991.
  47. Wirostko BM, Curtin K, Taylor SC, Paulson C, Pompoco C, Besch BM, Ranjan R, Ritch (2021). Risk of atrial fibrillation is increased in patients with exfoliation syndrome: the Utah project on exfoliation syndrome (UPEXS). Acta ophthalmologica, 100, e1002-e1009.
  48. Curtin K, Ulrich CM, Samowitz WS, Wolff RK, Duggan DJ, Makar KW, Caan BJ, Slattery M (2011). Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. International journal of molecular epidemiology and genetics, 2(1), 1-8.
  49. Ziv E, Dean E, Hu D, Martino A, Serie D, Curtin K, Campa D, Aftab B, Bracci P, Buda G, Zhao Y, Caswell-Jin J, Diasio R, Dumontet C, Dudzi'ski M, Fejerman L, Greenberg A, Huntsman S, Jamroziak K, Jurczyszyn A, Kumar S, Atanackovic D, Glenn M, Cannon-Albright LA, Jones B, Lee A, Marques H, Martin T, Martinez-Lopez J, Rajkumar V, Sainz J, Vangsted AJ, W'tek M, Wolf J, Slager S, Camp NJ, Canzian F, Vachon (2015). Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients. Nature communications, 6, 7539.
  50. Berndt SI, Camp NJ, Skibola CF, Vijai J, Wang Z, Gu J, Nieters A, Kelly RS, Smedby KE, Monnereau A, Cozen W, Cox A, Wang SS, Lan Q, Teras LR, Machado M, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Vajdic CM, Cocco P, Zhang Y, Giles GG, Zeleniuch-Jacquotte A, Lawrence C, Montalvan R, Burdett L, Hutchinson A, Ye Y, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Cunningham JM, Allmer C, Hjalgrim H, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Arnett DK, Zhi D, Leach JM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Sala N, Casabonne D, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Chaffee KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Leis JF, Weinberg JB, Caporaso NE, Norman AD, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RCH, Travis RC, Southey MC, Milne RL, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Villano DJ, Maria A, Spinelli JJ, Gascoyne RD, Connors JM, Bertrand KA, Giovannucci E, Kraft P, Kricker A, Turner J, Ennas MG, Ferri GM, Miligi L, Liang L, Ma B, Huang J, Crouch S, Park JH, Chatterjee N, North KE, Snowden JA, Wright J, Fraumeni JF, Offit K, Wu X, de Sanjose S, Cerhan JR, Chanock SJ, Rothman N, Slager S (2016). Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nature communications, 7, 10933.
  51. Law PJ, Berndt SI, Speedy HE, Camp NJ, Sava GP, Skibola CF, Holroyd A, Joseph V, Sunter NJ, Nieters A, Bea S, Monnereau A, Martin-Garcia D, Goldin LR, Clot G, Teras LR, Quintela I, Birmann BM, Jayne S, Cozen W, Majid A, Smedby KE, Lan Q, Dearden C, Brooks-Wilson AR, Hall AG, Purdue MP, Mainou-Fowler T, Vajdic CM, Jackson GH, Cocco P, Marr H, Zhang Y, Zheng T, Giles GG, Lawrence C, Call TG, Liebow M, Melbye M, Glimelius B, Mansouri L, Glenn M, Curtin K, Diver WR, Link BK, Conde L, Bracci PM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Boffetta P, Brennan P, Maynadie M, McKay J, Albanes D, Weinstein S, Wang Z, Caporaso NE, Morton LM, Severson RK, Riboli E, Vineis P, Vermeulen RC, Southey MC, Milne RL, Clavel J, Topka S, Spinelli JJ, Kraft P, Ennas MG, Summerfield G, Ferri GM, Harris RJ, Miligi L, Pettitt AR, North KE, Allsup DJ, Fraumeni JF, Bailey JR, Offit K, Pratt G, Hjalgrim H, Pepper C, Chanock SJ, Fegan C, Rosenquist R, de Sanjose S, Carracedo A, Dyer MJ, Catovsky D, Campo E, Cerhan JR, Allan JM, Rothman N, Houlston R, Slager (2017). Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Nature communications, 8, 14175.
  52. Oakley GM, Curtin K, Orb Q, Schaefer C, Orlandi RR, Alt J (2015). Familial risk of chronic rhinosinusitis with and without nasal polyposis: genetics or environment. International forum of allergy & rhinology, 5(4), 276-82.
  53. Alt JA, Thomas AJ, Curtin K, Wong J, Rudmik L, Orlandi R (2017). Mortality risk in patients with chronic rhinosinusitis and its association to asthma. International forum of allergy & rhinology, 7(6), 591-599.
  54. Smith KA, Orlandi RR, Oakley G, Meeks H, Curtin K, Alt J (2019). Long-term revision rates for endoscopic sinus surgery. International forum of allergy & rhinology, 9(4), 402-408.
  55. Gill AS, Smith KA, Meeks H, Oakley GM, Curtin K, LeClair L, Howe H, Orlandi RR, Alt J (2021). Asthma increases long-term revision rates of endoscopic sinus surgery in chronic rhinosinusitis with and without nasal polyposis. International forum of allergy & rhinology, 11(8), 1197-1206.
  56. Byun S, Affolter KE, Snow AK, Curtin K, Cannon AR, Cannon-Albright LA, Thota R, Neklason D (2021). Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors. Scientific reports, 11(1), 12303.
  57. Moore A, Kane E, Wang Z, Panagiotou OA, Teras LR, Monnereau A, Wong Doo N, Machiela MJ, Skibola CF, Slager SL, Salles G, Camp NJ, Bracci PM, Nieters A, Vermeulen RCH, Vijai J, Smedby KE, Zhang Y, Vajdic CM, Cozen W, Spinelli JJ, Hjalgrim H, Giles GG, Link BK, Clavel J, Arslan AA, Purdue MP, Tinker LF, Albanes D, Ferri GM, Habermann TM, Adami HO, Becker N, Benavente Y, Bisanzi S, Boffetta P, Brennan P, Brooks-Wilson AR, Canzian F, Conde L, Cox DG, Curtin K, Foretova L, Gapstur SM, Ghesquières H, Glenn M, Glimelius B, Jackson RD, Lan Q, Liebow M, Maynadie M, McKay J, Melbye M, Miligi L, Milne RL, Molina TJ, Morton LM, North KE, Offit K, Padoan M, Patel AV, Piro S, Ravichandran V, Riboli E, de Sanjose S, Severson RK, Southey MC, Staines A, Stewart C, Travis RC, Weiderpass E, Weinstein S, Zheng T, Chanock SJ, Chatterjee N, Rothman N, Birmann BM, Cerhan JR, Berndt S (2020). Genetically Determined Height and Risk of Non-hodgkin Lymphoma. Frontiers in oncology, 9, 1539.
  58. Glenn MJ, Madsen MJ, Davis E, Garner CD, Curtin K, Jones B, Williams JA, Tomasson MH, Camp N (2019). Elevated IgM and abnormal free light chain ratio are increased in relatives from high-risk chronic lymphocytic leukemia pedigrees. Blood cancer journal, 9(3), 25.
  59. Lupo PJ, Danysh HE, Plon SE, Curtin K, Malkin D, Hettmer S, Hawkins DS, Skapek SX, Spector LG, Papworth K, Melin B, Erhardt EB, Grufferman S, Schiffman J (2015). Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database. Cancer medicine, 4(5), 781-90.
  60. Wirostko BM, Curtin K, Ritch R, Thomas S, Allen-Brady K, Smith KR, Hageman GS, Allingham R (2016). Risk for Exfoliation Syndrome in Women With Pelvic Organ Prolapse : A Utah Project on Exfoliation Syndrome (UPEXS) Study. JAMA ophthalmology, 134(11), 1255-1262.
  61. Besch BM, Curtin K, Ritch R, Allingham RR, Wirostko B (2018). Association of Exfoliation Syndrome With Risk of Indirect Inguinal Hernia: The Utah Project on Exfoliation Syndrome. JAMA ophthalmology, 136(12), 1368-1374.
  62. Oakley GM, Curtin K, Pimentel R, Buchmann L, Hunt (2013). Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. JAMA otolaryngology-- head & neck surgery, 139(11), 1171-4.
  63. Oakley GM, Curtin K, Layfield L, Jarboe E, Buchmann LO, Hunt J (2014). Increased melanoma risk in individuals with papillary thyroid carcinoma. JAMA otolaryngology-- head & neck surgery, 140(5), 423-7.
  64. Samadder NJ, Smith KR, Hanson H, Pimentel R, Wong J, Boucher K, Akerley W, Gilcrease G, Ulrich CM, Burt RW, Curtin (2016). Familial Risk in Patients With Carcinoma of Unknown Primary. JAMA oncology, 2(3), 340-6.
  65. Colonna S, Curtin K, Johnson E, Kohlmann W, Wright J, Kirchhoff A, Tavtigian S, Schiffman (2019). Family History of Breast Cancer Associated with Breast Cancer in Survivors of Hodgkin Lymphoma. International journal of cancer and clinical research, 6(1),
  66. Shumway C, Curtin K, Taylor S, Sundar KM, Wirostko BM, Ritch (2021). Association between Obstructive Sleep Apnea and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome. Ophthalmology. Glaucoma, 4(3), 260-267.
  67. Taylor SC, Bernhisel AA, Curtin K, Allingham RR, Ritch R, Wirostko B (2019). Association between Chronic Obstructive Pulmonary Disease and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome. Ophthalmology. Glaucoma, 2(1), 3-10.
  68. Barnard ME, Martheswaran T, Van Meter M, Buys SS, Curtin K, Doherty J (2022). Body Mass Index and Mammographic Density in a Multiracial and Multiethnic Population-Based Study. Cancer epidemiology, biomarkers & prevention, 31(7), 1313-1323.
  69. Gill AS, Meeks H, Curtin K, Alt J (2022). Tobacco Use Increases the Adjusted Risk of Revision Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis. American journal of rhinology & allergy, 36(6), 19458924221105926.
  70. Rogers CR, Korous KM, Brooks E, De Vera MA, Tuuhetaufa F, Lucas T, Curtin K, Pesman C, Johnson W, Gallagher P, Moore J (2022). Early-Onset Colorectal Cancer Survival Differences and Potential Geographic Determinants Among Men and Women in Utah. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 42, 1-16.
  71. Kanth P, Yu Z, Keener MB, Koptiuch C, Kohlmann WK, Neklason DW, Westover M, Curtin (2022). Cancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions. The American journal of gastroenterology, 117(2), 336-342.
  72. Rogers CR, Brooks E, Curtin K, De Vera MA, Qeadan F, Rogers TN, Petersen E, Gallagher P, Pesmen C, Johnson W, Henley C, Hickman W, Newcomb E, Korous KM, Handley M (2021). Protocol for #iBeatCRC: a community-based intervention to increase early-onset colorectal cancer awareness using a sequential explanatory mixed-methods approach. BMJ open, 11(12), e048959.
  73. Moore A, Machiela MJ, Machado M, Wang SS, Kane E, Slager SL, Zhou W, Carrington M, Lan Q, Milne RL, Birmann BM, Adami HO, Albanes D, Arslan AA, Becker N, Benavente Y, Bisanzi S, Boffetta P, Bracci PM, Brennan P, Brooks-Wilson AR, Canzian F, Caporaso N, Clavel J, Cocco P, Conde L, Cox DG, Cozen W, Curtin K, De Vivo I, de Sanjose S, Foretova L, Gapstur SM, Ghesquières H, Giles GG, Glenn M, Glimelius B, Gao C, Habermann TM, Hjalgrim H, Jackson RD, Liebow M, Link BK, Maynadie M, McKay J, Melbye M, Miligi L, Molina TJ, Monnereau A, Nieters A, North KE, Offit K, Patel AV, Piro S, Ravichandran V, Riboli E, Salles G, Severson RK, Skibola CF, Smedby KE, Southey MC, Spinelli JJ, Staines A, Stewart C, Teras LR, Tinker LF, Travis RC, Vajdic CM, Vermeulen RCH, Vijai J, Weiderpass E, Weinstein S, Doo NW, Zhang Y, Zheng T, Chanock SJ, Rothman N, Cerhan JR, Dean M, Camp NJ, Yeager M, Berndt S (2021). Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes. Journal of translational genetics and genomics, 5, 200-217.
  74. Gill AS, Meeks H, Curtin K, Kelly K, Alt J (2023). Tobacco use increases the risk of chronic rhinosinusitis among patients undergoing endoscopic sinus surgery. Clinical otolaryngology, 48(3), 414-422.
  75. Berndt SI, Vijai J, Benavente Y, Camp NJ, Nieters A, Wang Z, Smedby KE, Kleinstern G, Hjalgrim H, Besson C, Skibola CF, Morton LM, Brooks-Wilson AR, Teras LR, Breeze C, Arias J, Adami HO, Albanes D, Anderson KC, Ansell SM, Bassig B, Becker N, Bhatti P, Birmann BM, Boffetta P, Bracci PM, Brennan P, Brown EE, Burdett L, Cannon-Albright LA, Chang ET, Chiu BCH, Chung CC, Clavel J, Cocco P, Colditz G, Conde L, Conti DV, Cox DG, Curtin K, Casabonne D, De Vivo I, Diver WR, Dogan A, Edlund CK, Foretova L, Fraumeni JF Jr, Gabbas A, Ghesquières H, Giles GG, Glaser S, Glenn M, Glimelius B, Gu J, Habermann TM, Haiman CA, Haioun C, Hofmann JN, Holford TR, Holly EA, Hutchinson A, Izhar A, Jackson RD, Jarrett RF, Kaaks R, Kane E, Kolonel LN, Kong Y, Kraft P, Kricker A, Lake A, Lan Q, Lawrence C, Li D, Liebow M, Link BK, Magnani C, Maynadie M, McKay J, Melbye M, Miligi L, Milne RL, Molina TJ, Monnereau A, Montalvan R, North KE, Novak AJ, Onel K, Purdue MP, Rand KA, Riboli E, Riby J, Roman E, Salles G, Sborov DW, Severson RK, Shanafelt TD, Smith MT, Smith A, Song KW, Song L, Southey MC, Spinelli JJ, Staines A, Stephens D, Sutherland HJ, Tkachuk K, Thompson CA, Tilly H, Tinker LF, Travis RC, Turner J, Vachon CM, Vajdic CM, Van Den Berg A, Van Den Berg DJ, Vermeulen RCH, Vineis P, Wang SS, Weiderpass E, Weiner GJ, Weinstein S, Doo NW, Ye Y, Yeager M, Yu K, Zeleniuch-Jacquotte A, Zhang Y, Zheng T, Ziv E, Sampson J, Chatterjee N, Offit K, Cozen W, Wu X, Cerhan JR, Chanock SJ, Slager SL, Rothman (2022). Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. Leukemia, 36(12), 2835-2844.
  76. Patil A, Conley M, Pompoco C, Paulson C, Taylor S, Swiston C, Herrick JS, Ritch R, Curtin K, Wirostko (2023). Abdominal aortic aneurysm and exfoliation syndrome in Utah. Acta ophthalmologica, 101(4), 449-456.

Review

  1. Curtin K, Slattery ML, Samowitz W (2012). CpG island methylation in colorectal cancer: past, present and future. Pathology research international, 902674,
  2. Pompoco CJ, Curtin K, Taylor S, Paulson C, Shumway C, Conley M, Barker DJ, Swiston C, Stagg B, Ritch R, Wirostko B (2021). Summary of Utah Project on Exfoliation Syndrome (UPEXS): using a large database to identify systemic comorbidities. BMJ open ophthalmology, 6(1), e000803.
  3. Patil A, Conley M, Paulson C, Pompoco C, Wallace R, Swiston C, Ritch R, Curtin K, Wirostko (2023). Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings. Acta ophthalmologica, 101(5), 478-484.

Book Chapter

  1. Curtin, K (2014). Epidemiology of colorectal adenocarcinoma. xiv 317 pages,

Newspaper

  1. Curtin (2014). Methamphetamine Use Triples Parkinson's Risk. Interview with Pauline Anderson, published in Medscape Medical News - Psychiatry.

Video/Film/CD/Web/Podcast

  1. Curtin K, Theilen LH, Fraser A, Smith KR, Varner MW, Hageman G (2019).  A new study by researchers from the John A. Moran Eye Center’s Sharon Eccles Steele Center for Translational Medicine suggests women who experienced hypertensive disorders during pregnancy are at greater risk for a blinding eye disease. John Moran Eye Center News (online).