Sarah Franklin, PhD, is an Associate Professor of Cardiovascular Medicine at the University of Utah with a research laboratory in the Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI). She received her PhD from Brigham Young University and then received postdoctoral training at UCLA in the department of Anesthesiology.
Dr Franklin is also an Assistant Director with the Rural & Underserved Utah Training Experience (RUUTE) in the School of Medicine. She oversees the RUUTE summer research experiences for undergraduate and medical students and teaches the Research & Innovation Course over the summer. Dr. Franklin is passionate about exposing young individuals to new career paths in medicine and science, creating meaningful educational opportunities for students, and mentoring them along their academic journey. She grew up on a cattle ranch in rural Utah and loves to extend educational opportunities to all corners of the state.
Dr Franklin's research interests focus on understanding how the packaging of DNA around nucleosomes influences specific patterns of gene expression and how this packaging is modulated during disease to alter transcriptional activity. Specifically her research is aimed at understanding the mechanistic basis for how remodeling of chromatin induces the re-expression of fetal genes in the heart during the development of hypertrophy and failure. She has utilized a mouse model of pressure overload hypertrophy, a novel method for isolation and fractionation of cardiac nuclei and state-of-the-art mass spectrometry to characterize the protein constituents of chromatin from normal and diseased hearts. This work has allowed her to identify a number of novel chromatin binding proteins whose abundance is differentially regulated during heart failure progression. Her laboratory has now begun to evaluate the specific role of these proteins on chromatin structure and heart morphology and physiology using isolated cell and animal models.
Education History
| Fellowship |
University of California, Department of Anesthesiology |
Postdoctoral Fellow |
|---|---|---|
| Doctoral Training |
Brigham Young University Biochemistry |
Ph.D. |
| Undergraduate |
Brigham Young University Biochemistry |
B.S. |
| Undergraduate |
College of Eastern Utah Chemistry |
A.S. |
Selected Publications
- Szulik MW, Davis K, Bakhtina A, Azarcon P, Bia R, Horiuchi E, Franklin S (2020). Transcriptional regulation by methyltransferases and their role in the heart: highlighting novel emerging functionality. Am J Physiol Heart Circ Physiol, 319(4), H847-H865.
- Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, DellItalia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS (2021). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal, 32(18), 1293-1312.
- Ludlam WG, Aoba T, Cullar J, Bueno-Carrasco MT, Makaju A, Moody JD, Franklin S, Valpuesta JM, Willardson BM (2019). Molecular architecture of the Bardet-Biedl syndrome protein 2-7-9 subcomplex. J Biol Chem, 294(44), 16385-16399.
- Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S (2018). Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Rep, 29(2), 270-282.e5.
- Cullar J, Ludlam WG, Tensmeyer NC, Aoba T, Dhavale M, Santiago C, Bueno-Carrasco MT, Mann MJ, Plimpton RL, Makaju A, Franklin S, Willardson BM, Valpuesta JM (2019). Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly. Nat Commun, 10(1), 2865.
- Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S (2018). Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Proc Natl Acad Sci U S A, 115(33), E7871-E7880.
- Tracy C, Warren JS, Szulik M, Wang L, Garcia J, Makaju A, Russell K, Miller M, Franklin S (2017). The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology. Curr Opin Physiol, 1, 140-152.
- Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, Engel ME (2017). GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Biochem J, 474(17), 2951.
- Tracy C, Warren J, Szulik M, Wang L, Garcia J, Makaju A, Russel K, Miller M, Franklin S (2017). The Smyd family of methyltransferases: Role in cardiac and skeletal muscle physiology and pathology. [Review]. Curr Opin Physiol, 1, 140-152.
- Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM (2016). The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. Am J Physiol Heart Circ Physiol, 311(5), H1234-H1247.
- Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, Engel ME (2016). GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Biochem J, 473(19), 3355-69.
- Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, Vondriska TM (2016). Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J Biol Chem, 291(30), 15428-46.
- Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV (2015). Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PLoS One, 10(3), e0118974.
- Plimpton RL, Cullar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa JL, Valpuesta JM, Willardson BM (2015). Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Proc Natl Acad Sci U S A, 112(8), 2413-8.
- Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnczky G, Kwon O, Chen JN (2015). Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife, 4.
- Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM (2014). Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife, 3.
- Kumar P P, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon AM (2014). TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome. PLoS Genet, 10(3), e1004247.
- Monte E, Mouillesseaux K, Chen H, Kimball T, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S (2013). Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. Am J Physiol Heart Circ Physiol, 305(11), H1624-38.
- Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y (2013). PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab, 2(4), 405-16.
- Franklin S, Zhang M, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM (2010). Specialized compartments of cardiac nuclei exhibit distinct proteome anatomy. Mol Cell Proteomics, 10(1).