Derek J. Dosdall

Derek J. Dosdall, PhD

Languages spoken: English

Academic Information

Departments Primary - Surgery , Adjunct - Internal Medicine

Divisions: Cardiothoracic Surgery , Cardiovascular Medicine

Derek J. Dosdall, PhD, is an associate professor at the University of Utah in the Depatment of Surgery, Division of Cardiothoracic Surgery. He has adjunct appointments in the Department of Bioengineering and the Deparmtment of Internal Medicine, Division of Cardiovascular Medicine. He received his PhD in Bioengineering from Arizona State University and did postdoctoral training at the University of Alabama at Birmingham.

His research interests are focused on mapping of cardiac arrhythmias. He has developed chronic animal models of atrial fibrillation to investigate the substrate and conduction changes that occur in the cardiac tissue over time. He is working to determine the role of fibrosis in conduction disturbances and the development of atrial fibrillation. He is also studying the role of the specialized conduction system in the ventricles and the onset and maintenance of dangerous cardiac arrhythmias.

Education History

Postdoctoral Training University of Alabama at Birmingham
 Postdoctoral Training
Doctoral Training Arizona State University
 PhD
Graduate Training Arizona State University
 MS
Undergraduate Brigham Young University
 BS

Selected Publications

Journal Article

  1. Ishidoya Y, Kwan E, Hunt B, Lange M, Sharma T, Dosdall DJ, Macleod RS, Kholmovski EG, Bunch TJ, Ranjan R (2024). Effective ablation settings that predict chronic scar after atrial ablation with HELIOSTAR™ multi-electrode radiofrequency balloon catheter. J Interv Card Electrophysiol. (Read full article)
  2. Kwan E, Ghafoori E, Good W, Regouski M, Moon B, Fish JM, Hsu E, Polejaeva IA, MacLeod RS, Dosdall DJ, Ranjan R (2024). Diffuse functional and structural abnormalities in fibrosis: Potential structural basis for sustaining atrial fibrillation. Heart Rhythm. (Read full article)
  3. Kwan E, Hunt B, Paccione EN, Orkild BA, Bergquist JA, Ishidoya Y, Yazaki K, Mendes JK, DiBella EVR, MacLeod RS, Dosdall DJ, Ranjan R (2024). Functional and Structural Remodeling as Atrial Fibrillation Progresses in a Persistent Atrial Fibrillation Canine Model. JACC Clin Electrophysiol. (Read full article)
  4. Dong J, Kwan E, Bergquist JA, Dosdall DJ, DiBella EV, MacLeod RS, Stoddard GJ, Konstantidinis K, Steinberg BA, Bunch TJ, Ranjan R (2024). Left atrial functional changes associated with repeated catheter ablations for atrial fibrillation. J Cardiovasc Electrophysiol. (Read full article)
  5. Hunt B, Kwan E, Paccione E, Orkild B, Yazaki K, Bergquist J, Dong J, MacLeod RS, Dosdall DJ, Ranjan R (2024). Are Drivers Recurring or Ephemeral? Observations from Serial Mapping of Persistent Atrial Fibrillation. Europace. (Read full article)
  6. Dong J, Kwan E, Bergquist JA, Steinberg BA, Dosdall DJ, DiBella EVR, MacLeod RS, Bunch TJ, Ranjan R (2024). Ablation-induced left atrial mechanical dysfunction recovers in weeks after ablation. J Interv Card Electrophysiol. (Read full article)
  7. Hirahara AM, Khan MS, Ishidoya Y, Smego D, Roman O, Ranjan R, Krueger L, Hoareau G, Selzman CH, Dosdall DJ (2023). Canine Model of Ischemia-Induced Ventricular Tachycardia. J Surg Res, 293, 196-203. (Read full article)
  8. Hunt B, Kwan E, Tasdizen T, Bergquist J, Lange M, Orkild B, MacLeod RS, Dosdall DJ, Ranjan R (2023). Transfer Learning for Improved Classification of Drivers in Atrial Fibrillation. Comput Cardiol (2010), 50. (Read full article)
  9. Paccione EN, Lange M, Orkild BA, Bergquist JA, Kwan E, Hunt B, Dosdall D, Macleod RS, Ranjan R (2023). Effects of Biventricular Pacing Locations on Anti-Tachycardia Pacing Success in a Patient-Specific Model. Comput Cardiol (2010), 2023. (Read full article)
  10. Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall DJ (2023). A canine model of chronic ischemic heart failure. Am J Physiol Heart Circ Physiol, 324(6), H751-H761. (Read full article)
  11. Hirahara AM, Khan MS, Gharbia OA, Lange M, Ishidoya Y, Smego D, Ranjan R, Stoddard GJ, Selzman CH, Dosdall DJ (2023). Antitachycardia pacing at the His bundle is safer than conventional right ventricular antitachycardia pacing in a canine myocardial ischemic injury model. J Cardiovasc Electrophysiol, 34(5), 1249-1256. (Read full article)
  12. Kamali R, Gillete K, Tate J, Abhyankar DA, Dosdall DJ, Plank G, Bunch TJ, Macleod RS, Ranjan R (2022). Treatment Planning for Atrial Fibrillation Using Patient-Specific Models Showing the Importance of Fibrillatory-Areas. Ann Biomed Eng, 51(2), 329-342. (Read full article)
  13. Kamali R, Kwan E, Regouski M, Bunch TJ, Dosdall DJ, Hsu E, Macleod RS, Polejaeva I, Ranjan R (2023). Contribution of atrial myofiber architecture to atrial fibrillation. PLoS One, 18(1), e0279974. (Read full article)
  14. Khan MS, Kyriakopoulos CP, Taleb I, Dranow E, Scott M, Ranjan R, Yin M, Tseliou E, Alharethi R, Caine W, Shaw RM, Selzman CH, Drakos SG, Dosdall DJ (2022). Baseline QRS duration associates with cardiac recovery in patients with continuous-flow left ventricular assist device implantation. Am Heart J Plus, 22, 100211. (Read full article)
  15. Lange M, Kwan E, Dosdall DJ, MacLeod RS, Bunch TJ, Ranjan R (2022). Case report: Personalized computational model guided ablation for left atrial flutter. Front Cardiovasc Med, 9. (Read full article)
  16. Ishidoya Y, Kwan E, Dosdall DJ, Macleod RS, Navaravong L, Steinberg BA, Bunch TJ, Ranjan R (2022). Short-term natural course of esophageal thermal injury after ablation for atrial fibrillation. J Cardiovasc Electrophysiol, 33(7), 1450-1459. (Read full article)
  17. Ishidoya Y, Kwan E, Dosdall DJ, Macleod RS, Navaravong L, Steinberg BA, Jared Bunch T, Ranjan R (2022). Shorter distance between the esophagus and the left atrium is associated with higher rates of esophageal thermal injury after radiofrequency ablation. J Cardiovasc Electrophysiol, 33(7), 1460-1471. (Read full article)
  18. Shah AR, Khan MS, Lange M, Hirahara AM, Stoddard G, Ranjan R, Dosdall DJ (2021). During Early VF in Rabbit Hearts, His Bundle Pacing is Less Effective Than Working Myocardial Pacing in Modulating Left Ventricular Activation Rates. Cardiovasc Eng Technol, 13(3), 452-465. (Read full article)
  19. Lange M, Hirahara AM, Ranjan R, Stoddard GJ, Dosdall DJ (2021). Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation. PLoS One, 16(10), e0258285. (Read full article)
  20. Khan MS, Lange M, Ranjan R, Sharma V, Glotzbach JP, Selzman C, Dosdall DJ (2021). Premature atrial stimulation accentuates conduction abnormalities in cardiac surgery patients that develop postoperative atrial fibrillation. J Electrocardiol, 69, 36-43. (Read full article)
  21. Kamali R, Kump J, Ghafoori E, Lange M, Hu N, Bunch TJ, Dosdall DJ, Macleod RS, Ranjan R (2021). Area Available for Atrial Fibrillation to Propagate Is an Important Determinant of Recurrence After Ablation. JACC Clin Electrophysiol, 7(7), 896-908. (Read full article)
  22. Hirahara AM, Lange M, Shah A, Khan MS, Ranjan R, Stoddard G, Dosdall DJ (2020). His bundle pacing shows similar ventricular electrical activation as sinus: selective and nonselective His pacing indistinguishable. Am J Physiol Heart Circ Physiol, 320(1), H13-H22. (Read full article)
  23. Kamali R, Schroeder J, DiBella E, Steinberg B, Han F, Dosdall DJ, Macleod RS, Ranjan R (2020). Reproducibility of clinical late gadolinium enhancement magnetic resonance imaging in detecting left atrial scar after atrial fibrillation ablation. J Cardiovasc Electrophysiol, 31(11), 2824-2832. (Read full article)
  24. Khan MS, Yamashita K, Sharma V, Ranjan R, Selzman CH, Dosdall DJ (2019). Perioperative Biomarkers Predicting Postoperative Atrial Fibrillation Risk After Coronary Artery Bypass Grafting: A Narrative Review. J Cardiothorac Vasc Anesth, 34(7), 1933-1941. (Read full article)
  25. Shah AR, Khan MS, Hirahara AM, Lange M, Ranjan R, Dosdall DJ (2020). In Vitro/Ex Vivo Investigation of Modified Utah Electrode Array to Selectively Sense and Pace the Sub-Surface Cardiac His Bundle. ACS Biomater Sci Eng, 6(6), 3335-3348. (Read full article)
  26. Khan MS, Yamashita K, Sharma V, Ranjan R, Dosdall DJ (2020). RNAs and Gene Expression Predicting Postoperative Atrial Fibrillation in Cardiac Surgery Patients Undergoing Coronary Artery Bypass Grafting. J Clin Med, 9(4). (Read full article)
  27. Shah AR, Khan MS, Hirahara AM, Lange M, Ranjan R, Dosdall DJ (2020). A real-time system for selectively sensing and pacing the His-bundle during sinus rhythm and ventricular fibrillation. Biomed Eng Online, 19(1), 19. (Read full article)
  28. Yamashita K, Kwan E, Kamali R, Ghafoori E, Steinberg BA, MacLeod RS, Dosdall DJ, Ranjan R (2020). Blanking period after radiofrequency ablation for atrial fibrillation guided by ablation lesion maturation based on serial MR imaging. J Cardiovasc Electrophysiol, 31(2), 450-456. (Read full article)
  29. Yamashita K, Kamali R, Kwan E, MacLeod RS, Dosdall DJ, Ranjan R (2019). Effective Ablation Settings That Predict Chronic Scar After Left Atrial Ablation. JACC Clin Electrophysiol, 6(2), 143-152. (Read full article)
  30. Reno CM, Bayles J, Huang Y, Oxspring M, Hirahara AM, Dosdall DJ, Fisher SJ (2019). Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats. Diabetes, 68(11), 2107-2119. (Read full article)
  31. Yamashita K, Silvernagel J, Kwan E, Kamali R, Ghafoori E, MacLeod R, Dosdall DJ, Ranjan R (2019). Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long-term chronic canine atrial fibrillation model. Pacing Clin Electrophysiol, 42(7), 930-936. (Read full article)
  32. Yamashita K, Hu N, Ranjan R, Selzman CH, Dosdall DJ (2018). Clinical Risk Factors for Postoperative Atrial Fibrillation among Patients after Cardiac Surgery. Thorac Cardiovasc Surg, 67(2), 107-116. (Read full article)
  33. Yamashita K, Ghafoori E, Silvernagel J, Ashton J, Dosdall DJ, MacLeod R, Ranjan R (2019). The effective contact force to minimize edema relative to chronic lesion formation during radiofrequency ablation in ventricular wall. Int Heart J, 60(6), 1407-1414. (Read full article)
  34. Angel N, Li LI, Macleod RS, Marrouche N, Ranjan R, Dosdall DJ (2015). Diverse Fibrosis Architecture and Premature Stimulation Facilitate Initiation of Reentrant Activity Following Chronic Atrial Fibrillation. J Cardiovasc Electrophysiol, 26(12), 1352-60. (Read full article)
  35. Huang J, Dosdall DJ, Cheng KA, Li L, Rogers JM, Ideker RE (2014). The importance of Purkinje activation in long duration ventricular fibrillation. J Am Heart Assoc, 3(1), e000495. (Read full article)
  36. Robichaux RP, Dosdall DJ, Osorio J, Garner NW, Li L, Huang J, Ideker RE (2010). Periods of highly synchronous, non-reentrant endocardial activation cycles occur during long-duration ventricular fibrillation. J Cardiovasc Electrophysiol, 21(11), 1266-73. (Read full article)
  37. Dosdall DJ, Fast VG, Ideker RE (2010). Mechanisms of defibrillation. Annu Rev Biomed Eng, 12, 233-58. (Read full article)

Book Chapter

  1. Dosdall DJ, Ideker RE (2014). Mechanisms of Ventricular Tachycardia and Fibrillation. In Dosdall DJ|Ideker RE (Ed.), Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition (pp. 475-482). (Read full article)
  2. Dosdall DJ, Tabereaux PB, Ideker RE (2012). Advances in Mapping of Ventricular Fibrillation and Defibrillation: Role of the Purkinje System. In Dosdall DJ|Tabereaux PB|Ideker RE (Ed.), Cardiac Mapping: Fourth Edition (pp. 459-466). (Read full article)
  3. Kay GN, Dosdall DJ, Shepard RB (2011). Cardiac Electrical Stimulation. In Kay GN|Dosdall DJ|Shepard RB (Ed.), Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy (pp. 3-39). (Read full article)
  4. Ideker RE, Dosdall DJ (2009). Critical points and the upper limit of vulnerability for defibrillation. In Ideker RE|Dosdall DJ (Ed.), Cardiac Bioelectric Therapy: Mechanisms and Practical Implications (pp. 165-187). (Read full article)
  5. Dosdall DJ, Ideker RE (2009). Cardiac arrhythmias. In Dosdall DJ|Ideker RE (Ed.), TASER® Conducted Electrical Weapons: Physiology, Pathology, and Law (pp. 119-131). (Read full article)
  6. Tabereaux PB, Dosdall DJ, Ideker RE (2009). Mapping of Ventricular Tachycardia and Fibrillation: Role of the Purkinje System. In Tabereaux PB|Dosdall DJ|Ideker RE (Ed.), Cardiac Mapping, Third Edition (pp. 411-422). (Read full article)
  7. Dosdall DJ, Huang J, Ideker RE (2009). Mechanisms of Defibrillation. In Dosdall DJ|Huang J|Ideker RE (Ed.), Ventricular Arrhythmias and Sudden Cardiac Death (pp. 277-288). (Read full article)

Conference Proceedings

  1. Hunt BKwan EDosdall DMacLeod RSRanjan R (2021). Siamese Neural Networks for Small Dataset Classification of Electrograms. In Hunt B|Kwan E|Dosdall D|MacLeod RS|Ranjan R (Ed.), Comput Cardiol (2010), 2021-September. (Read full article)
  2. Hunt B, Kwan E, McMillan M, Dosdall D, MacLeod R, Ranjan R (2020). Deep Learning Based Prediction of Atrial Fibrillation Disease Progression with Endocardial Electrograms in a Canine Model. In Hunt B|Kwan E|McMillan M|Dosdall D|MacLeod R|Ranjan R (Ed.), Comput Cardiol (2010), 2020-September. (Read full article)
  3. Angel N, Kholmovski EG, Ghafoori E, Dosdall DJ, MacLeod RS, Ranjan R (2020). Regions of High Dominant Frequency in Chronic Atrial Fibrillation Anchored to Areas of Atrial Fibrosis. Comput Cardiol (2010), United States, 46. (Read full article)
  4. Dong H, Roussel T, Jackson D, Naber J, Koenig S, Keynton R, Dosdal D, Ideker R (2010). Characterization of thin-film microelectrode array and signal conditioning microchip for high spatial resolution surface laplacian measurement. In Dong H|Roussel T|Jackson D|Naber J|Koenig S|Keynton R|Dosdal D|Ideker R (Ed.), Proceedings of IEEE Sensors, 2464-2467. (Read full article)
  5. Dong HJackson DRoussel TDosdall DIdeker RNaber JKoenig SKeynton R (2010). Design and characterization of a signal conditioning microchip and Thin-film microelectrode array for high spatial resolution cardiac mapping. In Dong H|Jackson D|Roussel T|Dosdal D|Ideker R|Naber J|Koenig S|Keynton R (Ed.), IFMBE Proc, 31 IFMBE, 1417-1420. (Read full article)
  6. Dosdall DJ, Huang J, Ideker RE (2009). Differential electrograms computed from unipolar endocardial recordings improve Purkinje activation identification. In Dosdall DJ|Huang J|Ideker RE (Ed.), Comput Cardiol, 36, 225-228. (Read full article)
  7. Dosdall DJ, Sweeney JD, Brandon TA (2003). Rapid Current Switching With An Endovascular Electrode Configuration Significantly Decreases Implantable Defibrillator Thresholds. In Dosdall DJ|Sweeney JD|Brandon TA (Ed.), Alliance for Engineering in Medicine and Biology. Proceedings of the Annual Conference, 1, 179-182. (Read full article)

Abstract

  1. Reighard JSweeney JDosdall DBrandon T (2000). Correlation of the defibrillation threshold and the upper limit of vulnerability for multipulse biphasic waveforms [Abstract]. Ann Biomed Eng, 28(SUPPL. 1). (Read full article)

Patent

  1. Dosdall DJ, Ranjan R (2018). Implantable cardiac devices and methods for delivering low energy, pain-free defibrillation signals for ventricular arrhythmias. U.S. Patent No. US10765875B2. Washington, D.C.:U.S. Patent and Trademark Office.
  2. Ideker R, Dosdall D, Ruse J, Ruse G, Ruse R, Bohanan S (2011). Apparatus and Method for Treating Atrial Fibrillation and Atrial Tachycardia. U.S. Patent No. 7986992. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Ideker R, Dosdall D, Ruse J, Ruse G, Ruse R, Bohanan S (2011). Apparatus and Method for Treating Ventricular Fibrillation and Ventricular Tachycardia. U.S. Patent No. 7920918. Washington, D.C.:U.S. Patent and Trademark Office.

Clinical Trials