Joshua L. Andersen

Joshua L. Andersen, PhD

Languages spoken: English

Academic Information

Departments Primary - Oncological Sciences

Academic Office Information

Josh.Andersen@hci.utah.edu

Education History

Postdoctoral Fellowship Duke University Medical Center
 Postdoctoral Fellow
Graduate Training University of Utah School of Medicine
 PhD
Undergraduate Brigham Young University
 BS

Selected Publications

Journal Article

  1. Egbert CM, Warr LR, Pennington KL, Thornton MM, Vaughan AJ, Ashworth SW, Heaton MJ, English N, Torres MP, Andersen JL (2022). The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions. J Mol Biol, 435(2), 167890.
  2. Pennington KL, McEwan CM, Woods J, Muir CM, Pramoda Sahankumari AG, Eastmond R, Balasooriya ER, Egbert CM, Kaur S, Heaton T, McCormack KK, Piccolo SR, Kurokawa M, Andersen JL (2021). SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1. Mol Cancer Res, 20(2), 231-243.
  3. Kannangara AR, Poole DM, McEwan CM, Youngs JC, Weerasekara VK, Thornock AM, Lazaro MT, Balasooriya ER, Oh LM, Soderblom EJ, Lee JJ, Simmons DL, Andersen JL (2021). BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. EMBO Rep, 22(10), e51136.
  4. Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Mschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, OHare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL (2021). TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun, 12(1), 5337.
  5. Chandrasekharan B, Montllor-Albalate C, Colin AE, Andersen JL, Jang YC, Reddi AR (2020). Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway. Biochem Biophys Res Commun, 534, 720-726.
  6. Hashemi MM, Holden BS, Coburn J, Taylor MF, Weber S, Hilton B, Zaugg AL, McEwan C, Carson R, Andersen JL, Price JC, Deng S, Savage PB (2019). Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins. Front Microbiol, 10, 210.
  7. Montllor-Albalate C, Colin AE, Chandrasekharan B, Bolaji N, Andersen JL, Wayne Outten F, Reddi AR (2018). Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae. Redox Biol, 21, 101064.
  8. Tellez Freitas CM, Burrell HR, Valdoz JC, Hamblin GJ, Raymond CM, Cox TD, Johnson DK, Andersen JL, Weber KS, Bridgewater LC (2019). The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response. Sci Rep, 9(1), 934.
  9. Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price JC (2019). Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. Oncotarget, 10(4), 449-479.
  10. Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD, Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman BT, Andersen JL (2017). Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol, 37(20).
  11. Mortenson JB, Heppler LN, Banks CJ, Weerasekara VK, Whited MD, Piccolo SR, Johnson WE, Thompson JW, Andersen JL (2015). Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. J Biol Chem, 290(20), 12487-96.
  12. Weerasekara VK, Panek DJ, Broadbent DG, Mortenson JB, Mathis AD, Logan GN, Prince JT, Thomson DM, Thompson JW, Andersen JL (2014). Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. Mol Cell Biol, 34(24), 4379-88.
  13. Johnson ES, Lindblom KR, Robeson A, Stevens RD, Ilkayeva OR, Newgard CB, Kornbluth S, Andersen JL (2013). Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. J Biol Chem, 288(20), 14463-14475.
  14. Kim J, Parrish AB, Kurokawa M, Matsuura K, Freel CD, Andersen JL, Johnson CE, Kornbluth S (2012). Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis. EMBO J, 31(5), 1279-92.
  15. Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S (2011). A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. Mol Cell, 43(5), 834-42.
  16. Andersen JL, Kornbluth S (2011). Meeting the (N-terminal) end with acetylation. Cell, 146(4), 503-5.
  17. Andersen JL, Johnson CE, Freel CD, Parrish AB, Day JL, Buchakjian MR, Nutt LK, Thompson JW, Moseley MA, Kornbluth S (2009). Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J, 28(20), 3216-27.
  18. Andersen JL, Kornbluth S (2009). A cut above the other caspases. Mol Cell, 35(6), 733-4.
  19. Nutt LK, Buchakjian MR, Gan E, Darbandi R, Yoon SY, Wu JQ, Miyamoto YJ, Gibbons JA, Andersen JL, Freel CD, Tang W, He C, Kurokawa M, Wang Y, Margolis SS, Fissore RA, Kornbluth S (2008). Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell, 16(6), 856-66.
  20. Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V (2006). HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. PLoS Pathog, 2(12), e127.
  21. Ardon O, Zimmerman ES, Andersen JL, DeHart JL, Blackett J, Planelles V (2006). Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr. J Virol, 80(8), 3694-700.
  22. Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V (2005). ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ, 12(4), 326-34.
  23. Dehart JL, Andersen JL, Zimmerman ES, Ardon O, An DS, Blackett J, Kim B, Planelles V (2005). The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integration. J Virol, 79(3), 1389-96.
  24. Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V (2004). Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol, 24(21), 9286-94.

Review

  1. Lpez-Palacios TP, Andersen JL (2022). Kinase regulation by liquid-liquid phase separation. [Review]. Trends Cell Biol.
  2. Banks CJ, Andersen JL (2019). Mechanisms of SOD1 regulation by post-translational modifications. [Review]. Redox Biol, 26, 101270.
  3. Pennington KL, Chan TY, Torres MP, Andersen JL (2018). The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions. [Review]. Oncogene, 37(42), 5587-5604.
  4. Andersen JL, Kornbluth S (2012). The tangled circuitry of metabolism and apoptosis. [Review]. Mol Cell, 49(3), 399-410.
  5. Andersen JL, Le Rouzic E, Planelles V (2008). HIV-1 Vpr: mechanisms of G2 arrest and apoptosis. [Review]. Exp Mol Pathol, 85(1), 2-10.
  6. Andersen JL, Planelles V (2005). The role of Vpr in HIV-1 pathogenesis. [Review]. Curr HIV Res, 3(1), 43-51.

Commentary

  1. Andersen JL, Kornbluth S (2012). Mcl-1 rescues a glitch in the matrix. Nat Cell Biol, 14(6), 563-5.