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Margit M. Janát-Amsbury, M.D., Ph.D.

Languages spoken: English, Spanish, German, French, Czech, Dutch

Academic Information

Departments: Pharmaceutics and Pharmaceutical Chemistry - Adjunct Associate Professor, Bioengineering - Adjunct Assistant Professor

Academic Office Information

margit.janat-amsbury@hsc.utah.edu

Research Interests

  • Ovarian Neoplasms
  • Gynecologic Oncology
  • Drug Delivery Systems
  • Nanotechnology
  • Cancer Stem Cell Research
  • Animal Model Development
  • Personalized Health Care
MARGIT M. JANÁT-AMSBURY is holding a faculty appointment as Assistant Professor with the Division of Gynecologic Oncology in Department of Gynecology and Obstetrics, at the University of Utah and is the Research Director for Gynecologic Oncology. She received her M.D., Ph.D. in Gynecologic Oncology at Universität zu Köln (University of Cologne), Germany, did her clinical fellowships at Mount Sinai Hospital, New York, at the Academisch Ziekenhuis Maastricht at the University of Maastricht in the Netherlands and conducted her postdoctoral research studies at the University of Utah.
Prof. Janát-Amsbury focuses on the development of animal models for novel drug-, and gene carriers for clinical use in cancer therapy focusing mainly on gynecological malignancies. Her laboratory specializes in the design and development of innovative delivery systems and linking the areas of stem-cell-research, nano-medicine, macromolecular drug delivery, pharmaceutics and bioengineering to clinical applications. Delivery systems investigated by the Janát-Amsbury group are tailored to the tumor immunology of gynecological malignancies, and also target other areas of interest from the broad field of Obstetrics and Gynecology, including reproductive endocrinology and infertility, maternal fetal medicine as well as benign conditions as uterine fibroids and endometrioses.
Prof. Janát-Amsbury's research aims to develop novel diagnostic and therapeutic tools specifically for ovarian, endometrial and cervical cancer to facilitate faster market entry for new therapeutics. She has extensive clinical trial experience in oncology as an investigator and as a clinician in Europe and the United States and also held appointments at the University of Maastricht in the Netherlands and at Baylor College of Medicine in Houston, Texas, where she focused on translational research, being a lead-investigator in the first ever in humans applied polymeric IL-12 delivery system conducting a Phase 1 clinical trial in humans treating patients with recurrent ovarian cancer under a gene therapy protocol she developed. This clinical trial is currently open for recruitment here at Huntsman Cancer Institute GOG170-Q: A Phase II Evaluation of Intraperitoneal EGEN-001 (IL-12 plasmind formulated with PEG-PEI-cholesterol lipopolymer) in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer)
Prof. Janát-Amsbury was recruited back to the University of Utah by the department of gynecology and obstetrics, division of gynecologic oncology in fall 2007 where she focuses on establishing a translational research program linking basic scientists and clinicians together for the benefit of researching new paths to diagnose and cure gynecologic cancers. Her research has led to new patents and is being funded by the NIH.

Research Statement

My research focuses on the development and translation of new drug and gene carriers for clinical use in cancer therapy, with a particular interest in gynecological malignancies including breast cancer and tumor immunology. The translational focus is oriented to link specialties like Nanomedicine, Pharmaceutical Chemistry and Bioengineering to the field of Obstetrics and Gynecology with main interest for Gynecologic Oncology.

Education History

Fellowship University of Maastricht, Academisch Ziekenhuis (AZM), Dept. of OB/Gyn
Obstetrics and Gynecology
Clinical Fellow
Research Fellow University of Utah, Department of Pharmaceutics and Pharmaceutical Chemistry, Biomedical Polymers
Pharmaceutical Chemistry, Drug- and Gene Delivery
Postdoctoral Research Fellow
Residency Universitat zu Köln, Department of Obstetrics and Gynecology
Obstetrics and Gynecology
Resident
Internship/Residency Mount Sinai School of Medicine
Medical Oncology
Intern/Resident
Internship/Residency Universitat zu Köln, Department of Obstetrics and Gynecology
Obstetrics & Gynecology
Intern/Resident
Internship/Residency Universitat zu Köln, Department of Visceral and Vascular Surgery
Surgery
Intern/Resident
Professional Medical Universitat zu Köln
Molecular Biology/Oncology
M.D., Ph.D.
Professional Medical Universitat zu Köln, Medical School
Medicine
M.D.

Global Impact

Presentations

Description Country
Invited Lecture-12th International Symposium on Polymer Therapeutics (ISPT) Spain