Jack Skalicky, PhD is a research professor in the Department of Biochemistry at the University of Utah and is the director of the University of Utah Health Sciences Nuclear Magnetic Resonance core. Dr. Skalicky's research effort is focused on two distinct topics (1) biochemistry and structural biology of human MIT (Microtubule Interacting and Trafficking) proteins and their interaction with Endosomal Sorting Complexes Required for Transport (ESCRT) proteins and (2) structure-dynamics-function studies of model enzyme systems, i.e., how internal protein motions contribute to enzyme catalysis.
Education History
Postdoctoral Fellowship |
The State University at Buffalo Biomolecular NMR |
Postdoctoral Fellow |
---|---|---|
Postdoctoral Fellowship |
University of British Columbia Biomolecular NMR |
Postdoctoral Fellow |
Doctoral Training |
University of Colorado Chemistry |
Ph.D. |
Graduate Training |
University of Northern Colorado Chemistry |
M.A. |
Undergraduate |
University of Wisconsin Biology and Chemistry |
B.S. |
Selected Publications
- Nathaniel Talledge, John McCullough, Dawn Wenzel, Henry C Nguyen, Matthew S Lalonde, Monika Bajorek, Jack Skalicky, Adam Frost, Wesley I Sundqust (2018). The ESCRT-III proteins IST1 and CHMP1B assemble around nucleic acids.
- Davulcu O, Peng Y, Brschweiler R, Skalicky JJ, Chapman MS (2017). Elevated μs-ms timescale backbone dynamics in the transition state analog form of arginine kinase. J Struct Biol, 200(3), 258-266.
- Currie SL, Doane JJ, Evans KS, Bhachech N, Madison BJ, Lau DKW, McIntosh LP, Skalicky JJ, Clark KA, Graves BJ (2017). ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain. J Mol Biol, 429(20), 2975-2995.
- Peng Y, Hansen AL, Bruschweiler-Li L, Davulcu O, Skalicky JJ, Chapman MS, Brschweiler R (2017). The Michaelis Complex of Arginine Kinase Samples the Transition State at a Frequency That Matches the Catalytic Rate. J Am Chem Soc, 139(13), 4846-4853.
- Godsey MH, Davulcu O, Nix JC, Skalicky JJ, Brschweiler RP, Chapman MS (2016). The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase. Structure, 24(10), 1658-1667.
- Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton RS (2016). Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J Biol Chem, 291(13), 7205-20.
- Chapman BK, Davulcu O, Skalicky JJ, Brschweiler RP, Chapman MS (2015). Parsimony in Protein Conformational Change. Structure, 23(7), 1190-8.
- Caballe A, Wenzel DM, Agromayor M, Alam SL, Skalicky JJ, Kloc M, Carlton JG, Labrador L, Sundquist WI, Martin-Serrano J (2015). ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. Elife, 4, e06547.
- Davulcu O, Niu X, Bruschweiler-Li L, Bruschweiler R, Skalicky JJ, Chapman MS (2014). Backbone resonance assignments of the 42 kDa enzyme arginine kinase in the transition state analogue form. Biomol NMR Assign, 8(2), 335-8.
- Skalicky JJ, Arii J, Wenzel DM, Stubblefield WM, Katsuyama A, Uter NT, Bajorek M, Myszka DG, Sundquist WI (2012). Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem, 287(52), 43910-26.
- Wei X, Henriksen NM, Skalicky JJ, Harper MK, Cheatham TE 3rd, Ireland CM, Van Wagoner RM (2011). Araiosamines A-D: tris-bromoindole cyclic guanidine alkaloids from the marine sponge Clathria (Thalysias) araiosa. J Org Chem, 76(14), 5515-23.
- Davulcu O, Skalicky JJ, Chapman MS (2011). Rate-limiting domain and loop motions in arginine kinase. Biochemistry, 50(19), 4011-8.
- Niu X, Bruschweiler-Li L, Davulcu O, Skalicky JJ, Bruschweiler R, Chapman MS (2011). Arginine kinase: joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility. J Mol Biol, 405(2), 479-96.
- Nguyen TK, Tran VM, Victor XV, Skalicky JJ, Kuberan B (2010). Characterization of uniformly and atom-specifically (13)C-labeled heparin and heparan sulfate polysaccharide precursors using (13)C NMR spectroscopy and ESI mass spectrometry. Carbohydr Res, 345(15), 2228-32.
- Paulsen RB, Seth PP, Swayze EE, Griffey RH, Skalicky JJ, Cheatham TE 3rd, Davis DR (2010). Inhibitor-induced structural change in the HCV IRES domain IIa RNA. Proc Natl Acad Sci U S A, 107(16), 7263-8.
- Gowd KH, Yarotskyy V, Elmslie KS, Skalicky JJ, Olivera BM, Bulaj G (2010). Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry, 49(12), 2741-52.
Global Impact
Education History
Type | School | Degree |
---|---|---|
Postdoctoral Fellowship | University of British Columbia Biomolecular NMR |
Postdoctoral Fellow |