Jack J. Skalicky

Jack J. Skalicky, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Jack Skalicky, PhD is a research professor in the Department of Biochemistry at the University of Utah and is the director of the University of Utah Health Sciences Nuclear Magnetic Resonance core. Dr. Skalicky's research effort is focused on two distinct topics (1) biochemistry and structural biology of human MIT (Microtubule Interacting and Trafficking) proteins and their interaction with Endosomal Sorting Complexes Required for Transport (ESCRT) proteins and (2) structure-dynamics-function studies of model enzyme systems, i.e., how internal protein motions contribute to enzyme catalysis.

Education History

Undergraduate University of Wisconsin
 BS
Graduate Training University of Northern Colorado
 MA
Doctoral Training University of Colorado
 PhD
Postdoctoral Fellowship University of British Columbia
 Postdoctoral Fellow
Postdoctoral Fellowship The State University at Buffalo
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Gowd KH, Yarotskyy V, Elmslie KS, Skalicky JJ, Olivera BM, Bulaj (2010). Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry, 49(12), 2741-52.
  2. Davulcu O, Skalicky JJ, Chapman M (2011). Rate-limiting domain and loop motions in arginine kinase. Biochemistry, 50(19), 4011-8.
  3. Davulcu O, Peng Y, Brüschweiler R, Skalicky JJ, Chapman M (2017). Elevated ¿s-ms timescale backbone dynamics in the transition state analog form of arginine kinase. Journal of structural biology, 200(3), 258-266.
  4. Nguyen TK, Tran VM, Victor XV, Skalicky JJ, Kuberan (2010). Characterization of uniformly and atom-specifically (13)C-labeled heparin and heparan sulfate polysaccharide precursors using (13)C NMR spectroscopy and ESI mass spectrometry. Carbohydrate research, 345(15), 2228-32.
  5. Peng Y, Hansen AL, Bruschweiler-Li L, Davulcu O, Skalicky JJ, Chapman MS, Brüschweiler (2017). The Michaelis Complex of Arginine Kinase Samples the Transition State at a Frequency That Matches the Catalytic Rate. Journal of the American Chemical Society, 139(13), 4846-4853.
  6. Skalicky JJ, Arii J, Wenzel DM, Stubblefield WM, Katsuyama A, Uter NT, Bajorek M, Myszka DG, Sundquist W (2012). Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. The Journal of biological chemistry, 287(52), 43910-26.
  7. Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton R (2016). Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin ¿O§-GVIIJ. The Journal of biological chemistry, 291(13), 7205-20.
  8. Niu X, Bruschweiler-Li L, Davulcu O, Skalicky JJ, Bruschweiler R, Chapman M (2011). Arginine kinase: joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility. Journal of molecular biology, 405(2), 479-96.
  9. Currie SL, Doane JJ, Evans KS, Bhachech N, Madison BJ, Lau DKW, McIntosh LP, Skalicky JJ, Clark KA, Graves B (2017). ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain. Journal of molecular biology, 429(20), 2975-2995.
  10. Wei X, Henriksen NM, Skalicky JJ, Harper MK, Cheatham TE 3rd, Ireland CM, Van Wagoner R (2011). Araiosamines A-D: tris-bromoindole cyclic guanidine alkaloids from the marine sponge Clathria (Thalysias) araiosa. The Journal of organic chemistry, 76(14), 5515-23.
  11. Paulsen RB, Seth PP, Swayze EE, Griffey RH, Skalicky JJ, Cheatham TE 3rd, Davis D (2010). Inhibitor-induced structural change in the HCV IRES domain IIa RNA. Proceedings of the National Academy of Sciences of the United States of America, 107(16), 7263-8.
  12. Chapman BK, Davulcu O, Skalicky JJ, Brüschweiler RP, Chapman M (2015). Parsimony in Protein Conformational Change. Structure (London, England, 23(7), 1190-8.
  13. Godsey MH, Davulcu O, Nix JC, Skalicky JJ, Brüschweiler RP, Chapman M (2016). The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase. Structure (London, England, 24(10), 1658-1667.
  14. Davulcu O, Niu X, Bruschweiler-Li L, Bruschweiler R, Skalicky JJ, Chapman M (2014). Backbone resonance assignments of the 42 kDa enzyme arginine kinase in the transition state analogue form. Biomolecular NMR assignments, 8(2), 335-8.
  15. Caballe A, Wenzel DM, Agromayor M, Alam SL, Skalicky JJ, Kloc M, Carlton JG, Labrador L, Sundquist WI, Martin-Serrano (2015). ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. eLife, 4, e06547.

Other

  1. Nathaniel Talledge, John McCullough, Dawn Wenzel, Henry C. Nguyen, Matthew S. Lalonde, Monika Bajorek, Jack Skalicky, Adam Frost, Wesley I. Sundqus (2018). The ESCRT-III proteins IST1 and CHMP1B assemble around nucleic acids.