F. Edward Dudek, PhD

Languages spoken: English

Academic Information

Departments: Neurosurgery - Professor

Academic Office Information

ed.dudek@hsc.utah.edu

(801) 581-6354

College of Health
Neurosurgery
383 Colorow Building, Room: 383
Salt Lake City, UT 84108
Dr. Dudek received his B.S. in Biological Sciences from the University of California, Irvine in June, 1969, as well as his Ph.D. degree in 1973. Dr. Dudek went on to complete a postdoctoral fellowship in the Department of Ophthalmology Research from the College of Physicians and Surgeons at Columbia University in New York from Feb 1973 to Feb 1974. From April 1974to September 1974 he was a Post-Doctoral Research Associate in the Department of Psychobiology, University of California, Irvine, California. He was then a Postdoctoral Research Associate at the Marine Biomedical Institute and Department of Physiology and Biophysics at the University of Texas Medical Branch in Galveston, TX from October 1974 to July 1975.

In August of 1975 Dr. Dudek became an Assistant Professor in the Department of Physiology at Tulane University School of Medicine in New Orleans, LA until June 1980. At that time, Dr. Dudek was promoted to Associate Professor, also at Tulane University School of Medicine. In 1984 Dr. Dudek was made Professor in the Department of Physiology at Tulane University School of Medicine, where he resided until 1987. July 1987 – June 1992 Dr. Dudek was Professor and Associate Director of the Mental Retardation Research Center, at the University of California at Los Angeles School of Medicine. Dr. Dudek was then a Professor in the Department of Biomedical Sciences at Colorado State University in Fort Collins, CO, where he also served as Chair for the department of Anatomy and Neurobiology from July 1992 to June 2000 and Associate Director of the Molecular, Cellular and Integrative Neuroscience Program from July 2002-December 2005. In March 2005 Dr. Dudek was made Professor and Chair of the Department of Physiology at the University of Utah School of Medicine.

Education History

Postdoctoral Training Marine Biomedical Institute and Dept. of Physiology & Biophysics, University of Texas Medical Branch
Physiology and Biophysics 		Postdoctoral Training
Postdoctoral Training University of California, Dept. of Psychobiology
Neurophysiology 		Postdoctoral Training
Postdoctoral Training Columbia University, Dept. of Ophthalmology Research, College of Physicians and Surgeons
Sensory Physiology 		Postdoctoral Training
Doctoral Training University of California, Dept. of Developmental and Cell Biology
Neurophysiology 		Ph.D.
Undergraduate University of California
Biological Sciences 		B.Sc.

Selected Publications

  1. Shao LR, Dudek FE (2022). Enhanced Burst Discharges in the CA1 Area of the Immature Versus Adult Hippocampus: Patterns and Cellular Mechanisms. J Neurophysiol, 128(6), 1566-1577.
  2. Barker BS, Spampanato J, McCarren HS, Berger K, Jackson CE, Yeung DT, Dudek FE, McDonough JH (2021). The Kv7 Modulator, Retigabine, is an Efficacious Antiseizure Drug for Delayed Treatment of Organophosphate-induced Status Epilepticus. Neuroscience, 463, 143-158.
  3. Spampanato J, Bealer SL, Smolik M, Dudek FE (2020). Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine. J Pharmacol Exp Ther, 375(1), 59-68.
  4. Barker BS, Spampanato J, McCarren HS, Smolik M, Jackson CE, Hornung EN, Yeung DT, Dudek FE, McDonough JH (2019). Screening for Efficacious Anticonvulsants and Neuroprotectants in Delayed Treatment Models of Organophosphate-induced Status Epilepticus. Neuroscience, 425, 280-300.
  5. Spampanato J, Pouliot W, Bealer SL, Roach B, Dudek FE (2019). Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure. Epilepsia, 60(7), 1387-1398.
  6. Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee KW (2019). Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning. Front Pharmacol, 10, 560.
  7. Sawant-Pokam PM, Suryavanshi P, Mendez JM, Dudek FE, Brennan KC (2017). Mechanisms of Neuronal Silencing After Cortical Spreading Depression. Cereb Cortex, 27(2), 1311-1325.
  8. Pouliot W, Bealer SL, Roach B, Dudek FE (2016). A rodent model of human organophosphate exposure producing status epilepticus and neuropathology. Neurotoxicology, 56, 196-203.
  9. Kadam SD, Dudek FE (2016). Temporal progression of evoked field potentials in neocortical slices after unilateral hypoxia-ischemia in perinatal rats: Correlation with cortical epileptogenesis. Neuroscience, 316, 232-48.
  10. Bercum FM, Rodgers KM, Benison AM, Smith ZZ, Taylor J, Kornreich E, Grabenstatter HL, Dudek FE, Barth DS (2015). Maternal Stress Combined with Terbutaline Leads to Comorbid Autistic-Like Behavior and Epilepsy in a Rat Model. J Neurosci, 35(48), 15894-902.
  11. Zayachkivsky A, Lehmkuhle MJ, Ekstrand JJ, Dudek FE (2015). Ischemic injury suppresses hypoxia-induced electrographic seizures and the background EEG in a rat model of perinatal hypoxic-ischemic encephalopathy. J Neurophysiol, 114(5), 2753-63.
  12. Pitkanen A, Lukasiuk K, Dudek FE, Staley KJ (2015). Epileptogenesis.LID - 10.1101/cshperspect.a022822 [doi]LID - a022822 [pii]. Cold Spring Harb Perspect Med, 5(10).
  13. Zayachkivsky A, Lehmkuhle MJ, Dudek FE (2015). Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System. J Vis Exp, (101), e52554.
  14. Rodgers KM, Dudek FE, Barth DS (2015). Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy. J Neurosci, 35(24), 9194-204.
  15. Trandafir CC, Pouliot WA, Dudek FE, Ekstrand JJ (2015). Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. Neuroscience, 284, 601-610.
  16. Spampanato J, Dudek FE (2014). Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus. Epilepsia, 55(9), e94-8.
  17. Dingledine R, Varvel NH, Dudek FE (2014). When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Adv Exp Med Biol, 813, 109-22.