James E. Cox

James E. Cox, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Education History

Doctoral Training Ohio State University
 PhD
Undergraduate University of Kentucky
 BA, BS

Selected Publications

Journal Article

  1. VanSant-Webb C, Low HK, Kuramoto J, Stanley CE, Qiang H, Su A, Ross AN, Cooper CG, Cox JE, Summers SA, Evason KJ, Ducker GS (2024). Phospholipid isotope tracing suggests β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma. Biochim Biophys Acta Mol Cell Biol Lipids, 159514. (Read full article)
  2. Hansen DT, Rueb NJ, Levinzon ND, Cheatham TE 3rd, Gaston R Jr, Tanvir Ahmed K, Osburn-Staker S, Cox JE, Dudley GB, Barrios AM (2024). The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Bioorg Med Chem Lett, 104, 129740. (Read full article)
  3. Xiao T, English AM, Wilson ZN, Maschek JA, Cox JE, Hughes AL (2024). The phospholipids cardiolipin and phosphatidylethanolamine differentially regulate MDC biogenesis. J Cell Biol, 223(5). (Read full article)
  4. Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Lang MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K (2024). Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. J Clin Invest. (Read full article)
  5. Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ (2023). Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res, 65(2), 100434. (Read full article)
  6. Shahtout JL, Eshima H, Ferrara PJ, Maschek JA, Cox JE, Drummond MJ, Funai K (2023). Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity. J Cachexia Sarcopenia Muscle, 15(1), 319-330. (Read full article)
  7. Freeman SM, Catrow JL, Cox JE, Turano A, Rich MA, Ihrig HP, Poudyal N, Chang CT, Gese EM, Young JK, Olsen AL (2024). Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote (Canis latrans). Comp Med, 74(1), 3-11. (Read full article)
  8. Li Y, Chaurasia B, Rahman MM, Kaddai V, Maschek JA, Berg JA, Wilkerson JL, Mahmassani ZS, Cox J, Wei P, Meikle PJ, Atkinson D, Wang L, Poss AM, Playdon MC, Tippetts TS, Mousa EM, Nittayaboon K, Anandh Babu PV, Drummond MJ, Clevers H, Shayman JA, Hirabayashi Y, Holland WL, Rutter J, Edgar BA, Summers SA (2023). Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Gastroenterology, 165(5), 1136-1150. (Read full article)
  9. Li F, Lin Z, Krug PJ, Catrow JL, Cox JE, Schmidt EW (2023). Animal FAS-like polyketide synthases produce diverse polypropionates. Proc Natl Acad Sci U S A, 120(38), e2305575120. (Read full article)
  10. Zhao J, Ballard C, Cohen AJ, Ringham B, Zhao B, Wang H, Zuspan K, Rebentisch A, Locklear BA, Dahl M, Maschek JA, Cox JE, Joss-Moore LA (2023). Postnatal growth restriction impairs rat lung structure and function. Anat Rec (Hoboken). (Read full article)
  11. Miljkovic M, Seguin A, Jia X, Cox JE, Catrow JL, Bergonia H, Phillips JD, Stephens WZ, Ward DM (2023). Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. J Biol Chem, 299(7), 104877. (Read full article)
  12. Sharma R, Antypiuk A, Vance SZ, Manwani D, Pearce Q, Cox JE, An X, Yazdanbakhsh K, Vinchi F (2023). Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease. Blood, 141(25), 3091-3108. (Read full article)
  13. Berg JA, Zhou Y, Ouyang Y, Cluntun AA, Waller TC, Conway ME, Nowinski SM, Van Ry T, George I, Cox JE, Wang B, Rutter J (2023). Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns. Nat Cell Biol, 25(4), 616-625. (Read full article)
  14. Ferrara PJ, Lang MJ, Johnson JM, Watanabe S, McLaughlin KL, Maschek JA, Verkerke ARP, Siripoksup P, Chaix A, Cox JE, Fisher-Wellman KH, Funai K (2023). Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice. Life Metab, 2(2). (Read full article)
  15. Eshima H, Shahtout JL, Siripoksup P, Pearson MJ, Mahmassani ZS, Ferrara PJ, Lyons AW, Maschek JA, Peterlin AD, Verkerke ARP, Johnson JM, Salcedo A, Petrocelli JJ, Miranda ER, Anderson EJ, Boudina S, Ran Q, Cox JE, Drummond MJ, Funai K (2023). Lipid hydroperoxides promote sarcopenia through carbonyl stress. Elife, 12. (Read full article)
  16. Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J (2023). Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science, 379(6636), 996-1003. (Read full article)
  17. Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K (2023). Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Sci Adv, 9(8), eade7864. (Read full article)
  18. Oka SI, Sreedevi K, Shankar TS, Yedla S, Arowa S, James A, Stone KG, Olmos K, Sabry AD, Horiuchi A, Cawley KM, Overy SA, Tong M, Byun J, Xu X, Kashyap S, Mourad Y, Vehra O, Calder D, Lunde T, Liu T, Li H, Mashchek JA, Cox J, Saijoh Y, Drakos SG, Warren JS (2022). PERM1 regulates energy metabolism in the heart via ERRα/PGC-1α axis. Front Cardiovasc Med, 9, 1033457. (Read full article)
  19. Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA (2022). An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice. Science, 378(6617), 290-295. (Read full article)
  20. Poss AM, Krick B, Maschek JA, Haaland B, Cox JE, Karra P, Ibele AR, Hunt SC, Adams TD, Holland WL, Playdon MC, Summers SA (2022). Following Roux-en-Y gastric bypass surgery, serum ceramides demarcate patients that will fail to achieve normoglycemia and diabetes remission. Med, 3(7), 452-467.e4. (Read full article)
  21. Li Y, Talbot CL, Chandravanshi B, Ksiazek A, Sood A, Chowdhury KH, Maschek JA, Cox J, Babu AKS, Paz HA, Babu PVA, Meyerholz DK, Wankhade UD, Holland W, Shyong Tai E, Summers SA, Chaurasia B (2022). Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis. Sci Rep, 12(1), 7273. (Read full article)
  22. Marcero JR, Cox JE, Bergonia HA, Medlock AE, Phillips JD, Dailey HA (2021). The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors. Blood Adv, 5(23), 4831-4841. (Read full article)
  23. Jadhav S, Protchenko O, Li F, Baratz E, Shakoury-Elizeh M, Maschek A, Cox J, Philpott CC (2021). Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1. Free Radic Biol Med, 175, 18-27. (Read full article)
  24. Nuebel E, Morgan JT, Fogarty S, Winter JM, Lettlova S, Berg JA, Chen YC, Kidwell CU, Maschek JA, Clowers KJ, Argyriou C, Chen L, Wittig I, Cox JE, Roh-Johnson M, Braverman N, Bonkowsky J, Gygi SP, Rutter J (2021). The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. EMBO Rep, 22(10), e51991. (Read full article)
  25. Ferrara PJ, Verkerke ARP, Maschek JA, Shahtout JL, Siripoksup P, Eshima H, Johnson JM, Petrocelli JJ, Mahmassani ZS, Green TD, McClung JM, Cox JE, Drummond MJ, Funai K (2021). Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding. FASEB J, 35(10), e21867. (Read full article)
  26. Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers SA (2020). Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study. J Clin Endocrinol Metab, 106(8), e3098-e3109. (Read full article)
  27. Huffaker TB, Ekiz HA, Barba C, Lee SH, Runtsch MC, Nelson MC, Bauer KM, Tang WW, Mosbruger TL, Cox JE, Round JL, Voth WP, OConnell RM (2021). A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages. Nat Commun, 12(1), 2620. (Read full article)
  28. Yan D, Franzini A, Pomicter AD, Halverson BJ, Antelope O, Mason CC, Ahmann JM, Senina AV, Vellore NA, Jones CL, Zabriskie MS, Than H, Xiao MJ, van Scoyk A, Patel AB, Clair PM, Heaton WL, Owen SC, Andersen JL, Egbert CM, Reisz JA, DAlessandro A, Cox JE, Gantz KC, Redwine HM, Iyer SM, Khorashad JS, Rajabi N, Olsen CA, OHare T, Deininger MW (2019). SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA. Blood Cancer Discov, 2(3), 266-287. (Read full article)
  29. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K (2019). Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. J Clin Invest, 131(8). (Read full article)
  30. Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG (2020). The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab, 33(3), 629-648.e10. (Read full article)
  31. Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott CC (2020). Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis. Hepatology, 73(3), 1176-1193. (Read full article)
  32. Chaurasia B, Ying L, Talbot CL, Maschek JA, Cox J, Schuchman EH, Hirabayashi Y, Holland WL, Summers SA (2020). Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes. Mol Metab, 45, 101145. (Read full article)
  33. Liou TG, Adler FR, Cahill BC, Cox DR, Cox JE, Grant GJ, Hanson KE, Hartsell SC, Hatton ND, Helms MN, Jensen JL, Kartsonaki C, Li Y, Leung DT, Marvin JE, Middleton EA, Osburn-Staker SM, Packer KA, Shakir SM, Sturrock AB, Tardif KD, Warren KJ, Waddoups LJ, Weaver LJ, Zimmerman E, Paine R 3rd (2020). SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection. Physiol Rep, 9(4), e14761. (Read full article)
  34. Cortes-Selva D, Gibbs L, Maschek JA, Nascimento M, Van Ry T, Cox JE, Amiel E, Fairfax KC (2021). Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure. PLoS Pathog, 17(1), e1009198. (Read full article)
  35. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED (2020). Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nat Metab, 2(11), 1248-1264. (Read full article)
  36. Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, DeBerardinis RJ, Rutter J (2020). Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. Elife, 9. (Read full article)
  37. Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ (2020). Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. Elife, 9. (Read full article)
  38. Naylor BC, Catrow JL, Maschek JA, Cox JE (2020). QSRR Automator: A Tool for Automating Retention Time Prediction in Lipidomics and Metabolomics. Metabolites, 10(6). (Read full article)
  39. Poss AM, Maschek JA, Cox JE, Hauner BJ, Hopkins PN, Hunt SC, Holland WL, Summers SA, Playdon MC (2019). Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease. J Clin Invest, 130(3), 1363-1376. (Read full article)
  40. Weinheimer C, Wang H, Comstock JM, Singh P, Wang Z, Locklear BA, Goodwin KL, Maschek JA, Cox JE, Baack ML, Joss-Moore LA (2020). Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Reprod Sci, 27(2), 631-643. (Read full article)
  41. Schober ME, Requena DF, Maschek JA, Cox J, Parra L, Lolofie A (2019). Effects of controlled cortical impact and docosahexaenoic acid on rat pup fatty acid profiles. Behav Brain Res, 378, 112295. (Read full article)
  42. Varedi A, Rahman H, Kumar D, Catrow JL, Cox JE, Liu T, Florell SR, Boucher KM, Okwundu N, Burnett WJ, VanBrocklin MW, Grossman D (2020). ASA Suppresses PGE2 in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma. Pharmaceuticals (Basel), 13(1). (Read full article)
  43. Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K (2019). Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Mol Metab, 31, 55-66. (Read full article)
  44. Chalermwat C, Thosapornvichai T, Wongkittichote P, Phillips JD, Cox JE, Jensen AN, Wattanasirichaigoon D, Jensen LT (2019). Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. FEMS Yeast Res, 19(8). (Read full article)
  45. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brs LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019). Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv, 5(9), eaax8352. (Read full article)
  46. Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA (2019). Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Science, 365(6451), 386-392. (Read full article)
  47. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, OConnell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL (2018). T cell-mediated regulation of the microbiota protects against obesity. Science, 365(6451). (Read full article)
  48. Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB (2019). Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. Elife, 8. (Read full article)
  49. Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J (2019). Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab, 29(5), 1119-1134.e12. (Read full article)
  50. Ganeshan K, Nikkanen J, Man K, Leong YA, Sogawa Y, Maschek JA, Van Ry T, Chagwedera DN, Cox JE, Chawla A (2019). Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Cell, 177(2), 399-413.e12. (Read full article)
  51. Washburn RL, Cox JE, Muhlestein JB, May HT, Carlquist JF, Le VT, Anderson JL, Horne BD (2019). Pilot Study of Novel Intermittent Fasting Effects on Metabolomic and Trimethylamine N-oxide Changes During 24-hour Water-Only Fasting in the FEELGOOD Trial. Nutrients, 11(2). (Read full article)
  52. Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price JC (2019). Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. Oncotarget, 10(4), 449-479. (Read full article)
  53. Kumar D, Rahman H, Tyagi E, Liu T, Li C, Lu R, Lum D, Holmen SL, Maschek JA, Cox JE, VanBrocklin MW, Grossman D (2018). Aspirin Suppresses PGE2 and Activates AMP Kinase to Inhibit Melanoma Cell Motility, Pigmentation, and Selective Tumor Growth In Vivo. Cancer Prev Res (Phila), 11(10), 629-642. (Read full article)
  54. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr (2018). Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Blood, 132(10), 987-998. (Read full article)
  55. Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S (2018). Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Proc Natl Acad Sci U S A, 115(33), E7871-E7880. (Read full article)
  56. Ward DM, Chen OS, Li L, Kaplan J, Bhuiyan SA, Natarajan SK, Bard M, Cox JE (2018). Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. J Biol Chem, 293(27), 10782-10795. (Read full article)
  57. Deering-Rice CE, Nguyen N, Lu Z, Cox JE, Shapiro D, Romero EG, Mitchell VK, Burrell KL, Veranth JM, Reilly CA (2018). Activation of TRPV3 by Wood Smoke Particles and Roles in Pneumotoxicity. Chem Res Toxicol, 31(5), 291-301. (Read full article)
  58. Szaniawski MA, Spivak AM, Cox JE, Catrow JL, Hanley T, Williams ESCP, Tremblay MJ, Bosque A, Planelles V (2018). SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition. mBio, 9(3). (Read full article)
  59. Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami RS (2018). Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model. Benef Microbes, 9(3), 495-513. (Read full article)
  60. Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S (2017). Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. J Mol Cell Cardiol, 113, 39-50. (Read full article)
  61. Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB (2017). The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab, 6(11), 1468-1479. (Read full article)
  62. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ (2016). Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell Metab, 26(3), 509-522.e6. (Read full article)
  63. Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J (2017). Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol, 19(9), 1027-1036. (Read full article)
  64. Cox JE, Thummel CS, Tennessen JM (2017). Metabolomic Studies in Drosophila. Genetics, 206(3), 1169-1185. (Read full article)
  65. Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, OConnell RM, Tebo AE, Round JL (2015). A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci Transl Med, 9(380). (Read full article)
  66. Li H, Chawla G, Hurlburt AJ, Sterrett MC, Zaslaver O, Cox J, Karty JA, Rosebrock AP, Caudy AA, Tennessen JM (2017). Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth. Proc Natl Acad Sci U S A, 114(6), 1353-1358. (Read full article)
  67. Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG (2016). Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning. JACC Basic Transl Sci, 1(6), 432-444. (Read full article)
  68. McClelland EE, Ramagopal UA, Rivera J, Cox J, Nakouzi A, Prabu MM, Almo SC, Casadevall A (2016). A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals. PLoS Pathog, 12(9), e1005849. (Read full article)
  69. Hibbs JB Jr, Vavrin Z, Cox JE (2016). Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose. Redox Biol, 8, 271-84. (Read full article)
  70. Nam H, Jones D, Cooksey RC, Gao Y, Sink S, Cox J, McClain DA (2016). Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes, 65(6), 1521-33. (Read full article)
  71. Robinson GL, Philip B, Guthrie MR, Cox JE, Robinson JP, VanBrocklin MW, Holmen SL (2016). In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation. Cancer Res Front, 2(2), 311-329. (Read full article)
  72. Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB (2015). Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell Metab, 22(4), 669-81. (Read full article)
  73. Frech TM, Revelo MP, Ryan JJ, Shah AA, Gordon J, Domsic R, Hant F, Assassi S, Shanmugam VK, Hinchcliff M, Steen V, Khanna D, Bernstein EJ, Cox J, Luem N, Drakos S (2015). Cardiac metabolomics and autopsy in a patient with early diffuse systemic sclerosis presenting with dyspnea: a case report. J Med Case Rep, 9, 136. (Read full article)
  74. Simcox JA, Mitchell TC, Gao Y, Just SF, Cooksey R, Cox J, Ajioka R, Jones D, Lee SH, King D, Huang J, McClain DA (2014). Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. Diabetes, 64(4), 1108-19. (Read full article)
  75. Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV (2015). Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PLoS One, 10(3), e0118974. (Read full article)
  76. Philip M, Funkhouser SA, Chiu EY, Phelps SR, Delrow JJ, Cox J, Fink PJ, Abkowitz JL (2015). Heme exporter FLVCR is required for T cell development and peripheral survival. J Immunol, 194(4), 1677-85. (Read full article)
  77. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A (2015). Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science, 347(6217), 75-8. (Read full article)
  78. Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D (2015). Detection and in vitro metabolism of AOD9604. Drug Test Anal, 7(1), 31-8. (Read full article)
  79. Kohl KD, Weiss RB, Cox J, Dale C, Dearing MD (2014). Gut microbes of mammalian herbivores facilitate intake of plant toxins. Ecol Lett, 17(10), 1238-46. (Read full article)
  80. Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, Winge DR (2014). The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab, 20(2), 253-66. (Read full article)
  81. Van Vranken JG, Bricker DK, Dephoure N, Gygi SP, Cox JE, Thummel CS, Rutter J (2014). SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab, 20(2), 241-52. (Read full article)
  82. Tennessen JM, Barry WE, Cox J, Thummel CS (2014). Methods for studying metabolism in Drosophila. Methods, 68(1), 105-15. (Read full article)
  83. Tennessen JM, Bertagnolli NM, Evans J, Sieber MH, Cox J, Thummel CS (2014). Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis. G3 (Bethesda), 4(5), 839-50. (Read full article)
  84. Hintze KJ, Cox JE, Rompato G, Benninghoff AD, Ward RE, Broadbent J, Lefevre M (2014). Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer. Gut Microbes, 5(2), 183-91. (Read full article)
  85. Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S (2013). Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. J Mol Cell Cardiol, 64, 20-9. (Read full article)
  86. Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, McClain DA (2013). Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice. FASEB J, 27(7), 2845-54. (Read full article)
  87. Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, Concepcion GP, Olivera BM, Schmidt EW (2013). A bacterial source for mollusk pyrone polyketides. Chem Biol, 20(1), 73-81. (Read full article)
  88. Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV (2013). Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PLoS One, 8(3), e57821. (Read full article)
  89. McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J, Simcox JA, Yoon D, Prchal JT, Gordeuk VR (2013). Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. J Mol Med (Berl), 91(1), 59-67. (Read full article)
  90. Lin Z, Falkinham JO 3rd, Tawfik KA, Jeffs P, Bray B, Dubay G, Cox JE, Schmidt EW (2012). Burkholdines from Burkholderia ambifaria: antifungal agents and possible virulence factors. J Nat Prod, 75(9), 1518-23. (Read full article)
  91. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J (2012). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337(6090), 96-100. (Read full article)
  92. Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Mschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede NS (2012). Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood, 119(24), 5621-31. (Read full article)
  93. Donia MS, Fricke WF, Partensky F, Cox J, Elshahawi SI, White JR, Phillippy AM, Schatz MC, Piel J, Haygood MG, Ravel J, Schmidt EW (2011). Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis. Proc Natl Acad Sci U S A, 108(51), E1423-32. (Read full article)
  94. Fung C, Brown A, Cox J, Callaway C, McKnight R, Lane R (2014). Novel thromboxane A2 analog-induced IUGR mouse model. J Dev Orig Health Dis, 2(5), 291-301. (Read full article)
  95. Gleason JE, Corrigan DJ, Cox JE, Reddi AR, McGinnis LA, Culotta VC (2011). Analysis of hypoxia and hypoxia-like states through metabolite profiling. PLoS One, 6(9), e24741. (Read full article)
  96. Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott CC (2010). Metabolic response to iron deficiency in Saccharomyces cerevisiae. J Biol Chem, 285(19), 14823-33. (Read full article)
  97. Cox J, Williams S, Grove K, Lane RH, Aagaard-Tillery KM (2009). A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. Am J Obstet Gynecol, 201(3), 281.e1-9. (Read full article)
  98. Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D (2009). Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol, 11(3), 320-7. (Read full article)
  99. Cox JE, Priestley ND (2005). Nonactin biosynthesis: the product of the resistance gene degrades nonactin stereospecifically to form homochiral nonactate dimers. J Am Chem Soc, 127(22), 7976-7. (Read full article)

Letter

  1. Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai K (2019). Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. [Letter to the editor]. Nat Metab, 1(9), 876-885. (Read full article)

Other

  1. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED (2020). Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nat Metab (2(12), p. 1498). Germany. (Read full article)