James Eric Cox, PhD

James Eric Cox, PhD, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Education History

Undergraduate University of Kentucky
 BA, BS
Doctoral Training Ohio State University
 PhD

Selected Publications

Journal Article

  1. Cox J, Williams S, Grove K, Lane RH, Aagaard-Tillery KM (2009). A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. Am J Obstet Gynecol, 201(3), 281.e1-9.
  2. Deering-Rice CE, Nguyen N, Lu Z, Cox JE, Shapiro D, Romero EG, Mitchell VK, Burrell KL, Veranth JM, Reilly C (2018). Activation of TRPV3 by Wood Smoke Particles and Roles in Pneumotoxicity. Chemical research in toxicology, 31(5), 291-301.
  3. Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Müschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede N (2012). Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood, 119(24), 5621-31.
  4. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA J (2018). Glutamine via ¿-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Blood, 132(10), 987-998.
  5. Schober ME, Requena DF, Maschek JA, Cox J, Parra L, Lolofie (2020). Effects of controlled cortical impact and docosahexaenoic acid on rat pup fatty acid profiles. Behavioural brain research, 378, 112295.
  6. Ganeshan K, Nikkanen J, Man K, Leong YA, Sogawa Y, Maschek JA, Van Ry T, Chagwedera DN, Cox JE, Chawla (2019). Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Cell, 177(2), 399-413.e12.
  7. Nam H, Jones D, Cooksey RC, Gao Y, Sink S, Cox J, McClain D (2016). Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes, 65(6), 1521-33.
  8. Simcox JA, Mitchell TC, Gao Y, Just SF, Cooksey R, Cox J, Ajioka R, Jones D, Lee SH, King D, Huang J, McClain D (2015). Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. Diabetes, 64(4), 1108-19.
  9. Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, McClain D (2013). Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice. FASEB journal, 27(7), 2845-54.
  10. Ferrara PJ, Verkerke ARP, Maschek JA, Shahtout JL, Siripoksup P, Eshima H, Johnson JM, Petrocelli JJ, Mahmassani ZS, Green TD, McClung JM, Cox JE, Drummond MJ, Funai (2021). Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding. FASEB journal, 35(10), e21867.
  11. Cox JE, Thummel CS, Tennessen J (2017). Metabolomic Studies in Drosophila. Genetics, 206(3), 1169-1185.
  12. Jadhav S, Protchenko O, Li F, Baratz E, Shakoury-Elizeh M, Maschek A, Cox J, Philpott C (2021). Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1. Free radical biology & medicine, 175, 18-27.
  13. Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott C (2021). Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis. Hepatology (Baltimore, Md.), 73(3), 1176-1193.
  14. Cox JE, Priestley N (2005). Nonactin biosynthesis: the product of the resistance gene degrades nonactin stereospecifically to form homochiral nonactate dimers. Journal of the American Chemical Society, 127(22), 7976-7.
  15. Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott C (2010). Metabolic response to iron deficiency in Saccharomyces cerevisiae. The Journal of biological chemistry, 285(19), 14823-33.
  16. Ward DM, Chen OS, Li L, Kaplan J, Bhuiyan SA, Natarajan SK, Bard M, Cox J (2018). Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. The Journal of biological chemistry, 293(27), 10782-10795.
  17. Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers S (2021). Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study. The Journal of clinical endocrinology and metabolism, 106(8), e3098-e3109.
  18. Poss AM, Maschek JA, Cox JE, Hauner BJ, Hopkins PN, Hunt SC, Holland WL, Summers SA, Playdon M (2020). Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease. The Journal of clinical investigation, 130(3), 1363-1376.
  19. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai (2021). Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. The Journal of clinical investigation, 131(8),
  20. Philip M, Funkhouser SA, Chiu EY, Phelps SR, Delrow JJ, Cox J, Fink PJ, Abkowitz J (2015). Heme exporter FLVCR is required for T cell development and peripheral survival. Journal of immunology (Baltimore, Md., 194(4), 1677-85.
  21. Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina (2013). Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. Journal of molecular and cellular cardiology, 64, 20-9.
  22. Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina (2017). Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. Journal of molecular and cellular cardiology, 113, 39-50.
  23. Lin Z, Falkinham JO 3rd, Tawfik KA, Jeffs P, Bray B, Dubay G, Cox JE, Schmidt E (2012). Burkholdines from Burkholderia ambifaria: antifungal agents and possible virulence factors. Journal of natural products, 75(9), 1518-23.
  24. Donia MS, Fricke WF, Partensky F, Cox J, Elshahawi SI, White JR, Phillippy AM, Schatz MC, Piel J, Haygood MG, Ravel J, Schmidt E (2011). Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis. Proceedings of the National Academy of Sciences of the United States of America, 108(51), E1423-32.
  25. Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin (2018). Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Proceedings of the National Academy of Sciences of the United States of America, 115(33), E7871-E7880.
  26. Li H, Chawla G, Hurlburt AJ, Sterrett MC, Zaslaver O, Cox J, Karty JA, Rosebrock AP, Caudy AA, Tennessen J (2017). Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth. Proceedings of the National Academy of Sciences of the United States of America, 114(6), 1353-1358.
  27. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter (2012). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science (New York, N.Y.), 337(6090), 96-100.
  28. Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers S (2019). Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Science (New York, N.Y.), 365(6451), 386-392.
  29. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost (2015). Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science (New York, N.Y.), 347(6217), 75-8.
  30. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round J (2019). T cell-mediated regulation of the microbiota protects against obesity. Science (New York, N.Y.), 365(6451),
  31. McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J, Simcox JA, Yoon D, Prchal JT, Gordeuk V (2013). Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. Journal of molecular medicine (Berlin, Germany), 91(1), 59-67.
  32. Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, Concepcion GP, Olivera BM, Schmidt E (2013). A bacterial source for mollusk pyrone polyketides. Chemistry & biology, 20(1), 73-81.
  33. Tennessen JM, Barry WE, Cox J, Thummel C (2014). Methods for studying metabolism in Drosophila. Methods (San Diego, Calif.), 68(1), 105-15.
  34. Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin (2009). Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nature cell biology, 11(3), 320-7.
  35. Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter (2017). Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nature cell biology, 19(9), 1027-1036.
  36. Chalermwat C, Thosapornvichai T, Wongkittichote P, Phillips JD, Cox JE, Jensen AN, Wattanasirichaigoon D, Jensen L (2019). Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. FEMS yeast research, 19(8),
  37. Nuebel E, Morgan JT, Fogarty S, Winter JM, Lettlova S, Berg JA, Chen YC, Kidwell CU, Maschek JA, Clowers KJ, Argyriou C, Chen L, Wittig I, Cox JE, Roh-Johnson M, Braverman N, Bonkowsky J, Gygi SP, Rutter (2021). The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. EMBO reports, 22(10), e51991.
  38. Kohl KD, Weiss RB, Cox J, Dale C, Dearing M (2014). Gut microbes of mammalian herbivores facilitate intake of plant toxins. Ecology letters, 17(10), 1238-46.
  39. Van Vranken JG, Bricker DK, Dephoure N, Gygi SP, Cox JE, Thummel CS, Rutter (2014). SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell metabolism, 20(2), 241-52.
  40. Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor E (2015). Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell metabolism, 22(4), 669-81.
  41. Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima (2019). Glycogen Synthase Kinase-3¿ Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell metabolism, 29(5), 1119-1134.e12.
  42. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva C (2017). Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell metabolism, 26(3), 509-522.e6.
  43. Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, Winge D (2014). The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell metabolism, 20(2), 253-66.
  44. Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos S (2021). The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell metabolism, 33(3), 629-648.e10.
  45. McClelland EE, Ramagopal UA, Rivera J, Cox J, Nakouzi A, Prabu MM, Almo SC, Casadevall (2016). A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals. PLoS pathogens, 12(9), e1005849.
  46. Cortes-Selva D, Gibbs L, Maschek JA, Nascimento M, Van Ry T, Cox JE, Amiel E, Fairfax K (2021). Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure. PLoS pathogens, 17(1), e1009198.
  47. Gleason JE, Corrigan DJ, Cox JE, Reddi AR, McGinnis LA, Culotta V (2011). Analysis of hypoxia and hypoxia-like states through metabolite profiling. PloS one, 6(9), e24741.
  48. Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev A (2015). Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PloS one, 10(3), e0118974.
  49. Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev A (2013). Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PloS one, 8(3), e57821.
  50. Frech TM, Revelo MP, Ryan JJ, Shah AA, Gordon J, Domsic R, Hant F, Assassi S, Shanmugam VK, Hinchcliff M, Steen V, Khanna D, Bernstein EJ, Cox J, Luem N, Drakos (2015). Cardiac metabolomics and autopsy in a patient with early diffuse systemic sclerosis presenting with dyspnea: a case report. Journal of medical case reports, 9, 136.
  51. Weinheimer C, Wang H, Comstock JM, Singh P, Wang Z, Locklear BA, Goodwin KL, Maschek JA, Cox JE, Baack ML, Joss-Moore L (2020). Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Reproductive sciences (Thousand Oaks, Calif.), 27(2), 631-643.
  52. Kumar D, Rahman H, Tyagi E, Liu T, Li C, Lu R, Lum D, Holmen SL, Maschek JA, Cox JE, VanBrocklin MW, Grossman (2018). Aspirin Suppresses PGE2 and Activates AMP Kinase to Inhibit Melanoma Cell Motility, Pigmentation, and Selective Tumor Growth In Vivo. Cancer prevention research (Philadelphia, Pa.), 11(10), 629-642.
  53. Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami R (2018). Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model. Beneficial microbes, 9(3), 495-513.
  54. Fung C, Brown A, Cox J, Callaway C, McKnight R, Lane (2011). Novel thromboxane A2 analog-induced IUGR mouse model. Journal of developmental origins of health and disease, 2(5), 291-301.
  55. Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round J (2017). A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Science translational medicine, 9(380),
  56. Washburn RL, Cox JE, Muhlestein JB, May HT, Carlquist JF, Le VT, Anderson JL, Horne B (2019). Pilot Study of Novel Intermittent Fasting Effects on Metabolomic and Trimethylamine N-oxide Changes During 24-hour Water-Only Fasting in the FEELGOOD Trial. Nutrients, 11(2),
  57. Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner (2015). Detection and in vitro metabolism of AOD9604. Drug testing and analysis, 7(1), 31-8.
  58. Huffaker TB, Ekiz HA, Barba C, Lee SH, Runtsch MC, Nelson MC, Bauer KM, Tang WW, Mosbruger TL, Cox JE, Round JL, Voth WP, O'Connell R (2021). A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages. Nature communications, 12(1), 2620.
  59. Hintze KJ, Cox JE, Rompato G, Benninghoff AD, Ward RE, Broadbent J, Lefevre (2014). Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer. Gut microbes, 5(2), 183-91.
  60. Varedi A, Rahman H, Kumar D, Catrow JL, Cox JE, Liu T, Florell SR, Boucher KM, Okwundu N, Burnett WJ, VanBrocklin MW, Grossman (2020). ASA Suppresses PGE2 in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma. Pharmaceuticals (Basel, Switzerland), 13(1),
  61. Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price J (2019). Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. Oncotarget, 10(4), 449-479.
  62. Szaniawski MA, Spivak AM, Cox JE, Catrow JL, Hanley T, Williams ESCP, Tremblay MJ, Bosque A, Planelles (2018). SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition. mBio, 9(3),
  63. Tennessen JM, Bertagnolli NM, Evans J, Sieber MH, Cox J, Thummel C (2014). Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis. G3 (Bethesda, Md.), 4(5), 839-50.
  64. Naylor BC, Catrow JL, Maschek JA, Cox J (2020). QSRR Automator: A Tool for Automating Retention Time Prediction in Lipidomics and Metabolomics. Metabolites, 10(6),
  65. Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor E (2019). Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. eLife, 8,
  66. Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, DeBerardinis RJ, Rutter (2020). Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. eLife, 9,
  67. Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva C (2020). Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. eLife, 9,
  68. Hibbs JB Jr, Vavrin Z, Cox J (2016). Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose. Redox biology, 8, 271-84.
  69. Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor E (2017). The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Molecular metabolism, 6(11), 1468-1479.
  70. Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai (2020). Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Molecular metabolism, 31, 55-66.
  71. Chaurasia B, Ying L, Talbot CL, Maschek JA, Cox J, Schuchman EH, Hirabayashi Y, Holland WL, Summers S (2021). Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes. Molecular metabolism, 45, 101145.
  72. Liou TG, Adler FR, Cahill BC, Cox DR, Cox JE, Grant GJ, Hanson KE, Hartsell SC, Hatton ND, Helms MN, Jensen JL, Kartsonaki C, Li Y, Leung DT, Marvin JE, Middleton EA, Osburn-Staker SM, Packer KA, Shakir SM, Sturrock AB, Tardif KD, Warren KJ, Waddoups LJ, Weaver LJ, Zimmerman E, Paine R 3r (2021). SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection. Physiological reports, 9(4), e14761.
  73. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai (2019). Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Science advances, 5(9), eaax8352.
  74. Robinson GL, Philip B, Guthrie MR, Cox JE, Robinson JP, VanBrocklin MW, Holmen S (2016). In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation. Cancer research frontiers, 2(2), 311-329.
  75. Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos S (2016). Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning. JACC. Basic to translational science, 1(6), 432-444.
  76. Marcero JR, Cox JE, Bergonia HA, Medlock AE, Phillips JD, Dailey H (2021). The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors. Blood advances, 5(23), 4831-4841.
  77. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel E (2020). Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nature metabolism, 2(11), 1248-1264.
  78. Yan D, Franzini A, Pomicter AD, Halverson BJ, Antelope O, Mason CC, Ahmann JM, Senina AV, Vellore NA, Jones CL, Zabriskie MS, Than H, Xiao MJ, van Scoyk A, Patel AB, Clair PM, Heaton WL, Owen SC, Andersen JL, Egbert CM, Reisz JA, D'Alessandro A, Cox JE, Gantz KC, Redwine HM, Iyer SM, Khorashad JS, Rajabi N, Olsen CA, O'Hare T, Deininger M (2021). SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA. Blood cancer discovery, 2(3), 266-287.
  79. Oka SI, Sreedevi K, Shankar TS, Yedla S, Arowa S, James A, Stone KG, Olmos K, Sabry AD, Horiuchi A, Cawley KM, O'very SA, Tong M, Byun J, Xu X, Kashyap S, Mourad Y, Vehra O, Calder D, Lunde T, Liu T, Li H, Mashchek JA, Cox J, Saijoh Y, Drakos SG, Warren J (2022). PERM1 regulates energy metabolism in the heart via ERR¿/PGC-1¿ axis. Frontiers in cardiovascular medicine, 9, 1033457.
  80. Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham H (2022). An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice. Science (New York, N.Y.), 378(6617), 290-295.
  81. Poss AM, Krick B, Maschek JA, Haaland B, Cox JE, Karra P, Ibele AR, Hunt SC, Adams TD, Holland WL, Playdon MC, Summers S (2022). Following Roux-en-Y gastric bypass surgery, serum ceramides demarcate patients that will fail to achieve normoglycemia and diabetes remission. Med (New York, N.Y.), 3(7), 452-467.e4.
  82. Li Y, Talbot CL, Chandravanshi B, Ksiazek A, Sood A, Chowdhury KH, Maschek JA, Cox J, Babu AKS, Paz HA, Babu PVA, Meyerholz DK, Wankhade UD, Holland W, Shyong Tai E, Summers SA, Chaurasia (2022). Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis. Scientific reports, 12(1), 7273.
  83. VanSant-Webb C, Low HK, Kuramoto J, Stanley CE, Qiang H, Su A, Ross AN, Cooper CG, Cox JE, Summers SA, Evason KJ, Ducker G (2024). Phospholipid isotope tracing suggests ß-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1869(6), 159514.
  84. Xiao T, English AM, Wilson ZN, Maschek JA, Cox JE, Hughes A (2024). The phospholipids cardiolipin and phosphatidylethanolamine differentially regulate MDC biogenesis. The Journal of cell biology, 223(5),
  85. Hansen DT, Rueb NJ, Levinzon ND, Cheatham TE 3rd, Gaston R Jr, Tanvir Ahmed K, Osburn-Staker S, Cox JE, Dudley GB, Barrios A (2024). The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Bioorganic & medicinal chemistry letters, 104, 129740.
  86. Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Lang MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai (2024). Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. The Journal of clinical investigation, 134(11),
  87. Freeman SM, Catrow JL, Cox JE, Turano A, Rich MA, Ihrig HP, Poudyal N, Chang CT, Gese EM, Young JK, Olsen A (2024). Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote (Canis latrans). Comparative medicine, 74(1), 3-11.
  88. Shahtout JL, Eshima H, Ferrara PJ, Maschek JA, Cox JE, Drummond MJ, Funai (2024). Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity. Journal of cachexia, sarcopenia and muscle, 15(1), 319-330.
  89. Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva C (2024). Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. Journal of lipid research, 65(2), 100434.
  90. Li Y, Chaurasia B, Rahman MM, Kaddai V, Maschek JA, Berg JA, Wilkerson JL, Mahmassani ZS, Cox J, Wei P, Meikle PJ, Atkinson D, Wang L, Poss AM, Playdon MC, Tippetts TS, Mousa EM, Nittayaboon K, Anandh Babu PV, Drummond MJ, Clevers H, Shayman JA, Hirabayashi Y, Holland WL, Rutter J, Edgar BA, Summers S (2023). Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Gastroenterology, 165(5), 1136-1150.
  91. Li F, Lin Z, Krug PJ, Catrow JL, Cox JE, Schmidt E (2023). Animal FAS-like polyketide synthases produce diverse polypropionates. Proceedings of the National Academy of Sciences of the United States of America, 120(38), e2305575120.
  92. Zhao J, Ballard C, Cohen AJ, Ringham B, Zhao B, Wang H, Zuspan K, Rebentisch A, Locklear BA, Dahl M, Maschek JA, Cox JE, Joss-Moore L (2023). Postnatal growth restriction impairs rat lung structure and function. Anatomical record (Hoboken, N.J.,
  93. Miljkovic M, Seguin A, Jia X, Cox JE, Catrow JL, Bergonia H, Phillips JD, Stephens WZ, Ward D (2023). Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. The Journal of biological chemistry, 299(7), 104877.
  94. Sharma R, Antypiuk A, Vance SZ, Manwani D, Pearce Q, Cox JE, An X, Yazdanbakhsh K, Vinchi (2023). Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease. Blood, 141(25), 3091-3108.
  95. Ferrara PJ, Lang MJ, Johnson JM, Watanabe S, McLaughlin KL, Maschek JA, Verkerke ARP, Siripoksup P, Chaix A, Cox JE, Fisher-Wellman KH, Funai (2023). Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice. Life metabolism, 2(2),
  96. Berg JA, Zhou Y, Ouyang Y, Cluntun AA, Waller TC, Conway ME, Nowinski SM, Van Ry T, George I, Cox JE, Wang B, Rutter (2023). Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns. Nature cell biology, 25(4), 616-625.
  97. Eshima H, Shahtout JL, Siripoksup P, Pearson MJ, Mahmassani ZS, Ferrara PJ, Lyons AW, Maschek JA, Peterlin AD, Verkerke ARP, Johnson JM, Salcedo A, Petrocelli JJ, Miranda ER, Anderson EJ, Boudina S, Ran Q, Cox JE, Drummond MJ, Funai (2023). Lipid hydroperoxides promote sarcopenia through carbonyl stress. eLife, 12,
  98. Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter (2023). Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science (New York, N.Y.), 379(6636), 996-1003.
  99. Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai (2023). Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Science advances, 9(8), eade7864.
  100. Acuña-Pilarte K, Reichert EC, Green YS, Halberg LM, Golkowski M, Maguire KM, Mimche PN, Kamdem SD, Hu PA, Wright J, Ducker GS, Voth WP, O'Connell RM, McFarland SA, Egal ESA, Chaix A, Summers SA, Reelitz JW, Maschek JA, Cox JE, Evason KJ, Koh M (2025). HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-¿B pathway. Hepatology (Baltimore, Md.), 82(2), 438-453.
  101. Choi RH, Karasawa T, Meza CA, Maschek JA, Manuel AM, Nikolova LS, Fisher-Wellman KH, Cox JE, Chaix A, Funai (2025). Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle. Obesity (Silver Spring, Md.), 33(5), 974-985.
  102. Wong S, Bertram KR, Balasubramaniam SS, Raghuram N, Knight T, Maschek JA, Cox JE, Hughes A (2025). Alterations in Lipid Saturation Trigger Remodeling of the Outer Mitochondrial Membrane. Molecular biology of the cell, mbcE25010033.
  103. Hughes EP, Manna AK, Sun W, Osburn-Staker SM, Aamodt S, Warren KJ, Cox JE, Tantin (2025). Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation. Frontiers in immunology, 16, 1548636.
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  107. Verma S, Giagnocavo SD, Curtin MC, Arumugam M, Osburn-Staker SM, Wang G, Atkinson A, Nix DA, Lum DH, Cox JE, Hilgendorf K (2024). Zinc-alpha-2-glycoprotein Secreted by Triple-Negative Breast Cancer Promotes Peritumoral Fibrosis. Cancer research communications, 4(7), 1655-1666.
  108. Klag KA, Bell R, Jia X, Seguin A, Maschek JA, Bronner M, Cox JE, Round JL, Ward D (2024). Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2. Nutrients, 16(12),
  109. Karasawa T, Hee Choi R, Meza CA, Maschek JA, Cox JE, Funai (2024). Skeletal muscle PGC-1¿ remodels mitochondrial phospholipidome but does not alter energy efficiency for ATP synthesis. bioRxiv,
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  111. Duerre DJ, Hansen JK, John SV, Jen A, Carrillo ND, Bui H, Bao Y, Fabregat M, Catrow JL, Chen LY, Overmyer KA, Shishkova E, Pearce Q, Keller MP, Anderson RA, Cryns VL, Attie AD, Cox JE, Coon JJ, Fan J, Galmozzi (2025). Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue. Nature metabolism, 7(5), 1018-1033.
  112. Naderi J, Johnson AK, Thakkar H, Chandravanshi B, Ksiazek A, Anand A, Vincent V, Tran A, Kalimireddy A, Singh P, Sood A, Das A, Talbot CL, Distefano IA, Maschek JA, Cox J, Li Y, Summers SA, Atkinson DJ, Turapov T, Ratcliff JA, Fung J, Shabbir A, Shabeer Yassin M, Shiow STE, Holland WL, Pitt GS, Chaurasia (2025). Ceramide-induced FGF13 impairs systemic metabolic health. Cell metabolism, 37(5), 1206-1222.e8.

Letter

  1. Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai (2019). Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. Nature metabolism, 1(9), 876-885.

Other

  1. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel E (2020). Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nature metabolism, 2(12), 1498.