Samuel M. Brown

Samuel M. Brown, MD, MS

Languages spoken: English, Russian, Spanish

Academic Information

Departments Primary - Internal Medicine

Divisions: Public Health

Board Certification

  • American Board of Internal Medicine (Sub: Critical Care Medicine)
  • American Board of Internal Medicine (Sub: Pulmonary Disease)

Samuel M. Brown is the Vice President of Research and a Research Professor at Intermountain Health and a Professor of Medicine at the University of Utah. An experienced clinical trialist, he leads a diverse group of investigative teams that focus on high-quality clinical trials, applied epidemiology, implementation science, pragmatic trials, and genomics.

Education History

Fellowship University of Utah School of Medicine/SLC VA Hospital, Department of Anesthesia
 Fellow
Fellowship University of Utah
 Fellow
Graduate Training University of Utah
 MS
Residency Massachusetts General Hospital
 Resident
Internship Massachusetts General Hospital
 Intern
Professional Medical Harvard Medical School
 MD
Undergraduate Harvard College
 AB

Selected Publications

Journal Article

  1. Rahmati K, Brown SM, Bledsoe JR, Passey P, Taillac PP, Youngquist ST, Samore MM, Hough CL, Peltan ID (2024). Validation and comparison of triage-based screening strategies for sepsis. Am J Emerg Med, 85, 140-147. (Read full article)
  2. Ma KC, Surie D, Lauring AS, Martin ET, Leis AM, Papalambros L, Gaglani M, Columbus C, Gottlieb RL, Ghamande S, Peltan ID, Brown SM, Ginde AA, Mohr NM, Gibbs KW, Hager DN, Saeed S, Prekker ME, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Khan A, Hough CL, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Parikh B, Exline MC, Vaughn IA, Ramesh M, Safdar B, Mosier J, Harris ES, Shapiro NI, Felzer J, Zhu Y, Grijalva CG, Halasa N, Chappell JD, Womack KN, Rhoads JP, Baughman A, Swan SA, Johnson CA, Rice TW, Casey JD, Blair PW, Han JH, Ellington S, Lewis NM, Thornburg N, Paden CR, Atherton LJ, Self WH, Dawood FS, DeCuir J (2024). Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity-IVY Network, 26 Hospitals, October 18, 2023-March 9, 2024. Clin Infect Dis. (Read full article)
  3. Peltan ID, Bledsoe JR, Jacobs JR, Groat D, Klippel C, Adamson M, Hooper GA, Tinker NJ, Foster RA, Stenehjem EA, Moores Todd TD, Balls A, Avery J, Brunson G, Jones J, Bair J, Dorais A, Samore MH, Hough CL, Brown SM (2024). Effectiveness and Safety of an Emergency Department Code Sepsis Protocol: A Pragmatic Clinical Trial. Ann Am Thorac Soc. (Read full article)
  4. Ma KC, Surie D, Lauring AS, Martin ET, Leis AM, Papalambros L, Gaglani M, Columbus C, Gottlieb RL, Ghamande S, Peltan ID, Brown SM, Ginde AA, Mohr NM, Gibbs KW, Hager DN, Saeed S, Prekker ME, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Khan A, Hough CL, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Parikh B, Exline MC, Vaughn IA, Ramesh M, Safdar B, Mosier J, Harris ES, Shapiro NI, Felzer J, Zhu Y, Grijalva CG, Halasa N, Chappell JD, Womack KN, Rhoads JP, Baughman A, Swan SA, Johnson CA, Rice TW, Casey JD, Blair PW, Han JH, Ellington S, Lewis NM, Thornburg N, Paden CR, Atherton LJ, Self WH, Dawood FS, DeCuir J (2024). Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity - IVY Network, 26 Hospitals, October 18, 2023-March 9, 2024. (Read full article)
  5. Bose S, Groat D, Stollings JL, Barney P, Dinglas VD, Goodspeed VM, Carmichael H, Mir-Kasimov M, Jackson JC, Needham DM, Brown SM, Sevin CM, APICS-01 Study Team (2024). Prescription of potentially inappropriate medications after an intensive care unit stay for acute respiratory failure. Aust Crit Care. (Read full article)
  6. Hendrickson KW, Cirulis MM, Burk RE, Lanspa MJ, Peltan ID, Marshall H, Groat D, Jephson A, Beesley SJ, Brown SM (2024). Identifying predictors and determining mortality rates of septic cardiomyopathy and sepsis-related cardiogenic shock: A retrospective, observational study. PLoS One, 19(4), e0299876. (Read full article)
  7. Myers LC, Peltan ID, Thai KK, Kipnis P, Desai M, Devis Y, Clancy H, Lu YW, Brown SM, Go AS, Neugebauer RS, Liu VX, Walkey AJ (2024). Predicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation. J Hosp Med. (Read full article)
  8. Surie D, Yuengling KA, DeCuir J, Zhu Y, Lauring AS, Gaglani M, Ghamande S, Peltan ID, Brown SM, Ginde AA, Martinez A, Mohr NM, Gibbs KW, Hager DN, Ali H, Prekker ME, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Leis AM, Khan A, Hough CL, Bender WS, Duggal A, Bendall EE, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Exline MC, Shapiro NI, Columbus C, Vaughn IA, Ramesh M, Mosier JM, Safdar B, Casey JD, Talbot HK, Rice TW, Halasa N, Chappell JD, Grijalva CG, Baughman A, Womack KN, Swan SA, Johnson CA, Lwin CT, Lewis NM, Ellington S, McMorrow ML, Martin ET, Self WH, Investigating Respiratory Viruses in the Acutely Ill IVY Network (2024). Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults. JAMA Netw Open, 7(4), e244954. (Read full article)
  9. Callahan SJ, Beck E, Blagev D, Harris D, Lanspa M, Brown S, Reilly CA, Paine Iii R, Warren KJ (2024). Vitamin E Acetate is Associated with Select Proinflammatory Cytokines: An Analysis of a 2020-2022 Cohort of EVALI Patients. Am J Respir Crit Care Med. (Read full article)
  10. DeCuir J, Payne AB, Self WH, Rowley EAK, Dascomb K, DeSilva MB, Irving SA, Grannis SJ, Ong TC, Klein NP, Weber ZA, Reese SE, Ball SW, Barron MA, Naleway AL, Dixon BE, Essien I, Bride D, Natarajan K, Fireman B, Shah AB, Okwuazi E, Wiegand R, Zhu Y, Lauring AS, Martin ET, Gaglani M, Peltan ID, Brown SM, Ginde AA, Mohr NM, Gibbs KW, Hager DN, Prekker M, Mohamed A, Srinivasan V, Steingrub JS, Khan A, Busse LW, Duggal A, Wilson JG, Chang SY, Mallow C, Kwon JH, Exline MC, Columbus C, Vaughn IA, Safdar B, Mosier JM, Harris ES, Casey JD, Chappell JD, Grijalva CG, Swan SA, Johnson C, Lewis NM, Ellington S, Adams K, Tenforde MW, Paden CR, Dawood FS, Fleming-Dutra KE, Surie D, Link-Gelles R, CDC COVID-19 Vaccine Effectiveness Collaborators (2024). Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024. MMWR Morb Mortal Wkly Rep, 73(8), 180-188. (Read full article)
  11. Hooper GA, Butler AM, Guidry D, Kumar N, Brown K, Beninati W, Brown SM, Peltan ID (2024). Relationship Between Resuscitation Team Members' Self-Efficacy and Team Competence During In-Hospital Cardiac Arrest. Crit Care Explor, 6(1), e1029. (Read full article)
  12. Carr JR, Knox DB, Butler AM, Lum MM, Jacobs JR, Jephson AR, Jones BE, Brown SM, Dean NC (2023). ICU Utilization After Implementation of Minor Severe Pneumonia Criteria in Real-Time Electronic Clinical Decision Support. Crit Care Med. (Read full article)
  13. Lewis NM, Zhu Y, Peltan ID, Gaglani M, McNeal T, Ghamande S, Steingrub JS, Shapiro NI, Duggal A, Bender WS, Taghizadeh L, Brown SM, Hager DN, Gong MN, Mohamed A, Exline MC, Khan A, Wilson JG, Qadir N, Chang SY, Ginde AA, Mohr NM, Mallow C, Lauring AS, Johnson NJ, Gibbs KW, Kwon JH, Columbus C, Gottlieb RL, Raver C, Vaughn IA, Ramesh M, Johnson C, Lamerato L, Safdar B, Casey JD, Rice TW, Halasa N, Chappell JD, Grijalva CG, Talbot HK, Baughman A, Womack KN, Swan SA, Harker E, Price A, DeCuir J, Surie D, Ellington S, Self WH, Investigating Respiratory Viruses in the Acutely Ill IVY Network (2023). Vaccine Effectiveness Against Influenza A-Associated Hospitalization, Organ Failure, and Death: United States, 2022-2023. Clin Infect Dis. (Read full article)
  14. Young ED, Ferguson SH, Brewer LM, Schiedermayer BF, Brown SM, Leither LM (2023). Using a novel in-mask non-invasive ventilator microphone to improve talker intelligibility in healthy and hospitalised adults. Int J Speech Lang Pathol, 1-16. (Read full article)
  15. Surie D, Yuengling KA, DeCuir J, Zhu Y, Gaglani M, Ginde AA, Talbot HK, Casey JD, Mohr NM, Ghamande S, Gibbs KW, Files DC, Hager DN, Ali H, Prekker ME, Gong MN, Mohamed A, Johnson NJ, Steingrub JS, Peltan ID, Brown SM, Leis AM, Khan A, Hough CL, Bender WS, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Exline MC, Lauring AS, Shapiro NI, Columbus C, Vaughn IA, Ramesh M, Safdar B, Halasa N, Chappell JD, Grijalva CG, Baughman A, Rice TW, Womack KN, Han JH, Swan SA, Mukherjee I, Lewis NM, Ellington S, McMorrow ML, Martin ET, Self WH, IVY Network (2023). Disease Severity of Respiratory Syncytial Virus Compared with COVID-19 and Influenza Among Hospitalized Adults Aged ≥60 Years - IVY Network, 20 U.S. States, February 2022-May 2023. MMWR Morb Mortal Wkly Rep, 72(40), 1083-1088. (Read full article)
  16. Han JH, Jackson JC, Orun OM, Brown SM, Casey JD, Clark L, Collins SP, Cordero K, Ginde AA, Gong MN, Hough CL, Iwashyna TJ, Kiehl AL, Lauck A, Leither LM, Lindsell CJ, Patel MB, Raman R, Rice TW, Ringwood NJ, Sheppard KL, Semler MW, Thompson BT, Ely EW, Self WH, National Heart Lung and Blood Institute PETAL Clinical Trials Network (2023). Modifiable in-hospital factors for 12-month global cognition, post-traumatic stress disorder symptoms, and depression symptoms in adults hospitalized with COVID-19. Influenza Other Respir Viruses, 17(9), e13197. (Read full article)
  17. Harris BRE, Butler A, Hirshberg EL, Hopkins RO, Butler J, Orme J, Brown SM, Beesley SJ (2023). Trainees' Experience of Family Presence during Intensive Care Unit Procedures. ATS Sch, 4(4), 469-473. (Read full article)
  18. Surie D, Bonnell LN, DeCuir J, Gaglani M, McNeal T, Ghamande S, Steingrub JS, Shapiro NI, Busse LW, Prekker ME, Peltan ID, Brown SM, Hager DN, Ali H, Gong MN, Mohamed A, Khan A, Wilson JG, Qadir N, Chang SY, Ginde AA, Huynh D, Mohr NM, Mallow C, Martin ET, Lauring AS, Johnson NJ, Casey JD, Gibbs KW, Kwon JH, Baughman A, Chappell JD, Hart KW, Grijalva CG, Rhoads JP, Swan SA, Keipp Talbot H, Womack KN, Zhu Y, Tenforde MW, Adams K, Self WH, McMorrow ML (2023). Comparison of mRNA vaccine effectiveness against COVID-19-associated hospitalization by vaccination source: Immunization information systems, electronic medical records, and self-report-IVY Network, February 1-August 31, 2022. Vaccine, 41(29), 4249-4256. (Read full article)
  19. Brown SM, Barkauskas CE, Grund B, Sharma S, Phillips AN, Leither L, Peltan ID, Lanspa M, Gilstrap DL, Mourad A, Lane K, Beitler JR, Serra AL, Garcia I, Almasri E, Fayed M, Hubel K, Harris ES, Middleton EA, Barrios MAG, Mathews KS, Goel NN, Acquah S, Mosier J, Hypes C, Salvagio Campbell E, Khan A, Hough CL, Wilson JG, Levitt JE, Duggal A, Dugar S, Goodwin AJ, Terry C, Chen P, Torbati S, Iyer N, Sandkovsky US, Johnson NJ, Robinson BRH, Matthay MA, Aggarwal NR, Douglas IS, Casey JD, Hache-Marliere M, Georges Youssef J, Nkemdirim W, Leshnower B, Awan O, Pannu S, OMahony DS, Manian P, Awori Hayanga JW, Wortmann GW, Tomazini BM, Miller RF, Jensen JU, Murray DD, Bickell NA, Zatakia J, Burris S, Higgs ES, Natarajan V, Dewar RL, Schechner A, Kang N, Arenas-Pinto A, Hudson F, Ginde AA, Self WH, Rogers AJ, Oldmixon CF, Morin H, Sanchez A, Weintrob AC, Cavalcanti AB, Davis-Karim A, Engen N, Denning E, Taylor Thompson B, Gelijns AC, Kan V, Davey VJ, Lundgren JD, Babiker AG, Neaton JD, Lane HC, ACTIV-3bTherapeutics for Severely Ill Inpatients with COVID-19 TESICO Study Group (2023). Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial. Lancet Respir Med, 11(9), 791-803. (Read full article)
  20. Warren KJ, Beck EM, Callahan SJ, Helms MN, Middleton E, Maddock S, Carr JR, Harris D, Blagev DP, Lanspa MJ, Brown SM, Paine R 3rd (2023). Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype. Respir Res, 24(1), 162. (Read full article)
  21. Lanspa MJ, Dugar SP, Prigmore HL, Boyd JS, Rupp JD, Lindsell CJ, Rice TW, Qadir N, Lim GW, Shiloh AL, Dieiev V, Gong MN, Fox SW, Hirshberg EL, Khan A, Kornfield J, Schoeneck JH, Macklin N, Files DC, Gibbs KW, Prekker ME, Parsons-Moss D, Bown M, Olsen TD, Knox DB, Cirulis MM, Mehkri O, Duggal A, Tenforde MW, Patel MM, Self WH, Brown SM, Influenza and Other Viruses in the Acutely Ill Network (2023). Early Serial Echocardiographic and Ultrasonographic Findings in Critically Ill Patients With COVID-19. CHEST Crit Care, 1(1), 100002. (Read full article)
  22. Kojima N, Adams K, Self WH, Gaglani M, McNeal T, Ghamande S, Steingrub JS, Shapiro NI, Duggal A, Busse LW, Prekker ME, Peltan ID, Brown SM, Hager DN, Ali H, Gong MN, Mohamed A, Exline MC, Khan A, Wilson JG, Qadir N, Chang SY, Ginde AA, Withers CA, Mohr NM, Mallow C, Martin ET, Lauring AS, Johnson NJ, Casey JD, Stubblefield WB, Gibbs KW, Kwon JH, Baughman A, Chappell JD, Hart KW, Jones ID, Rhoads JP, Swan SA, Womack KN, Zhu Y, Surie D, McMorrow ML, Patel MM, Tenforde MW, Investigating Respiratory Viruses in the Acutely Ill IVY Network (2023). Changing Severity and Epidemiology of Adults Hospitalized With Coronavirus Disease 2019 (COVID-19) in the United States After Introduction of COVID-19 Vaccines, March 2021-August 2022. Clin Infect Dis. (Read full article)
  23. DeCuir J, Surie D, Zhu Y, Gaglani M, Ginde AA, Douin DJ, Talbot HK, Casey JD, Mohr NM, McNeal T, Ghamande S, Gibbs KW, Files DC, Hager DN, Phan M, Prekker ME, Gong MN, Mohamed A, Johnson NJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Bender WS, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Exline MC, Lauring AS, Shapiro NI, Columbus C, Gottlieb R, Vaughn IA, Ramesh M, Lamerato LE, Safdar B, Halasa N, Chappell JD, Grijalva CG, Baughman A, Womack KN, Rhoads JP, Hart KW, Swan SA, Lewis N, McMorrow ML, Self WH, IVY Network (2023). Effectiveness of Monovalent mRNA COVID-19 Vaccination in Preventing COVID-19-Associated Invasive Mechanical Ventilation and Death Among Immunocompetent Adults During the Omicron Variant Period - IVY Network, 19 U.S. States, February 1, 2022-January 31, 2023. MMWR Morb Mortal Wkly Rep, 72(17), 463-468. (Read full article)
  24. Hooper GA, Stenehjem EA, Bledsoe JR, Brown SM, Peltan ID (2023). Reply to Adelman et al. Clin Infect Dis. (Read full article)
  25. Self WH, Shotwell MS, Gibbs KW, de Wit M, Files DC, Harkins M, Hudock KM, Merck LH, Moskowitz A, Apodaca KD, Barksdale A, Safdar B, Javaheri A, Sturek JM, Schrager H, Iovine N, Tiffany B, Douglas IS, Levitt J, Busse LW, Ginde AA, Brown SM, Hager DN, Boyle K, Duggal A, Khan A, Lanspa M, Chen P, Puskarich M, Vonderhaar D, Venkateshaiah L, Gentile N, Rosenberg Y, Troendle J, Bistran-Hall AJ, DeClercq J, Lavieri R, Joly MM, Orr M, Pulley J, Rice TW, Schildcrout JS, Semler MW, Wang L, Bernard GR, Collins SP, ACTIV-4 Host Tissue Investigators (2023). Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials. JAMA, 329(14), 1170-1182. (Read full article)
  26. Brown SM, Katz MJ, Ginde AA, Juneja K, Ramchandani M, Schiffer JT, Vaca C, Gottlieb RL, Tian Y, Elboudwarej E, Hill JA, Gilson R, Rodriguez L, Hedskog C, Chen S, Montezuma-Rusca JM, Osinusi A, Paredes R (2023). Consistent Effects of Early Remdesivir on Symptoms and Disease Progression Across At-Risk Outpatient Subgroups: Treatment Effect Heterogeneity in PINETREE Study. Infect Dis Ther, 12(4), 1189-1203. (Read full article)
  27. Grissom CK, Lanspa MJ, Groat D, Jacobs JR, Carpenter L, Kuttler KG, Leither L, Peltan ID, Brown SM, Srivastava R (2023). Implementation of Lung-Protective Ventilation in Patients With Acute Respiratory Failure. Crit Care Med, 51(6), 797-807. (Read full article)
  28. Kaizer AM, Shapiro NI, Wild J, Brown SM, Cwik BJ, Hart KW, Jones AE, Pulia MS, Self WH, Smith C, Smith SA, Ng PC, Thompson BT, Rice TW, Lindsell CJ, Ginde AA (2022). Lopinavir/ritonavir for treatment of non-hospitalized patients with COVID-19: a randomized clinical trial. Int J Infect Dis, 128, 223-229. (Read full article)
  29. Hooper GA, Klippel CJ, McLean SR, Stenehjem EA, Webb BJ, Murnin ER, Hough CL, Bledsoe JR, Brown SM, Peltan ID (2023). Concordance Between Initial Presumptive Versus Final Adjudicated Diagnoses of Infection Among Patients Meeting Sepsis-3 Criteria in the Emergency Department. Clin Infect Dis. (Read full article)
  30. National Heart Lung and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, Hough CL, Huang W, Iwashyna TJ, Jones AE, Khan A, Lai P, Liu KD, Miller CD, Oldmixon K, Park PK, Rice TW, Ringwood N, Semler MW, Steingrub JS, Talmor D, Thompson BT, Yealy DM, Self WH (2023). Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med, 388(6), 499-510. (Read full article)
  31. Bose S, Groat D, Dinglas VD, Akhlaghi N, Banner-Goodspeed V, Beesley SJ, Greene T, Hopkins RO, Mir-Kasimov M, Sevin CM, Turnbull AE, Jackson JC, Needham DM, Brown SM, Addressing Post-Intensive Care Syndrome APICS-01 Study Team (2023). Association Between Unmet Nonmedication Needs After Hospital Discharge and Readmission or Death Among Acute Respiratory Failure Survivors: A Multicenter Prospective Cohort Study. Crit Care Med, 51(2), 212-221. (Read full article)
  32. Seth B, Kalva T, Eakin MN, Bose S, Mir-Kasimov M, Sevin CM, Jackson JC, Brown SM, Needham DM, Dinglas VD, Addressing Post-Intensive Care Syndrome APICS-01 research group (2023). Acute Respiratory Failure Survivors' Feedback on a Phone-Based Follow-Up Using a Core Outcome Set. Ann Am Thorac Soc, 20(5), 763-765. (Read full article)
  33. Admon AJ, Iwashyna TJ, Kamphuis LA, Gundel SJ, Sahetya SK, Peltan ID, Chang SY, Han JH, Vranas KC, Mayer KP, Hope AA, Jolley SE, Caldwell E, Monahan ML, Hauschildt K, Brown SM, Aggarwal NR, Thompson BT, Hough CL, National Heart Lung and Blood Institute PETAL Network (2023). Assessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months. JAMA Netw Open, 6(2), e2255795. (Read full article)
  34. Turnbull AE, Lee EM, Dinglas VD, Beesley S, Bose S, Banner-Goodspeed V, Hopkins RO, Jackson JC, Mir-Kasimov M, Sevin CM, Brown SM, Needham DM, APICS-01 Study Team (2023). Health Expectations and Quality of Life After Acute Respiratory Failure: A Multicenter Prospective Cohort Study. Chest. (Read full article)
  35. Lewis NM, Murray N, Adams K, Surie D, Gaglani M, Ginde AA, McNeal T, Ghamande S, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Ali H, Prekker ME, Frosch AE, Exline MC, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Lauring AS, Khan A, Hough CL, Busse LW, Bender W, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Chappell JD, Halasa N, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Lindsell CJ, Hart KW, Rhoads JP, McMorrow ML, Tenforde MW, Self WH, Patel MM, Influenza and Other Viruses in the Acutely Ill IVY Network (2022). Absolute and Relative Vaccine Effectiveness of Primary and Booster Series of COVID-19 Vaccines (mRNA and Adenovirus Vector) Against COVID-19 Hospitalizations in the United States, December 2021-April 2022. Open Forum Infect Dis, 10(1), ofac698. (Read full article)
  36. Surie D, DeCuir J, Zhu Y, Gaglani M, Ginde AA, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, McNeal T, Ghamande S, Gibbs KW, Files DC, Hager DN, Ali H, Taghizadeh L, Gong MN, Mohamed A, Johnson NJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Khan A, Bender WS, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Exline MC, Lauring AS, Shapiro NI, Columbus C, Halasa N, Chappell JD, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Womack KN, Rhoads JP, Hart KW, Swan SA, Lewis NM, McMorrow ML, Self WH, IVY Network (2022). Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19-Associated Hospitalization Among Immunocompetent Adults Aged ≥65 Years - IVY Network, 18 States, September 8-November 30, 2022. MMWR Morb Mortal Wkly Rep, 71(5152), 1625-1630. (Read full article)
  37. Campbell RA, Manne BK, Banerjee M, Middleton EA, Ajanel A, Schwertz H, Denorme F, Stubben C, Montenont E, Saperstein S, Page L, Tolley ND, Lim DL, Brown SM, Grissom CK, Sborov DW, Krishnan A, Rondina MT (2022). IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. J Clin Invest, 132(23). (Read full article)
  38. Turbyfill C, Adams K, Tenforde MW, Murray NL, Gaglani M, Ginde AA, McNeal T, Ghamande S, Douin DJ, Keipp Talbot H, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Clark Files D, Hager DN, Shehu A, Prekker ME, Frosch AE, Exline MC, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Lauring AS, Khan A, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, June Gordon A, Qadir N, Chang SY, Mallow C, Rivas C, Kwon JH, Halasa N, Chappell JD, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Rhoads JP, Lindsell CJ, Hart KW, McMorrow M, Surie D, Self WH, Patel MM (2022). Comparison of test-negative and syndrome-negative controls in SARS-CoV-2 vaccine effectiveness evaluations for preventing COVID-19 hospitalizations in the United States. Vaccine, 40(48), 6979-6986. (Read full article)
  39. Peltan ID, Knighton AJ, Barney BJ, Wolfe D, Jacobs JR, Klippel C, Allen L, Lanspa MJ, Leither LM, Brown SM, Srivastava R, Grissom CK (2022). Delivery of Lung Protective Ventilation for Acute Respiratory Distress Syndrome: A Hybrid Implementation-Effectiveness Trial. Ann Am Thorac Soc. (Read full article)
  40. Surie D, Bonnell L, Adams K, Gaglani M, Ginde AA, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, McNeal T, Ghamande S, Gibbs KW, Files DC, Hager DN, Shehu A, Frosch AP, Erickson HL, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Khan A, Bender WS, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Rivas C, Kwon JH, Exline MC, Lauring AS, Shapiro NI, Halasa N, Chappell JD, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Womack KN, Hart KW, Swan SA, Zhu Y, DeCuir J, Tenforde MW, Patel MM, McMorrow ML, Self WH, IVY Network (2022). Effectiveness of Monovalent mRNA Vaccines Against COVID-19-Associated Hospitalization Among Immunocompetent Adults During BA.1/BA.2 and BA.4/BA.5 Predominant Periods of SARS-CoV-2 Omicron Variant in the United States - IVY Network, 18 States, December 26, 2021-August 31, 2022. MMWR Morb Mortal Wkly Rep, 71(42), 1327-1334. (Read full article)
  41. Turnbull AE, Lee EM, Dinglas VD, Beesley S, Bose S, Banner-Goodspeed V, Hopkins RO, Jackson JC, Mir-Kasimov M, Sevin CM, Brown SM, Needham DM, APICS-01 Study Team (2022). Fulfillment of Patient Expectations after Acute Respiratory Failure: A Multicenter Prospective Cohort Study. Ann Am Thorac Soc, 20(4), 566-573. (Read full article)
  42. Adams K, Rhoads JP, Surie D, Gaglani M, Ginde AA, McNeal T, Talbot HK, Casey JD, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Frosch AE, Exline MC, Mohamed A, Johnson NJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Lauring AS, Khan A, Busse LW, Duggal A, Wilson JG, Chang SY, Mallow C, Kwon JH, Chappell JD, Halasa N, Grijalva CG, Lindsell CJ, Lester SN, Thornburg NJ, Park S, McMorrow ML, Patel MM, Tenforde MW, Self WH, Influenza and other Viruses in the AcutelY ill IVY Network (2022). Vaccine effectiveness of primary series and booster doses against covid-19 associated hospital admissions in the United States: living test negative design study. BMJ, 379, e072065. (Read full article)
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  136. Wiegers SE, Ryan T, Arrighi JA, Brown SM, Canaday B, Damp JB, Diaz-Gomez JL, Figueredo VM, Garcia MJ, Gillam LD, Griffin BP, Kirkpatrick JN, Klarich KW, Lui GK, Maffett S, Naqvi TZ, Patel AR, Poulin MF, Rose GA, Swaminathan M (2019). 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): A Report of the ACC Competency Management Committee. Catheter Cardiovasc Interv, 94(3), 481-505. (Read full article)
  137. Brown SM, Bose S, Banner-Goodspeed V, Beesley SJ, Dinglas VD, Hopkins RO, Jackson JC, Mir-Kasimov M, Needham DM, Sevin CM, Addressing Post Intensive Care Syndrome 01 APICS-01 study team (2019). Approaches to Addressing Post-Intensive Care Syndrome among Intensive Care Unit Survivors. A Narrative Review. Ann Am Thorac Soc, 16(8), 947-956. (Read full article)
  138. Writing Committee Members, Wiegers SE, Ryan T, Arrighi JA, Brown SM, Canaday B, Damp JB, Diaz-Gomez JL, Figueredo VM, Garcia MJ, Gillam LD, Griffin BP, Kirkpatrick JN, Klarich KW, Lui GK, Maffett S, Naqvi TZ, Patel AR, Poulin MF, Rose GA, Swaminathan M, ACC Competency Management Committee, Arrighi JA, Mendes LA, Adams JE 3rd, Brush JE Jr, Dec GW Jr, Denktas A, Fernandes S, Freeman R, Hahn RT, Halperin JL, Housholder-Hughes SD, Khan SS, Klarich KW, Lin CH, Marine JE, McPherson JA, Niazi K, Ryan T, Solomon MA, Spicer RL, Tam M, Wang A, Weissman G, Weitz HH, Williams ES (2019). 2019 ACC/AHA/ASE Advanced Training Statement on Echocardiography (Revision of the 2003 ACC/AHA Clinical Competence Statement on Echocardiography): A Report of the ACC Competency Management Committee. J Am Soc Echocardiogr, 32(8), 919-943. (Read full article)
  139. Tang Y, Brown S, Sorensen J, Harley JB (2019). Reduced Rank Least Squares for Real-Time Short Term Estimation of Mean Arterial Blood Pressure in Septic Patients Receiving Norepinephrine. IEEE J Transl Eng Health Med, 7, 4100209. (Read full article)
  140. National Heart Lung and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC (2019). Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med, 380(21), 1997-2008. (Read full article)
  141. Brown SM, Grissom CK, Moss M, Rice TW, Schoenfeld D, Hou PC, Thompson BT, Brower RG, NIHNHLBI PETAL Network Collaborators (2016). Nonlinear Imputation of Pao2/Fio2 From Spo2/Fio2 Among Patients With Acute Respiratory Distress Syndrome. Chest, 150(2), 307-13. (Read full article)
  142. Godard S, Herry C, Westergaard P, Scales N, Brown S, Burns K, Mehta S, Jacono F, Kubelik D, Maziak DE, Marshall J, Martin C, Seely A (2015). Practice variation in spontaneous breathing trial performance and documentation. Can Respir J. (Read full article)
  143. Brown SM, Tate MQ, Jones JP, Kuttler KG, Lanspa MJ, Rondina MT, Grissom CK, Mathews VJ (2015). Coefficient of Variation of Coarsely Sampled Heart Rate is Associated With Early Vasopressor Independence in Severe Sepsis and Septic Shock. J Intensive Care Med, 30(7), 420-5. (Read full article)
  144. Walkey AJ, Pencina KM, Knox D, Kuttler KG, DAgostino RB Sr, Benjamin EJ, Brown SM (2015). Five-Year Risk of Mechanical Ventilation in Community-Dwelling Adults: The Framingham-Intermountain Anticipating Life Support Study. J Am Geriatr Soc, 63(10), 2082-8. (Read full article)
  145. Lanspa MJ, Pittman JE, Hirshberg EL, Wilson EL, Olsen T, Brown SM, Grissom CK (2015). Association of left ventricular longitudinal strain with central venous oxygen saturation and serum lactate in patients with early severe sepsis and septic shock. Crit Care, 19(1), 304. (Read full article)
  146. Knox DB, Lanspa MJ, Kuttler KG, Brewer SC, Brown SM (2015). Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med, 41(5), 814-22. (Read full article)
  147. Brown SM, Grissom CK, Rondina MT, Hoidal JR, Scholand MB, Wolff RK, Morris AH, Paine R 3rd, NIHNHLBI ARDS Network (2015). Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome. Exp Lung Res, 41(3), 155-62. (Read full article)
  148. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom CK (2015). Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. J Gerontol A Biol Sci Med Sci, 70(2), 225-31. (Read full article)
  149. Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR 3rd, Morris AH, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network (2015). Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med, 43(2), 288-95. (Read full article)
  150. Pratt CM, Hirshberg EL, Jones JP, Kuttler KG, Lanspa MJ, Wilson EL, Hopkins RO, Brown SM (2015). Long-term outcomes after severe shock. Shock, 43(2), 128-32. (Read full article)
  151. Brown SM, Tate Q, Jones JP, Knox DB, Kuttler KG, Lanspa M, Rondina MT, Grissom CK, Behera S, Mathews VJ, Morris A (2013). Initial fractal exponent of heart rate variability is associated with success of early resuscitation in patients with severe sepsis or septic shock: a prospective cohort study. J Crit Care, 28(6), 959-63. (Read full article)
  152. Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP, Intermountain Healthcare Intensive Medicine Clinical Program (2013). Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med, 188(1), 77-82. (Read full article)
  153. Brown SM, Lanspa MJ, Jones JP, Kuttler KG, Li Y, Carlson R, Miller RR 3rd, Hirshberg EL, Grissom CK, Morris AH (2013). Survival after shock requiring high-dose vasopressor therapy. Chest, 143(3), 664-671. (Read full article)
  154. Brown SM, Pittman J, Miller Iii RR, Horton KD, Markewitz B, Hirshberg E, Jones J, Grissom CK (2011). Right and left heart failure in severe H1N1 influenza A infection. Eur Respir J, 37(1), 112-8. (Read full article)

Review

  1. Leither LM, Buckel W, Brown SM (2022). Care of the Seriously Ill Patient with SARS-CoV-2. [Review]. Med Clin North Am, 106(6), 949-960. (Read full article)
  2. Casey JD, Beskow LM, Brown J, Brown SM, Gayat, Ng Gong M, Harhay MO, Jaber S, Jentzer JC, Laterre PF, Marshall JC, Matthay MA, Rice TW, Rosenberg Y, Turnbull AE, Ware LB, Self WH, Mebazaa A, Collins SP (2022). Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19. [Review]. Lancet Respir Med, 10, 700-714. (Read full article)
  3. Moskowitz A, Shotwell MS, Gibbs KW, Harkins M, Rosenberg Y, Troendle J, Merck LH, Files DC, de Wit M, Hudock K, Thompson BT, Gong MN, Ginde AA, Douin DJ, Brown SM, Rubin E, Joly MM, Wang L, Lindsell CJ, Bernard GR, Semler MW, Collins SP, Self WH (2022). Oxygen-Free Days as an Outcome Measure in Clinical Trials of Therapies for COVID-19 and Other Causes of New Onset Hypoxemia. [Review]. Chest, 162, 804-814. (Read full article)

Edited Book

  1. Brown SM, Blaivas M, Hirshberg E, Kasal J, Pustavoitau A (Eds.) (2015). Comprehensive Critical Care Ultrasound. Chicago, IL: Society of Critical Care Medicine.

Commentary

  1. Brown SM, Paine R 3rd (2019). Asking Causal Questions of Observational Data: The Quest Continues. Ann Am Thorac Soc, 16(8), 977-979. (Read full article)

Case Report

  1. Knox DB, Lee V, Leither L, Brown SM (2021). New-Onset Systemic Capillary Leak Syndrome in an Adult Patient with COVID-19. Case Rep Crit Care, 2021, 8098942. (Read full article)
  2. Winward J, Lyckholm L, Brown SM, Mokadem M (2020). Case of relapsing sulfasalazine-induced hypersensitivity syndrome upon re-exposure. BMJ Case Rep, 13(9), e235803. (Read full article)
  3. Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, OBrien EA, Ilstrup SJ, Christensen RD (2019). First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Transfusion, 59(10), 3089-3092. (Read full article)

Editorial

  1. Brown SM (2024). Uncertain Answers - Proton-Pump Inhibition in the ICU. N Engl J Med, 391(1), 78-79. (Read full article)
  2. Peltan ID, Brown SM (2022). What Next? New Drugs, Old Drugs, and New Challenges in Choosing Treatments for Covid-19. NEJM Evid, 1(9), EVIDe2200189. (Read full article)
  3. Lanspa MJ, Brown SM (2020). What We Might Find If We Only Looked. Chest, 159(5), 1715-1716. (Read full article)
  4. Bose S, Hoenig B, Karamourtopoulos M, Banner-Goodspeed V, Brown S (2021). Beyond survival: identifying what matters to survivors of critical illness. Crit Care, 25(1), 129. (Read full article)
  5. Brown SM (2019). The number needed to mourn. Intensive Care Med, 45(8), 1154-1155. (Read full article)

Letter

  1. Lanspa MJ, Cirulis MM, Wiley BM, Olsen TD, Wilson EL, Beesley SM, Brown SM, Hirshberg EL, Grissom CK (2021). Response. [Letter to the editor]. Chest, 160(3), e319-e320. (Read full article)
  2. Lanspa MJ, Olsen TD, Wilson EL, Beesley SM, Brown SM, Hirshberg EL, Grissom CK, Cirulis MM, Wiley BM (2021). Response. [Letter to the editor]. Chest, 159(4), 1685-1686. (Read full article)
  3. Peltan ID, Brown SM, Hough CL (2019). In reply. [Letter to the editor]. Ann Emerg Med, 74(4), 607-608. (Read full article)
  4. Hirshberg EL, Lanspa MJ, Brown SM, Dean NC, Grissom CK (2019). The authors reply. [Letter to the editor]. Crit Care Med, 47(8), e724-e726. (Read full article)
  5. Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ, Shahul S, Brown SM (2018). The authors reply. [Letter to the editor]. Crit Care Med, 46(10), e1013-e1014. (Read full article)
  6. Brown SM (2007). Tiotropium in combination with placebo, salmeterol, or fluticasone salmeterol for chronic obstructive pulmonary disease: possible confounding effect of treatment withdrawal? [Letter to the editor]. Ann Intern Med, 147(12), 882; author reply 882-3. (Read full article)

Other

  1. Adams K, Rhoads JP, Surie D, Gaglani M, Ginde AA, McNeal T, Ghamande S, Huynh D, Talbot HK, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hicks M, Hager DN, Ali H, Prekker ME, Frosch AE, Exline MC, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Lauring AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Chappell JD, Halasa N, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Lindsell CJ, Hart KW, Lester SN, Thornburg NJ, Park S, McMorrow ML, Patel MM, Tenforde MW, Self WH (2022). Vaccine Effectiveness of Primary Series and Booster Doses against Omicron Variant COVID-19-Associated Hospitalization in the United States. United States. (Read full article)
  2. Lauring AS, Tenforde MW, Chappell JD, Gaglani M, Ginde AA, McNeal T, Ghamande S, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Exline MC, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Halasa N, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Womack KN, Rhoads JP, Lindsell CJ, Hart KW, Zhu Y, Adams K, Schrag SJ, Olson SM, Kobayashi M, Verani JR, Patel MM, Self WH, Influenza and Other Viruses in the Acutely Ill IVY Network (2022). Clinical Severity and mRNA Vaccine Effectiveness for Omicron, Delta, and Alpha SARS-CoV-2 Variants in the United States: A Prospective Observational Study. United States. (Read full article)
  3. Stefano LD, Ogburn EL, Ram M, Scharfstein DO, Li T, Khanal P, Baksh SN, McBee N, Gruber J, Gildea MR, Goldenberg NA, Bennani Y, Brown SM, Buckel WR, Clement ME, Mulligan MJ, O Halloran JA, Rauseo AM, Self WH, Semler MW, Seto T, Stout JE, Ulrich RJ, Victory J, Bierer BE, Hanley DF, Freilich D, Pandemic Response COVID-19 Research Collaboration Platform for HCQCQ Pooled Analyses (2022). Hydroxychloroquine/Chloroquine for the Treatment of Hospitalized Patients with COVID-19: An Individual Participant Data Meta-Analysis. United States. (Read full article)
  4. Tenforde MW, Patel MM, Ginde AA, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Gaglani M, McNeal T, Ghamande S, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Exline MC, Gong MN, Mohamed A, Henning DJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CT, Busse L, Lohuis CCT, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Gershengorn HB, Babcock HM, Kwon JH, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Lindsell CJ, Hart KW, Zhu Y, Olson SM, Stephenson M, Schrag SJ, Kobayashi M, Verani JR, Self WH, Influenza and Other Viruses in the Acutely Ill IVY Network (2021). Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States. medRxiv. United States. (Read full article)
  5. Murray DD, Babiker AG, Baker JV, Barkauskas CE, Brown SM, Chang CC, Davey VJ, Gelijns AC, Ginde AA, Grund B, Higgs E, Hudson F, Kan VL, Lane HC, Murray TA, Paredes R, Parmar MKB, Pett S, Phillips AN, Polizzotto MN, Reilly C, Sandkovsky U, Sharma S, Teitelbaum M, Thompson BT, Young BE, Neaton JD, Lundgren JD (2021). Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3). medRxiv. United States. (Read full article)

Patent

  1. Brown SM (2012). Apparatus, systems, and methods for accessing the airway with medical instruments without interruption of assisted respiration (licensed to ReddyPort, LLC). U.S. Patent No. WO2012100016 A1. Washington, D.C.:U.S. Patent and Trademark Office.