Constantine P. Georgopoulos, PhD

Languages spoken: English, French, Modern Greek (1453-)

Academic Information

Departments: Biochemistry - Research Professor

Academic Office Information

costa@biochem.utah.edu

(801) 581-8033

Emma Eccles Jones Research Building
Biochemistry
15 North Medical Drive East, Room: 4520
Salt Lake City, UT 84112

Research Interests

  • Heat Shock Proteins
  • Chaperones
  • Protein Folding
  • E. Coli DnaK and GroEL Chaperone Machines
  • Host-Bacteriophage Interaction

Education History

Postdoctoral Fellowship Stanford University, Department of Biochemistry
Biochemistry 		Postdoctoral Fellow
Doctoral Training Massachusetts Institute of Technology
Microbiology 		Ph.D.
Undergraduate Amherst College
Physics 		B.A.

Selected Publications

  1. Bruel N, Castanie-Cornet MP, Cirinesi AM, Koningstein G, Georgopoulos C, Luirink J, Genevaux P (2012). Hsp33 controls elongation factor-Tu stability and allows Escherichia coli growth in the absence of the major DnaK and trigger factor chaperones. J Biol Chem, 287(53), 44435-46.
  2. Ang D, Georgopoulos C (2012). An ORFan no more: the bacteriophage T4 39.2 gene product, NwgI, modulates GroEL chaperone function. Genetics, 190(3), 989-1000.
  3. Perrody E, Cirinesi AM, Desplats C, Keppel F, Schwager F, Tranier S, Georgopoulos C, Genevaux P (2012). A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor sigma32 of Escherichia coli. PLoS Genet, 8(11), e1003037.
  4. Sakr S, Cirinesi AM, Ullers RS, Schwager F, Georgopoulos C, Genevaux P (2010). Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones. J Biol Chem, 285(30), 23506-14.
  5. Horne BE, Li T, Genevaux P, Georgopoulos C, Landry SJ (2010). The Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain. J Biol Chem, 285(28), 21679-88.